HK1214239A1 - 製備膽汁酸衍生物的方法 - Google Patents
製備膽汁酸衍生物的方法Info
- Publication number
- HK1214239A1 HK1214239A1 HK16102102.3A HK16102102A HK1214239A1 HK 1214239 A1 HK1214239 A1 HK 1214239A1 HK 16102102 A HK16102102 A HK 16102102A HK 1214239 A1 HK1214239 A1 HK 1214239A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- acid derivatives
- bile acid
- preparing bile
- preparing
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261718966P | 2012-10-26 | 2012-10-26 | |
PCT/US2013/066917 WO2014066819A1 (en) | 2012-10-26 | 2013-10-25 | Process for preparing bile acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1214239A1 true HK1214239A1 (zh) | 2016-07-22 |
Family
ID=50545344
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18112593.6A HK1253301A1 (zh) | 2012-10-26 | 2016-02-24 | 製備膽汁酸衍生物的方法 |
HK16102102.3A HK1214239A1 (zh) | 2012-10-26 | 2016-02-24 | 製備膽汁酸衍生物的方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18112593.6A HK1253301A1 (zh) | 2012-10-26 | 2016-02-24 | 製備膽汁酸衍生物的方法 |
Country Status (21)
Country | Link |
---|---|
US (2) | US9777038B2 (zh) |
EP (1) | EP2912013B1 (zh) |
JP (1) | JP6272888B2 (zh) |
KR (1) | KR102068381B1 (zh) |
CN (2) | CN108250264A (zh) |
AU (1) | AU2013334122B2 (zh) |
BR (1) | BR112015009395A2 (zh) |
CA (1) | CA2889592A1 (zh) |
CY (1) | CY1119731T1 (zh) |
DK (1) | DK2912013T3 (zh) |
ES (1) | ES2655034T3 (zh) |
HK (2) | HK1253301A1 (zh) |
HU (1) | HUE036887T2 (zh) |
IL (1) | IL238454B (zh) |
MX (1) | MX361653B (zh) |
NO (1) | NO2968302T3 (zh) |
NZ (2) | NZ745013A (zh) |
PL (1) | PL2912013T3 (zh) |
PT (1) | PT2912013T (zh) |
SG (1) | SG11201503247UA (zh) |
WO (1) | WO2014066819A1 (zh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2655034T3 (es) | 2012-10-26 | 2018-02-16 | Intercept Pharmaceuticals, Inc. | Proceso para preparar derivados del ácido biliar |
RS64050B1 (sr) | 2014-05-29 | 2023-04-28 | Bar Pharmaceuticals S R L | Derivati holana za upotrebu u lečenju i/ili prevenciji fxr i tgr5/gpbar1 posredovanih bolesti |
WO2016079518A1 (en) | 2014-11-19 | 2016-05-26 | Dextra Laboratories Limited | 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators |
CN107207558B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-6,7-二酮类固醇 |
EP3221333B1 (en) | 2014-11-19 | 2019-07-24 | NZP UK Limited | 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators |
PT3221331T (pt) | 2014-11-19 | 2019-12-23 | Nzp Uk Ltd | Esteroides 6-alquil-7-hidroxi-4-en-3-ona como intermediários para a produção de moduladores de fxr esteroidais |
CN104672290B (zh) * | 2015-01-05 | 2017-06-06 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途 |
EP3253382B1 (en) | 2015-02-06 | 2021-11-17 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions for combination therapy |
WO2017053826A1 (en) * | 2015-09-24 | 2017-03-30 | Intercept Pharmaceuticals, Inc. | Methods and intermediates for the preparation bile acid derivatives |
CN108348533A (zh) * | 2015-11-06 | 2018-07-31 | 英特塞普特医药品公司 | 制备奥贝胆酸及其衍生物的方法 |
US20200262865A1 (en) * | 2016-02-15 | 2020-08-20 | Alexander Khoruts | Compositions and methods for treating clostridium associated diseases |
AU2017249226B2 (en) | 2016-04-13 | 2021-07-15 | Intercept Pharmaceuticals, Inc. | Methods of treating cancer |
TW201738254A (zh) * | 2016-04-19 | 2017-11-01 | 英特賽普醫藥品公司 | 奧貝膽酸及其衍生物之製備方法 |
GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
CA3038534A1 (en) * | 2016-09-30 | 2018-04-05 | Intercept Pharmaceuticals, Inc. | Crystalline forms of a bile acid derivative |
US11472831B2 (en) * | 2017-07-24 | 2022-10-18 | Intercept Pharmaceuticals, Inc. | Isotopically labeled bile acid derivatives |
