HK1249512A1 - 具有作為phd抑制劑的活性的稠合雙環雜芳基衍生物 - Google Patents
具有作為phd抑制劑的活性的稠合雙環雜芳基衍生物Info
- Publication number
- HK1249512A1 HK1249512A1 HK18109089.3A HK18109089A HK1249512A1 HK 1249512 A1 HK1249512 A1 HK 1249512A1 HK 18109089 A HK18109089 A HK 18109089A HK 1249512 A1 HK1249512 A1 HK 1249512A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- activity
- bicyclic heteroaryl
- fused bicyclic
- heteroaryl derivatives
- phd inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1504565.1A GB201504565D0 (en) | 2015-03-18 | 2015-03-18 | Novel compounds |
| PCT/JP2016/059782 WO2016148306A1 (en) | 2015-03-18 | 2016-03-17 | Fused bicyclic heteroaryl derivatives having activity as phd inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1249512A1 true HK1249512A1 (zh) | 2018-11-02 |
Family
ID=53051992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18109089.3A HK1249512A1 (zh) | 2015-03-18 | 2018-07-13 | 具有作為phd抑制劑的活性的稠合雙環雜芳基衍生物 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US10287286B2 (zh) |
| EP (1) | EP3271357B1 (zh) |
| JP (1) | JP6726681B2 (zh) |
| KR (1) | KR102609431B1 (zh) |
| CN (1) | CN107531698A (zh) |
| AU (1) | AU2016234209B2 (zh) |
| BR (1) | BR112017019653B1 (zh) |
| CA (1) | CA2979024C (zh) |
| CL (1) | CL2017002354A1 (zh) |
| CO (1) | CO2017009353A2 (zh) |
| CR (1) | CR20170468A (zh) |
| DK (1) | DK3271357T3 (zh) |
| DO (1) | DOP2017000209A (zh) |
| EA (1) | EA035739B1 (zh) |
| EC (1) | ECSP17069696A (zh) |
| ES (1) | ES2774052T3 (zh) |
| GB (1) | GB201504565D0 (zh) |
| GE (1) | GEP20207095B (zh) |
| HK (1) | HK1249512A1 (zh) |
| HU (1) | HUE047918T2 (zh) |
| IL (1) | IL254277B (zh) |
| MX (1) | MX2017011902A (zh) |
| MY (1) | MY194873A (zh) |
| NZ (1) | NZ735631A (zh) |
| PE (1) | PE20180656A1 (zh) |
| PH (1) | PH12017501699A1 (zh) |
| PT (1) | PT3271357T (zh) |
| SG (1) | SG11201707280VA (zh) |
| TN (1) | TN2017000384A1 (zh) |
| UA (1) | UA123668C2 (zh) |
| WO (1) | WO2016148306A1 (zh) |
| ZA (1) | ZA201706612B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017222417B2 (en) | 2016-02-24 | 2020-07-09 | Pfizer Inc. | Pyrazolo[1,5-a]pyrazin-4-yl derivatives as JAK-inhibitors |
| US11254668B2 (en) | 2017-08-14 | 2022-02-22 | Pfizer Inc. | Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives |
| EP3808747A4 (en) * | 2018-09-13 | 2022-03-09 | Kissei Pharmaceutical Co., Ltd. | IMIDAZOPYRIDINONE COMPOUND |
| CN110950806A (zh) * | 2019-11-14 | 2020-04-03 | 安庆博曼生物技术有限公司 | 四乙基氯化铵催化嘧啶环羟基氯代制备方法 |
| US11718622B2 (en) | 2020-03-16 | 2023-08-08 | Exelixis Inc. | Heterocyclic adenosine receptor antagonists |
| EP4232444A1 (en) * | 2020-10-20 | 2023-08-30 | Amgen Inc. | Heterocyclic spiro compounds and methods of use |
| AR127501A1 (es) | 2021-10-28 | 2024-01-31 | Insilico Medicine Ip Ltd | Inhibidores de la proteína que contiene el dominio de prolil hidroxilasa (phd) y usos de los mismos |
| WO2023111990A1 (en) * | 2021-12-17 | 2023-06-22 | Akebia Therapeutics, Inc. | Selective phd1 inhibitor compounds, compositions, and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209621A (en) | 1979-04-27 | 1980-06-24 | American Cyanamid Company | (Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-a]pyrimidines |
