HK1253301A1 - 製備膽汁酸衍生物的方法 - Google Patents

製備膽汁酸衍生物的方法

Info

Publication number
HK1253301A1
HK1253301A1 HK18112593.6A HK18112593A HK1253301A1 HK 1253301 A1 HK1253301 A1 HK 1253301A1 HK 18112593 A HK18112593 A HK 18112593A HK 1253301 A1 HK1253301 A1 HK 1253301A1
Authority
HK
Hong Kong
Prior art keywords
acid derivatives
bile acid
preparing bile
preparing
derivatives
Prior art date
Application number
HK18112593.6A
Other languages
English (en)
Inventor
R‧佩利恰里
A‧焦伊洛
Original Assignee
英特塞普特醫藥品公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 英特塞普特醫藥品公司 filed Critical 英特塞普特醫藥品公司
Publication of HK1253301A1 publication Critical patent/HK1253301A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK18112593.6A 2012-10-26 2016-02-24 製備膽汁酸衍生物的方法 HK1253301A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26

Publications (1)

Publication Number Publication Date
HK1253301A1 true HK1253301A1 (zh) 2019-06-14

Family

ID=50545344

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18112593.6A HK1253301A1 (zh) 2012-10-26 2016-02-24 製備膽汁酸衍生物的方法
HK16102102.3A HK1214239A1 (zh) 2012-10-26 2016-02-24 製備膽汁酸衍生物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16102102.3A HK1214239A1 (zh) 2012-10-26 2016-02-24 製備膽汁酸衍生物的方法

Country Status (21)

