CY1121828T1 - Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα - Google Patents
Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμαInfo
- Publication number
- CY1121828T1 CY1121828T1 CY20191100784T CY191100784T CY1121828T1 CY 1121828 T1 CY1121828 T1 CY 1121828T1 CY 20191100784 T CY20191100784 T CY 20191100784T CY 191100784 T CY191100784 T CY 191100784T CY 1121828 T1 CY1121828 T1 CY 1121828T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dna fragment
- dna
- dna fragments
- maternal plasma
- fetal dna
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 8
- 230000001605 fetal effect Effects 0.000 title abstract 3
- 230000008774 maternal effect Effects 0.000 title abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Algebra (AREA)
- General Physics & Mathematics (AREA)
Abstract
Υπεβλήθη σε ανάλυση δείγμα μητρικού πλάσματος εγκύου γυναίκας. Το δείγμα περιλαμβάνει θραύσματα DNA ελεύθερα κυττάρων, προέλευσης από μητρικά κύτταρα και εμβρυϊκά κύτταρα. Για καθένα από πολλά θραύσματα DNA: λαμβάνονται μία ή περισσότερες καταγραφές αλληλουχιών, συμπεριλαμβανομένων αμφότερων των άκρων του θραύσματος DNA- οι καταγραφές αλληλουχιών ευθυγραμμίζονται με ένα γονιδίωμα αναφοράς, για να προκύψουν ευθυγραμμισμένες θέσεις για αμφότερα τα άκρα· τέλος, οι ευθυγραμμισμένες θέσεις χρησιμοποιούνται για τον καθορισμό του μεγέθους του θραύσματος DNA. Για καθένα από πολλαπλά μεγέθη, καθορίζεται μια ποσότητα από ένα σύνολο πολλαπλών θραυσμάτων DNA από το δείγμα πλάσματος που αντιστοιχεί στο καθορισμένο μέγεθος. Υπολογίζεται η τιμή μιας πρώτης παραμέτρου, βάσει των ποσοτήτων θραυσμάτων DNA σε πολλαπλά μεγέθη, η οποία παρέχει μια στατιστική μέτρηση ενός προφίλ μεγέθους θραυσμάτων DNA. Η τιμή συγκρίνεται με μια τιμή βαθμονόμησης, για να εκτιμηθεί μια κλασματική συγκέντρωση εμβρυϊκού DNA.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261608623P | 2012-03-08 | 2012-03-08 | |
US201261621451P | 2012-04-06 | 2012-04-06 | |
EP13757943.9A EP2823062B1 (en) | 2012-03-08 | 2013-03-08 | Size-based analysis of fetal dna fraction in maternal plasma |
PCT/IB2013/000312 WO2013132305A1 (en) | 2012-03-08 | 2013-03-08 | Size-based analysis of fetal dna fraction in maternal plasma |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121828T1 true CY1121828T1 (el) | 2020-07-31 |
Family
ID=49114635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100784T CY1121828T1 (el) | 2012-03-08 | 2019-07-24 | Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα |
Country Status (18)
Country | Link |
---|---|
US (7) | US9892230B2 (el) |
EP (10) | EP3882358A1 (el) |
JP (6) | JP6073382B2 (el) |
CN (3) | CN107630081B (el) |
AU (4) | AU2013229186B2 (el) |
CA (2) | CA2865523C (el) |
CY (1) | CY1121828T1 (el) |
DK (5) | DK2860266T3 (el) |
ES (3) | ES2659487T3 (el) |
HK (7) | HK1200194A1 (el) |
HR (1) | HRP20191300T1 (el) |
HU (1) | HUE044746T2 (el) |
LT (1) | LT3301193T (el) |
PL (1) | PL3301193T3 (el) |
PT (1) | PT3301193T (el) |
RS (1) | RS59073B1 (el) |
SI (1) | SI3301193T1 (el) |
WO (1) | WO2013132305A1 (el) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
MX357692B (es) | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
JP6153874B2 (ja) | 2011-02-09 | 2017-06-28 | ナテラ, インコーポレイテッド | 非侵襲的出生前倍数性呼び出しのための方法 |
WO2012177792A2 (en) | 2011-06-24 | 2012-12-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of a genetic variation |
US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2013052907A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
EP4148739A1 (en) | 2012-01-20 | 2023-03-15 | Sequenom, Inc. | Diagnostic processes that factor experimental conditions |
