HRP20080242T3 - Purification process for bacterial cytolysin - Google Patents
Purification process for bacterial cytolysinInfo
- Publication number
- HRP20080242T3 HRP20080242T3 HR20080242T HRP20080242T HRP20080242T3 HR P20080242 T3 HRP20080242 T3 HR P20080242T3 HR 20080242 T HR20080242 T HR 20080242T HR P20080242 T HRP20080242 T HR P20080242T HR P20080242 T3 HRP20080242 T3 HR P20080242T3
- Authority
- HR
- Croatia
- Prior art keywords
- extract
- bacterial
- bacterial cytolysin
- cytolysin
- cell culture
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 5
- 102000004503 Perforin Human genes 0.000 title abstract 4
- 108010056995 Perforin Proteins 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title 1
- 238000004113 cell culture Methods 0.000 abstract 2
- 239000003599 detergent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011045 prefiltration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0421083.7A GB0421083D0 (en) | 2004-09-22 | 2004-09-22 | Purification process |
| PCT/EP2005/010258 WO2006032499A1 (en) | 2004-09-22 | 2005-09-20 | Purification process for bacterial cytolysin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080242T3 true HRP20080242T3 (en) | 2008-09-30 |
Family
ID=33397075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080242T HRP20080242T3 (en) | 2004-09-22 | 2008-06-02 | Purification process for bacterial cytolysin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070231876A1 (xx) |
| EP (1) | EP1791860B1 (xx) |
| JP (1) | JP4934591B2 (xx) |
| AT (1) | ATE393165T1 (xx) |
| CA (1) | CA2580113C (xx) |
| CY (1) | CY1107960T1 (xx) |
| DE (1) | DE602005006294T2 (xx) |
| DK (1) | DK1791860T3 (xx) |
| ES (1) | ES2304724T3 (xx) |
| GB (1) | GB0421083D0 (xx) |
| HR (1) | HRP20080242T3 (xx) |
| PL (1) | PL1791860T3 (xx) |
| PT (1) | PT1791860E (xx) |
| SI (1) | SI1791860T1 (xx) |
| WO (1) | WO2006032499A1 (xx) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1601689E (pt) | 2003-03-13 | 2008-01-04 | Glaxosmithkline Biolog Sa | Processo de purificação para citolisina bacteriana |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| PT3017827T (pt) | 2005-12-22 | 2019-01-28 | Glaxosmithkline Biologicals Sa | Vacina conjugada polissacarídica pneumocócica |
| AU2007281044A1 (en) * | 2006-08-03 | 2008-02-07 | Newcastle Innovation Limited | Treatment and prevention of allergic airways diseases |
| RS54349B1 (en) | 2007-06-26 | 2016-02-29 | Glaxosmithkline Biologicals S.A. | VACCINE CONTAINING STREPTOCOCCUS PNEUMONIAE Capsular POLYSACCHARIDE CONJUGATES |
| WO2009094730A1 (en) * | 2008-02-01 | 2009-08-06 | Newcastle Innovation Limited | Vaccine compositions |
| TR201808222T4 (tr) | 2009-09-03 | 2018-07-23 | Pfizer Vaccines Llc | PCSK9 aşısı. |
| US9878029B2 (en) | 2011-03-22 | 2018-01-30 | Serum Institute Of India Private Limited | Process for preparation of polysaccharides |
| PT2699587T (pt) * | 2011-04-22 | 2019-09-05 | Wyeth Llc | Composições relacionadas com uma toxina de clostridium difficile mutante e métodos da mesma |
| AR086405A1 (es) | 2011-05-17 | 2013-12-11 | Glaxosmithkline Biolog Sa | Vacuna de streptococcus pneumoniae |
| PE20212335A1 (es) | 2014-01-21 | 2021-12-16 | Pfizer | Composiciones inmunogenicas que comprenden antigenos sacaridos capsulares conjugados y usos de los mismos |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| IL252915B2 (en) | 2015-01-15 | 2024-04-01 | Pfizer | Immunogenic preparations for use in pneumococcal vaccines |
| RU2721128C2 (ru) | 2015-07-21 | 2020-05-18 | Пфайзер Инк. | Иммуногенные композиции, содержащие конъюгированные антигены капсульного сахарида, наборы, содержащие эти композиции, и их применения |
| JP6884145B2 (ja) | 2015-11-20 | 2021-06-09 | ファイザー・インク | 肺炎連鎖球菌ワクチンにおいて用いるための免疫原性組成物 |
| GB201603029D0 (en) * | 2016-02-22 | 2016-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| KR102467074B1 (ko) | 2016-08-05 | 2022-11-11 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| CA3031799A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| MA47223A (fr) | 2016-12-30 | 2019-11-06 | Sutrovax Inc | Conjugués polypeptide-antigène avec des acides aminés non naturels |
| KR102459629B1 (ko) | 2017-01-20 | 2022-10-28 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| BR112020014978A2 (pt) | 2018-02-05 | 2020-12-22 | Sanofi Pasteur, Inc. | Composição de conjugado polissacarídeo-proteína pneumocócico multivalente |
