HRP20090681T1 - Derivati 2-fenilpropionske kiseline i farmaceutski pripravci koji ih sadrže - Google Patents
Derivati 2-fenilpropionske kiseline i farmaceutski pripravci koji ih sadrže Download PDFInfo
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- HRP20090681T1 HRP20090681T1 HR20090681T HRP20090681T HRP20090681T1 HR P20090681 T1 HRP20090681 T1 HR P20090681T1 HR 20090681 T HR20090681 T HR 20090681T HR P20090681 T HRP20090681 T HR P20090681T HR P20090681 T1 HRP20090681 T1 HR P20090681T1
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- Croatia
- Prior art keywords
- trifluoromethanesulfonyloxy
- phenyl
- propionamide
- alkyl
- cycloalkyl
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- YPGCWEMNNLXISK-UHFFFAOYSA-N hydratropic acid Chemical class OC(=O)C(C)C1=CC=CC=C1 YPGCWEMNNLXISK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 10
- 230000002265 prevention Effects 0.000 claims abstract 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims abstract 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims abstract 2
- 206010016654 Fibrosis Diseases 0.000 claims abstract 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims abstract 2
- 201000004681 Psoriasis Diseases 0.000 claims abstract 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims abstract 2
- 230000004761 fibrosis Effects 0.000 claims abstract 2
- 208000028867 ischemia Diseases 0.000 claims abstract 2
- 201000001441 melanoma Diseases 0.000 claims abstract 2
- 230000010410 reperfusion Effects 0.000 claims abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 229940080818 propionamide Drugs 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 6
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- -1 1-piperidyl Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- VHWJSJBTUWUEAL-UHFFFAOYSA-N propanamide;hydrochloride Chemical compound Cl.CCC(N)=O VHWJSJBTUWUEAL-UHFFFAOYSA-N 0.000 claims 3
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical group CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- 229910003827 NRaRb Inorganic materials 0.000 claims 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 150000003222 pyridines Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- YPGCWEMNNLXISK-SSDOTTSWSA-N (R)-hydratropic acid Chemical class OC(=O)[C@H](C)C1=CC=CC=C1 YPGCWEMNNLXISK-SSDOTTSWSA-N 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 abstract 2
- 108090001007 Interleukin-8 Proteins 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 2
- 229940096397 interleukin-8 Drugs 0.000 abstract 2
- 210000000440 neutrophil Anatomy 0.000 abstract 2
- 230000007170 pathology Effects 0.000 abstract 2
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 abstract 1
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 abstract 1
- 108010018951 Interleukin-8B Receptors Proteins 0.000 abstract 1
- 206010034277 Pemphigoid Diseases 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 abstract 1
- 208000000594 bullous pemphigoid Diseases 0.000 abstract 1
- 230000003399 chemotactic effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 150000005599 propionic acid derivatives Chemical class 0.000 abstract 1
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A61P17/06—Antipsoriatics
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- A61P19/00—Drugs for skeletal disorders
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
Spojevi derivata 2-(R)-fenilpropionske kiseline, naznačeni time, da su opće formule (I) i njihove farmaceutski prihvatljive soli, gdjeR' skupina je izabrana između-H, OH ikada R' je H, R je izabran između- H, C1-C5-alkil, C3-C6-cikloalkil, C2-C5-alkenil, C1-C5-alkoksi; - heteroaril skupine izabrane između supstituiranog ili nesupstituiranog piridina, pirimidina, pirola, tiofena, indola, tiazola, oksazola; - aminokiselinskog ostatka koji se sastoji od ravnog ili razgranatog C1-C6-alkil, C3-C6-cikloalkil, C2-C6-alkenil, C1-C6-fenilalkil, supstituiranog jednom daljnjom karboksi (COOH) skupinom; - ostatka formule -CH2-CH2-Z-(CH2-CH2O)nR' gdje R' je H ili C1-C5-alkil, n je cijeli broj od 0 do 2 te Z je kisik ili sumpor; - ostatka formule -(CH2)n-NRaRb gdje n je cijeli broj od 0 do 5 i svaki od Ra i Rb, koji mogu biti jednaki ili različiti, je C1-C6-alkil, C2-C6-alkenil ili alternativno Ra i Rb zajedno s atomom dušika na koji su vezani formiraju heterocikl sa 3 do 7 članova formule (II) gdje W predstavlja jednostruku vezu, O, S, N-Rc, pri čemu Rc je H, C1-C6-alkil ili C1-C6-alkilfenil, te n je cijeli broj od 0 do 3, -ostatka formule SO2Rd gdje Rd je C1-C6-alkil, C3-C6-cikloalkil, C2-C6-alkenil, aril i heteroaril; kada R' je OH, R je izabran izmeđuH, C1-C5-alkil, C3-C6-cikloalkil, C2-C5-alkenil. Patent sadrži još 7 patentnih zahtjeva.
