HRP20031085B1 - Technical synthesis mehtod for producing tropenol - Google Patents

Technical synthesis mehtod for producing tropenol

Info

Publication number
HRP20031085B1
HRP20031085B1 HR20031085A HRP20031085A HRP20031085B1 HR P20031085 B1 HRP20031085 B1 HR P20031085B1 HR 20031085 A HR20031085 A HR 20031085A HR P20031085 A HRP20031085 A HR P20031085A HR P20031085 B1 HRP20031085 B1 HR P20031085B1
Authority
HR
Croatia
Prior art keywords
tropenol
mehtod
optionally
salts
technical synthesis
Prior art date
Application number
HR20031085A
Other languages
English (en)
Croatian (hr)
Inventor
Walter Rapp Armin
Sobotta Rainer
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20031085(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Publication of HRP20031085A2 publication Critical patent/HRP20031085A2/hr
Publication of HRP20031085B1 publication Critical patent/HRP20031085B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lock And Its Accessories (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
HR20031085A 2001-06-28 2003-12-24 Technical synthesis mehtod for producing tropenol HRP20031085B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131200 2001-06-28
PCT/EP2002/006290 WO2003002562A1 (fr) 2001-06-28 2002-06-08 Procede de synthese technique permettant de produire du tropenol

Publications (2)

Publication Number Publication Date
HRP20031085A2 HRP20031085A2 (en) 2004-04-30
HRP20031085B1 true HRP20031085B1 (en) 2011-12-31

Family

ID=7689774

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20031085A HRP20031085B1 (en) 2001-06-28 2003-12-24 Technical synthesis mehtod for producing tropenol
HR20090110A HRP20090110A2 (en) 2001-06-28 2009-02-23 Tehnical synthesys method for producing tropenol

Family Applications After (1)

Application Number Title Priority Date Filing Date
HR20090110A HRP20090110A2 (en) 2001-06-28 2009-02-23 Tehnical synthesys method for producing tropenol

Country Status (41)

Country Link
US (1) US6610849B2 (fr)
EP (3) EP1404673B1 (fr)
JP (2) JP4485192B2 (fr)
KR (3) KR100886342B1 (fr)
CN (2) CN1288154C (fr)
AR (1) AR039056A1 (fr)
AT (3) ATE527257T1 (fr)
AU (2) AU2002257820B2 (fr)
BG (2) BG66398B1 (fr)
BR (1) BR0210664B1 (fr)
CA (1) CA2451573C (fr)
CO (1) CO5650166A2 (fr)
CY (1) CY1107681T1 (fr)
CZ (1) CZ296187B6 (fr)
DE (2) DE50209948D1 (fr)
DK (3) DK1475379T3 (fr)
EA (2) EA009808B1 (fr)
EC (1) ECSP034927A (fr)
EE (1) EE05403B1 (fr)
EG (1) EG23203A (fr)
ES (3) ES2242022T3 (fr)
HK (2) HK1068613A1 (fr)
HR (2) HRP20031085B1 (fr)
HU (2) HU230379B1 (fr)
IL (2) IL159239A0 (fr)
ME (1) MEP42608A (fr)
MX (1) MXPA03011516A (fr)
MY (1) MY122932A (fr)
NO (1) NO328154B1 (fr)
NZ (2) NZ530770A (fr)
PE (1) PE20030123A1 (fr)
PL (1) PL209520B1 (fr)
PT (2) PT1404673E (fr)
RS (1) RS50436B (fr)
SA (1) SA02230194B1 (fr)
SI (2) SI1404673T1 (fr)
SK (1) SK288022B6 (fr)
TW (1) TW574220B (fr)
UA (2) UA76761C2 (fr)
WO (1) WO2003002562A1 (fr)
ZA (1) ZA200308895B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) * 2002-05-31 2004-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Industrial process for preparing tropenol
US20090162562A1 (en) * 2007-12-24 2009-06-25 Bangalore Aswatha Nagaraj Methods for Applying Thermal Barrier Coating Systems
EP2240477B8 (fr) * 2008-01-10 2014-12-10 Generics [UK] Limited Nouveau procédé de préparation d'esters de scopine
WO2011015884A1 (fr) 2009-08-07 2011-02-10 Generics [Uk] Limited Procédé pour préparer des esters de scopine
NZ624602A (en) 2009-08-07 2015-11-27 Generics Uk Ltd Anhydrate of tiotropium bromide
CN102351856B (zh) * 2011-08-24 2013-05-01 商丘市韶华药业有限公司 一种α-托品醇的纯化方法
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
DK2607351T3 (en) * 2011-12-22 2017-06-06 Cerbios-Pharma S A CONTINUOUS PROCEDURE FOR ALKYLICATION OF CYCLIC TERTIARY AMINES
CN113292574B (zh) * 2020-02-21 2022-05-03 四川大学 一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) * 2020-04-13 2021-09-21 石家庄四药有限公司 异丙托溴铵的合成方法
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JP2899418B2 (ja) * 1994-04-19 1999-06-02 ノイロサーチ アクティーゼルスカブ トロパン誘導体、それらの製造及び用途
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

