HK1254651A1 - 吡唑並[1，5-a]嘧啶-3-甲酰胺的環醚衍生物 - Google Patents

吡唑並[1，5-a]嘧啶-3-甲酰胺的環醚衍生物

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Publication number
HK1254651A1
HK1254651A1 HK18113618.5A HK18113618A HK1254651A1 HK 1254651 A1 HK1254651 A1 HK 1254651A1 HK 18113618 A HK18113618 A HK 18113618A HK 1254651 A1 HK1254651 A1 HK 1254651A1
Authority
HK
Hong Kong
Prior art keywords
carboxyamide
pyrazolo
pyrimidine
cyclic ether
ether derivatives
Prior art date
Application number
HK18113618.5A
Other languages
English (en)
Inventor
Christoph Hoenke
Barbara Bertani
Marco Ferrara
Giacomo Fossati
Sara Frattini
Riccardo Giovannini
Scott Hobson
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of HK1254651A1 publication Critical patent/HK1254651A1/zh

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Physical Education & Sports Medicine (AREA)
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  • Addiction (AREA)
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  • Communicable Diseases (AREA)
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  • AIDS & HIV (AREA)
HK18113618.5A 2015-10-13 2018-10-24 吡唑並[1，5-a]嘧啶-3-甲酰胺的環醚衍生物 HK1254651A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15189600.8A EP3156405A1 (en) 2015-10-13 2015-10-13 Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
PCT/EP2016/074380 WO2017064082A1 (en) 2015-10-13 2016-10-12 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide

Publications (1)

Publication Number Publication Date
HK1254651A1 true HK1254651A1 (zh) 2019-07-26

Family

ID=54293164

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HK18113618.5A HK1254651A1 (zh) 2015-10-13 2018-10-24 吡唑並[1，5-a]嘧啶-3-甲酰胺的環醚衍生物

Country Status (30)

Country Link
US (5) US10023575B2 (zh)
EP (2) EP3156405A1 (zh)
JP (1) JP6626965B2 (zh)
KR (1) KR102611558B1 (zh)
CN (2) CN114181213A (zh)
AU (1) AU2016338602B2 (zh)
BR (1) BR112018004347B1 (zh)
CA (1) CA3001929C (zh)
CL (1) CL2018000856A1 (zh)
CO (1) CO2018003756A2 (zh)
DK (1) DK3362453T3 (zh)
EA (1) EA035350B1 (zh)
ES (1) ES2912223T3 (zh)
HK (1) HK1254651A1 (zh)
HR (1) HRP20220595T1 (zh)
IL (1) IL258070B (zh)
LT (1) LT3362453T (zh)
MA (1) MA42988B1 (zh)
MX (1) MX2018004524A (zh)
MY (1) MY195169A (zh)
NZ (1) NZ740119A (zh)
PE (2) PE20190778A1 (zh)
PH (1) PH12018500796A1 (zh)
PL (1) PL3362453T3 (zh)
PT (1) PT3362453T (zh)
RS (1) RS63218B1 (zh)
SA (1) SA518391334B1 (zh)
SI (1) SI3362453T1 (zh)
UA (1) UA124576C2 (zh)
WO (1) WO2017064082A1 (zh)

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EP3156405A1 (en) * 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
RU2671964C1 (ru) * 2017-08-30 2018-11-08 Сиа Эволед Пиразоло[1,5-а]пиримидинкарбоксилаты гадолиния и органические светодиоды на их основе
TWI745836B (zh) * 2019-01-18 2021-11-11 大陸商蘇州亞盛藥業有限公司 作為mcl-1抑製劑的大螺環醚
CN110339197A (zh) * 2019-06-24 2019-10-18 中山大学 一种防治血管性痴呆的磷酸二酯酶9a抑制剂的用途

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MA42988B1 (fr) 2022-04-29
CN114181213A (zh) 2022-03-15
EP3156405A1 (en) 2017-04-19
EA035350B1 (ru) 2020-05-29
US10875867B2 (en) 2020-12-29
US20230286993A1 (en) 2023-09-14
BR112018004347B1 (pt) 2023-12-05
US20200039991A1 (en) 2020-02-06
LT3362453T (lt) 2022-05-25
EA201890922A1 (ru) 2018-11-30
US20210032259A1 (en) 2021-02-04
JP2018534279A (ja) 2018-11-22
PH12018500796A1 (en) 2018-10-29
ES2912223T3 (es) 2022-05-25
PE20190778A1 (es) 2019-06-06
EP3362453A1 (en) 2018-08-22
UA124576C2 (uk) 2021-10-13
MA42988A (fr) 2021-04-07
MY195169A (en) 2023-01-11
PE20181447A1 (es) 2018-09-12
PL3362453T3 (pl) 2022-07-25
WO2017064082A1 (en) 2017-04-20
SI3362453T1 (sl) 2022-06-30
AU2016338602B2 (en) 2020-07-16
BR112018004347A2 (pt) 2018-10-09
SA518391334B1 (ar) 2021-03-29
MX2018004524A (es) 2018-06-27
US11691977B2 (en) 2023-07-04
CL2018000856A1 (es) 2018-07-27
JP6626965B2 (ja) 2019-12-25
PT3362453T (pt) 2022-05-04
AU2016338602A1 (en) 2018-03-15
RS63218B1 (sr) 2022-06-30
EP3362453B1 (en) 2022-03-30
CO2018003756A2 (es) 2018-07-10
CA3001929A1 (en) 2017-04-20
HRP20220595T1 (hr) 2022-06-10
US10479794B2 (en) 2019-11-19
US10023575B2 (en) 2018-07-17
KR102611558B1 (ko) 2023-12-11
DK3362453T3 (da) 2022-06-07
CN108137602B (zh) 2021-09-28
US20170101411A1 (en) 2017-04-13
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NZ740119A (en) 2022-02-25
IL258070A (en) 2018-05-31
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IL258070B (en) 2020-06-30

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