HK1245844A1 - 母體血漿中胎兒dna分數的基於大小的分析 - Google Patents

母體血漿中胎兒dna分數的基於大小的分析

Info

Publication number
HK1245844A1
HK1245844A1 HK18104992.0A HK18104992A HK1245844A1 HK 1245844 A1 HK1245844 A1 HK 1245844A1 HK 18104992 A HK18104992 A HK 18104992A HK 1245844 A1 HK1245844 A1 HK 1245844A1
Authority
HK
Hong Kong
Prior art keywords
size
based analysis
fetal dna
maternal plasma
dna fraction
Prior art date
Application number
HK18104992.0A
Other languages
English (en)
Inventor
Yuk Ming Dennis Lo
Kwan Chee Chan
Wenli Zheng
Peiyong Jiang
Jiawei Liao
Wai Kwun Rossa Chiu
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49114635&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1245844(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of HK1245844A1 publication Critical patent/HK1245844A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10Ploidy or copy number detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10Sequence alignment; Homology search
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
HK18104992.0A 2012-03-08 2018-04-17 母體血漿中胎兒dna分數的基於大小的分析 HK1245844A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261608623P 2012-03-08 2012-03-08
US201261621451P 2012-04-06 2012-04-06

Publications (1)

Publication Number Publication Date
HK1245844A1 true HK1245844A1 (zh) 2018-08-31

Family

ID=49114635

Family Applications (7)

Application Number Title Priority Date Filing Date
HK15100609.6A HK1200194A1 (zh) 2012-03-08 2015-01-20 母體血漿中胎兒 分數的基於大小的分析
HK15102503.9A HK1202135A1 (zh) 2012-03-08 2015-03-11 母體血漿中胎兒 分數的基於大小的分析
HK15106797.5A HK1206394A1 (zh) 2012-03-08 2015-07-16 用於癌症等級分類的 規格分析
HK18104074.1A HK1245842A1 (zh) 2012-03-08 2018-03-23 母體血漿中胎兒dna分數的基於大小的分析
HK18104992.0A HK1245844A1 (zh) 2012-03-08 2018-04-17 母體血漿中胎兒dna分數的基於大小的分析
HK18105610.9A HK1246361A1 (zh) 2012-03-08 2018-04-30 母體血漿中胎兒dna分數的基於大小的分析
HK19100179.2A HK1261405A1 (zh) 2012-03-08 2019-01-04 基於大小分析母體血漿中的胎兒dna分數

Family Applications Before (4)

Application Number Title Priority Date Filing Date
HK15100609.6A HK1200194A1 (zh) 2012-03-08 2015-01-20 母體血漿中胎兒 分數的基於大小的分析
HK15102503.9A HK1202135A1 (zh) 2012-03-08 2015-03-11 母體血漿中胎兒 分數的基於大小的分析
HK15106797.5A HK1206394A1 (zh) 2012-03-08 2015-07-16 用於癌症等級分類的 規格分析
HK18104074.1A HK1245842A1 (zh) 2012-03-08 2018-03-23 母體血漿中胎兒dna分數的基於大小的分析

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK18105610.9A HK1246361A1 (zh) 2012-03-08 2018-04-30 母體血漿中胎兒dna分數的基於大小的分析
HK19100179.2A HK1261405A1 (zh) 2012-03-08 2019-01-04 基於大小分析母體血漿中的胎兒dna分數

Country Status (18)

