HK1244425A1 - 含靶向與效應組件的分子構建體 - Google Patents
含靶向與效應組件的分子構建體Info
- Publication number
- HK1244425A1 HK1244425A1 HK18102897.0A HK18102897A HK1244425A1 HK 1244425 A1 HK1244425 A1 HK 1244425A1 HK 18102897 A HK18102897 A HK 18102897A HK 1244425 A1 HK1244425 A1 HK 1244425A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- targeting
- effector elements
- molecular constructs
- constructs
- molecular
- Prior art date
Links
- 239000012636 effector Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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US201562137737P | 2015-03-24 | 2015-03-24 | |
PCT/CN2016/071184 WO2016112870A1 (en) | 2015-01-16 | 2016-01-18 | Molecular constructs with targeting and effector elements |
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WO (1) | WO2016112870A1 (zh) |
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DK2992017T3 (da) | 2013-05-02 | 2021-01-25 | Anaptysbio Inc | Antistoffer rettet mod programmeret død-1 (pd-1) |
JP6313530B1 (ja) * | 2015-01-16 | 2018-04-18 | アカデミア シニカAcademia Sinica | 標的化成分及びエフェクター成分を有する分子構築物 |
CA2978942A1 (en) | 2015-03-13 | 2016-09-22 | Cytomx Therapeutics, Inc. | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
WO2016184426A1 (en) * | 2015-05-20 | 2016-11-24 | Tse-Wen Chang | Molecular constructs with targeting and effector elements and their applications |
CN108368170B (zh) | 2015-07-13 | 2022-04-15 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
CN108431045B (zh) * | 2015-09-01 | 2022-05-13 | 免疫功坊股份有限公司 | 用以预防血栓形成及/或治疗血栓的分子构建体 |
MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
US11583593B2 (en) | 2016-01-14 | 2023-02-21 | Synthis Therapeutics, Inc. | Antibody-ALK5 inhibitor conjugates and their uses |
KR20230149857A (ko) | 2016-07-07 | 2023-10-27 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
WO2018026642A1 (en) * | 2016-08-03 | 2018-02-08 | The Feinstein Institute For Medical Research | C1q and hmgb1 fusion proteins and uses thereof |
CA3040348A1 (en) | 2016-10-19 | 2018-04-26 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods for treating cancer |
BR112019008859A2 (pt) | 2016-11-01 | 2019-07-09 | Anaptysbio Inc | anticorpos direcionados contra a morte programada 1 (pd-1) |
EP3555125A4 (en) * | 2016-12-15 | 2019-11-20 | The Brigham and Women's Hospital, Inc. | TISSUE BIOLOGICAL PRODUCTS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISORDERS |
CN110382545A (zh) | 2017-01-09 | 2019-10-25 | 泰萨罗公司 | 用抗pd-1抗体治疗癌症的方法 |
KR102361890B1 (ko) * | 2017-03-16 | 2022-02-10 | 임문워크 아이엔씨 | 링커 유닛 및 이를 포함하는 분자 구조물 |
WO2018183762A1 (en) | 2017-03-29 | 2018-10-04 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating cancer |
US11866507B2 (en) | 2017-04-11 | 2024-01-09 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained CD3 binding and methods of using the same |
EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
CA3068056A1 (en) * | 2017-06-22 | 2018-12-27 | Development Center For Biotechnology | Asymmetric heterodimeric fc-scfv fusion anti-globo h and anti-cd3 bispecifc antibody and uses thereof in cancer therapy |
CN110799538B (zh) * | 2017-08-28 | 2023-08-01 | 西雅图免疫公司 | 抗cd3抗体及其制备和使用方法 |
KR102396217B1 (ko) * | 2017-09-19 | 2022-05-09 | 임문워크 아이엔씨 | 알부민과의 결합 친화성이 증대된 약학 구조물 |
EP3703676A4 (en) * | 2017-11-04 | 2021-12-15 | Advanced Proteome Therapeutics, Inc. | COMPOSITION AND PROCESS FOR MODIFYING POLYPEPTIDES |
BR112020010450A2 (pt) | 2017-11-28 | 2020-11-24 | Chugai Seiyaku Kabushiki Kaisha | polipeptídeo que inclui domínio de ligação a antígeno e seção transportadora |
CN108152489A (zh) * | 2017-12-19 | 2018-06-12 | 长沙维世尔生物科技有限公司 | 一种用于软骨骨质免疫组化抗原修复的方法 |
CN109957023A (zh) * | 2017-12-25 | 2019-07-02 | 深圳宾德生物技术有限公司 | 一种靶向cd22的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
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