Also Published As

Publication number Publication date
RS50436B (sr) 2009-12-31
ATE527257T1 (de) 2011-10-15
ECSP034927A (es) 2004-02-26
HU230036B1 (hu) 2015-05-28
HRP20031085A2 (en) 2004-04-30
SK662004A3 (en) 2004-06-08
MEP42608A (en) 2011-02-10
DK1475379T3 (da) 2007-09-03
EA006393B1 (ru) 2005-12-29
ATE294801T1 (de) 2005-05-15
EP1404673B1 (fr) 2005-05-04
MY122932A (en) 2006-05-31
WO2003002562A1 (fr) 2003-01-09
ES2285318T3 (es) 2007-11-16
ES2242022T3 (es) 2005-11-01
DK1404673T3 (da) 2005-06-13
JP4485192B2 (ja) 2010-06-16
SA02230194B1 (ar) 2008-03-08
US20030022917A1 (en) 2003-01-30
EA009808B1 (ru) 2008-04-28
CN1520413A (zh) 2004-08-11
DE50209948D1 (de) 2007-05-24
JP2004536830A (ja) 2004-12-09
DK1808435T3 (da) 2012-01-16
HU230379B1 (hu) 2016-03-29
DE50203015D1 (de) 2005-06-09
JP2010043116A (ja) 2010-02-25
AU2002257820B2 (en) 2008-05-08
CY1107681T1 (el) 2013-04-18
SK288022B6 (sk) 2012-12-03
CA2451573C (fr) 2010-09-21
AU2008201565B2 (en) 2012-03-01
US6610849B2 (en) 2003-08-26
SI1404673T1 (en) 2005-10-31
UA86031C2 (ru) 2009-03-25
CN1288154C (zh) 2006-12-06
CN1982309A (zh) 2007-06-20
BG108462A (bg) 2005-01-31
PT1404673E (pt) 2005-07-29
PE20030123A1 (es) 2003-03-31
EP1808435B1 (fr) 2011-10-05
AU2008201565A1 (en) 2008-05-01
CA2451573A1 (fr) 2003-01-09
UA76761C2 (uk) 2006-09-15
KR100530661B1 (ko) 2005-11-22
HUP0400332A2 (hu) 2004-08-30
BR0210664B1 (pt) 2013-12-03
PT1475379E (pt) 2007-05-31
IL159239A0 (en) 2004-06-01
IL159239A (en) 2010-05-17
HK1103404A1 (en) 2007-12-21
ZA200308895B (en) 2004-06-09
EA200501081A1 (ru) 2006-06-30
HUP0400332A3 (en) 2007-06-28
ES2374981T3 (es) 2012-02-23
HK1068613A1 (en) 2005-04-29
EP1808435A1 (fr) 2007-07-18
BG66398B1 (bg) 2013-12-31
NZ530770A (en) 2005-11-25
KR100866272B1 (ko) 2008-11-03
KR20030078793A (ko) 2003-10-08
KR20080065313A (ko) 2008-07-11
CZ2004149A3 (cs) 2004-05-12
TW574220B (en) 2004-02-01
PL209520B1 (pl) 2011-09-30
EG23203A (en) 2004-07-31
KR100886342B1 (ko) 2009-03-03
PL366942A1 (en) 2005-02-07
CZ296187B6 (cs) 2006-01-11
EP1404673A1 (fr) 2004-04-07
ATE359285T1 (de) 2007-05-15
CN1982309B (zh) 2010-06-09
AR039056A1 (es) 2005-02-09
YU101103A (en) 2006-05-25
BR0210664A (pt) 2004-08-10
KR20040023631A (ko) 2004-03-18
NO20035633D0 (no) 2003-12-17
HRP20090110A2 (en) 2009-04-30
MXPA03011516A (es) 2004-03-18
SI1475379T1 (sl) 2007-08-31
EA200301292A1 (ru) 2004-06-24
EE200400045A (et) 2004-04-15
EP1475379B1 (fr) 2007-04-11
NZ541395A (en) 2007-03-30
CO5650166A2 (es) 2006-06-30
NO328154B1 (no) 2009-12-21
EE05403B1 (et) 2011-04-15
EP1475379A1 (fr) 2004-11-10
BG111461A (en) 2013-08-30

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