EP3757210B1 (en) | 2012-03-02 | 2022-08-24 | Sequenom, Inc. | Methods for enriching cancer nucleic acid from a biological sample |
US9892230B2 (en) * | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
ES2902401T3 (es) * | 2012-05-21 | 2022-03-28 | Sequenom Inc | Métodos y procesos para la evaluación no invasiva de variaciones genéticas |
US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP3561072A1 (en) | 2012-12-10 | 2019-10-30 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP2971100A1 (en) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primers for dna methylation analysis |
FI2981921T3 (fi) | 2013-04-03 | 2023-03-09 | Sequenom Inc | Menetelmiä ja prosesseja geneettisten variaatioiden ei-invasiiviseen arviointiin |
KR102665592B1 (ko) | 2013-05-24 | 2024-05-21 | 시쿼넘, 인코포레이티드 | 유전적 변이의 비침습 평가를 위한 방법 및 프로세스 |
AU2014284180B2 (en) | 2013-06-21 | 2020-03-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10174375B2 (en) | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
MY181069A (en) | 2013-10-04 | 2020-12-17 | Sequenom Inc | Methods and processes for non-invasive assessment of genetic variations |
US10438691B2 (en) | 2013-10-07 | 2019-10-08 | Sequenom, Inc. | Non-invasive assessment of chromosome alterations using change in subsequence mappability |
AU2014340239B2 (en) | 2013-10-21 | 2019-11-28 | Verinata Health, Inc. | Method for improving the sensitivity of detection in determining copy number variations |
CN105829589B (zh) | 2013-11-07 | 2021-02-02 | 小利兰·斯坦福大学理事会 | 用于分析人体微生物组及其组分的无细胞核酸 |
GB2520765A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Multiplex detection of nucleic acids |
ES2784450T3 (es) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Métodos y sistemas para detectar variantes genéticas |
GB2524948A (en) * | 2014-03-07 | 2015-10-14 | Oxford Gene Technology Operations Ltd | Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest |
WO2015138774A1 (en) | 2014-03-13 | 2015-09-17 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
MA39951A (fr) | 2014-05-09 | 2017-03-15 | Lifecodexx Ag | Détection de l'adn provenant d'un type spécifique de cellule et méthodes associées |
KR102566176B1 (ko) | 2014-05-30 | 2023-08-10 | 베리나타 헬스, 인코포레이티드 | 태아 아-염색체 홀배수체 및 복제수 변이 탐지 |
EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
WO2016011982A1 (zh) * | 2014-07-25 | 2016-01-28 | 深圳华大基因股份有限公司 | 确定生物样本中游离核酸比例的方法、装置及其用途 |
WO2016019042A1 (en) * | 2014-07-30 | 2016-02-04 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US11072814B2 (en) | 2014-12-12 | 2021-07-27 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
US11242559B2 (en) | 2015-01-13 | 2022-02-08 | The Chinese University Of Hong Kong | Method of nuclear DNA and mitochondrial DNA analysis |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
US10319463B2 (en) * | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
CN104789686B (zh) * | 2015-05-06 | 2018-09-07 | 浙江安诺优达生物科技有限公司 | 检测染色体非整倍性的试剂盒和装置 |
WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
EP3298169A4 (en) | 2015-05-18 | 2018-10-24 | Karius Inc. | Compositions and methods for enriching populations of nucleic acids |
EP3666902B1 (en) | 2015-05-22 | 2024-07-03 | Medicover Public Co Ltd | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing |
CA2993362A1 (en) | 2015-07-23 | 2017-01-26 | The Chinese University Of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
AU2016319189B2 (en) * | 2015-09-11 | 2022-07-07 | Centre Hospitalier Universitaire De Montpellier | Non-invasive methods for assessing genetic integrity of pluripotent stem cells |
WO2017050244A1 (en) * | 2015-09-22 | 2017-03-30 | The Chinese University Of Hong Kong | Accurate quantification of fetal dna fraction by shallow-depth sequencing of maternal plasma dna |