WO2019020067A1 (zh) * | 2017-07-26 | 2019-01-31 | 正大天晴药业集团股份有限公司 | 甾体类衍生物fxr激动剂的制备方法 |
GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
MX2021014585A (es) | 2019-05-30 | 2022-01-11 | Intercept Pharmaceuticals Inc | Composiciones farmaceuticas que comprenden un agonista de fxr y un fibrato para usarse en el tratamiento de la enfermedad hepatica colestatica. |
KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
AU2021275038A1 (en) | 2020-05-19 | 2022-12-22 | Kallyope, Inc. | AMPK activators |
WO2021263039A1 (en) | 2020-06-26 | 2021-12-30 | Kallyope, Inc. | Ampk activators |
EP4215540A1 (en) | 2020-09-18 | 2023-07-26 | Seoul National University R & DB Foundation | Method for mass-producing sodium taurodeoxycholate |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5216015A (en) | 1991-02-05 | 1993-06-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having hypocholesterolemic properties |
DE60205891T2 (de) | 2001-03-12 | 2006-06-22 | Intercept Pharmaceuticals, Inc. | Steroide als agonisten für fxr |
EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
US7932244B2 (en) * | 2006-06-27 | 2011-04-26 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions |
EP2303026B1 (en) | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
EA020310B1 (ru) * | 2008-07-30 | 2014-10-30 | Интерсепт Фармасьютикалз, Инк. | Модуляторы рецептора tgr5 и их применение |
JP5639073B2 (ja) * | 2008-11-19 | 2014-12-10 | インターセプト ファーマシューティカルズ, インコーポレイテッド | Tgr5モジュレーターおよびその使用方法 |
ES2655034T3 (es) | 2012-10-26 | 2018-02-16 | Intercept Pharmaceuticals, Inc. | Proceso para preparar derivados del ácido biliar |
-
2013
- 2013-10-25 ES ES13849263.2T patent/ES2655034T3/es active Active
- 2013-10-25 PL PL13849263T patent/PL2912013T3/pl unknown
- 2013-10-25 NZ NZ745013A patent/NZ745013A/en not_active IP Right Cessation
- 2013-10-25 EP EP13849263.2A patent/EP2912013B1/en active Active
- 2013-10-25 WO PCT/US2013/066917 patent/WO2014066819A1/en active Application Filing
- 2013-10-25 BR BR112015009395A patent/BR112015009395A2/pt not_active Application Discontinuation
- 2013-10-25 SG SG11201503247UA patent/SG11201503247UA/en unknown
- 2013-10-25 HU HUE13849263A patent/HUE036887T2/hu unknown
- 2013-10-25 JP JP2015539862A patent/JP6272888B2/ja not_active Expired - Fee Related
- 2013-10-25 DK DK13849263.2T patent/DK2912013T3/en active
- 2013-10-25 AU AU2013334122A patent/AU2013334122B2/en not_active Ceased
- 2013-10-25 MX MX2015005286A patent/MX361653B/es active IP Right Grant
- 2013-10-25 CN CN201810282054.XA patent/CN108250264A/zh active Pending
- 2013-10-25 CN CN201380068062.XA patent/CN105102425B/zh not_active Expired - Fee Related
- 2013-10-25 US US14/438,323 patent/US9777038B2/en active Active
- 2013-10-25 PT PT138492632T patent/PT2912013T/pt unknown
- 2013-10-25 KR KR1020157012805A patent/KR102068381B1/ko active IP Right Grant
- 2013-10-25 CA CA2889592A patent/CA2889592A1/en not_active Abandoned
- 2013-10-25 NZ NZ707389A patent/NZ707389A/en not_active IP Right Cessation
-
2014
- 2014-03-14 NO NO14725812A patent/NO2968302T3/no unknown
-
2015
- 2015-04-26 IL IL238454A patent/IL238454B/en active IP Right Grant
-
2016
- 2016-02-24 HK HK18112593.6A patent/HK1253301A1/zh unknown
- 2016-02-24 HK HK16102102.3A patent/HK1214239A1/zh not_active IP Right Cessation
-
2017
- 2017-08-21 US US15/681,609 patent/US10202414B2/en not_active Expired - Fee Related
-
2018
- 2018-01-03 CY CY20181100003T patent/CY1119731T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20221023 |