Country Link
US (7) US9892230B2 (zh)
EP (10) EP3301193B1 (zh)
JP (7) JP6073382B2 (zh)
CN (3) CN107630081B (zh)
AU (4) AU2013229186B2 (zh)
CA (2) CA3010254C (zh)
CY (1) CY1121828T1 (zh)
DK (5) DK3301193T3 (zh)
ES (3) ES2761624T3 (zh)
HK (7) HK1200194A1 (zh)
HR (1) HRP20191300T1 (zh)
HU (1) HUE044746T2 (zh)
LT (1) LT3301193T (zh)
PL (1) PL3301193T3 (zh)
PT (1) PT3301193T (zh)
RS (1) RS59073B1 (zh)
SI (1) SI3301193T1 (zh)
WO (1) WO2013132305A1 (zh)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US10017812B2 (en) 2010-05-18 2018-07-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CN107312844B (zh) 2009-11-06 2021-01-22 香港中文大学 基于大小的基因组分析
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2013209499B2 (en) 2012-01-20 2018-05-10 Sequenom, Inc. Diagnostic processes that factor experimental conditions
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
ES2902401T3 (es) * 2012-05-21 2022-03-28 Sequenom Inc Métodos y procesos para la evaluación no invasiva de variaciones genéticas
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
MX367963B (es) 2012-09-04 2019-09-11 Guardant Health Inc Métodos para detectar mutaciones raras y variación en el número de copias.
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6410726B2 (ja) 2012-12-10 2018-10-24 レゾリューション バイオサイエンス, インコーポレイテッド 標的化ゲノム解析のための方法
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
FI2981921T3 (fi) 2013-04-03 2023-03-09 Sequenom Inc Menetelmiä ja prosesseja geneettisten variaatioiden ei-invasiiviseen arviointiin
KR102665592B1 (ko) 2013-05-24 2024-05-21 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
CA2915628C (en) 2013-06-21 2020-04-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
JP6525434B2 (ja) 2013-10-04 2019-06-05 セクエノム, インコーポレイテッド 遺伝子の変異の非侵襲的な評価のための方法および処理
CA2925111C (en) 2013-10-07 2024-01-16 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
JP6534191B2 (ja) 2013-10-21 2019-06-26 ベリナタ ヘルス インコーポレイテッド コピー数変動を決定することにおける検出の感度を向上させるための方法
KR102649364B1 (ko) 2013-11-07 2024-03-20 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
GB2520765A (en) * 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
CA2934822A1 (en) 2013-12-28 2015-07-02 Guardant Health, Inc. Methods and systems for detecting genetic variants
GB2524948A (en) * 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
EP3117011B1 (en) 2014-03-13 2020-05-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
CN107223159A (zh) 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
EP3149199B1 (en) 2014-05-30 2020-03-25 Verinata Health, Inc. Detecting, optionally fetal, sub-chromosomal aneuploidies and copy number variations
WO2016011982A1 (zh) * 2014-07-25 2016-01-28 深圳华大基因股份有限公司 确定生物样本中游离核酸比例的方法、装置及其用途
AU2015292311B2 (en) 2014-07-25 2022-01-20 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same
US11783911B2 (en) * 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US11072814B2 (en) 2014-12-12 2021-07-27 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US11242559B2 (en) 2015-01-13 2022-02-08 The Chinese University Of Hong Kong Method of nuclear DNA and mitochondrial DNA analysis
US10319463B2 (en) 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
WO2016127944A1 (en) 2015-02-10 2016-08-18 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
CN104789686B (zh) * 2015-05-06 2018-09-07 浙江安诺优达生物科技有限公司 检测染色体非整倍性的试剂盒和装置
EP3294906B1 (en) 2015-05-11 2024-07-10 Natera, Inc. Methods for determining ploidy
CA2986036C (en) 2015-05-18 2022-07-26 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
ES2790533T3 (es) 2015-05-22 2020-10-28 Nipd Genetics Public Company Ltd Análisis paralelo múltiplex de regiones genómicas blanco para análisis prenatales no invasivos
IL305462A (en) 2015-07-23 2023-10-01 Univ Hong Kong Chinese DNA fragmentation pattern analysis suitable clean