KR101848438B1 (ko) * | 2015-10-29 | 2018-04-13 | 바이오코아 주식회사 | 디지털 pcr을 이용한 산전진단 방법 |
HUE050491T2 (hu) | 2015-11-10 | 2020-12-28 | Eurofins Lifecodexx Gmbh | Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között |
DK3374525T3 (da) | 2015-11-11 | 2021-04-06 | Resolution Bioscience Inc | Højeffektiv konstruktion af dna-biblioteker |
JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
EP3433613A4 (en) | 2016-03-24 | 2020-05-13 | Biological Dynamics, Inc. | DISPOSABLE FLUID CARTRIDGE AND COMPONENTS |
WO2017165864A1 (en) | 2016-03-25 | 2017-09-28 | Karius, Inc. | Synthetic nucleic acid spike-ins |
US11200963B2 (en) | 2016-07-27 | 2021-12-14 | Sequenom, Inc. | Genetic copy number alteration classifications |
EP3504347A4 (en) | 2016-08-25 | 2020-04-29 | Resolution Bioscience, Inc. | METHODS FOR DETECTING GENOMIC COPY CHANGES IN DNA SAMPLES |
CN109890984B (zh) * | 2016-10-19 | 2024-03-29 | 香港中文大学 | 通过母体血浆dna的甲基化和大小谱分析进行胎龄评估 |
CN110100013A (zh) | 2016-10-24 | 2019-08-06 | 香港中文大学 | 用于肿瘤检测的方法和*** |
WO2018085862A2 (en) | 2016-11-07 | 2018-05-11 | Grail, Inc. | Methods of identifying somatic mutational signatures for early cancer detection |
KR20230062684A (ko) | 2016-11-30 | 2023-05-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
CN106591451B (zh) * | 2016-12-14 | 2020-06-23 | 北京贝瑞和康生物技术有限公司 | 测定胎儿游离dna含量的方法及其用于实施该方法的装置 |
JP7237003B2 (ja) | 2017-01-24 | 2023-03-10 | セクエノム, インコーポレイテッド | 遺伝子片の評価のための方法およびプロセス |
CA3051509A1 (en) | 2017-01-25 | 2018-08-02 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
WO2018191563A1 (en) | 2017-04-12 | 2018-10-18 | Karius, Inc. | Sample preparation methods, systems and compositions |
US11342047B2 (en) | 2017-04-21 | 2022-05-24 | Illumina, Inc. | Using cell-free DNA fragment size to detect tumor-associated variant |
US10818379B2 (en) | 2017-05-08 | 2020-10-27 | Biological Dynamics, Inc. | Methods and systems for analyte information processing |
EP3658684B1 (en) | 2017-07-26 | 2023-08-30 | The Chinese University Of Hong Kong | Enhancement of cancer screening using cell-free viral nucleic acids |
KR20200085783A (ko) | 2017-10-27 | 2020-07-15 | 주노 다이어그노스틱스, 인크. | 초저용량 액체 생검을 위한 장치, 시스템 및 방법 |
US11168356B2 (en) * | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
JP2021509266A (ja) * | 2017-12-19 | 2021-03-25 | バイオロジカル ダイナミクス,インク. | 無細胞dna断片を検出および定量化するための方法とデバイス |
CN116121340A (zh) | 2017-12-19 | 2023-05-16 | 生物动力学公司 | 用于从生物样品中检测多种分析物的方法和装置 |
JP2021518106A (ja) * | 2018-03-13 | 2021-08-02 | ガーダント ヘルス, インコーポレイテッド | 治療用核酸構築物の非侵襲的な検出およびモニタリングのための方法 |
EP3765592A4 (en) | 2018-03-16 | 2021-12-08 | Karius Inc. | SERIES OF SAMPLES TO DIFFERENTIATE TARGET NUCLEIC ACIDS FROM CONTAMINATING NUCLEIC ACIDS |
CA3094717A1 (en) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
US11883833B2 (en) | 2018-04-02 | 2024-01-30 | Biological Dynamics, Inc. | Dielectric materials |
US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
WO2019226822A1 (en) * | 2018-05-23 | 2019-11-28 | The Regents Of The University Of California | Methods of analyzing capped ribonucleic acids |
WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
WO2020104394A1 (en) | 2018-11-19 | 2020-05-28 | Sistemas Genómicos, S.L. | Method and computer program product for analysis of fetal dna by massive sequencing |
US20200199656A1 (en) * | 2018-12-19 | 2020-06-25 | The Chinese University Of Hong Kong | Cell-free dna end characteristics |
US11929148B2 (en) | 2019-03-13 | 2024-03-12 | Grail, Llc | Systems and methods for enriching for cancer-derived fragments using fragment size |