| US4572910A (en) * | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| DK135184A (da) | 1983-03-03 | 1984-10-10 | Riker Laboratories Inc | Triazol(4,3-c)- og triazol(1,5-c)pyrimidiner |
| CA2413802A1 (en) | 2000-06-30 | 2002-01-10 | Mark R. Schmitt | Substituted-triazolopyrimidines as anticancer agents |
| JP2010065026A (ja) | 2008-08-13 | 2010-03-25 | Ishihara Sangyo Kaisha Ltd | ピリジル−トリアゾロピリミジン誘導体又はその塩、並びにそれらを含有する有害生物防除剤 |
| JP2010065024A (ja) | 2008-08-14 | 2010-03-25 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリミジン誘導体又はその塩を含有する有害生物防除剤 |
| PL2455381T3 (pl) * | 2009-07-17 | 2014-10-31 | Japan Tobacco Inc | Triazolopirydynowy związek i jego działanie jako inhibitora hydroksylazy prolinowej i środka indukującego wytwarzanie erytropoetyny |
| JP2011168582A (ja) * | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
| US20150239889A1 (en) | 2012-08-23 | 2015-08-27 | Mitsubishi Tanabe Pharma Corporation | Pyrazolopyrimidine compound |
-
2015
- 2015-03-18 GB GBGB1504565.1A patent/GB201504565D0/en not_active Ceased
-
2016
- 2016-03-17 GE GEAP201614608A patent/GEP20207095B/en unknown
- 2016-03-17 BR BR112017019653-0A patent/BR112017019653B1/pt active IP Right Grant
- 2016-03-17 US US15/558,824 patent/US10287286B2/en active Active
- 2016-03-17 HU HUE16715122A patent/HUE047918T2/hu unknown
- 2016-03-17 MX MX2017011902A patent/MX2017011902A/es active IP Right Grant
- 2016-03-17 DK DK16715122.4T patent/DK3271357T3/da active
- 2016-03-17 PE PE2018000126A patent/PE20180656A1/es unknown
- 2016-03-17 KR KR1020177030091A patent/KR102609431B1/ko active IP Right Grant
- 2016-03-17 SG SG11201707280VA patent/SG11201707280VA/en unknown
- 2016-03-17 ES ES16715122T patent/ES2774052T3/es active Active
- 2016-03-17 CN CN201680022416.0A patent/CN107531698A/zh active Pending
- 2016-03-17 CR CR20170468A patent/CR20170468A/es unknown
- 2016-03-17 PT PT167151224T patent/PT3271357T/pt unknown
- 2016-03-17 EA EA201792057A patent/EA035739B1/ru unknown
- 2016-03-17 TN TNP/2017/000384A patent/TN2017000384A1/en unknown
- 2016-03-17 NZ NZ735631A patent/NZ735631A/en unknown
- 2016-03-17 EP EP16715122.4A patent/EP3271357B1/en active Active
- 2016-03-17 JP JP2017549107A patent/JP6726681B2/ja active Active
- 2016-03-17 WO PCT/JP2016/059782 patent/WO2016148306A1/en active Application Filing
- 2016-03-17 AU AU2016234209A patent/AU2016234209B2/en active Active
- 2016-03-17 MY MYPI2017703420A patent/MY194873A/en unknown
- 2016-03-17 UA UAA201708877A patent/UA123668C2/uk unknown
- 2016-03-17 CA CA2979024A patent/CA2979024C/en active Active
-
2017
- 2017-09-03 IL IL254277A patent/IL254277B/en active IP Right Grant
- 2017-09-14 CO CONC2017/0009353A patent/CO2017009353A2/es unknown
- 2017-09-15 CL CL2017002354A patent/CL2017002354A1/es unknown
- 2017-09-15 PH PH12017501699A patent/PH12017501699A1/en unknown
- 2017-09-18 DO DO2017000209A patent/DOP2017000209A/es unknown
- 2017-10-02 ZA ZA2017/06612A patent/ZA201706612B/en unknown
- 2017-10-18 EC ECIEPI201769696A patent/ECSP17069696A/es unknown
-
2018
- 2018-07-13 HK HK18109089.3A patent/HK1249512A1/zh unknown
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