CY1121828T1 - Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα - Google Patents

Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα

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CY1121828T1
CY1121828T1 CY20191100784T CY191100784T CY1121828T1 CY 1121828 T1 CY1121828 T1 CY 1121828T1 CY 20191100784 T CY20191100784 T CY 20191100784T CY 191100784 T CY191100784 T CY 191100784T CY 1121828 T1 CY1121828 T1 CY 1121828T1
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Cyprus
Prior art keywords
dna fragment
dna
dna fragments
maternal plasma
fetal dna
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CY20191100784T
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English (en)
Inventor
Yuk-Ming Dennis Lo
Kwan Chee Chan
Wenli Zheng
Peiyong Jiang
Jiawei LIAO
Rossa Wai Kwun Chiu
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The Chinese University Of Hong Kong
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Application filed by The Chinese University Of Hong Kong filed Critical The Chinese University Of Hong Kong
Publication of CY1121828T1 publication Critical patent/CY1121828T1/el

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Abstract

Υπεβλήθη σε ανάλυση δείγμα μητρικού πλάσματος εγκύου γυναίκας. Το δείγμα περιλαμβάνει θραύσματα DNA ελεύθερα κυττάρων, προέλευσης από μητρικά κύτταρα και εμβρυϊκά κύτταρα. Για καθένα από πολλά θραύσματα DNA: λαμβάνονται μία ή περισσότερες καταγραφές αλληλουχιών, συμπεριλαμβανομένων αμφότερων των άκρων του θραύσματος DNA- οι καταγραφές αλληλουχιών ευθυγραμμίζονται με ένα γονιδίωμα αναφοράς, για να προκύψουν ευθυγραμμισμένες θέσεις για αμφότερα τα άκρα· τέλος, οι ευθυγραμμισμένες θέσεις χρησιμοποιούνται για τον καθορισμό του μεγέθους του θραύσματος DNA. Για καθένα από πολλαπλά μεγέθη, καθορίζεται μια ποσότητα από ένα σύνολο πολλαπλών θραυσμάτων DNA από το δείγμα πλάσματος που αντιστοιχεί στο καθορισμένο μέγεθος. Υπολογίζεται η τιμή μιας πρώτης παραμέτρου, βάσει των ποσοτήτων θραυσμάτων DNA σε πολλαπλά μεγέθη, η οποία παρέχει μια στατιστική μέτρηση ενός προφίλ μεγέθους θραυσμάτων DNA. Η τιμή συγκρίνεται με μια τιμή βαθμονόμησης, για να εκτιμηθεί μια κλασματική συγκέντρωση εμβρυϊκού DNA.
CY20191100784T 2012-03-08 2019-07-24 Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα CY1121828T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261608623P 2012-03-08 2012-03-08
US201261621451P 2012-04-06 2012-04-06
EP13757943.9A EP2823062B1 (en) 2012-03-08 2013-03-08 Size-based analysis of fetal dna fraction in maternal plasma
PCT/IB2013/000312 WO2013132305A1 (en) 2012-03-08 2013-03-08 Size-based analysis of fetal dna fraction in maternal plasma

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CY1121828T1 true CY1121828T1 (el) 2020-07-31

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US (7) US9892230B2 (el)
EP (10) EP3882358A1 (el)
JP (6) JP6073382B2 (el)
CN (3) CN107630081B (el)
AU (4) AU2013229186B2 (el)
CA (2) CA2865523C (el)
CY (1) CY1121828T1 (el)
DK (5) DK2860266T3 (el)
ES (3) ES2659487T3 (el)
HK (7) HK1200194A1 (el)
HR (1) HRP20191300T1 (el)
HU (1) HUE044746T2 (el)
LT (1) LT3301193T (el)
PL (1) PL3301193T3 (el)
PT (1) PT3301193T (el)
RS (1) RS59073B1 (el)
SI (1) SI3301193T1 (el)
WO (1) WO2013132305A1 (el)

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CA2865523A1 (en) 2013-09-12
HUE044746T2 (hu) 2019-11-28
PL3301193T3 (pl) 2019-10-31
HK1200194A1 (en) 2015-07-31
JP6073382B2 (ja) 2017-02-01
US20180157793A1 (en) 2018-06-07
EP3617324B1 (en) 2022-05-25
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ES2729504T3 (es) 2019-11-04

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