US20180245037A1 (en) * 2015-09-11 2018-08-30 INSERM (Institut National de la Sante et de la Researche Medicale) Non-Invasive Methods for Assessing Genetic Integrity of Pluripotent Stem Cells
IL293187B2 (en) * 2015-09-22 2024-03-01 Univ Hong Kong Chinese Accurate quantification of a fetal DNA fragment using deep-shallow sequencing of maternal plasma DNA
KR101848438B1 (ko) * 2015-10-29 2018-04-13 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
DK3168309T3 (da) 2015-11-10 2020-06-22 Eurofins Lifecodexx Gmbh Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn
DK3374525T3 (da) 2015-11-11 2021-04-06 Resolution Bioscience Inc Højeffektiv konstruktion af dna-biblioteker
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
JP2019518223A (ja) 2016-03-24 2019-06-27 バイオロジカル ダイナミクス,インク. 使い捨て可能な流体カートリッジおよびコンポーネント
WO2017165864A1 (en) 2016-03-25 2017-09-28 Karius, Inc. Synthetic nucleic acid spike-ins
EP3491560A1 (en) 2016-07-27 2019-06-05 Sequenom, Inc. Genetic copy number alteration classifications
IL264971B1 (en) 2016-08-25 2024-06-01 Resolution Bioscience Inc Methods for identifying changes in a genomic copy in DNA samples
EP3529377B1 (en) 2016-10-19 2023-04-05 The Chinese University Of Hong Kong Gestational age assessment by methylation and size profiling of maternal plasma dna
SG11201903509QA (en) 2016-10-24 2019-05-30 Univ Hong Kong Chinese Methods and systems for tumor detection
CA3040930A1 (en) 2016-11-07 2018-05-11 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
KR102529113B1 (ko) 2016-11-30 2023-05-08 더 차이니즈 유니버시티 오브 홍콩 소변 및 기타 샘플에서의 무세포 dna의 분석
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CN106591451B (zh) * 2016-12-14 2020-06-23 北京贝瑞和康生物技术有限公司 测定胎儿游离dna含量的方法及其用于实施该方法的装置
WO2018140521A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
US10633713B2 (en) 2017-01-25 2020-04-28 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
US10697008B2 (en) 2017-04-12 2020-06-30 Karius, Inc. Sample preparation methods, systems and compositions
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
EP3622084A4 (en) 2017-05-08 2021-02-17 Biological Dynamics, Inc. METHODS AND SYSTEMS FOR PROCESSING ANALYTICAL INFORMATION
CA3070898A1 (en) 2017-07-26 2019-01-31 The Chinese University Of Hong Kong Enhancement of cancer screening using cell-free viral nucleic acids
AU2018355575A1 (en) 2017-10-27 2020-05-21 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
US11168356B2 (en) * 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
CN112041464A (zh) * 2017-12-19 2020-12-04 生物动力学公司 用于检测及量化无细胞dna片段的方法和装置
AU2018388641B2 (en) 2017-12-19 2023-09-07 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
JP2021518106A (ja) * 2018-03-13 2021-08-02 ガーダント ヘルス, インコーポレイテッド 治療用核酸構築物の非侵襲的な検出およびモニタリングのための方法
WO2019178157A1 (en) 2018-03-16 2019-09-19 Karius, Inc. Sample series to differentiate target nucleic acids from contaminant nucleic acids
CN112654431A (zh) 2018-04-02 2021-04-13 生物动力学公司 介电材料
WO2019195268A2 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US20210348224A1 (en) * 2018-05-23 2021-11-11 The Regents Of The University Of California Methods of Analyzing Capped Ribonucleic Acids
CA3111887A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
WO2020104394A1 (en) 2018-11-19 2020-05-28 Sistemas Genómicos, S.L. Method and computer program product for analysis of fetal dna by massive sequencing
CA3123474A1 (en) 2018-12-19 2020-06-25 The Chinese University Of Hong Kong Cell-free dna end characteristics
WO2020186024A1 (en) 2019-03-13 2020-09-17 Grail, Inc. Systems and methods for enriching for cancer-derived fragments using fragment size
CN110136794A (zh) * 2019-05-22 2019-08-16 湖北可汗广电文化有限公司 一种基于人工智能的母婴全生命周期健康医疗服务***
