HK1253576A1 - 作為mnk抑制劑的吡咯並嘧啶化合物 - Google Patents
作為mnk抑制劑的吡咯並嘧啶化合物Info
- Publication number
- HK1253576A1 HK1253576A1 HK18112781.8A HK18112781A HK1253576A1 HK 1253576 A1 HK1253576 A1 HK 1253576A1 HK 18112781 A HK18112781 A HK 18112781A HK 1253576 A1 HK1253576 A1 HK 1253576A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrropyrimidine
- mnks
- inhibitors
- compounds
- pyrropyrimidine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1520499.3A GB201520499D0 (en) | 2015-11-20 | 2015-11-20 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1253576A1 true HK1253576A1 (zh) | 2019-06-21 |
Family
ID=55133105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18112781.8A HK1253576A1 (zh) | 2015-11-20 | 2018-10-08 | 作為mnk抑制劑的吡咯並嘧啶化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10604524B2 (zh) |
| EP (2) | EP3792264B1 (zh) |
| JP (1) | JP6946290B2 (zh) |
| CN (1) | CN108368114B (zh) |
| AU (1) | AU2016355103B2 (zh) |
| CA (1) | CA3003554C (zh) |
| ES (1) | ES2872775T3 (zh) |
| GB (1) | GB201520499D0 (zh) |
| HK (1) | HK1253576A1 (zh) |
| WO (1) | WO2017085483A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | ＭｎＫ抑制劑及其相關方法 |
| MX2019009653A (es) | 2017-02-14 | 2019-12-19 | Effector Therapeutics Inc | Inhibidores de mnk sustituidos con piperidina y metodos relacionados con los mismos. |
| CN109020957B (zh) * | 2017-06-12 | 2023-01-13 | 南京天印健华医药科技有限公司 | 作为mnk抑制剂的杂环化合物 |
| AU2019366947A1 (en) | 2018-10-24 | 2021-06-03 | Effector Therapeutics, Inc. | Crystalline forms of Mnk inhibitors |
| CN110903286B (zh) * | 2019-12-16 | 2021-09-24 | 沈阳药科大学 | 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| MX9709867A (es) * | 1995-06-07 | 1998-03-31 | Pfizer | Derivados de pirimidina condensados con un anillo heterociclico, composiciones que contienen los mismos, y uso de los mismos. |
| BR9713552A (pt) * | 1996-11-27 | 2000-01-25 | Pfizer | Derivados de pirimidina bicìclicos condensados |
| BR9916746A (pt) | 1999-06-03 | 2005-01-11 | Abbott Lab | Compostos anti-inflamatórios que inibem adesão de célula |
| WO2005069865A2 (en) | 2004-01-13 | 2005-08-04 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| WO2006014325A2 (en) | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
| TW200730527A (en) * | 2005-12-02 | 2007-08-16 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| WO2007115822A1 (en) * | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having mnkl /mnk2 inhibiting activity for pharmaceutical compositions |
| EP1889847A1 (en) * | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| WO2009065596A2 (en) * | 2007-11-22 | 2009-05-28 | Develogen Aktiengesellschaft | Use of mnk inhibitors for the treatment of alzheimer's disease |
| JP5626748B2 (ja) * | 2008-07-02 | 2014-11-19 | キッコーマン株式会社 | ペプチド含有調味料 |
| BR112012021453A2 (pt) | 2010-02-26 | 2017-02-21 | Boehringer Ingelheim Int | tienopirimidina, sua composição farmacêutica e seu uso |
| JP5575274B2 (ja) | 2010-02-26 | 2014-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物のためのｍｎｋｌ／ｍｎｋ２阻害活性を有する４−［シクロアルキルオキシ（ヘテロ）アリールアミノ］チエノ「２，３−ｄ］ピリミジン |
| CA2899662A1 (en) | 2013-02-01 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Substituted pyrazolopyrimidinylamino-indazoles |
| WO2014135480A1 (en) | 2013-03-06 | 2014-09-12 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
| CN104744446B (zh) * | 2013-12-30 | 2019-06-25 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
-
2015
- 2015-11-20 GB GBGB1520499.3A patent/GB201520499D0/en not_active Ceased
-
2016
- 2016-11-16 CA CA3003554A patent/CA3003554C/en active Active
- 2016-11-16 EP EP20204385.7A patent/EP3792264B1/en active Active
- 2016-11-16 ES ES16801015T patent/ES2872775T3/es active Active
- 2016-11-16 US US15/776,574 patent/US10604524B2/en active Active
- 2016-11-16 JP JP2018525743A patent/JP6946290B2/ja active Active
- 2016-11-16 EP EP16801015.5A patent/EP3377494B1/en active Active
- 2016-11-16 CN CN201680067666.6A patent/CN108368114B/zh active Active
- 2016-11-16 WO PCT/GB2016/053579 patent/WO2017085483A1/en active Application Filing
- 2016-11-16 AU AU2016355103A patent/AU2016355103B2/en active Active
-
2018
- 2018-10-08 HK HK18112781.8A patent/HK1253576A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3792264B1 (en) | 2024-01-03 |
| EP3377494A1 (en) | 2018-09-26 |
| ES2872775T3 (es) | 2021-11-02 |
| EP3377494B1 (en) | 2021-03-03 |
| EP3792264A1 (en) | 2021-03-17 |
| JP2018534316A (ja) | 2018-11-22 |
| US10604524B2 (en) | 2020-03-31 |
| CN108368114B (zh) | 2023-10-24 |
| CA3003554C (en) | 2023-08-29 |
| WO2017085483A1 (en) | 2017-05-26 |
| US20180346469A1 (en) | 2018-12-06 |
| CN108368114A (zh) | 2018-08-03 |
| JP6946290B2 (ja) | 2021-10-06 |
| CA3003554A1 (en) | 2017-05-26 |
| GB201520499D0 (en) | 2016-01-06 |
| AU2016355103B2 (en) | 2021-07-08 |
| AU2016355103A1 (en) | 2018-05-31 |
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