HK1209427A1 - Azaheterocycles as bir2 and/or bir3 inhibitors bir2 / bir3 - Google Patents
Azaheterocycles as bir2 and/or bir3 inhibitors bir2 / bir3Info
- Publication number
- HK1209427A1 HK1209427A1 HK15110299.0A HK15110299A HK1209427A1 HK 1209427 A1 HK1209427 A1 HK 1209427A1 HK 15110299 A HK15110299 A HK 15110299A HK 1209427 A1 HK1209427 A1 HK 1209427A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bir2
- bir3
- azaheterocycles
- inhibitors
- bir3 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261683253P | 2012-08-15 | 2012-08-15 | |
PCT/EP2013/066458 WO2014026882A1 (en) | 2012-08-15 | 2013-08-06 | Azaheterocycles as bir2 and/or bir3 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1209427A1 true HK1209427A1 (en) | 2016-04-01 |
Family
ID=48948413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15110299.0A HK1209427A1 (en) | 2012-08-15 | 2015-10-20 | Azaheterocycles as bir2 and/or bir3 inhibitors bir2 / bir3 |
Country Status (21)
Country | Link |
---|---|
US (1) | US9422332B2 (ru) |
EP (1) | EP2885275A1 (ru) |
JP (1) | JP6203261B2 (ru) |
KR (1) | KR20150042792A (ru) |
CN (1) | CN104540806B (ru) |
AU (1) | AU2013304214A1 (ru) |
BR (1) | BR112015003201A2 (ru) |
CA (1) | CA2878106A1 (ru) |
CL (1) | CL2015000333A1 (ru) |
CO (1) | CO7180196A2 (ru) |
CR (1) | CR20150041A (ru) |
EA (1) | EA201590347A1 (ru) |
HK (1) | HK1209427A1 (ru) |
IL (1) | IL237063A0 (ru) |
MA (1) | MA37896A1 (ru) |
MX (1) | MX2015001905A (ru) |
PE (1) | PE20150674A1 (ru) |
PH (1) | PH12015500185A1 (ru) |
SG (1) | SG11201500581WA (ru) |
WO (1) | WO2014026882A1 (ru) |
ZA (1) | ZA201500342B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
ES2899002T3 (es) * | 2016-03-22 | 2022-03-09 | Inst Nat Sante Rech Med | Nuevos derivados y su uso como inhibidores selectivos de Caspasa-2 |
JP6953435B2 (ja) * | 2016-05-09 | 2021-10-27 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二量体化合物 |
CN106265764B (zh) | 2016-08-18 | 2018-03-16 | 广州威溶特医药科技有限公司 | Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101094833A (zh) * | 2004-07-12 | 2007-12-26 | 伊邓药品公司 | 四肽类似物 |
EP1773348A4 (en) * | 2004-07-12 | 2009-05-20 | Idun Pharmaceuticals Inc | TETRA PEPTIDE ANALOGS |
WO2011059763A2 (en) * | 2009-10-28 | 2011-05-19 | Joyant Pharmaceuticals, Inc. | Dimeric smac mimetics |
-
2013
- 2013-08-06 US US14/419,288 patent/US9422332B2/en not_active Expired - Fee Related
- 2013-08-06 BR BR112015003201A patent/BR112015003201A2/pt active Search and Examination
- 2013-08-06 PE PE2015000194A patent/PE20150674A1/es not_active Application Discontinuation
- 2013-08-06 MX MX2015001905A patent/MX2015001905A/es unknown
- 2013-08-06 EA EA201590347A patent/EA201590347A1/ru unknown
- 2013-08-06 CN CN201380035682.3A patent/CN104540806B/zh not_active Expired - Fee Related
- 2013-08-06 WO PCT/EP2013/066458 patent/WO2014026882A1/en active Application Filing
- 2013-08-06 SG SG11201500581WA patent/SG11201500581WA/en unknown
