HK1212729A1 - 核糖核酸調節子組合物和使用方法 - Google Patents

核糖核酸調節子組合物和使用方法

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Publication number
HK1212729A1
HK1212729A1 HK16100493.4A HK16100493A HK1212729A1 HK 1212729 A1 HK1212729 A1 HK 1212729A1 HK 16100493 A HK16100493 A HK 16100493A HK 1212729 A1 HK1212729 A1 HK 1212729A1
Authority
HK
Hong Kong
Prior art keywords
riboregulator
mehtods
compositions
riboregulator compositions
Prior art date
Application number
HK16100493.4A
Other languages
English (en)
Inventor
Alexander A Green
Peng Yin
James J Collins
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of HK1212729A1 publication Critical patent/HK1212729A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
HK16100493.4A 2012-11-06 2016-01-18 核糖核酸調節子組合物和使用方法 HK1212729A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722825P 2012-11-06 2012-11-06
US201361843934P 2013-07-09 2013-07-09
PCT/US2013/068818 WO2014074648A2 (en) 2012-11-06 2013-11-06 Riboregulator compositions and methods of use

Publications (1)

Publication Number Publication Date
HK1212729A1 true HK1212729A1 (zh) 2016-06-17

Family

ID=49585679

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16100493.4A HK1212729A1 (zh) 2012-11-06 2016-01-18 核糖核酸調節子組合物和使用方法

Country Status (7)

Country Link
US (2) US9550987B2 (zh)
EP (2) EP2917349B1 (zh)
JP (2) JP6130923B2 (zh)
KR (1) KR20150083115A (zh)
CN (2) CN104968786B (zh)
HK (1) HK1212729A1 (zh)
WO (1) WO2014074648A2 (zh)

