HRP20090161T1 - Non steroidal glucocorticoid receptor modulators - Google Patents

Non steroidal glucocorticoid receptor modulators

Info

Publication number: HRP20090161T1
Authority: HR; Croatia
Prior art keywords: alkyl; halogen; cyano; hetero; aryl
Prior art date: 2005-02-14

Application number

HR20090161T

Other languages

English (en)

Croatian (hr)

Inventor

Plate Ralf

Jenny Rudolf Zaman Guido

Harold Han Hermkens Pedro

Gerardus Johannes Maria Jans Christiaan

Christian Buijsman Rogier

Petrus Antonius De Man Adrianus

Giovanni Martino Conti Paolo

James Lusher Scott

Hendrik Abraham Dokter Willem

Original Assignee

N.V. Organon

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-14

Filing date

2009-03-17

Publication date

2009-05-31

2009-03-17 Application filed by N.V. Organon filed Critical N.V. Organon

2009-05-31 Publication of HRP20090161T1 publication Critical patent/HRP20090161T1/xx

Links

229940117965 Glucocorticoid receptor modulator Drugs 0.000 title 1
230000003637 steroidlike Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 31
229910052736 halogen Inorganic materials 0.000 abstract 16
150000002367 halogens Chemical class 0.000 abstract 16
125000004093 cyano group Chemical group *C#N 0.000 abstract 9
125000003118 aryl group Chemical group 0.000 abstract 8
125000005842 heteroatom Chemical group 0.000 abstract 8
125000003342 alkenyl group Chemical group 0.000 abstract 7
125000003545 alkoxy group Chemical group 0.000 abstract 6
125000000304 alkynyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000005262 alkoxyamine group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
-1 amino, hydroxyl Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

HR20090161T 2005-02-14 2009-03-17 Non steroidal glucocorticoid receptor modulators HRP20090161T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05101086		2005-02-14
PCT/EP2006/050906 WO2006084917A1 (en)	2005-02-14	2006-02-14	Non steroidal glucocorticoid receptor modulators

Publications (1)

Publication Number	Publication Date
HRP20090161T1 true HRP20090161T1 (en)	2009-05-31

Family

ID=34938730

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20090161T HRP20090161T1 (en)	2005-02-14	2009-03-17	Non steroidal glucocorticoid receptor modulators

Country Status (30)

Country	Link
US (1)	US8133885B2 (es)
EP (1)	EP1853601B1 (es)
JP (1)	JP4922950B2 (es)
KR (1)	KR101285454B1 (es)
CN (1)	CN101119995B (es)
AR (1)	AR054329A1 (es)
AT (1)	ATE422497T1 (es)
AU (1)	AU2006212192B2 (es)
BR (1)	BRPI0607341A2 (es)
CA (1)	CA2597748C (es)
CY (1)	CY1109038T1 (es)
DE (1)	DE602006005138D1 (es)
DK (1)	DK1853601T3 (es)
ES (1)	ES2321227T3 (es)
HR (1)	HRP20090161T1 (es)
IL (1)	IL184374A (es)
MX (1)	MX2007008786A (es)
MY (1)	MY147632A (es)
NO (1)	NO20073702L (es)
NZ (1)	NZ556469A (es)
PE (1)	PE20061037A1 (es)
PL (1)	PL1853601T3 (es)
PT (1)	PT1853601E (es)
RS (1)	RS50778B (es)
RU (1)	RU2409577C2 (es)
SI (1)	SI1853601T1 (es)
TW (1)	TWI370129B (es)
UA (1)	UA91352C2 (es)
WO (1)	WO2006084917A1 (es)
ZA (1)	ZA200705899B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI297685B (en)	2002-04-04	2008-06-11	Organon Nv	Non-steroidal progesterone receptor modulators
CA2676670C (en)	2007-02-02	2012-03-13	Pfizer Products Inc.	Tricyclic compounds, compositions, and methods
TW200914029A (en) *	2007-05-07	2009-04-01	Organon Nv	New progesterone receptor modulators
US8063037B2 (en)	2007-05-07	2011-11-22	N. V. Organon	Progesterone receptor modulators
EP2364146B1 (en)	2008-11-07	2019-06-19	University of Sheffield	Medicament and method of diagnosis
HUE048410T2 (hu) *	2015-09-15	2020-07-28	Leo Pharma As	Nem szteroid glükokortikoid receptor modulátorok helyi gyógyszer bejuttatásra

