HK92292A - Analogues of antibiotic cc-1065 - Google Patents

Analogues of antibiotic cc-1065

Info

Publication number
HK92292A
HK92292A HK922/92A HK92292A HK92292A HK 92292 A HK92292 A HK 92292A HK 922/92 A HK922/92 A HK 922/92A HK 92292 A HK92292 A HK 92292A HK 92292 A HK92292 A HK 92292A
Authority
HK
Hong Kong
Prior art keywords
analogues
antibiotic
Prior art date
Application number
HK922/92A
Other languages
English (en)
Inventor
Robert Charles Kelly
Martha Ann Warpehoski
Wendell Wierenga
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of HK92292A publication Critical patent/HK92292A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
HK922/92A 1984-02-21 1992-11-19 Analogues of antibiotic cc-1065 HK92292A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58183684A 1984-02-21 1984-02-21
US69436385A 1985-01-24 1985-01-24

Publications (1)

Publication Number Publication Date
HK92292A true HK92292A (en) 1992-11-27

Family

ID=27078429

Family Applications (1)

Application Number Title Priority Date Filing Date
HK922/92A HK92292A (en) 1984-02-21 1992-11-19 Analogues of antibiotic cc-1065

Country Status (5)

Country Link
EP (1) EP0154445B1 (xx)
JP (2) JP2545060B2 (xx)
CA (2) CA1238907A (xx)
DE (1) DE3570670D1 (xx)
HK (1) HK92292A (xx)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3783588T2 (de) * 1986-04-17 1993-06-09 Kyowa Hakko Kogyo Kk Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren.
DE3750612T2 (de) * 1986-12-19 1995-03-02 Upjohn Co Cc-1065 analoge.
US5332837A (en) * 1986-12-19 1994-07-26 The Upjohn Company CC-1065 analogs
US4994578A (en) * 1987-11-27 1991-02-19 Meiji Seika Kaisha, Ltd. Certain anti-tumor duocarmycin antibiotics from streptomyces
JP2562935B2 (ja) * 1988-04-28 1996-12-11 明治製菓株式会社 抗腫瘍性物質ｓｆ２５８２誘導体
EP0318056A3 (en) * 1987-11-27 1990-12-19 Meiji Seika Kaisha Ltd. Novel antibiotics and process for preparing the same
JP2642165B2 (ja) * 1988-07-22 1997-08-20 協和醗酵工業株式会社 新規ｄｃ−８９化合物およびその製造法
US5084468A (en) * 1988-08-11 1992-01-28 Kyowa Hakko Kogyo Co., Ltd. Dc-88a derivatives
US5541339A (en) * 1988-09-12 1996-07-30 The Upjohn Company CC-1065 analogs having two CPI subunits
MX9203460A (es) * 1988-09-12 1992-09-01 Upjohn Co Nuevos analogos cc-1065 que tienen dos subunidades cpi.
US5008271A (en) * 1988-10-21 1991-04-16 Kyowa Hakko Kogyo Co., Ltd. DC-88A derivatives
JP2598116B2 (ja) * 1988-12-28 1997-04-09 協和醗酵工業株式会社 新規物質ｄｃ１１３
US5187186A (en) * 1989-07-03 1993-02-16 Kyowa Hakko Kogyo Co., Ltd. Pyrroloindole derivatives
JP2510335B2 (ja) * 1989-07-03 1996-06-26 協和醗酵工業株式会社 Ｄｃ―８８ａ誘導体
AU648313B2 (en) * 1990-04-25 1994-04-21 Pharmacia & Upjohn Company Novel CC-1065 analogs
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
US5248692A (en) * 1990-06-11 1993-09-28 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives as anti-tumor agents
EP0520435A3 (en) * 1991-06-28 1993-05-05 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
ES2149768T3 (es) * 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5248691A (en) * 1992-09-03 1993-09-28 Eli Lilly And Company Furanoindolines
AU689566B2 (en) * 1994-04-01 1998-04-02 Kyowa Hakko Kogyo Co. Ltd. DC-89 derivatives
US5641780A (en) * 1994-04-22 1997-06-24 Kyowa Hakko Kogyo Co., Ltd. Pyrrolo-indole derivatives
CN1051552C (zh) * 1994-11-29 2000-04-19 杏林制药株式会社 丙烯酰胺衍生物及其制造方法
US6251933B1 (en) 1996-12-13 2001-06-26 The Cancer Research Campaign Technology Limited Seco precursors of cyclopropylindolines and their use as prodrugs
GB9625913D0 (en) * 1996-12-13 1997-01-29 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their seco precursors,and their use as prodrugs
EP0983248B1 (en) * 1997-05-22 2004-07-14 The Scripps Research Institute Analogs of duocarmycin and cc-1065
CN101671335A (zh) 2001-05-31 2010-03-17 梅达莱克斯公司 细胞毒素、其有用的前体药物、连接基团和稳定剂
US7691962B2 (en) 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
MX2008009956A (es) * 2006-02-02 2008-12-12 Syntarga Bv Analogos de cc-1065 solubles en agua y sus conjugados.
EP2121667B1 (en) 2007-02-21 2016-06-08 E. R. Squibb & Sons, L.L.C. Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
AU2009320481C1 (en) 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
RU2578719C9 (ru) 2010-04-21 2016-10-10 Синтарга Б.В. Новые конъюгаты аналогов сс-1065 и бифункциональные линкеры
CN104220442B (zh) 2012-04-05 2016-11-23 内尔维阿诺医学科学有限公司 烷化剂
WO2015044003A1 (en) * 2013-09-25 2015-04-02 Nerviano Medical Sciences S.R.L. THIENO[2,3-e]INDOLE DERIVATIVES AS NEW ANTITUMOR AGENTS
PL3092010T3 (pl) 2014-01-10 2019-01-31 Synthon Biopharmaceuticals B.V. Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
CA2935430C (en) 2014-01-10 2018-09-18 Synthon Biopharmaceuticals B.V. Duocarmycin adcs for use in treatment of endometrial cancer
PL3069735T3 (pl) 2014-01-10 2018-08-31 Synthon Biopharmaceuticals B.V. ADC duokarmycyny do zastosowania w leczeniu raka pęcherza

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423229A (en) * 1980-11-18 1983-12-27 The Upjohn Company Composition of matter and process

Also Published As

Publication number Publication date
EP0154445B1 (en) 1989-05-31
JPH08225573A (ja) 1996-09-03
CA1238907A (en) 1988-07-05
EP0154445A1 (en) 1985-09-11
CA1293248C (en) 1991-12-17
JPS60193989A (ja) 1985-10-02
DE3570670D1 (en) 1989-07-06
JP2545060B2 (ja) 1996-10-16

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)