Country Link
US (2) US9777038B2 (zh)
EP (1) EP2912013B1 (zh)
JP (1) JP6272888B2 (zh)
KR (1) KR102068381B1 (zh)
CN (2) CN108250264A (zh)
AU (1) AU2013334122B2 (zh)
BR (1) BR112015009395A2 (zh)
CA (1) CA2889592A1 (zh)
CY (1) CY1119731T1 (zh)
DK (1) DK2912013T3 (zh)
ES (1) ES2655034T3 (zh)
HK (2) HK1253301A1 (zh)
HU (1) HUE036887T2 (zh)
IL (1) IL238454B (zh)
MX (1) MX361653B (zh)
NO (1) NO2968302T3 (zh)
NZ (2) NZ707389A (zh)
PL (1) PL2912013T3 (zh)
PT (1) PT2912013T (zh)
SG (1) SG11201503247UA (zh)
WO (1) WO2014066819A1 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX361653B (es) 2012-10-26 2018-12-13 Intercept Pharmaceuticals Inc Procedimiento para la preparación de derivados del ácido biliar.
PL3626725T3 (pl) * 2014-05-29 2023-04-03 Bar Pharmaceuticals S.R.L. Pochodne cholanu do zastosowania w leczeniu i/lub zapobieganiu chorobom, w których pośredniczy fxr i tgr5/gpbar1
CA2968309A1 (en) 2014-11-19 2016-05-26 NZP UK Limited 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
EP3221332B1 (en) 2014-11-19 2019-04-24 NZP UK Limited 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators
US20170327531A1 (en) 2014-11-19 2017-11-16 NZP UK Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
MX2017006565A (es) 2014-11-19 2018-01-26 Nzp Uk Ltd Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr).
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
MA40814A1 (fr) 2015-02-06 2019-08-30 Intercept Pharmaceuticals Inc Compositions pharmaceutiques pour thérapie combinée
US11072631B2 (en) * 2015-09-24 2021-07-27 Intercept Pharmaceuticals, Inc. Methods and intermediates for the preparation bile acid derivatives
JP6749406B2 (ja) * 2015-11-06 2020-09-02 インターセプト ファーマシューティカルズ， インコーポレイテッド オベチコール酸およびその誘導体の調製方法
WO2017142895A1 (en) * 2016-02-15 2017-08-24 Regents Of The University Of Minnesota Compositions and methods for treating clostridium associated diseases
JP6968821B2 (ja) 2016-04-13 2021-11-17 インターセプト ファーマシューティカルズ， インコーポレイテッド 癌を治療する方法
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
WO2018064441A1 (en) * 2016-09-30 2018-04-05 Intercept Pharmaceuticals, Inc Crystalline forms of a bile acid derivative
CN111050772A (zh) * 2017-07-24 2020-04-21 英特塞普特医药品公司 同位素标记的胆汁酸衍生物
EP3660030A4 (en) * 2017-07-26 2021-04-21 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. METHOD OF MANUFACTURING STEROID-DERIVATIVE FXR AGONISTS
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
JP2022536060A (ja) 2019-05-30 2022-08-12 インターセプト ファーマシューティカルズ， インコーポレイテッド 胆汁鬱滞性肝疾患の処置で使用するためのｆｘｒアゴニストおよびフィブラートを含む医薬組成物
BR112022006546A2 (pt) 2019-10-07 2022-08-30 Kallyope Inc Agonistas de gpr119
BR112022023359A2 (pt) 2020-05-19 2023-04-18 Kallyope Inc Ativadores de ampk
EP4172162A1 (en) 2020-06-26 2023-05-03 Kallyope, Inc. Ampk activators
JP2023542365A (ja) 2020-09-18 2023-10-06 ソウル大学校産学協力団 タウロデオキシコール酸ナトリウムの大量生産方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216015A (en) 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
JP4021327B2 (ja) 2001-03-12 2007-12-12 インターセプト ファーマスーティカル インコーポレイテッド Ｆｘｒに対する作用薬としてのステロイド
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
SI2040713T1 (sl) * 2006-06-27 2014-11-28 Intercept Pharmaceuticals, Inc. Derivati žolčne kisline kot FXR ligandi za preprečevanje ali zdravljenje bolezni ali stanj, posredovanih s FXR
US9943614B2 (en) 2008-06-17 2018-04-17 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
WO2010014836A2 (en) 2008-07-30 2010-02-04 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
ES2592452T3 (es) * 2008-11-19 2016-11-30 Intercept Pharmaceuticals, Inc. Moduladores de TGR5 y métodos de uso de los mismos
MX361653B (es) 2012-10-26 2018-12-13 Intercept Pharmaceuticals Inc Procedimiento para la preparación de derivados del ácido biliar.

Also Published As

Publication number Publication date
BR112015009395A2 (pt) 2017-07-04
CA2889592A1 (en) 2014-05-01
US10202414B2 (en) 2019-02-12
KR20150074062A (ko) 2015-07-01
NO2968302T3 (zh) 2018-02-03
AU2013334122B2 (en) 2017-11-02
CY1119731T1 (el) 2018-06-27
NZ707389A (en) 2018-08-31
PT2912013T (pt) 2018-01-03
JP6272888B2 (ja) 2018-01-31
SG11201503247UA (en) 2015-06-29
MX2015005286A (es) 2015-10-29
KR102068381B1 (ko) 2020-01-20
CN105102425B (zh) 2018-04-10
NZ745013A (en) 2019-08-30
DK2912013T3 (en) 2018-01-15
US20180079776A1 (en) 2018-03-22
WO2014066819A1 (en) 2014-05-01
CN105102425A (zh) 2015-11-25
US9777038B2 (en) 2017-10-03
IL238454B (en) 2018-11-29
MX361653B (es) 2018-12-13
PL2912013T3 (pl) 2018-05-30
IL238454A0 (en) 2015-06-30
AU2013334122A1 (en) 2015-05-14
EP2912013A4 (en) 2016-06-01
US20150291653A1 (en) 2015-10-15
EP2912013B1 (en) 2017-10-11
JP2015533852A (ja) 2015-11-26
CN108250264A (zh) 2018-07-06
ES2655034T3 (es) 2018-02-16
EP2912013A1 (en) 2015-09-02
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28

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