CN110136794A (zh) * | 2019-05-22 | 2019-08-16 | 湖北可汗广电文化有限公司 | 一种基于人工智能的母婴全生命周期健康医疗服务*** |
AU2020333348B2 (en) * | 2019-08-19 | 2023-11-23 | Green Cross Genome Corporation | Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments |
CA3158101A1 (en) | 2019-11-27 | 2021-06-03 | M. Cyrus MAHER | Systems and methods for evaluating longitudinal biological feature data |
US20210265007A1 (en) * | 2020-02-05 | 2021-08-26 | The Chinese University Of Hong Kong | Molecular analyses using long cell-free fragments in pregnancy |
US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
JP2024523401A (ja) | 2021-06-21 | 2024-06-28 | ガーダント ヘルス, インコーポレイテッド | コピー数情報に基づく組織起源分析のための方法および組成物 |
WO2023056065A1 (en) | 2021-09-30 | 2023-04-06 | Guardant Health, Inc. | Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements |
Family Cites Families (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
WO2001027857A2 (en) | 1999-10-13 | 2001-04-19 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
GB0016742D0 (en) | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
US6664056B2 (en) | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
US8898021B2 (en) | 2001-02-02 | 2014-11-25 | Mark W. Perlin | Method and system for DNA mixture analysis |
JP2002272497A (ja) | 2001-03-15 | 2002-09-24 | Venture Link Co Ltd | 癌の診断方法、およびその診断用ベクター |
EP1370692A2 (fr) | 2001-03-23 | 2003-12-17 | Gencell S.A. | Procedes de purification et de detection de sequences cibles d'adn double brin par interaction triple helice. |
IL161267A0 (en) | 2001-10-05 | 2004-09-27 | Combinatorx Inc | Combinations for the treatment of immunoinflammatory disorders |
US20030180765A1 (en) | 2002-02-01 | 2003-09-25 | The Johns Hopkins University | Digital amplification for detection of mismatch repair deficient tumor cells |
US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
CA2477761A1 (en) | 2002-03-01 | 2003-09-12 | Ravgen, Inc. | Methods for detection of genetic disorders |
JP2006512924A (ja) | 2002-08-15 | 2006-04-20 | ジェンザイム・コーポレーション | 脳内皮細胞発現パターン |
US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
EP1601785A4 (en) | 2003-02-28 | 2007-02-07 | Ravgen Inc | METHOD FOR DETECTING GENETIC DISEASES |
US8394582B2 (en) | 2003-03-05 | 2013-03-12 | Genetic Technologies, Inc | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
AU2003901671A0 (en) | 2003-04-02 | 2003-05-01 | The University Of Adelaide | Comparative genomic hybridization |
RU2249820C1 (ru) | 2003-08-18 | 2005-04-10 | Лактионов Павел Петрович | Способ ранней диагностики заболеваний, связанных с нарушением функционирования генетического аппарата клетки |
US20050282213A1 (en) | 2003-09-22 | 2005-12-22 | Trisogen Biotechnology Limited Partnership | Methods and kits useful for detecting an alteration in a locus copy number |
CN101985619B (zh) | 2003-10-08 | 2014-08-20 | 波士顿大学信托人 | 染色体异常的产前诊断方法 |
DE60328193D1 (de) | 2003-10-16 | 2009-08-13 | Sequenom Inc | Nicht invasiver Nachweis fötaler genetischer Merkmale |
US20050221341A1 (en) | 2003-10-22 | 2005-10-06 | Shimkets Richard A | Sequence-based karyotyping |
CA2544178A1 (en) | 2003-10-30 | 2005-05-19 | Tufts-New England Medical Center | Prenatal diagnosis using cell-free fetal dna in amniotic fluid |
DE102004036285A1 (de) | 2004-07-27 | 2006-02-16 | Advalytix Ag | Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe |
CN1779688A (zh) | 2004-11-22 | 2006-05-31 | 寰硕数码股份有限公司 | 交互式医疗信息***及方法 |
CA2601221C (en) | 2005-03-18 | 2013-08-06 | The Chinese University Of Hong Kong | A method for the detection of chromosomal aneuploidies |
ATE406463T1 (de) | 2005-04-06 | 2008-09-15 | Maurice Stroun | Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislauf |
US20070122823A1 (en) | 2005-09-01 | 2007-05-31 | Bianchi Diana W | Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis |
ES2739484T3 (es) | 2006-02-02 | 2020-01-31 | Univ Leland Stanford Junior | Prueba genética fetal no invasiva mediante análisis digital |
CA2647793C (en) | 2006-02-28 | 2016-07-05 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
CA2688032C (en) | 2007-05-24 | 2015-11-03 | Apceth Gmbh & Co. Kg | Cd34 stem cell-related methods and compositions |
US20100112590A1 (en) | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
CA2900927C (en) | 2007-07-23 | 2018-08-14 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
US20090053719A1 (en) * | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
SI2200622T2 (sl) | 2007-09-19 | 2015-09-30 | Pluristem Ltd. | Adherentne celice iz adipoznih ali placentnih tkiv in njihova uporaba pri terapiji |
WO2009051842A2 (en) | 2007-10-18 | 2009-04-23 | The Johns Hopkins University | Detection of cancer by measuring genomic copy number and strand length in cell-free dna |
CA3069082C (en) | 2008-09-20 | 2022-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
US8835110B2 (en) * | 2008-11-04 | 2014-09-16 | The Johns Hopkins University | DNA integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy |
RU2011143425A (ru) | 2009-03-31 | 2013-05-10 | Оридис Биомаркерс Гмбх | Способ диагностики рака и мониторинга лечения рака |
WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
ES2720282T3 (es) | 2009-11-05 | 2019-07-19 | Univ Hong Kong Chinese | Análisis genómico fetal a partir de una muestra biológica materna |
MX357692B (es) | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
CN102597272A (zh) | 2009-11-12 | 2012-07-18 | 艾索特里克斯遗传实验室有限责任公司 | 基因座的拷贝数分析 |
EP2848703A1 (en) | 2010-01-19 | 2015-03-18 | Verinata Health, Inc | Simultaneous determination of aneuploidy and fetal fraction |
AU2011207544A1 (en) | 2010-01-19 | 2012-09-06 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
WO2011090556A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
US20130210645A1 (en) | 2010-02-18 | 2013-08-15 | The Johns Hopkins University | Personalized tumor biomarkers |
US20130143214A1 (en) | 2010-06-04 | 2013-06-06 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
EP4269623A3 (en) | 2010-11-30 | 2024-03-06 | The Chinese University Of Hong Kong | Analysis of a biological sample of an organism for chromosomal deletions or amplifications associated with cancer |
US20130059738A1 (en) | 2011-04-28 | 2013-03-07 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
US20150211070A1 (en) | 2011-09-22 | 2015-07-30 | Immu-Metrix, Llc | Compositions and methods for analyzing heterogeneous samples |
US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2013052907A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP2771483A1 (en) | 2011-10-25 | 2014-09-03 | ONCOTYROL - Center for Personalized Cancer Medicine GmbH | Method for diagnosing a disease based on plasma-dna distribution |
WO2013062856A1 (en) | 2011-10-27 | 2013-05-02 | Verinata Health, Inc. | Set membership testers for aligning nucleic acid samples |
FR2981833B1 (fr) | 2011-10-28 | 2013-12-06 | Oreal | Sachet de conditionnement de produit cosmetique |
US9757458B2 (en) | 2011-12-05 | 2017-09-12 | Immunomedics, Inc. | Crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in hematopoietic cancer cells |
WO2013086464A1 (en) | 2011-12-07 | 2013-06-13 | The Broad Institute, Inc. | Markers associated with chronic lymphocytic leukemia prognosis and progression |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US20130261984A1 (en) | 2012-03-30 | 2013-10-03 | Illumina, Inc. | Methods and systems for determining fetal chromosomal abnormalities |