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4054572A (en)	1973-04-26	1977-10-18	Akzona Incorporated	Hexahydro pyridine [1,2d] dibenza [b,f] (1,4)-diazepines
TWI297685B (en) *	2002-04-04	2008-06-11	Organon Nv	Non-steroidal progesterone receptor modulators
US7074806B2 (en) *	2002-06-06	2006-07-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

2006
- 2006-02-08 TW TW095104232A patent/TWI370129B/zh not_active IP Right Cessation
- 2006-02-13 AR ARP060100496A patent/AR054329A1/es not_active Application Discontinuation
- 2006-02-13 PE PE2006000165A patent/PE20061037A1/es not_active Application Discontinuation
- 2006-02-14 ES ES06708243T patent/ES2321227T3/es active Active
- 2006-02-14 SI SI200630260T patent/SI1853601T1/sl unknown
- 2006-02-14 DK DK06708243T patent/DK1853601T3/da active
- 2006-02-14 UA UAA200707948A patent/UA91352C2/ru unknown
- 2006-02-14 JP JP2007554580A patent/JP4922950B2/ja not_active Expired - Fee Related
- 2006-02-14 NZ NZ556469A patent/NZ556469A/en not_active IP Right Cessation
- 2006-02-14 AT AT06708243T patent/ATE422497T1/de active
- 2006-02-14 CN CN2006800047247A patent/CN101119995B/zh not_active Expired - Fee Related
- 2006-02-14 PT PT06708243T patent/PT1853601E/pt unknown
- 2006-02-14 RU RU2007134226/04A patent/RU2409577C2/ru not_active IP Right Cessation
- 2006-02-14 PL PL06708243T patent/PL1853601T3/pl unknown
- 2006-02-14 KR KR1020077020365A patent/KR101285454B1/ko not_active IP Right Cessation
- 2006-02-14 CA CA2597748A patent/CA2597748C/en not_active Expired - Fee Related
- 2006-02-14 MY MYPI20060600A patent/MY147632A/en unknown
- 2006-02-14 MX MXMX07008786A patent/MX2007008786A/es active IP Right Grant
- 2006-02-14 US US11/816,113 patent/US8133885B2/en not_active Expired - Fee Related
- 2006-02-14 WO PCT/EP2006/050906 patent/WO2006084917A1/en active Application Filing
- 2006-02-14 BR BRPI0607341-7A patent/BRPI0607341A2/pt not_active IP Right Cessation
- 2006-02-14 DE DE602006005138T patent/DE602006005138D1/de active Active
- 2006-02-14 EP EP06708243A patent/EP1853601B1/en active Active
- 2006-02-14 RS RSP-2009/0118A patent/RS50778B/sr unknown
- 2006-02-14 AU AU2006212192A patent/AU2006212192B2/en not_active Ceased
2007
- 2007-07-03 IL IL184374A patent/IL184374A/en not_active IP Right Cessation
- 2007-07-18 ZA ZA200705899A patent/ZA200705899B/en unknown
- 2007-07-18 NO NO20073702A patent/NO20073702L/no not_active Application Discontinuation
2009
- 2009-03-17 HR HR20090161T patent/HRP20090161T1/xx unknown
- 2009-04-29 CY CY20091100472T patent/CY1109038T1/el unknown