CA3147613A1 (en) * 2019-08-19 2021-02-25 Chang-Seok Ki Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments
US20210166813A1 (en) 2019-11-27 2021-06-03 Grail, Inc. Systems and methods for evaluating longitudinal biological feature data
CN116004786A (zh) * 2020-02-05 2023-04-25 香港中文大学 使用孕妇体内的长游离片段进行的分子分析
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
JP2024523401A (ja) 2021-06-21 2024-06-28 ガーダント ヘルス, インコーポレイテッド コピー数情報に基づく組織起源分析のための方法および組成物
EP4409024A1 (en) 2021-09-30 2024-08-07 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
ATE444532T1 (de) 1999-10-13 2009-10-15 Sequenom Inc Verfahren zur identifizierung von polymorphen genetischen markern
GB0016742D0 (en) 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
US6664056B2 (en) 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
US8898021B2 (en) 2001-02-02 2014-11-25 Mark W. Perlin Method and system for DNA mixture analysis
JP2002272497A (ja) 2001-03-15 2002-09-24 Venture Link Co Ltd 癌の診断方法、およびその診断用ベクター
WO2002077274A2 (fr) 2001-03-23 2002-10-03 Gencell S.A. Procedes de purification et de detection de sequences cibles d'adn double brin par interaction triple helice.
DK1448205T3 (da) 2001-10-05 2011-12-12 Zalicus Inc Kombinationer til behandling af immunoinflammatoriske sygdomme
US20030180765A1 (en) 2002-02-01 2003-09-25 The Johns Hopkins University Digital amplification for detection of mismatch repair deficient tumor cells
IL163600A0 (en) 2002-03-01 2005-12-18 Ravgen Inc Methods for detection of genetic disorders
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
JP2006512924A (ja) 2002-08-15 2006-04-20 ジェンザイム・コーポレーション 脳内皮細胞発現パターン
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
EP1601785A4 (en) 2003-02-28 2007-02-07 Ravgen Inc METHOD FOR DETECTING GENETIC DISEASES
US8394582B2 (en) 2003-03-05 2013-03-12 Genetic Technologies, Inc Identification of fetal DNA and fetal cell markers in maternal plasma or serum
AU2003901671A0 (en) 2003-04-02 2003-05-01 The University Of Adelaide Comparative genomic hybridization
RU2249820C1 (ru) 2003-08-18 2005-04-10 Лактионов Павел Петрович Способ ранней диагностики заболеваний, связанных с нарушением функционирования генетического аппарата клетки
US20050282213A1 (en) 2003-09-22 2005-12-22 Trisogen Biotechnology Limited Partnership Methods and kits useful for detecting an alteration in a locus copy number
CA2541706C (en) 2003-10-08 2014-02-18 The Trustees Of Boston University Methods for prenatal diagnosis of chromosomal abnormalities
EP1524321B2 (en) 2003-10-16 2014-07-23 Sequenom, Inc. Non-invasive detection of fetal genetic traits
US20050221341A1 (en) 2003-10-22 2005-10-06 Shimkets Richard A Sequence-based karyotyping
US20070212689A1 (en) 2003-10-30 2007-09-13 Bianchi Diana W Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid
DE102004036285A1 (de) 2004-07-27 2006-02-16 Advalytix Ag Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe
CN1779688A (zh) 2004-11-22 2006-05-31 寰硕数码股份有限公司 交互式医疗信息***及方法
TWI367259B (en) 2005-03-18 2012-07-01 Univ Hong Kong Chinese A method for the detection of chromosomal aneuploidies
EP1712639B1 (en) 2005-04-06 2008-08-27 Maurice Stroun Method for the diagnosis of cancer by detecting circulating DNA and RNA
US20070122823A1 (en) 2005-09-01 2007-05-31 Bianchi Diana W Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis
DK2385143T3 (en) 2006-02-02 2016-09-19 Univ Leland Stanford Junior Non-invasive fetal genetic screening by digital analysis
US7799531B2 (en) 2006-02-28 2010-09-21 University Of Louisville Research Foundation Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
ES2430071T3 (es) 2007-05-24 2013-11-18 Apceth Gmbh & Co. Kg Células madre CD34- mesenquimales para su uso en terapia génica de cicatrización de heridas
LT2557520T (lt) 2007-07-23 2021-05-25 The Chinese University Of Hong Kong Nukleorūgščių sekos disbalanso nustatymas