US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
US20150197785A1 (en) | 2012-08-10 | 2015-07-16 | The Broad Institute, Inc. | Methods and apparatus for analyzing and quantifying dna alterations in cancer |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US9769123B2 (en) | 2012-09-06 | 2017-09-19 | Intel Corporation | Mitigating unauthorized access to data traffic |
DK3536807T3 (da) | 2012-09-20 | 2024-02-05 | Univ Hong Kong Chinese | Ikkeinvasiv bestemmelse af foster- eller tumormethylom fra plasma |
US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
US20140287937A1 (en) | 2013-02-21 | 2014-09-25 | Toma Biosciences, Inc. | Methods for assessing cancer |
US10017807B2 (en) | 2013-03-15 | 2018-07-10 | Verinata Health, Inc. | Generating cell-free DNA libraries directly from blood |
WO2014151117A1 (en) | 2013-03-15 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
CA2921628A1 (en) | 2013-08-19 | 2015-02-26 | Singular Bio, Inc. | Assays for single molecule detection and use thereof |
US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
AU2014340239B2 (en) | 2013-10-21 | 2019-11-28 | Verinata Health, Inc. | Method for improving the sensitivity of detection in determining copy number variations |
GB201319779D0 (en) | 2013-11-08 | 2013-12-25 | Cartagenia N V | Genetic analysis method |
US10465238B2 (en) | 2013-12-19 | 2019-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Quantification of mutant alleles and copy number variation using digital PCR with nonspecific DNA-binding dyes |
GB2524948A (en) | 2014-03-07 | 2015-10-14 | Oxford Gene Technology Operations Ltd | Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest |
EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
WO2015175705A1 (en) | 2014-05-13 | 2015-11-19 | Board Of Regents, The University Of Texas System | Gene mutations and copy number alterations of egfr, kras and met |
KR102566176B1 (ko) | 2014-05-30 | 2023-08-10 | 베리나타 헬스, 인코포레이티드 | 태아 아-염색체 홀배수체 및 복제수 변이 탐지 |
CA2953469A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
CN106795562B (zh) | 2014-07-18 | 2022-03-25 | 香港中文大学 | Dna混合物中的组织甲基化模式分析 |
EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
CA2957657A1 (en) | 2014-08-22 | 2016-02-25 | Resolution Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
ES2925014T3 (es) | 2014-09-12 | 2022-10-13 | Univ Leland Stanford Junior | Identificación y uso de ácidos nucleicos circulantes |
PT3191993T (pt) | 2014-09-12 | 2022-06-20 | Illumina Cambridge Ltd | Detectar expansões de repetição com dados de sequenciação de leituras curtas |
EP3018213A1 (en) | 2014-11-04 | 2016-05-11 | Genesupport SA | Method for determining the presence of a biological condition by determining total and relative amounts of two different nucleic acids |
EP3218523B1 (en) | 2014-11-14 | 2020-02-12 | Liquid Genomics Inc. | Use of circulating cell-free rna for diagnosis and/or monitoring cancer |
US11072814B2 (en) | 2014-12-12 | 2021-07-27 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
US20170342500A1 (en) | 2014-12-19 | 2017-11-30 | Danmarks Tekniske Universitet | Method for identification of tissue or organ localization of a tumour |
WO2016109452A1 (en) | 2014-12-31 | 2016-07-07 | Guardant Health , Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
US10319463B2 (en) | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
EP3265079A4 (en) | 2015-03-03 | 2019-01-02 | Caris MPI, Inc. | Molecular profiling for cancer |
CA2983833C (en) | 2015-05-01 | 2024-05-14 | Guardant Health, Inc. | Diagnostic methods |
