HK1245777A1 - 用作nadph氧化酶抑制劑的氨基噻二唑衍生物 - Google Patents

用作nadph氧化酶抑制劑的氨基噻二唑衍生物

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Publication number
HK1245777A1
HK1245777A1 HK18105173.8A HK18105173A HK1245777A1 HK 1245777 A1 HK1245777 A1 HK 1245777A1 HK 18105173 A HK18105173 A HK 18105173A HK 1245777 A1 HK1245777 A1 HK 1245777A1
Authority
HK
Hong Kong
Prior art keywords
oxidase inhibitors
nadph oxidase
thiadiazole derivatives
amido thiadiazole
amido
Prior art date
Application number
HK18105173.8A
Other languages
English (en)
Inventor
Peter Machin
Andrew Sharpe
Christopher James Lock
Mark S Chambers
Alastair Hodges
Vivienne Allen
John M Ellard
Original Assignee
Genkyotex Suisse Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genkyotex Suisse Sa filed Critical Genkyotex Suisse Sa
Publication of HK1245777A1 publication Critical patent/HK1245777A1/zh

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
HK18105173.8A 2014-12-17 2018-04-20 用作nadph氧化酶抑制劑的氨基噻二唑衍生物 HK1245777A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14198597.8A EP3034500A1 (en) 2014-12-17 2014-12-17 Amido thiazole derivatives as NADPH oxidase inhibitors
PCT/IB2015/059659 WO2016098005A1 (en) 2014-12-17 2015-12-16 Amido thiadiazole derivatives as nadph oxidase inhibitors

Publications (1)

Publication Number Publication Date
HK1245777A1 true HK1245777A1 (zh) 2018-08-31

Family

ID=52146189

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105173.8A HK1245777A1 (zh) 2014-12-17 2018-04-20 用作nadph氧化酶抑制劑的氨基噻二唑衍生物

Country Status (13)

Country Link
US (2) US10130619B2 (zh)
EP (2) EP3034500A1 (zh)
JP (1) JP2017537948A (zh)
KR (1) KR20170094263A (zh)
CN (1) CN107207489A (zh)
AU (1) AU2015365465B2 (zh)
BR (1) BR112017012846A2 (zh)
CA (1) CA2971357A1 (zh)
HK (1) HK1245777A1 (zh)
IL (1) IL252928A0 (zh)
MX (1) MX2017007884A (zh)
RU (1) RU2017121044A (zh)
WO (1) WO2016098005A1 (zh)

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EP3034500A1 (en) * 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors
WO2018081167A1 (en) 2016-10-24 2018-05-03 Yumanity Therapeutics Compounds and uses thereof
US11873298B2 (en) 2017-10-24 2024-01-16 Janssen Pharmaceutica Nv Compounds and uses thereof
EP3479843A1 (en) 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer
MX2021011488A (es) * 2019-03-22 2021-11-17 Yumanity Therapeutics Inc Compuestos y usos de estos.
WO2020243459A1 (en) * 2019-05-31 2020-12-03 Ideaya Biosciences, Inc. Thiadiazolyl derivatives as dna polymerase theta inhibitors
CN110590706B (zh) * 2019-11-06 2021-07-27 四平市精细化学品有限公司 一种n-甲基吡咯烷的制备方法
TW202237595A (zh) * 2020-12-02 2022-10-01 美商愛德亞生物科學公司 作為DNA聚合酶θ抑制劑之經取代噻二唑基衍生物
TW202315618A (zh) * 2021-06-11 2023-04-16 美商愛德亞生物科學公司 作為DNA聚合酶θ抑制劑之O-聯結噻二唑基化合物
WO2023060573A1 (en) * 2021-10-15 2023-04-20 Beijing Danatlas Pharmaceutical Co., Ltd. Novel thiadiazolyl derivatives of dna polymerase theta inhibitors
KR102422881B1 (ko) * 2021-11-08 2022-07-20 (주)셀로스바이오텍 신규 옥사다이아졸 유도체 및 이의 용도
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions

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US20170348296A1 (en) 2017-12-07
US20190046515A1 (en) 2019-02-14
WO2016098005A1 (en) 2016-06-23
US10130619B2 (en) 2018-11-20
CA2971357A1 (en) 2016-06-23
IL252928A0 (en) 2017-08-31
KR20170094263A (ko) 2017-08-17
CN107207489A (zh) 2017-09-26
EP3233847A1 (en) 2017-10-25
BR112017012846A2 (pt) 2017-12-26
JP2017537948A (ja) 2017-12-21
EP3034500A1 (en) 2016-06-22
AU2015365465A1 (en) 2017-06-29
AU2015365465B2 (en) 2019-12-12
RU2017121044A3 (zh) 2019-03-22
MX2017007884A (es) 2017-12-14
RU2017121044A (ru) 2018-12-17

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