EA200301292A1 - Способ синтеза тропенола для его получения в промышленном масштабе - Google Patents

Способ синтеза тропенола для его получения в промышленном масштабе

Info

Publication number
EA200301292A1
EA200301292A1 EA200301292A EA200301292A EA200301292A1 EA 200301292 A1 EA200301292 A1 EA 200301292A1 EA 200301292 A EA200301292 A EA 200301292A EA 200301292 A EA200301292 A EA 200301292A EA 200301292 A1 EA200301292 A1 EA 200301292A1
Authority
EA
Eurasian Patent Office
Prior art keywords
industrial scale
tropenol
synthesis
preparation
international
Prior art date
Application number
EA200301292A
Other languages
English (en)
Other versions
EA006393B1 (ru
Inventor
Армин Вальтер Рапп
Райнер Зоботта
Original Assignee
Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200301292(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг filed Critical Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Publication of EA200301292A1 publication Critical patent/EA200301292A1/ru
Publication of EA006393B1 publication Critical patent/EA006393B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lock And Its Accessories (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В заявке описывается новый, допускающий возможность его осуществления в промышленном масштабе способ получения тропенола, необязательно в виде его кислотно-аддитивных солей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200301292A 2001-06-28 2002-06-08 Способ синтеза тропенола для его получения в промышленном масштабе EA006393B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131200 2001-06-28
PCT/EP2002/006290 WO2003002562A1 (de) 2001-06-28 2002-06-08 Technische syntheseverfahren zur herstellung von tropenol

Publications (2)

Publication Number Publication Date
EA200301292A1 true EA200301292A1 (ru) 2004-06-24
EA006393B1 EA006393B1 (ru) 2005-12-29

Family

ID=7689774

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200301292A EA006393B1 (ru) 2001-06-28 2002-06-08 Способ синтеза тропенола для его получения в промышленном масштабе
EA200501081A EA009808B1 (ru) 2001-06-28 2002-06-08 Производные тропенола - исходный материал для получения терапевтически эффективных соединений

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200501081A EA009808B1 (ru) 2001-06-28 2002-06-08 Производные тропенола - исходный материал для получения терапевтически эффективных соединений

Country Status (41)

Country Link
US (1) US6610849B2 (ru)
EP (3) EP1475379B1 (ru)
JP (2) JP4485192B2 (ru)
KR (3) KR100866272B1 (ru)
CN (2) CN1982309B (ru)
AR (1) AR039056A1 (ru)
AT (3) ATE359285T1 (ru)
AU (2) AU2002257820B2 (ru)
BG (2) BG66398B1 (ru)
BR (1) BR0210664B1 (ru)
CA (1) CA2451573C (ru)
CO (1) CO5650166A2 (ru)
CY (1) CY1107681T1 (ru)
CZ (1) CZ296187B6 (ru)
DE (2) DE50203015D1 (ru)
DK (3) DK1808435T3 (ru)
EA (2) EA006393B1 (ru)
EC (1) ECSP034927A (ru)
EE (1) EE05403B1 (ru)
EG (1) EG23203A (ru)
ES (3) ES2374981T3 (ru)
HK (2) HK1068613A1 (ru)
HR (2) HRP20031085B1 (ru)
HU (2) HU230036B1 (ru)
IL (2) IL159239A0 (ru)
ME (1) MEP42608A (ru)
MX (1) MXPA03011516A (ru)
MY (1) MY122932A (ru)
NO (1) NO328154B1 (ru)
NZ (2) NZ541395A (ru)
PE (1) PE20030123A1 (ru)
PL (1) PL209520B1 (ru)
PT (2) PT1475379E (ru)
RS (1) RS50436B (ru)
SA (1) SA02230194B1 (ru)
SI (2) SI1475379T1 (ru)
SK (1) SK288022B6 (ru)
TW (1) TW574220B (ru)
UA (2) UA76761C2 (ru)
WO (1) WO2003002562A1 (ru)
ZA (1) ZA200308895B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) * 2002-05-31 2004-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Industrial process for preparing tropenol
US20090162562A1 (en) * 2007-12-24 2009-06-25 Bangalore Aswatha Nagaraj Methods for Applying Thermal Barrier Coating Systems
JP6087492B2 (ja) * 2008-01-10 2017-03-01 ジェネリクス・［ユーケー］・リミテッド スコピンエステルを調製するための新規プロセス
CA2931876A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN102351856B (zh) * 2011-08-24 2013-05-01 商丘市韶华药业有限公司 一种α-托品醇的纯化方法
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
RS55996B1 (sr) * 2011-12-22 2017-09-29 Cerbios-Pharma S A Kontinuirani postupak za alkilaciju cikličnih tercijarnih amina
CN113292574B (zh) * 2020-02-21 2022-05-03 四川大学 一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) * 2020-04-13 2021-09-21 石家庄四药有限公司 异丙托溴铵的合成方法
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
WO1995028401A1 (en) * 1994-04-19 1995-10-26 Neurosearch A/S Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