US11243212B2 (en) | 2015-05-06 | 2022-02-08 | Seracare Life Sciences, Inc. | Liposomal preparations for non-invasive-prenatal or cancer screening |
WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
US20180211002A1 (en) | 2015-07-13 | 2018-07-26 | Agilent Technologies Belgium Nv | System and methodology for the analysis of genomic data obtained from a subject |
AU2016306292B2 (en) | 2015-08-07 | 2022-08-25 | Dana-Farber Cancer Institute, Inc. | Genetic abnormalities in plasma cell dyscrasias |
WO2017062867A1 (en) | 2015-10-09 | 2017-04-13 | Helmy Eltoukhy | Population based treatment recommender using cell free dna |
WO2017070497A1 (en) | 2015-10-21 | 2017-04-27 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for use of driver mutations in cll |
JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
US10982286B2 (en) | 2016-01-22 | 2021-04-20 | Mayo Foundation For Medical Education And Research | Algorithmic approach for determining the plasma genome abnormality PGA and the urine genome abnormality UGA scores based on cell free cfDNA copy number variations in plasma and urine |
EP4043581A1 (en) | 2016-05-27 | 2022-08-17 | Sequenom, Inc. | Method for generating a paralog assay system |
CN110100013A (zh) | 2016-10-24 | 2019-08-06 | 香港中文大学 | 用于肿瘤检测的方法和*** |
-
2013
- 2013-03-07 US US13/789,553 patent/US9892230B2/en active Active
- 2013-03-08 EP EP21172741.7A patent/EP3882358A1/en active Pending
- 2013-03-08 RS RS20190946A patent/RS59073B1/sr unknown
- 2013-03-08 CN CN201710977855.3A patent/CN107630081B/zh active Active
- 2013-03-08 EP EP17202838.3A patent/EP3301193B1/en active Active
- 2013-03-08 CA CA2865523A patent/CA2865523C/en active Active
- 2013-03-08 EP EP14193706.0A patent/EP2860266B1/en active Active
- 2013-03-08 EP EP19170660.5A patent/EP3575412B1/en active Active
- 2013-03-08 LT LTEP17202838.3T patent/LT3301193T/lt unknown
- 2013-03-08 SI SI201331518T patent/SI3301193T1/sl unknown
- 2013-03-08 EP EP24159028.0A patent/EP4382613A2/en active Pending
- 2013-03-08 CN CN201710962960.XA patent/CN107630070B/zh active Active
- 2013-03-08 JP JP2014560451A patent/JP6073382B2/ja active Active
- 2013-03-08 DK DK14193706.0T patent/DK2860266T3/en active
- 2013-03-08 AU AU2013229186A patent/AU2013229186B2/en active Active
- 2013-03-08 EP EP17209781.8A patent/EP3354748B1/en not_active Revoked
- 2013-03-08 ES ES13757943.9T patent/ES2659487T3/es active Active
- 2013-03-08 CA CA3010254A patent/CA3010254C/en active Active
- 2013-03-08 DK DK17209781.8T patent/DK3354748T3/da active
- 2013-03-08 EP EP22190763.7A patent/EP4112740B1/en active Active
- 2013-03-08 ES ES17202838T patent/ES2729504T3/es active Active
- 2013-03-08 EP EP20209747.3A patent/EP3800272B1/en active Active
- 2013-03-08 EP EP19201127.8A patent/EP3617324B1/en active Active
- 2013-03-08 CN CN201380013054.5A patent/CN104254618B/zh active Active
- 2013-03-08 DK DK13757943.9T patent/DK2823062T5/en active
- 2013-03-08 HU HUE17202838 patent/HUE044746T2/hu unknown
- 2013-03-08 PL PL17202838T patent/PL3301193T3/pl unknown
- 2013-03-08 WO PCT/IB2013/000312 patent/WO2013132305A1/en active Application Filing
- 2013-03-08 ES ES17209781T patent/ES2761624T3/es active Active
- 2013-03-08 EP EP13757943.9A patent/EP2823062B1/en active Active
- 2013-03-08 DK DK17202838.3T patent/DK3301193T3/da active
- 2013-03-08 PT PT17202838T patent/PT3301193T/pt unknown
- 2013-03-08 DK DK19201127.8T patent/DK3617324T3/da active
-
2015
- 2015-01-20 HK HK15100609.6A patent/HK1200194A1/xx unknown
- 2015-03-11 HK HK15102503.9A patent/HK1202135A1/xx unknown
- 2015-07-16 HK HK15106797.5A patent/HK1206394A1/xx unknown
-
2017
- 2017-01-04 JP JP2017000134A patent/JP6392904B2/ja active Active
- 2017-01-20 US US15/411,695 patent/US10741270B2/en active Active
- 2017-02-24 AU AU2017201258A patent/AU2017201258B2/en active Active
- 2017-05-05 US US15/587,662 patent/US10297342B2/en active Active
-
2018
- 2018-01-30 US US15/883,648 patent/US11217330B2/en active Active
- 2018-03-23 HK HK18104074.1A patent/HK1245842A1/zh unknown
- 2018-04-17 HK HK18104992.0A patent/HK1245844A1/zh unknown
- 2018-04-30 HK HK18105610.9A patent/HK1246361A1/zh unknown
- 2018-08-23 JP JP2018156137A patent/JP6721642B2/ja active Active
-
2019
- 2019-01-04 HK HK19100179.2A patent/HK1261405A1/zh unknown
- 2019-07-09 AU AU2019204917A patent/AU2019204917B2/en active Active
- 2019-07-18 HR HRP20191300TT patent/HRP20191300T1/hr unknown
- 2019-07-24 CY CY20191100784T patent/CY1121828T1/el unknown
-
2020
- 2020-06-18 JP JP2020105483A patent/JP6849257B2/ja active Active
- 2020-06-26 US US16/913,510 patent/US11031100B2/en active Active
-
2021
- 2021-02-25 JP JP2021028536A patent/JP7197209B2/ja active Active
- 2021-05-06 US US17/313,880 patent/US20210257053A1/en active Pending
- 2021-11-05 US US17/520,450 patent/US20220093212A1/en active Pending
-
2022
- 2022-05-17 AU AU2022203292A patent/AU2022203292A1/en active Pending
- 2022-12-08 JP JP2022196192A patent/JP2023017006A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1121828T1 (el) | Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα | |
CY1124376T1 (el) | Συνδυαστικη αναλυση μεγεθους και καταμετρησης στο μητρικο πλασμα για την ανιχνευση εμβρυϊκων υποχρωμοσωμικων ανωμαλιων | |
CY1121772T1 (el) | Χρησιμοποιηση μεγεθους θραυσματων του ελευθερου κυτταρων dna για προσδιορισμο παραλλαγων αριθμου αντιγραφων | |
CY1121741T1 (el) | Χρηση του μεγεθους θραυσματων εξωκυτταριου dna για τον προσδιορισμο παραλλαγης αριθμου αντιγραφων | |
ES2721051T3 (es) | Método para la evaluación no invasiva de variaciones genéticas | |
CY1124494T1 (el) | Μεθοδοι για τον προσδιορισμο του κλασματος εμβρυικων νουκλεϊκων οξεων σε μητρικα δειγματα | |
EP4279612A3 (en) | Analysis of fragmentation patterns of cell-free dna | |
CY1118888T1 (el) | Μεθοδος αναγνωρισης, επιλογης και αναλυσης καρκινικων κυτταρων | |
GB2484764B (en) | Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies | |
EA201500327A1 (ru) | Неинвазивное определение метилома плода или опухоли по плазме | |
CY1122239T1 (el) | Μεθοδος για την ανιχνευση ανωμαλιων στην αιμοσφαιρινη | |
WO2015048665A3 (en) | Method to estimate the age of tissues and cell types based on epigenetic markers | |
CY1118748T1 (el) | Πολυπλεγμενοι προσδιορισμοι βασιζομενοι σε απταμερη | |
GB2534067A (en) | Methods and systems for genomic analysis | |
EP4276194A3 (en) | Methods and processes for non-invasive assessment of genetic variations | |
EP3922731A3 (en) | Methods and processes for non-invasive assessment of genetic variations | |
CY1122030T1 (el) | Μεθοδος εκτιμησης της ποσοτητας μεθυλιωμενου τοπου σε ενα δειγμα | |
BR112012018458A2 (pt) | métodos e composições para diagnóstico pré-natal não invasivo de aneuploidias fetais | |
TW201144799A (en) | Fill sufficiency method and system | |
EP3575781A3 (en) | Test strips and method for reading test strips | |
PH12020500156A1 (en) | Enhancement of cancer screening using cell-free viral nucleic acids | |
TR201819546T4 (tr) | Numune tür kökeni için tespit yöntemleri. | |
CY1124409T1 (el) | Μεθοδος μη επεμβατικης προγεννητικης ανιχνευσης της ανευπλοειδιας του εμβρυικου χρωμοσωματος απο το μητρικο αιμα με βαση τη μεθοδο του βayes | |
WO2015023503A3 (en) | Compositions and methods for multimodal analysis of cmet nucleic acids | |
MX2015015015A (es) | Metodo para diagnosticar cancer. |