Claims (8)
1. Spojevi derivata 2-(R)-fenilpropionske kiseline, naznačeni time, da su opće formule (I)
[image]
i njihove farmaceutski prihvatljive soli,
gdje
R' skupina je izabrana između
-H, OH i
kada R' je H, R je izabran između
- H, C1-C5-alkil, C3-C6-cikloalkil, C2-C5-alkenil, C1-C5-alkoksi;
- heteroaril skupine izabrane između supstituiranog ili nesupstituiranog piridina, pirimidina, pirola, tiofena, indola, tiazola, oksazola;
- aminokiselinskog ostatka koji se sastoji od ravnog ili razgranatog C1-C6-alkil, C3-C6-cikloalkil, C2-C6-alkenil, C1-C6-fenilalkil, supstituiranog jednom daljnjom karboksi (COOH) skupinom;
- ostatka formule –CH2-CH2-Z-(CH2-CH2O)nR' gdje R' je H ili C1-C5-alkil, n je cijeli broj od 0 do 2 te Z je kisik ili sumpor;
- ostatka formule –(CH2)n-NRaRb gdje n je cijeli broj od 0 do 5 i svaki od Ra i Rb, koji mogu biti jednaki ili različiti, je C1-C6-alkil, C2-C6-alkenil ili alternativno Ra i Rb zajedno s atomom dušika na koji su vezani formiraju heterocikl sa 3 do 7 članova formule (II)
[image]
gdje W predstavlja jednostruku vezu, O, S, N-Rc, pri čemu Rc je H, C1-C6-alkil ili C1-C6-alkilfenil, te n je cijeli broj od 0 do 3,
-ostatka formule SO2Rd gdje Rd je C1-C6-alkil, C3-C6-cikloalkil, C2-C6-alkenil, aril i heteroaril;
kada R' je OH, R je izabran između
H, C1-C5-alkil, C3-C6-cikloalkil, C2-C5-alkenil.
2. Spojevi u skladu sa zahtjevom 1, naznačeni time, da
kada R' je H, R je izabran između
H, C1-C5-alkil, C3-C6-cikloalkil, C1-C5-alkoksi, C1-C2-karboksialkil;
heteroaril skupine izabrane između supstituiranog i nesupstituiranog piridina, tiazola, oksazola;
ostatka formule –(CH2)n-NRaRb gdje n je cijeli broj 2 ili 3, povoljnije 3 i skupina NraRb je N, N-dimetilamin, N,N-dietilamin, 1-piperidil, 1-pirolidinil, 4-morfolinil, 1-pirolidil, 1-piperazinil, 1-(4-metil)piperazinil;
ostatka formule SO2Rd gdje Rd je C1-C2-alkil, C3-C6-cikloalkil te
kada R' je OH, R je H, C1-C5-alkil, C3-C6-cikloalkil.
3. Spojevi u skladu sa zahtjevom 1 ili 2, naznačeni time, da su izabrani iz slijedeće skupine:
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-metansulfonil propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-metansulfonil propionamid natrijeva sol;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-metil propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-izopropoksi propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-ciklopentil propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[3-(N'-piperidinil)propil] propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[3-(N'-piperidinil)propil] propionamid hidroklorid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[2-(N'-pirolidinil)etil] propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[2-(N'-pirolidinil)etil] propionamid hidroklorid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[3-(N'-pirolidinil)propil] propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[3-(N'-pirolidinil)propil] propionamid hidroklorid;
R(+)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[2-(2-hidroksietoksi)etil] propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-[2-(4'-trifluorometil)tiazolil] propionamid;
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-metil-N-hidroksi propionamid.