Also Published As

Publication number Publication date
ATE294801T1 (de) 2005-05-15
TW574220B (en) 2004-02-01
AU2008201565A1 (en) 2008-05-01
HUP0400332A2 (hu) 2004-08-30
PE20030123A1 (es) 2003-03-31
SI1475379T1 (sl) 2007-08-31
BG111461A (en) 2013-08-30
SK662004A3 (en) 2004-06-08
HU230036B1 (hu) 2015-05-28
PT1475379E (pt) 2007-05-31
KR20040023631A (ko) 2004-03-18
CN1982309A (zh) 2007-06-20
AU2008201565B2 (en) 2012-03-01
EP1404673B1 (de) 2005-05-04
UA76761C2 (ru) 2006-09-15
KR100886342B1 (ko) 2009-03-03
JP4485192B2 (ja) 2010-06-16
AR039056A1 (es) 2005-02-09
AU2002257820B2 (en) 2008-05-08
NZ530770A (en) 2005-11-25
EP1475379A1 (de) 2004-11-10
CA2451573C (en) 2010-09-21
KR20030078793A (ko) 2003-10-08
WO2003002562A1 (de) 2003-01-09
HUP0400332A3 (en) 2007-06-28
EE200400045A (et) 2004-04-15
EE05403B1 (et) 2011-04-15
HRP20090110A2 (en) 2009-04-30
ES2374981T3 (es) 2012-02-23
ZA200308895B (en) 2004-06-09
SK288022B6 (sk) 2012-12-03
PL209520B1 (pl) 2011-09-30
HK1103404A1 (en) 2007-12-21
CY1107681T1 (el) 2013-04-18
CN1520413A (zh) 2004-08-11
KR20080065313A (ko) 2008-07-11
BR0210664B1 (pt) 2013-12-03
DE50203015D1 (de) 2005-06-09
CN1288154C (zh) 2006-12-06
HRP20031085B1 (en) 2011-12-31
NO328154B1 (no) 2009-12-21
BG66398B1 (bg) 2013-12-31
IL159239A (en) 2010-05-17
EA200501081A1 (ru) 2006-06-30
JP2004536830A (ja) 2004-12-09
EP1808435A1 (de) 2007-07-18
ATE527257T1 (de) 2011-10-15
ECSP034927A (es) 2004-02-26
CN1982309B (zh) 2010-06-09
IL159239A0 (en) 2004-06-01
EP1404673A1 (de) 2004-04-07
UA86031C2 (ru) 2009-03-25
EG23203A (en) 2004-07-31
BR0210664A (pt) 2004-08-10
HRP20031085A2 (en) 2004-04-30
CZ296187B6 (cs) 2006-01-11
SI1404673T1 (en) 2005-10-31
EP1808435B1 (de) 2011-10-05
CA2451573A1 (en) 2003-01-09
HK1068613A1 (en) 2005-04-29
EA006393B1 (ru) 2005-12-29
NO20035633D0 (no) 2003-12-17
US6610849B2 (en) 2003-08-26
DK1404673T3 (da) 2005-06-13
CZ2004149A3 (cs) 2004-05-12
EA009808B1 (ru) 2008-04-28
KR100866272B1 (ko) 2008-11-03
JP2010043116A (ja) 2010-02-25
ATE359285T1 (de) 2007-05-15
PT1404673E (pt) 2005-07-29
PL366942A1 (en) 2005-02-07
ES2242022T3 (es) 2005-11-01
MEP42608A (en) 2011-02-10
DK1475379T3 (da) 2007-09-03
EP1475379B1 (de) 2007-04-11
NZ541395A (en) 2007-03-30
BG108462A (bg) 2005-01-31
HU230379B1 (hu) 2016-03-29
MXPA03011516A (es) 2004-03-18
MY122932A (en) 2006-05-31
YU101103A (en) 2006-05-25
RS50436B (sr) 2009-12-31
KR100530661B1 (ko) 2005-11-22
SA02230194B1 (ar) 2008-03-08
US20030022917A1 (en) 2003-01-30
DK1808435T3 (da) 2012-01-16
DE50209948D1 (de) 2007-05-24
ES2285318T3 (es) 2007-11-16
CO5650166A2 (es) 2006-06-30

Similar Documents

Publication Publication Date Title
EA200400368A1 (ru) Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств
EA200400430A1 (ru) Способ получения гексагидрофуро[2,3-b]фуран-3-ола
EA200500017A1 (ru) Новые соединения
BR0308211A (pt) Cumarinas úteis como biomarcadores
EA200401304A1 (ru) Набор для ингаляции с ингаляционным порошком, содержащим тиотропий
NO20052884L (no) Substituerte indolpyridinforbindelser som anti-infeksjonsmidler.
IS7837A (is) Vetni framleitt með vatnsafli
CY1110064T1 (el) Παραγωγα φαινυλ-πιπεραζινης ως αναστολεις επαναπροσληψης σεροτονινης
RS51444B (sr) JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa
CY1113578T1 (el) 2,3-διυδρο-6-νιτροϊμιδαζο 2,1 -b-οξαζολια
CR7076S (es) Recipiente
SI1633697T1 (sl) Postopek za pripravo substituiranih 3-aril-butilaminskih spojin
BG111461A (en) TECHNICAL METHOD FOR OBTAINING TROPENOL
EA200400252A1 (ru) Стабильная полиморфная модификация флибансерина, способ её промышленного получения и её применение для получения лекарственных средств
IN2012DN00411A (ru)
EA200401428A1 (ru) Способ получения цефдинира
EA200700766A1 (ru) Способ получения производных [1,4,5]-оксадиазепина
EA200800324A1 (ru) Новый способ получения солей тиотропия
NO20052975D0 (no) Nye 2&#39;,5&#39;-oligoadenylsyreanaloger.
BR0312863A (pt) Derivados de aldeìdo de polietileno glicol
ATE466003T1 (de) Herstellung von 2-aminothiazol-5- carbonsäurederivaten
BRPI0415034A (pt) derivados de aminopiridina como inibidores de não-sintase induzìveis
TR200402546T4 (tr) Taksan türevleri hazırlamak için işlem.
EA200400876A1 (ru) Способ получения производных толуола
BR0311590A (pt) Agonistas de brs-3 não-peptìdicos

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY