HRP20000263B1 - Process for the preparation of thiazolidinedione derivatives - Google Patents

Process for the preparation of thiazolidinedione derivatives

Info

Publication number: HRP20000263B1
Authority: HR; Croatia
Prior art keywords: preparation; solvate; thiazolidinedione; thiazolidinedione derivatives; pyridyl
Prior art date: 1997-11-04

Application number

HR20000263A

Other languages

English (en)

Croatian (hr)

Inventor

Gordon Giles Robert

John Lewis Norman

Kirby Quick John

Original Assignee

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-04

Filing date

2000-05-04

Publication date

2009-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10821570&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20000263(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-05-04 Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.

2000-12-31 Publication of HRP20000263A2 publication Critical patent/HRP20000263A2/hr

2009-01-31 Publication of HRP20000263B1 publication Critical patent/HRP20000263B1/xx

Links

238000000034 method Methods 0.000 title abstract 3
150000001467 thiazolidinediones Chemical class 0.000 title 1
239000012453 solvate Substances 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
HCDYSWMAMRPMST-UHFFFAOYSA-N 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1C=C1SC(=O)NC1=O HCDYSWMAMRPMST-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 abstract 1
238000010531 catalytic reduction reaction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HR20000263A 1997-11-04 2000-05-04 Process for the preparation of thiazolidinedione derivatives HRP20000263B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9723295.3A GB9723295D0 (en)	1997-11-04	1997-11-04	Novel process
PCT/EP1998/006997 WO1999023095A1 (en)	1997-11-04	1998-10-27	Process for the preparation of thiazolidinedione derivatives

Publications (2)

Publication Number	Publication Date
HRP20000263A2 HRP20000263A2 (en)	2000-12-31
HRP20000263B1 true HRP20000263B1 (en)	2009-01-31

Family

ID=10821570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20000263A HRP20000263B1 (en)	1997-11-04	2000-05-04	Process for the preparation of thiazolidinedione derivatives

Country Status (44)

Country	Link
US (2)	US20060106221A1 (es)
EP (2)	EP1219620A1 (es)
JP (2)	JP3723448B2 (es)
KR (1)	KR100602551B1 (es)
CN (1)	CN1160351C (es)
AP (1)	AP1519A (es)
AR (1)	AR016660A1 (es)
AT (1)	ATE238302T1 (es)
AU (2)	AU1559599A (es)
BG (1)	BG64559B1 (es)
BR (1)	BR9814622A (es)
CA (1)	CA2309461A1 (es)
CO (1)	CO5011075A1 (es)
CZ (1)	CZ297209B6 (es)
DE (1)	DE69813869T2 (es)
DK (1)	DK1028960T3 (es)
DZ (1)	DZ2637A1 (es)
EA (1)	EA002722B1 (es)
EC (1)	ECSP082712A (es)
ES (1)	ES2197519T3 (es)
GB (1)	GB9723295D0 (es)
HK (2)	HK1048804A1 (es)
HR (1)	HRP20000263B1 (es)
HU (1)	HU224547B1 (es)
ID (1)	ID24644A (es)
IL (1)	IL135898A (es)
IN (1)	IN192870B (es)
MA (1)	MA26560A1 (es)
MY (1)	MY118605A (es)
NO (1)	NO315557B1 (es)
OA (1)	OA11521A (es)
PE (1)	PE129399A1 (es)
PL (1)	PL192503B1 (es)
PT (1)	PT1028960E (es)
RS (1)	RS49793B (es)
SA (1)	SA98190820B1 (es)
SI (1)	SI1028960T1 (es)
SK (1)	SK285233B6 (es)
TR (1)	TR200001239T2 (es)
TW (1)	TW538037B (es)
UA (1)	UA56269C2 (es)
UY (1)	UY25227A1 (es)
WO (1)	WO1999023095A1 (es)
ZA (1)	ZA9810033B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7091359B2 (en)	1997-11-04	2006-08-15	Smithkline Beecham Plc	Process for the preparation of thiazolidinedione derivatives
GB9723295D0 (en)	1997-11-04	1998-01-07	Smithkline Beecham Plc	Novel process
HU225919B1 (en) *	1999-12-18	2007-12-28	Richter Gedeon Nyrt	Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates
GB0023971D0 (en) *	2000-09-29	2000-11-15	Smithkline Beecham Plc	Novel pharmaceutical
GB0023970D0 (en) *	2000-09-29	2000-11-15	Smithkline Beecham Plc	Novel pharmaceutical
AU2002366812A1 (en) *	2001-12-20	2003-07-09	Teva Pharmaceutical Industries Ltd.	Hydrogenation of precursors to thiazolidinedione antihyperglycemics
GB0307259D0 (en) *	2003-03-28	2003-05-07	Glaxo Group Ltd	Process
GB2405403A (en) *	2003-08-29	2005-03-02	Cipla Ltd	Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
AR047541A1 (es) *	2004-02-13	2006-01-25	Sandoz Ag	Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas
EP1745043A1 (en) *	2004-05-12	2007-01-24	Medichem S.A.	Process for the preparation of rosiglitazone
CZ297266B6 (cs) *	2004-09-10	2006-10-11	Zentiva, A. S.	Zpusob prípravy rosiglitazonu
CZ297347B6 (cs) *	2004-09-21	2006-11-15	Zentiva, A. S.	Zpusob prípravy rosiglitazonu
CZ298424B6 (cs) *	2005-05-24	2007-09-26	Zentiva, A. S.	Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
CN102727489A (zh) *	2012-07-18	2012-10-17	西南大学	5-芳(杂环)亚甲基噻唑烷-2，4-二酮在制备ppar激动剂中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0306228A1 (en) *	1987-09-04	1989-03-08	Beecham Group Plc	Substituted thiazolidinedione derivatives
WO1992007838A1 (en) *	1990-10-30	1992-05-14	Beecham Group Plc	Thiazolidine dione derivatives
WO1992007839A1 (en) *	1990-10-30	1992-05-14	Beecham Group Plc	Thiazolidinedione derivatives

Family Cites Families (18)

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Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en)	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
CN1003445B (zh) *	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
US4812570A (en)	1986-07-24	1989-03-14	Takeda Chemical Industries, Ltd.	Method for producing thiazolidinedione derivatives
US5260445A (en) *	1987-09-04	1993-11-09	Beecham Group P.L.C.	2,4-thiazolidinediones
US6288095B1 (en) *	1987-09-04	2001-09-11	Beecham Group P.L.C.	Compounds
US5646169A (en) *	1987-09-04	1997-07-08	Beecham Group P.L.C.	Compounds for treating eating disorders in which blood glucose levels are raised
US5232925A (en) *	1987-09-04	1993-08-03	Beecham Group P.L.C.	Compounds
US5194443A (en) *	1987-09-04	1993-03-16	Beecham Group P.L.C.	Compounds
US20020049240A1 (en) *	1994-12-19	2002-04-25	Beecham Group P.1.C.	Novel compounds
GB9124513D0 (en) *	1991-11-19	1992-01-08	Smithkline Beecham Plc	Novel process
US6462337B1 (en) *	2000-04-20	2002-10-08	Agilent Technologies, Inc.	Mass spectrometer electrospray ionization
US5585495A (en)	1991-12-20	1996-12-17	The Upjohn Company	Reduction method for substituted 5-methylene-thiazolidinediones
GB9218830D0 (en)	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds
US5741803A (en) *	1992-09-05	1998-04-21	Smithkline Beecham Plc	Substituted thiazolidinedionle derivatives
US6632947B2 (en) *	1997-02-18	2003-10-14	Smithkline Beecham Plc	Process for the preparation of substituted thiazolidinedione
UY24886A1 (es)	1997-02-18	2001-08-27	Smithkline Beecham Plc	Tiazolidindiona
US7091359B2 (en) *	1997-11-04	2006-08-15	Smithkline Beecham Plc	Process for the preparation of thiazolidinedione derivatives
GB9723295D0 (en)	1997-11-04	1998-01-07	Smithkline Beecham Plc	Novel process

1997
- 1997-11-04 GB GBGB9723295.3A patent/GB9723295D0/en not_active Ceased
1998
- 1998-10-27 CN CNB98810959XA patent/CN1160351C/zh not_active Expired - Fee Related
- 1998-10-27 HU HU0100144A patent/HU224547B1/hu not_active IP Right Cessation
- 1998-10-27 CA CA002309461A patent/CA2309461A1/en not_active Abandoned
- 1998-10-27 TR TR2000/01239T patent/TR200001239T2/xx unknown
- 1998-10-27 AT AT98959834T patent/ATE238302T1/de active
- 1998-10-27 AU AU15595/99A patent/AU1559599A/en not_active Abandoned
- 1998-10-27 IL IL13589898A patent/IL135898A/xx unknown
- 1998-10-27 UA UA2000042451A patent/UA56269C2/uk unknown
- 1998-10-27 BR BR9814622-0A patent/BR9814622A/pt not_active Application Discontinuation
- 1998-10-27 RS YUP-338/00A patent/RS49793B/sr unknown
- 1998-10-27 SK SK650-2000A patent/SK285233B6/sk not_active IP Right Cessation
- 1998-10-27 DE DE69813869T patent/DE69813869T2/de not_active Expired - Lifetime
- 1998-10-27 AP APAP/P/2000/001808A patent/AP1519A/en active
- 1998-10-27 CZ CZ20001633A patent/CZ297209B6/cs not_active IP Right Cessation
- 1998-10-27 SI SI9830468T patent/SI1028960T1/xx unknown
- 1998-10-27 WO PCT/EP1998/006997 patent/WO1999023095A1/en active IP Right Grant
- 1998-10-27 ES ES98959834T patent/ES2197519T3/es not_active Expired - Lifetime
- 1998-10-27 KR KR1020007004783A patent/KR100602551B1/ko not_active IP Right Cessation
- 1998-10-27 EP EP02075969A patent/EP1219620A1/en not_active Withdrawn
- 1998-10-27 OA OA1200000131A patent/OA11521A/en unknown
- 1998-10-27 JP JP2000518965A patent/JP3723448B2/ja not_active Expired - Fee Related
- 1998-10-27 PT PT98959834T patent/PT1028960E/pt unknown
- 1998-10-27 EA EA200000484A patent/EA002722B1/ru not_active IP Right Cessation
- 1998-10-27 PL PL340366A patent/PL192503B1/pl not_active IP Right Cessation
- 1998-10-27 ID IDW20000822A patent/ID24644A/id unknown
- 1998-10-27 EP EP98959834A patent/EP1028960B1/en not_active Expired - Lifetime
- 1998-10-27 DK DK98959834T patent/DK1028960T3/da active
- 1998-10-28 UY UY25227A patent/UY25227A1/es not_active IP Right Cessation
- 1998-11-02 AR ARP980105505A patent/AR016660A1/es active IP Right Grant
- 1998-11-02 MY MYPI98004975A patent/MY118605A/en unknown
- 1998-11-02 MA MA25328A patent/MA26560A1/fr unknown
- 1998-11-03 ZA ZA9810033A patent/ZA9810033B/xx unknown
- 1998-11-03 TW TW087118222A patent/TW538037B/zh not_active IP Right Cessation
- 1998-11-03 IN IN3258DE1998 patent/IN192870B/en unknown
- 1998-11-03 PE PE1998001038A patent/PE129399A1/es not_active Application Discontinuation
- 1998-11-03 CO CO98064433A patent/CO5011075A1/es unknown
- 1998-11-03 DZ DZ980247A patent/DZ2637A1/xx active
- 1998-11-25 SA SA98190820A patent/SA98190820B1/ar unknown
2000
- 2000-04-27 NO NO20002174A patent/NO315557B1/no not_active IP Right Cessation
- 2000-05-04 HR HR20000263A patent/HRP20000263B1/xx not_active IP Right Cessation
- 2000-06-05 BG BG104505A patent/BG64559B1/bg unknown
2001
- 2001-02-02 HK HK02108713.7A patent/HK1048804A1/zh unknown
- 2001-02-02 HK HK01100772A patent/HK1032046A1/xx not_active IP Right Cessation
2002
- 2002-07-09 AU AU2002300593A patent/AU2002300593B8/en not_active Ceased
2004
- 2004-08-04 JP JP2004228226A patent/JP2004339235A/ja active Pending
2006
- 2006-01-05 US US11/326,003 patent/US20060106221A1/en not_active Abandoned
- 2006-10-18 US US11/550,506 patent/US7351832B2/en not_active Expired - Fee Related
2008
- 2008-07-08 EC EC2008002712A patent/ECSP082712A/es unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0306228A1 (en) *	1987-09-04	1989-03-08	Beecham Group Plc	Substituted thiazolidinedione derivatives
WO1992007838A1 (en) *	1990-10-30	1992-05-14	Beecham Group Plc	Thiazolidine dione derivatives
WO1992007839A1 (en) *	1990-10-30	1992-05-14	Beecham Group Plc	Thiazolidinedione derivatives

Also Published As

Publication number	Publication date
RS49793B (sr)	2008-06-05
HUP0100144A3 (en)	2002-04-29
JP2004339235A (ja)	2004-12-02
KR20010031720A (ko)	2001-04-16
HRP20000263A2 (en)	2000-12-31
US20070066662A1 (en)	2007-03-22
AP1519A (en)	2005-12-20
EP1028960B1 (en)	2003-04-23
EP1028960A1 (en)	2000-08-23
ES2197519T3 (es)	2004-01-01
SA98190820B1 (ar)	2006-10-29
OA11521A (en)	2004-02-09
CO5011075A1 (es)	2001-02-28
EA200000484A1 (ru)	2000-10-30
TW538037B (en)	2003-06-21
UA56269C2 (uk)	2003-05-15
UY25227A1 (es)	1999-05-14
YU33800A (sh)	2002-10-18
PE129399A1 (es)	2000-02-24
NO20002174D0 (no)	2000-04-27
ATE238302T1 (de)	2003-05-15
HK1048804A1 (zh)	2003-04-17
DZ2637A1 (fr)	2003-03-08
PL192503B1 (pl)	2006-10-31
ECSP082712A (es)	2008-08-29
BG64559B1 (bg)	2005-07-29
HUP0100144A2 (hu)	2001-08-28
DE69813869D1 (de)	2003-05-28
BR9814622A (pt)	2000-10-03
US7351832B2 (en)	2008-04-01
TR200001239T2 (tr)	2001-07-23
CN1160351C (zh)	2004-08-04
IL135898A0 (en)	2001-05-20
MY118605A (en)	2004-12-31
AU2002300593B2 (en)	2006-03-23
HU224547B1 (hu)	2005-10-28
AU2002300593B8 (en)	2006-05-04
KR100602551B1 (ko)	2006-07-19
PL340366A1 (en)	2001-01-29
BG104505A (en)	2001-01-31
GB9723295D0 (en)	1998-01-07
AP2000001808A0 (en)	2000-06-30
NO315557B1 (no)	2003-09-22
CZ297209B6 (cs)	2006-10-11
CZ20001633A3 (cs)	2000-10-11
MA26560A1 (fr)	2004-12-20
AU1559599A (en)	1999-05-24
DK1028960T3 (da)	2003-08-11
WO1999023095A1 (en)	1999-05-14
HK1032046A1 (en)	2001-07-06
ID24644A (id)	2000-07-27
PT1028960E (pt)	2003-09-30
JP2001521937A (ja)	2001-11-13
EP1219620A1 (en)	2002-07-03
DE69813869T2 (de)	2004-01-29
CN1278818A (zh)	2001-01-03
IN192870B (es)	2004-05-22
CA2309461A1 (en)	1999-05-14
JP3723448B2 (ja)	2005-12-07
IL135898A (en)	2005-08-31
SK6502000A3 (en)	2000-09-12
AR016660A1 (es)	2001-07-25
EA002722B1 (ru)	2002-08-29
US20060106221A1 (en)	2006-05-18
SI1028960T1 (en)	2003-10-31
NO20002174L (no)	2000-05-30
ZA9810033B (en)	2000-05-03
SK285233B6 (sk)	2006-09-07

