HK1257518A1 - 針對人白介素-2的免疫刺激性人源化單克隆抗體及其融合蛋白 - Google Patents

針對人白介素-2的免疫刺激性人源化單克隆抗體及其融合蛋白

Info

Publication number
HK1257518A1
HK1257518A1 HK18116440.2A HK18116440A HK1257518A1 HK 1257518 A1 HK1257518 A1 HK 1257518A1 HK 18116440 A HK18116440 A HK 18116440A HK 1257518 A1 HK1257518 A1 HK 1257518A1
Authority
HK
Hong Kong
Prior art keywords
stimulating
immune
monoclonal antibodies
fusion proteins
antibodies against
Prior art date
Application number
HK18116440.2A
Other languages
English (en)
Inventor
Natalia Arenas-Ramirez
Iwan Beuvink
Onur Boyman
Barbara Brannetti
Andreas Katopodis
Simone Popp
Catherine Regnier
Chao Zou
Original Assignee
Novartis Ag
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Zuerich filed Critical Novartis Ag
Publication of HK1257518A1 publication Critical patent/HK1257518A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
HK18116440.2A 2016-01-11 2018-12-21 針對人白介素-2的免疫刺激性人源化單克隆抗體及其融合蛋白 HK1257518A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277113P 2016-01-11 2016-01-11
PCT/IB2017/050127 WO2017122130A1 (en) 2016-01-11 2017-01-11 Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof

Publications (1)

Publication Number Publication Date
HK1257518A1 true HK1257518A1 (zh) 2019-10-25

Family

ID=57882113

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18116440.2A HK1257518A1 (zh) 2016-01-11 2018-12-21 針對人白介素-2的免疫刺激性人源化單克隆抗體及其融合蛋白

Country Status (14)

Country Link
US (2) US10889643B2 (zh)
EP (1) EP3402819A1 (zh)
JP (1) JP6993699B2 (zh)
KR (1) KR20180100224A (zh)
CN (2) CN116003593A (zh)
AU (1) AU2017208133B2 (zh)
BR (1) BR112018014150A2 (zh)
CA (1) CA3009001A1 (zh)
EA (1) EA039865B1 (zh)
HK (1) HK1257518A1 (zh)
IL (1) IL260218B2 (zh)
MA (1) MA43859A (zh)
MX (1) MX2018008592A (zh)
WO (1) WO2017122130A1 (zh)

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CN108473569A (zh) 2018-08-31
EA201891582A1 (ru) 2018-12-28
JP6993699B2 (ja) 2022-02-03
AU2017208133A1 (en) 2018-07-05
CN108473569B (zh) 2022-11-22
KR20180100224A (ko) 2018-09-07
JP2019511200A (ja) 2019-04-25
US11851484B2 (en) 2023-12-26
WO2017122130A9 (en) 2018-02-01
IL260218B (en) 2022-12-01
US10889643B2 (en) 2021-01-12
IL260218A (en) 2018-07-31
IL260218B2 (en) 2023-04-01
MA43859A (fr) 2018-11-21
US20210246200A1 (en) 2021-08-12
CA3009001A1 (en) 2017-07-20
CN116003593A (zh) 2023-04-25
BR112018014150A2 (pt) 2018-12-11
EA039865B1 (ru) 2022-03-22
WO2017122130A1 (en) 2017-07-20
MX2018008592A (es) 2018-12-10
US20190016797A1 (en) 2019-01-17
AU2017208133B2 (en) 2023-12-21
EP3402819A1 (en) 2018-11-21

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