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US9284602B2 (en) 2010-10-27 2016-03-15 President And Fellows Of Harvard College Compositions of toehold primer duplexes and methods of use
WO2012151328A2 (en) 2011-05-02 2012-11-08 President And Fellows Of Harvard College Spatial sequestration of dynamic nucleic acid circuits
WO2014074648A2 (en) 2012-11-06 2014-05-15 President And Fellows Of Harvard College Riboregulator compositions and methods of use
WO2015085209A1 (en) 2013-12-06 2015-06-11 President And Fellows Of Harvard College Paper-based synthetic gene networks
WO2016011089A1 (en) * 2014-07-14 2016-01-21 President And Fellows Of Harvard College Compositions comprising riboregulators and methods of use thereof
US10041109B2 (en) * 2015-04-17 2018-08-07 TotemID Inc. Method for detection of a nucleic acid target sequence
WO2017040829A1 (en) * 2015-09-02 2017-03-09 President And Fellows Of Harvard College Riboregulators regulated by external stimuli and methods of use thereof
WO2017087530A1 (en) * 2015-11-16 2017-05-26 President And Fellows Of Harvard College Compositions comprising riboregulators and methods of use thereof
JP7085999B2 (ja) 2016-02-17 2022-06-17 プレジデント アンド フェローズ オブ ハーバード カレッジ 分子プログラミングツール
US10550440B2 (en) 2016-02-26 2020-02-04 Arizona Board Of Regents On Behalf Of Arizona State University Synthetic translation-sensing riboswitches and uses thereof
WO2017205668A1 (en) * 2016-05-25 2017-11-30 Arizona Board Of Regents On Behalf Of Arizona State University Portable, low-cost pathogen detection and strain identification platform
WO2018009463A2 (en) 2016-07-05 2018-01-11 California Institute Of Technology Fractional initiator hybridization chain reaction
US11680269B2 (en) * 2016-08-01 2023-06-20 Arizona Board Of Regents On Behalf Of Arizona State University Ultraspecific riboregulators having robust single-nucleotide specificity and in vitro and in vivo uses thereof
US10941401B2 (en) 2016-08-01 2021-03-09 Arizona Board Of Regents On Behalf Of Arizona State University Synthetic near-threshold translational repressors
US11802318B2 (en) 2016-08-04 2023-10-31 Arizona Board Of Regents On Behalf Of Arizona State University Loop-mediated synthetic riboregulators
US10815519B2 (en) 2016-08-30 2020-10-27 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
WO2018053366A1 (en) * 2016-09-15 2018-03-22 President And Fellows Of Harvard College Prokaryote-inducible programmable therapy
CN107841510B (zh) * 2016-09-20 2021-02-09 中国科学院青岛生物能源与过程研究所 一种原核细胞转录后水平控制不同基因表达比例的方法
CN109923213B (zh) 2016-09-20 2023-02-28 哈佛学院院长及董事 分子验证***
US20180362944A1 (en) * 2017-06-12 2018-12-20 California Institute Of Technology CONDITIONAL GUIDE RNAs
CN107365782A (zh) * 2017-08-29 2017-11-21 廊坊梅花生物技术开发有限公司 一种基因工程菌及其应用
EP3728627A4 (en) * 2017-12-22 2021-08-25 The Governing Council of the University of Toronto SYNTHETIC BIOLOGICAL CIRCUITS TO DETECT TARGET ANALYTES USING A GLUCOMETER IN AN ACELLULAR SYSTEM
US11125743B2 (en) * 2018-02-20 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Detection of norovirus using norovirus-specific toehold switches
KR102182078B1 (ko) * 2018-06-19 2020-11-23 서울대학교산학협력단 박테리아에서의 고품질 재조합 단백질 생산을 위해 전사 완료 후 번역이 개시되는 유전자 발현 카세트
BR112021002609A2 (pt) * 2018-08-14 2021-05-11 President And Fellows Of Harvard College detecção in vitro de ácido nucleico
US11624702B2 (en) 2018-09-05 2023-04-11 Georgia Tech Research Corporation Systems and methods for quantifying analytes with minimal inter-sample variability
KR102163425B1 (ko) 2018-09-07 2020-10-08 한국화학연구원 중동호흡기증후군 바이러스 진단을 위한 세포-유리 시스템 및 이의 이용방법
CN109811071A (zh) * 2019-02-22 2019-05-28 中国科学院长春应用化学研究所 一种基于血糖仪检测的免标记、免分离便携式基因检测方法
KR102222646B1 (ko) * 2019-06-20 2021-03-03 한국화학연구원 구제역 바이러스 진단을 위한 리보조절인자 및 이의 용도
KR102323107B1 (ko) * 2019-10-25 2021-11-08 한국화학연구원 리보조절인자를 이용한 바이러스 진단을 위한 fet 통합 센서 및 이의 이용 방법
US20230022775A1 (en) * 2019-12-13 2023-01-26 President And Fellows Of Harvard College Riboregulators and methods of use thereof
WO2021219891A1 (en) 2020-05-01 2021-11-04 Enteromics Ltd. Ingestible and modular capsule for sample collection, monitoring, and/or data detection
WO2021252956A2 (en) 2020-06-12 2021-12-16 Arizona Board Of Regents On Behalf Of Arizona State University Rapid low-cost detection of sars-cov-2 using isothermal amplification and sensing methods
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WO2022023343A1 (en) 2020-07-27 2022-02-03 Moirai Biodesign, S.L. Rna molecule, use thereof and a process for detecting a disease by using thereof
US11873485B2 (en) 2021-01-26 2024-01-16 California Institute Of Technology Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas
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Also Published As

Publication number Publication date
US9550987B2 (en) 2017-01-24
JP2015533297A (ja) 2015-11-24
WO2014074648A3 (en) 2014-08-28
EP2917349A2 (en) 2015-09-16
EP2917349B1 (en) 2017-04-26
JP2017118881A (ja) 2017-07-06
WO2014074648A2 (en) 2014-05-15
CN108004238A (zh) 2018-05-08
CN104968786A (zh) 2015-10-07
KR20150083115A (ko) 2015-07-16
EP3216870A1 (en) 2017-09-13
US20150275203A1 (en) 2015-10-01
CN104968786B (zh) 2017-10-10
JP6130923B2 (ja) 2017-05-17
US20170175111A1 (en) 2017-06-22

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