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
KR20140107677A (ko) 2007-09-19 2014-09-04 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
WO2009051842A2 (en) 2007-10-18 2009-04-23 The Johns Hopkins University Detection of cancer by measuring genomic copy number and strand length in cell-free dna
DK2562268T3 (en) 2008-09-20 2017-03-27 Univ Leland Stanford Junior Non-invasive diagnosis of fetal aneuploidy by sequencing
WO2010053980A2 (en) * 2008-11-04 2010-05-14 The Johns Hopkins University Dna integrity assay (dia) for cancer diagnostics, using confocal fluorescence spectroscopy
WO2010112316A1 (en) 2009-03-31 2010-10-07 Oridis Biomed Forschungs- Und Entwicklungs Gmbh Method for diagnosis of cancer and monitoring of cancer treatments
WO2011053790A2 (en) 2009-10-30 2011-05-05 Fluidigm Corporation Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis
EP3783110B1 (en) 2009-11-05 2022-11-23 The Chinese University Of Hong Kong Fetal genomic analysis from a maternal biological sample
CN107312844B (zh) 2009-11-06 2021-01-22 香港中文大学 基于大小的基因组分析
WO2011060240A1 (en) 2009-11-12 2011-05-19 Genzyme Corporation Copy number analysis of genetic locus
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
CA2786564A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
GB2479471B (en) 2010-01-19 2012-02-08 Verinata Health Inc Method for determining copy number variations
EP2536854B1 (en) 2010-02-18 2017-07-19 The Johns Hopkins University Personalized tumor biomarkers
US20130143214A1 (en) 2010-06-04 2013-06-06 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
KR102489749B1 (ko) 2010-11-30 2023-01-17 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
US20130059738A1 (en) 2011-04-28 2013-03-07 Life Technologies Corporation Methods and compositions for multiplex pcr
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
AU2012312353A1 (en) 2011-09-22 2014-04-10 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2771483A1 (en) 2011-10-25 2014-09-03 ONCOTYROL - Center for Personalized Cancer Medicine GmbH Method for diagnosing a disease based on plasma-dna distribution
AU2012327251A1 (en) 2011-10-27 2013-05-23 Verinata Health, Inc. Set membership testers for aligning nucleic acid samples
FR2981833B1 (fr) 2011-10-28 2013-12-06 Oreal Sachet de conditionnement de produit cosmetique
US9757458B2 (en) 2011-12-05 2017-09-12 Immunomedics, Inc. Crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in hematopoietic cancer cells
US20140364439A1 (en) 2011-12-07 2014-12-11 The Broad Institute, Inc. Markers associated with chronic lymphocytic leukemia prognosis and progression
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US20130261984A1 (en) 2012-03-30 2013-10-03 Illumina, Inc. Methods and systems for determining fetal chromosomal abnormalities
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US20150197785A1 (en) 2012-08-10 2015-07-16 The Broad Institute, Inc. Methods and apparatus for analyzing and quantifying dna alterations in cancer
MX367963B (es) 2012-09-04 2019-09-11 Guardant Health Inc Métodos para detectar mutaciones raras y variación en el número de copias.
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US9769123B2 (en) 2012-09-06 2017-09-19 Intel Corporation Mitigating unauthorized access to data traffic
CA2884066C (en) 2012-09-20 2021-08-10 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US20140287937A1 (en) 2013-02-21 2014-09-25 Toma Biosciences, Inc. Methods for assessing cancer
EP2971097B1 (en) 2013-03-15 2018-08-01 Verinata Health, Inc Generating cell-free dna libraries directly from blood
EP3795696B1 (en) 2013-03-15 2023-04-26 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