Also Published As

Publication number	Publication date
NZ556469A (en)	2009-08-28
RU2007134226A (ru)	2009-03-20
US20090062262A1 (en)	2009-03-05
AR054329A1 (es)	2007-06-20
DK1853601T3 (da)	2009-05-18
DE602006005138D1 (de)	2009-03-26
IL184374A (en)	2012-02-29
ES2321227T3 (es)	2009-06-03
TW200640923A (en)	2006-12-01
PL1853601T3 (pl)	2009-07-31
KR101285454B1 (ko)	2013-07-15
JP4922950B2 (ja)	2012-04-25
CY1109038T1 (el)	2014-07-02
MY147632A (en)	2012-12-31
UA91352C2 (en)	2010-07-26
KR20070107750A (ko)	2007-11-07
JP2008530056A (ja)	2008-08-07
TWI370129B (en)	2012-08-11
CN101119995A (zh)	2008-02-06
AU2006212192A1 (en)	2006-08-17
IL184374A0 (en)	2007-10-31
ZA200705899B (en)	2008-07-30
CN101119995B (zh)	2012-01-25
WO2006084917A1 (en)	2006-08-17
RU2409577C2 (ru)	2011-01-20
MX2007008786A (es)	2007-08-03
EP1853601B1 (en)	2009-02-11
CA2597748C (en)	2013-09-24
NO20073702L (no)	2007-09-28
US8133885B2 (en)	2012-03-13
RS50778B (sr)	2010-08-31
SI1853601T1 (sl)	2009-06-30
BRPI0607341A2 (pt)	2010-03-23
ATE422497T1 (de)	2009-02-15
EP1853601A1 (en)	2007-11-14
PE20061037A1 (es)	2006-10-26
PT1853601E (pt)	2009-04-09
CA2597748A1 (en)	2006-08-17
AU2006212192B2 (en)	2011-06-16

Publication	Publication Date	Title
HRP20090161T1 (en)	2009-05-31	Non steroidal glucocorticoid receptor modulators
CY1114908T1 (el)	2016-12-14	Παραγωγα κινολινης ως αντιβακτηριακοι παραγοντες
AR077849A2 (es)	2011-09-28	Compuestos y composiciones como inhibidores de proteina quinasa
TW200734322A (en)	2007-09-16	Indole derivatives exhibiting PGD2 receptor antagonism
CY1111628T1 (el)	2015-10-07	Υποκατεστημενες ενωσεις δικυκλολακταμης
MX344669B (es)	2017-01-04	Agente antiplaquetas novedoso.
PE20090648A1 (es)	2009-05-29	Compuestos para el tratamiento de la hepatitis c
MX2009004426A (es)	2009-08-12	Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met.
NO20091409L (no)	2009-04-07	Pyridin-3-yl-derivater som immunmodulerende midler
MX2009012418A (es)	2010-03-10	Derivados de quinazolin-oxima como inhibidores de hsp90.
AR034448A1 (es)	2004-02-25	Uso de derivados de nucleosidos, dichos derivados de nucleosidos para dicho uso, composiciones farmaceuticas que los comprenden y uso de dichas composiciones
BRPI0715579A2 (pt)	2015-05-26	"composto, composição farmacêutica e uso de um composto"
AR076895A1 (es)	2011-07-13	Derivados de piridinquinazolinas para el control y/o prevencion de infecciones fungicas en plantas, composiciones que los contienen y proceso para prepararlos
BRPI0707491B8 (pt)	2021-05-25	compostos úteis como agentes moduladores de receptores de mineralocorticóides, os referidos agentes compreendendo os mesmos e composições farmacêuticas
BRPI0410714B8 (pt)	2021-05-25	derivados de quinazolina macrocíclicos, seu processo de preparação, composição farmacêutica que os compreende e uso
TNSN08311A1 (en)	2009-12-29	Indole sulfonamide modulators of progesterone receptors
TW200612936A (en)	2006-05-01	Indole derivatives
TW200630344A (en)	2006-09-01	Tetracyclic indole derivatives as antiviral agents
NO20054135L (no)	2005-09-23	Kipolinon/benzoksazin derivater og anvendelser derav
MY139612A (en)	2009-10-30	Benzoxazine derivatives as 5-th6 modulators and uses thereof
WO2010047737A3 (en)	2010-06-17	Antimicrobial indoline compounds for treatment of bacterial infections
MY136824A (en)	2008-11-28	Substituted benzoxazinones and uses thereof
CL2011000784A1 (es)	2011-10-07	Compuestos derivados de 7-h-pirazoli[3,4-e]-diasepina-6(5h)-ona sustituidos; procedimiento de preparacion; composicion farmaceutica, utiles como agentes antibacteriales.
DE602007001463D1 (de)	2009-08-13	Pyrimidin-, chinazolin-, pteridin- und triazinderivate
CY1113535T1 (el)	2016-06-22	Παραγωγα κινολινης ως αντιβακτηριακοι παραγοντες