| CA3089007A1 (en) | 2018-02-05 | 2019-08-08 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11951162B2 (en) | 2018-04-18 | 2024-04-09 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharides and immunogenic conjugate thereof |
| GB201807303D0 (en) | 2018-05-03 | 2018-06-20 | London School Of Hygeine & Tropical Medicine | Glyconjugate vaccines |
| WO2020120569A2 (en) | 2018-12-12 | 2020-06-18 | Glaxosmithkline Biologicals Sa | Modified carrier proteins for o-linked glycosylation |
| WO2020121159A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| EP3952906A1 (en) | 2019-04-10 | 2022-02-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| MX2022001241A (es) | 2019-07-31 | 2022-04-20 | Sanofi Pasteur Inc | Composiciones de conjugados neumococicos multivalentes polisacarido - proteina y metodos para usar los mismos. |
| MX2022010355A (es) | 2020-02-21 | 2022-09-21 | Pfizer | Purificacion de sacaridos. |
| US20230383324A1 (en) | 2020-10-22 | 2023-11-30 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| CN116744965A (zh) | 2020-11-04 | 2023-09-12 | 辉瑞大药厂 | 用于肺炎球菌疫苗的免疫原性组合物 |
| CA3218544A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| US20220387576A1 (en) | 2021-05-28 | 2022-12-08 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| PE20240090A1 (es) | 2021-05-28 | 2024-01-16 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos |
| WO2023135515A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
| WO2023218322A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
| WO2024110839A2 (en) | 2022-11-22 | 2024-05-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
| WO2024166008A1 (en) | 2023-02-10 | 2024-08-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT58804A (en) * | 1988-12-16 | 1992-03-30 | James Cleland Paton | Process for producing pneumolysine mutants and pneumococcus vaccines |
| DE4133707A1 (de) * | 1991-10-11 | 1993-04-15 | Behringwerke Ag | Verfahren zur reinigung von streptolysin o, intaktes streptolysin o erhaeltlich nach diesem verfahren und seine verwendung |
| US5652125A (en) * | 1996-06-10 | 1997-07-29 | Pharmacia S.P.A. | Process for preparing daunorubicin |
| AU740956B2 (en) * | 1997-07-21 | 2001-11-15 | Baxter Healthcare Sa | Modified immunogenic pneumolysin compositions as vaccines |
| PT1601689E (pt) * | 2003-03-13 | 2008-01-04 | Glaxosmithkline Biolog Sa | Processo de purificação para citolisina bacteriana |
| JP4578067B2 (ja) * | 2003-06-06 | 2010-11-10 | 宏 清水 | 局所医薬組成物 |
-
2004
- 2004-09-22 GB GBGB0421083.7A patent/GB0421083D0/en not_active Ceased
-
2005
- 2005-09-20 SI SI200530269T patent/SI1791860T1/sl unknown
- 2005-09-20 PT PT05797390T patent/PT1791860E/pt unknown
- 2005-09-20 WO PCT/EP2005/010258 patent/WO2006032499A1/en active IP Right Grant
- 2005-09-20 DK DK05797390T patent/DK1791860T3/da active
- 2005-09-20 JP JP2007531717A patent/JP4934591B2/ja not_active Expired - Fee Related
- 2005-09-20 ES ES05797390T patent/ES2304724T3/es active Active
- 2005-09-20 EP EP05797390A patent/EP1791860B1/en active Active
- 2005-09-20 CA CA2580113A patent/CA2580113C/en not_active Expired - Fee Related
- 2005-09-20 DE DE602005006294T patent/DE602005006294T2/de active Active
- 2005-09-20 AT AT05797390T patent/ATE393165T1/de active
- 2005-09-20 PL PL05797390T patent/PL1791860T3/pl unknown
- 2005-09-20 US US11/575,676 patent/US20070231876A1/en not_active Abandoned
-
2008
- 2008-05-26 CY CY20081100535T patent/CY1107960T1/el unknown
- 2008-06-02 HR HR20080242T patent/HRP20080242T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1791860T3 (pl) | 2008-09-30 |
| CY1107960T1 (el) | 2013-09-04 |
| CA2580113A1 (en) | 2006-03-30 |
| PT1791860E (pt) | 2008-05-20 |
| JP4934591B2 (ja) | 2012-05-16 |
| GB0421083D0 (en) | 2004-10-27 |
| CA2580113C (en) | 2018-01-16 |
| ATE393165T1 (de) | 2008-05-15 |
| ES2304724T3 (es) | 2008-10-16 |
| SI1791860T1 (sl) | 2008-08-31 |
| EP1791860A1 (en) | 2007-06-06 |
| WO2006032499A1 (en) | 2006-03-30 |
| EP1791860B1 (en) | 2008-04-23 |
| JP2008513408A (ja) | 2008-05-01 |
| DK1791860T3 (da) | 2008-07-14 |
| DE602005006294T2 (de) | 2008-08-14 |
| US20070231876A1 (en) | 2007-10-04 |
| DE602005006294D1 (de) | 2008-06-05 |
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