HRP20090334T1 - Kao inhibitori produkcije citokina za liječenje kroničnih upalnih bolesti - Google Patents

Kao inhibitori produkcije citokina za liječenje kroničnih upalnih bolesti

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Publication number
HRP20090334T1
HRP20090334T1 HR20090334T HRP20090334T HRP20090334T1 HR P20090334 T1 HRP20090334 T1 HR P20090334T1 HR 20090334 T HR20090334 T HR 20090334T HR P20090334 T HRP20090334 T HR P20090334T HR P20090334 T1 HRP20090334 T1 HR P20090334T1
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Croatia
Prior art keywords
alkyl
optionally
cr7r8
substituted
group
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HR20090334T
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English (en)
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Cogan Derek
Hao Ming-Hong
Mark Kamhi Victor
A. Miller Craig
Netherton M.R.
D. Swinamer Alan
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Boehringer Ingelheim Pharmaceuticals Inc.
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Publication of HRP20090334T1 publication Critical patent/HRP20090334T1/hr

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D513/04—Ortho-condensed systems

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Abstract

Spoj, naznačen time, da je formule (I) gdje: Ar1 je izabran između (i), (ii) i (iii) ispod: (i) ciklički ugljikovodik supstituiran s R1, R2 i Rx, (ii) gdje jedan od E ili F je dušik i drugi je ugljik, R1 je kovalentno vezan na E ili F, te kada je dušik N-R1 nema dvostruke veze između E i F; (iii) gdje c je benzenski prsten spojen na prsten d koji je 5 do 7 člani heterociklički prsten po izboru supstituiran s okso (=O) skupinom i jedna do dvije R skupina nezavisno jedna od druge je H ili C1-3 alkil; R1 je izabran iz skupine koju čine vodik, NO2, -N(Rc)2, J-C(O)-N(Rc)-, J-S(O)m-N(Rc)-, C1-6 alkilS(O)m-, ili R1 je izabran iz skupine koju čine C1-6 alkil, C3-7 cikloalkil, C1-5 alkoksil ili C3-7 cikloalkoksil, C1-5 alkiltiol ili C3-7 cikloalkiltiol, C1-5 acil, C1-5 alkoksikarbonil, C1-5 aciloksi, C1-5 acilamino, C2-5 alkenil, C2-5 alkinil, heterocikl, heterociklC1-6 alkil, heteroaril, heteroarilC1-6 alkil i nitril; pri čemu svaki od prije navedenih kada je to moguće može po izboru biti djelomično ili potpuno halogeniran ili može po izboru biti dalje supstituiran sa alkilsulfonilamino, aminokarboksil, alkoksil, amino, alkilamino, dialkilamino, hidroksil, okso, nitro ili nitril; R2 je izabran iz skupine koju čine: vodik, halogen, nitril, C1-5 alkilS(O)m-, arilS(O)m-, J-O-C(O)-O-, N(Rc)2-C(O)-(CH2)n-, C1-6 acetil, aroil, C1-6 alkoksikarbonil, C1-6 alkil, C3-7 cikloalkil, C1-6 alkoksi, C3-5 cikloalkoksi, C1-5 alkilC1-5alkoksi, hidroksi, hidroksiC1-5 alkil, te amino po izboru mono- ili di- supstituiran s C1-5 alkil, aril ili arilC1-5 alkil; pri čemu svaki od prije navedenih kada je to moguće može po izboru biti djelomično ili potpuno halogeniran ili može po izboru biti dalje supstituiran sa C1-3 alkil, alkilsulfonilamino, alkoksil, amino, alkilamino, dialkilamino, hidroksil, okso, nitro ili nitril; svaki Rx je izabran između C1-6 alkil ili C3-7 cikloalkil od kojih je svaki po izboru supstituiran sa C1-3 alkil i po izboru je potpuno ili djelomični halogeniran, C1-4 acil, aroil, C1-4 alkoksi, C1-5alkilS(O)m-, od kojih svaki može po izboru biti djelomično ili potpuno halogeniran, halogen, C1-6 alkoksikarbonil, karbociklosulfonil; svaki Rc je nezavisno vodik ili C1-5 alkil; D, A i B u formule (I) su svaki nezavisno izabrani između N ili CH gdje je atom vodika po izboru zamijenjen sa R6;Het je heterociklički ili heteroarilni prsten u kojem je Het po izboru supstituiran sa jednim do tri R5;m je 0, 1 ili 2; J je izabran između C1-10 alkil i C3-7 cikloalkil od koji je svaki po izbru upstituiran sa Rb;R3, R4, R6, R7 i R8 su svaki zasebno izbarani iz skuine koju čine vodik, halogen, C1-5 alkil, C1-5 alkoksi, C1-5 alkilC1-5 alkoksi, hidroksi, hidroksi C1-5 alkil ili amino po izboru mono- ili di- supstituiran sa C1-5 alkil, aril ili aril C1-5 alkil; R5 je: Ra, -O-Ra, -S(O)m-Ra, -N(Ra)2, -C(O)-Ra, -NH(CR7R8)n-Ra, N(Ra)2-(CH2)1-2-, -(CR7R8)n-Ra, -O(CR7R8)n-Ra, -C(O)-O(CR7R8)n-Ra, -C(O) (CR7R8)n-Ra-C(O)C(O)Ra, -C(O)C(O)ORa, -C(O)NHRa ili -C(O)NH(CR7R8)n-, od kojih svaki
HR20090334T 2004-03-09 2009-06-24 Kao inhibitori produkcije citokina za liječenje kroničnih upalnih bolesti HRP20090334T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55144504P 2004-03-09 2004-03-09
PCT/US2005/006997 WO2005090333A1 (en) 2004-03-09 2005-03-04 3-‘4-heterocyclyl -1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases

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HRP20090334T1 true HRP20090334T1 (hr) 2009-07-31

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US (2) US7214802B2 (hr)
EP (2) EP1887003A1 (hr)
JP (1) JP4850824B2 (hr)
KR (1) KR20060129077A (hr)
CN (1) CN1930144A (hr)
AR (1) AR048315A1 (hr)
AT (1) ATE432273T1 (hr)
AU (1) AU2005223738B2 (hr)
BR (1) BRPI0508561A (hr)
CA (1) CA2557856C (hr)
CY (1) CY1109333T1 (hr)
DE (1) DE602005014621D1 (hr)
DK (1) DK1725544T3 (hr)
EA (1) EA011634B1 (hr)
EC (1) ECSP066833A (hr)
ES (1) ES2327940T3 (hr)
HR (1) HRP20090334T1 (hr)
IL (1) IL177937A0 (hr)
MY (1) MY143000A (hr)
NO (1) NO20064120L (hr)
NZ (1) NZ550148A (hr)
PE (1) PE20051146A1 (hr)
PL (1) PL1725544T3 (hr)
PT (1) PT1725544E (hr)
RS (1) RS50796B (hr)
SI (1) SI1725544T1 (hr)
TW (1) TW200602313A (hr)
UA (1) UA85702C2 (hr)
WO (1) WO2005090333A1 (hr)
ZA (1) ZA200606177B (hr)

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