EP3726213A1 (en) 2013-08-19 2020-10-21 Singular Bio Inc. Assays for single molecule detection and use thereof
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
JP6534191B2 (ja) 2013-10-21 2019-06-26 ベリナタ ヘルス インコーポレイテッド コピー数変動を決定することにおける検出の感度を向上させるための方法
GB201319779D0 (en) 2013-11-08 2013-12-25 Cartagenia N V Genetic analysis method
US10465238B2 (en) 2013-12-19 2019-11-05 The Board Of Trustees Of The Leland Stanford Junior University Quantification of mutant alleles and copy number variation using digital PCR with nonspecific DNA-binding dyes
GB2524948A (en) 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
EP3805404A1 (en) 2014-05-13 2021-04-14 Board of Regents, The University of Texas System Gene mutations and copy number alterations of egfr, kras and met
EP3149199B1 (en) 2014-05-30 2020-03-25 Verinata Health, Inc. Detecting, optionally fetal, sub-chromosomal aneuploidies and copy number variations
MX2016016904A (es) 2014-06-26 2017-03-27 10X Genomics Inc Analisis de secuencias de acidos nucleicos.
ES2741400T3 (es) 2014-07-18 2020-02-10 Univ Hong Kong Chinese Análisis de patrones de metilación de tejidos en mezcla de ADN
AU2015292311B2 (en) 2014-07-25 2022-01-20 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same
EP3194612B1 (en) 2014-08-22 2024-07-03 Resolution Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
DK3191993T3 (da) 2014-09-12 2022-07-25 Illumina Cambridge Ltd Detektion af repeatudvidelser med short read-sekventeringsdata
CN107075730A (zh) 2014-09-12 2017-08-18 利兰·斯坦福青年大学托管委员会 循环核酸的鉴定及用途
EP3018213A1 (en) 2014-11-04 2016-05-11 Genesupport SA Method for determining the presence of a biological condition by determining total and relative amounts of two different nucleic acids
ES2790823T3 (es) 2014-11-14 2020-10-29 Liquid Genomics Inc Uso de ARN sin células circulante para el diagnóstico y/o la monitorización de cáncer
US11072814B2 (en) 2014-12-12 2021-07-27 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
WO2016097251A1 (en) 2014-12-19 2016-06-23 Danmarks Tekniske Universitet Method for identification of tissue or organ localization of a tumour
EP4123032A1 (en) 2014-12-31 2023-01-25 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US10319463B2 (en) 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
WO2016127944A1 (en) 2015-02-10 2016-08-18 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
AU2016226210A1 (en) 2015-03-03 2017-09-21 Caris Mpi, Inc. Molecular profiling for cancer
CA2983833C (en) 2015-05-01 2024-05-14 Guardant Health, Inc. Diagnostic methods
AU2016258171B2 (en) 2015-05-06 2021-12-09 LGC Clinical Diagnostics, Inc. Liposomal preparations for non-invasive-prenatal or cancer screening
EP3294906B1 (en) 2015-05-11 2024-07-10 Natera, Inc. Methods for determining ploidy
WO2017009372A2 (en) 2015-07-13 2017-01-19 Cartagenia Nv System and methodology for the analysis of genomic data obtained from a subject
US11124838B2 (en) 2015-08-07 2021-09-21 Dana-Farber Cancer Institute, Inc. Genetic abnormalities in plasma cell dyscrasias
WO2017062867A1 (en) 2015-10-09 2017-04-13 Helmy Eltoukhy Population based treatment recommender using cell free dna
WO2017070497A1 (en) 2015-10-21 2017-04-27 Dana-Farber Cancer Institute, Inc. Methods and compositions for use of driver mutations in cll
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
US10982286B2 (en) 2016-01-22 2021-04-20 Mayo Foundation For Medical Education And Research Algorithmic approach for determining the plasma genome abnormality PGA and the urine genome abnormality UGA scores based on cell free cfDNA copy number variations in plasma and urine
US20170342477A1 (en) 2016-05-27 2017-11-30 Sequenom, Inc. Methods for Detecting Genetic Variations
SG11201903509QA (en) 2016-10-24 2019-05-30 Univ Hong Kong Chinese Methods and systems for tumor detection