Legal Events

Date	Code	Title	Description
2000-12-31	A1OB	Publication of a patent application
2001-07-02	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2009-01-31	B1PR	Patent granted
2010-10-19	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20101019 Year of fee payment: 13
2012-04-28	PBON	Lapse due to non-payment of renewal fee	Effective date: 20111028

Publication	Publication Date	Title
HRP20000263B1 (en)	2009-01-31	Process for the preparation of thiazolidinedione derivatives
NZ504703A (en)	2002-12-20	Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use
RS50114B (sr)	2009-03-25	Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline
HUP0100509A3 (en)	2002-06-28	5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical, process for its preparation and its pharmaceutical use
MXPA03002580A (es)	2003-10-15	Nuevas formas polimorficas de maleato de 5-(4-(2-(n-metil-n-(2-piridil) amino)etoxi)bencil) tiazolidin-2, 4-diona y proceso para su preparacion.
NZ504704A (en)	2003-03-28	Hydrate of 5-[4-[2- (N-methyl-N- (2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2, 4-dione maleic acid salt
NO2009002I1 (no)	2009-03-02	5-{4-[2-(N-metyl-N-(2-pyridyl)amino)etoksy]benzyl}tiazolidin-2,4-dionmaleat(salter/solvater)+glimepirid
MY129475A (en)	2007-04-30	Process for the preparation of substituted thiazolidinedione
TR200002790T2 (tr)	2001-11-21	5-(4-(2-(N-metil-N-2-piridil) amino)etoksi) benzil)tiazolidin-2,4-dion içeren terkip
MX9701116A (es)	1998-04-30	Profarmacos de 5-(2-[4-(1,2-benzoisotiazol-3-il)-1-piperazinil]etil)-6-clor o-1,3-dihidro-2h-indol-2-ona.
RS50136B (sr)	2009-03-25	Derivati tiazolidindiona i njihova upotreba kao antidijabetika
HUP0003397A3 (en)	2002-02-28	Use of 5-(4-(2-(n-methyl-n-(2-pyridyl)amino)-ethoxy)benzyl)2,4-thiazolidinedione for producing medicament useful in the treatment of polycystic ovary syndrome and gestational diabetes
PT1349855E (pt)	2006-12-29	Sal misilato de 5-{4-[2-(n-metil-n-(2-piridil)amino)etoxi]benzil}tiazolidino-2, 4-diona
AP1715A (en)	2007-02-28	The hydrochloride salt of 5-[ 4 -[2 -(n-methyl-n- (2-pyridyl) amino) ethoxy]benzyl]thiazolidine -2,4-dione
AP1814A (en)	2008-01-04	Tartrate salts of thiazolidinedione derivative.
TR200103041T2 (tr)	2002-03-21	Yeni farmastik maddeler.
GB0021784D0 (en)	2000-10-18	Novel pharmaceutical
PT1446404E (pt)	2006-10-31	Edisilatos de rosiglitazona e sua utilizacao como antidiabeticos
GB0021978D0 (en)	2000-10-25	Novel pharmaceutical
AP1785A (en)	2007-10-04	Tartrate salt of thiazolidinedione derivative.
AP2002002684A0 (en)	2002-12-31	5-(4-(2-(n-methyl-n-(2- pyridyl) amino)ethoxy) benzyl) thiazolidine-2, 4-dione hydriodide as pharmaceutical.5-(4-(2-(n-methyl-n-(2- pyridyl) amino)ethoxy) benzyl) thiazolidine-2, 4-dione hydriodide as pharmaceutical.5-(4-(2-(n-methyl-n-(2- pyridyl) amino)ethoxy) benzyl) thiazolidine-2, 4-dione hydriodide as pharmaceutical.5-(4-(2-(n-methyl-n-(2-pyridyl) amino) ethoxy)benzyl) thiazolidine-2,4-dione hydriodide as pharmaceutical
Kozyrev et al.	1999	The application prospects of materials based on technical ceramics for repairing production
YU14503A (sh)	2006-01-16	Novi farmaceutski preparati
EP1295882A4 (en)	2004-06-30	METHOD FOR PRODUCING PIPERAZINE DERIVATIVES
ECSP003434A (es)	2000-07-21	Nuevos compuestos