4. Spojevi u skladu sa bilo kojim zahtjevom od 1 do 3, naznačeni time, da su
R(-)-2-[(4'-trifluorometansulfoniloksi)fenil]-N-metansulfonil propionamid i njegova natrijeva sol.
5. Spojevi u skladu sa bilo kojim zahtjevom od 1 do 4, naznačeni time, da se koriste kao lijekovi.
6. Uporaba spojeva u skladu sa bilo kojim zahtjevom od 1 do 4, naznačena time, da se koriste u pripravi lijekova za liječenje psorijaze, ulcerativnog kolitisa, melanoma, angiogeneze, kronične opstruktivne plućne bolesti (COPD), buloznog pemfigusa, reumatoidnog artritisa, idiopatske fibroze, glomerulonefritisa i za prevenciju i liječenje oštećenja uzrokovanih ishemijom i reperfuzijom.
7. Farmaceutski pripravci, naznačeni time, da sadrže spoj u skladu sa bilo kojim zahtjevom od 1 do 4 zajedno s prikladnom podlogom.
8. Postupak priprave spojeva formule (I) u skladu sa zahtjevom 1, gdje R' je H i R je SO2Rd, gdje Rd je C1-C2-alkil ili C3-C6-cikloalkil, naznačen time, da obuhvaća tretiranje R(-)-2-(4'-trifluorometansulfoniloksifenil) propionske kiseline s prikladnim sulfonamidom RdSO2NH2, gdje Rd je C1-C2-alkil ili C3-C6-cikloalkil, u prisutnosti kondenzacijskog sredstva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04101202 | 2004-03-23 | ||
| PCT/EP2005/051302 WO2005090295A2 (en) | 2004-03-23 | 2005-03-21 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090681T1 true HRP20090681T1 (hr) | 2010-02-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| HR20090681T HRP20090681T1 (hr) | 2004-03-23 | 2009-12-22 | Derivati 2-fenilpropionske kiseline i farmaceutski pripravci koji ih sadrže |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8039656B2 (hr) |
| EP (1) | EP1776336B1 (hr) |
| JP (1) | JP4871257B2 (hr) |
| CN (2) | CN1934077B (hr) |
| AT (1) | ATE444286T1 (hr) |
| AU (1) | AU2005223402B2 (hr) |
| CA (1) | CA2553705C (hr) |
| CY (1) | CY1109687T1 (hr) |
| DE (1) | DE602005016937D1 (hr) |
| DK (1) | DK1776336T3 (hr) |
| ES (1) | ES2333445T3 (hr) |
| HK (2) | HK1101392A1 (hr) |
| HR (1) | HRP20090681T1 (hr) |
| ME (1) | ME01763B (hr) |
| NO (1) | NO337685B1 (hr) |
| PL (1) | PL1776336T3 (hr) |
| PT (1) | PT1776336E (hr) |
| RS (1) | RS51109B (hr) |
| RU (1) | RU2375347C2 (hr) |
| SI (1) | SI1776336T1 (hr) |
| WO (1) | WO2005090295A2 (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DK1951663T3 (en) * | 2005-11-24 | 2016-10-10 | Dompé Farm S P A | (r)-arylkylaminoderivater og farmaceutiske sammensætninger indeholdende dem |
| CN101448784B (zh) * | 2006-05-18 | 2012-07-04 | 冬姆佩股份公司 | (2r)-2-[(4-磺酰基)氨基苯基]丙酰胺及含有它们的药物组合物 |
| WO2008075184A2 (en) * | 2006-12-19 | 2008-06-26 | Dompe' Pha.R.Ma S.P.A. | 2-aryl-2-fluoropropanoic acids and derivatives and pharmaceutical compositions containing them |
| EP2166006A1 (en) * | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
| EP2308484A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| EP2316820A1 (en) * | 2009-10-28 | 2011-05-04 | Dompe S.p.A. | 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them |
| MD480Z5 (ro) * | 2011-07-07 | 2012-09-30 | Эльвира АНДОН | Metodă de tratament al colitei ulceroase nespecifice acute |
| CN103159649B (zh) * | 2011-12-19 | 2016-03-09 | 天津市国际生物医药联合研究院 | 磺酰胺类化合物的制备及其应用 |
| CN103159650B (zh) * | 2011-12-19 | 2016-04-20 | 天津市国际生物医药联合研究院 | 芳香杂环磺酰胺类化合物的制备及其应用 |
| US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| EP3117835A1 (en) * | 2015-07-14 | 2017-01-18 | Dompé farmaceutici s.p.a. | Il-8 inhibitors for use in the treatment of certain urological disorders |
| HUE056606T2 (hu) * | 2016-01-15 | 2022-02-28 | Dompe Farm Spa | IL-8 inhibitorok kemoterápia által indukált perifériás neuropathia kezelésében történõ alkalmazásra |