Also Published As

Publication number Publication date
EP3354748B1 (en) 2019-10-16
US20130237431A1 (en) 2013-09-12
US20210257053A1 (en) 2021-08-19
JP2017063794A (ja) 2017-04-06
CN104254618B (zh) 2017-11-14
EP2823062A4 (en) 2015-10-07
ES2659487T3 (es) 2018-03-15
US11217330B2 (en) 2022-01-04
EP2860266B1 (en) 2017-02-08
US20200327960A1 (en) 2020-10-15
PL3301193T3 (pl) 2019-10-31
US10297342B2 (en) 2019-05-21
EP3882358A1 (en) 2021-09-22
AU2017201258B2 (en) 2019-04-18
HUE044746T2 (hu) 2019-11-28
DK2823062T5 (en) 2018-03-12
JP6849257B2 (ja) 2021-03-24
HK1200194A1 (zh) 2015-07-31
DK3301193T3 (da) 2019-07-22
EP3301193B1 (en) 2019-04-24
AU2019204917A1 (en) 2019-07-25
RS59073B1 (sr) 2019-09-30
US11031100B2 (en) 2021-06-08
WO2013132305A8 (en) 2013-11-21
ES2729504T3 (es) 2019-11-04
EP3800272A1 (en) 2021-04-07
HRP20191300T1 (hr) 2019-10-18
CN104254618A (zh) 2014-12-31
HK1246361A1 (zh) 2018-09-07
JP2021090438A (ja) 2021-06-17
CA3010254A1 (en) 2013-09-12
AU2022203292A1 (en) 2022-06-02
JP2020146069A (ja) 2020-09-17
CN107630081A (zh) 2018-01-26
EP2860266A1 (en) 2015-04-15
EP4112740B1 (en) 2024-02-28
EP3800272B1 (en) 2022-09-28
AU2013229186A1 (en) 2014-09-18
EP3617324A1 (en) 2020-03-04
HK1245842A1 (zh) 2018-08-31
EP4112740A1 (en) 2023-01-04
AU2017201258A1 (en) 2017-03-16
JP2018196390A (ja) 2018-12-13
CA2865523C (en) 2018-08-14
JP2024100931A (ja) 2024-07-26
US20170235877A1 (en) 2017-08-17
WO2013132305A1 (en) 2013-09-12
LT3301193T (lt) 2019-07-25
US20170132363A1 (en) 2017-05-11
JP6721642B2 (ja) 2020-07-15
JP6073382B2 (ja) 2017-02-01
HK1206394A1 (zh) 2016-01-08
DK2860266T3 (en) 2017-04-24
EP3301193A1 (en) 2018-04-04
EP2823062A1 (en) 2015-01-14
CY1121828T1 (el) 2020-07-31
JP6392904B2 (ja) 2018-09-19
US20180157793A1 (en) 2018-06-07
CA2865523A1 (en) 2013-09-12
EP2823062B1 (en) 2018-01-03
EP3617324B1 (en) 2022-05-25
HK1202135A1 (zh) 2015-09-18
SI3301193T1 (sl) 2019-08-30
US9892230B2 (en) 2018-02-13
US20220093212A1 (en) 2022-03-24
AU2019204917B2 (en) 2022-02-17
DK3354748T3 (da) 2020-01-02
EP3575412B1 (en) 2020-12-16
JP7197209B2 (ja) 2022-12-27
EP4382613A2 (en) 2024-06-12
AU2013229186B2 (en) 2016-11-24
CN107630070A (zh) 2018-01-26
EP3354748A1 (en) 2018-08-01
CA3010254C (en) 2023-11-28
JP2023017006A (ja) 2023-02-02
CN107630081B (zh) 2021-03-05
DK3617324T3 (da) 2022-06-27
PT3301193T (pt) 2019-07-17
HK1261405A1 (zh) 2020-01-03
CN107630070B (zh) 2021-04-30
EP3575412A1 (en) 2019-12-04
ES2761624T3 (es) 2020-05-20
JP2015510757A (ja) 2015-04-13
DK2823062T3 (en) 2018-03-05
US10741270B2 (en) 2020-08-11

Similar Documents

Publication Publication Date Title
HK1261405A1 (zh) 基於大小分析母體血漿中的胎兒dna分數
IL278867A (en) Mutational analysis of plasma DNA for cancer detection
EP2893060A4 (en) METHOD FOR INCREASING FETALENE FRACTIONS IN MATERNAL BLOOD
HK1202585A1 (zh) 用於分析大型植物群體中母體 的方法
IL235128A0 (en) Preparation of a sample of nucleic acids
EP2814984A4 (en) MIRNA ANALYSIS PROCEDURE
HK1177232A1 (zh) 用於測定母體樣品中胎兒核酸片斷的方法
LT3305918T (lt) Būdai, skirti epigenetinių sekų sudarymui
HK1203567A1 (zh) 確定雙胞胎中胎兒 百分比
EP2764112A4 (en) DIRECT NUCLEIC ACID ANALYSIS
EP3014001A4 (en) Massively parallel sequencing of random dna fragments for determination of fetal fraction
EP2891709A4 (en) NUCLEIC ACID ANALYSIS DEVICE
EP2845006A4 (en) SAMPLE INTRODUCTION SYSTEM
EP2978862A4 (en) DOUBLE-SINGLE ANTISOND COMPOSITIONS FOR DNA AND RNA DETECTION
EP2840129A4 (en) MICROCHANNEL CHIP FOR DNA ANALYSIS
EP2844773A4 (en) ANALYSIS OF BIOMARKERS USING SCODAPHORESIS
ZA201407867B (en) Ore analysis system
EP2900803A4 (en) MONOCELLULAR ANALYSIS DEVICES AND METHODS
EP2872652A4 (en) DEVICES AND METHODS FOR PREPARING AND ANALYZING NUCLEIC ACIDS
EP2891889A4 (en) DISCHARGE ELEMENT FOR ANALYSIS
EP2865759A4 (en) NUCLEIC ACID COMPLEX AND NUCLEIC ACID POLYSACCHARIDE COMPLEX
EP2840130A4 (en) MICROCHANNEL CHIP FOR DNA ANALYSIS
EP2831915A4 (en) DNA COMPUTING
GB201210756D0 (en) Analysis of small RNA