| EP3192504A1 (en) | 2016-01-15 | 2017-07-19 | Dompé farmaceutici S.p.A. | Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy |
| WO2018067548A1 (en) | 2016-10-03 | 2018-04-12 | The Children's Medicial Center Corporation | Prevention and treatment of diabetic nephropathy |
| EP3342407A1 (en) * | 2017-01-03 | 2018-07-04 | Dompé farmaceutici S.p.A. | Il-8 inihibitors for use in the treatment of some urological disorders |
| EP3409277A1 (en) | 2017-05-30 | 2018-12-05 | Dompé farmaceutici s.p.a. | Il-8 inhibitors for use in the treatment and/or prevention of bacterial secondary infections |
| EP3476390A1 (en) | 2017-10-24 | 2019-05-01 | Dompé farmaceutici S.p.A. | Il-8 inhibitors for use in the treatment of sarcomas |
| EP3498269A1 (en) * | 2017-12-12 | 2019-06-19 | Dompé farmaceutici S.p.A. | C5ar inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain |
| EP3868369A1 (en) | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of cancer-related fatigue |
| EP3868368A1 (en) | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof |
| EP4008325A1 (en) | 2020-12-02 | 2022-06-08 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitors for use in the treatment of covid-19 |
| IL296751A (en) | 2020-03-26 | 2022-11-01 | Dompe Farm Spa | cxcl8 inhibitors for use in the treatment of covid-19 |
| EP3884932A1 (en) | 2020-03-26 | 2021-09-29 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitors for use in the treatment of covid-19 |
| EP4052702A1 (en) | 2021-03-04 | 2022-09-07 | Dompé farmaceutici S.p.a. | Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of seizures |
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| ATE242208T1 (de) * | 1997-01-29 | 2003-06-15 | Pfizer | Sulfonylharnstoff-derivate und ihre verwendung in der kontrolle der interleukin-1-aktivität |
| IT1303249B1 (it) * | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
| ITMI20010395A1 (it) | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
| ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
| ITMI20012434A1 (it) * | 2001-11-20 | 2003-05-20 | Dompe Spa | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
| CA2511582C (en) * | 2003-02-06 | 2012-01-24 | Dompe S.P.A. | 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them |
| ATE521589T1 (de) * | 2003-09-25 | 2011-09-15 | Dompe Spa | Amidine und derivate davon und pharmazeutische zusammensetzungen, die diese enthalten |
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- 2005-03-21 EP EP05729779A patent/EP1776336B1/en active Active
- 2005-03-21 CN CN200580008890XA patent/CN1934077B/zh active Active
- 2005-03-21 JP JP2007504413A patent/JP4871257B2/ja active Active
- 2005-03-21 CA CA2553705A patent/CA2553705C/en active Active
- 2005-03-21 RS RSP-2009/0568A patent/RS51109B/sr unknown
- 2005-03-21 AT AT05729779T patent/ATE444286T1/de active
- 2005-03-21 US US10/592,572 patent/US8039656B2/en active Active
- 2005-03-21 DE DE602005016937T patent/DE602005016937D1/de active Active
- 2005-03-21 PL PL05729779T patent/PL1776336T3/pl unknown
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- 2005-03-21 DK DK05729779.8T patent/DK1776336T3/da active
- 2005-03-21 RU RU2006137272/04A patent/RU2375347C2/ru active
- 2005-03-21 PT PT05729779T patent/PT1776336E/pt unknown
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- 2005-03-21 AU AU2005223402A patent/AU2005223402B2/en active Active
- 2005-03-21 WO PCT/EP2005/051302 patent/WO2005090295A2/en active Application Filing
- 2005-03-21 SI SI200530869T patent/SI1776336T1/sl unknown
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