- 2013-08-06 EP EP13745838.6A patent/EP2885275A1/en not_active Withdrawn
- 2013-08-06 AU AU2013304214A patent/AU2013304214A1/en not_active Abandoned
- 2013-08-06 JP JP2015526932A patent/JP6203261B2/ja not_active Expired - Fee Related
- 2013-08-06 CA CA2878106A patent/CA2878106A1/en not_active Abandoned
- 2013-08-06 KR KR20157003782A patent/KR20150042792A/ko not_active Application Discontinuation
- 2013-08-06 MA MA37896A patent/MA37896A1/fr unknown
-
2015
- 2015-01-16 ZA ZA2015/00342A patent/ZA201500342B/en unknown
- 2015-01-28 CO CO15017272A patent/CO7180196A2/es unknown
- 2015-01-28 PH PH12015500185A patent/PH12015500185A1/en unknown
- 2015-01-29 CR CR20150041A patent/CR20150041A/es unknown
- 2015-02-02 IL IL237063A patent/IL237063A0/en unknown
- 2015-02-11 CL CL2015000333A patent/CL2015000333A1/es unknown
- 2015-10-20 HK HK15110299.0A patent/HK1209427A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2014026882A1 (en) | 2014-02-20 |
IL237063A0 (en) | 2015-03-31 |
JP2015526436A (ja) | 2015-09-10 |
CN104540806A (zh) | 2015-04-22 |
AU2013304214A1 (en) | 2015-02-12 |
CO7180196A2 (es) | 2015-02-09 |
EA201590347A1 (ru) | 2015-05-29 |
CN104540806B (zh) | 2017-05-03 |
CR20150041A (es) | 2015-03-13 |
MX2015001905A (es) | 2015-06-05 |
SG11201500581WA (en) | 2015-04-29 |
PH12015500185B1 (en) | 2015-04-20 |
US20150210739A1 (en) | 2015-07-30 |
ZA201500342B (en) | 2017-09-27 |
CL2015000333A1 (es) | 2015-11-06 |
JP6203261B2 (ja) | 2017-09-27 |
BR112015003201A2 (pt) | 2017-07-04 |
PH12015500185A1 (en) | 2015-04-20 |
US9422332B2 (en) | 2016-08-23 |
MA37896A1 (fr) | 2016-09-30 |
CA2878106A1 (en) | 2014-02-20 |
EP2885275A1 (en) | 2015-06-24 |
PE20150674A1 (es) | 2015-05-06 |
KR20150042792A (ko) | 2015-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1209632A1 (en) | Irak inhibitors and uses thereof -1 (irak) | |
HK1205989A1 (en) | Pallet and pallet system | |
HUE056893T2 (hu) | Lapok és hullámfront párhuzamos feldolgozása | |
EP2884135A4 (en) | THERMOREGULATOR AND THERMOREGULATOR COMPONENT | |
EP2920149A4 (en) | 3-AMINOCYCLOALKYL COMPOUNDS AS ROR-GAMMA-T-HEMMER AND USES THEREOF | |
EP2846784A4 (en) | COMPOUNDS USEFUL FOR STIMULATING PROTEIN DEGRADATION AND METHODS USING THE SAME | |
EP2828258A4 (en) | NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE | |
EP2809193A4 (en) | RFID PROTECTED ARTICLES AND ASSOCIATED METHODS | |
EP2833889A4 (en) | PROTEIN KINASE C HEMMER AND USES THEREOF | |
GB201201100D0 (en) | Polypeptides and methods | |
EP2815956A4 (en) | DRIVING INSTALLATION VESSEL AND DRIVING INSTALLATION METHOD USING THE VESSEL | |
HK1203198A1 (en) | Substituted phenylimidazopyrazoles and use thereof | |
GB201002083D0 (en) | Apparatus for improving and/or maintaining numerical ability | |
HK1209427A1 (en) | Azaheterocycles as bir2 and/or bir3 inhibitors bir2 / bir3 | |
HK1212997A1 (zh) | 酮酰胺免疫蛋白酶體抑制劑 | |
EP2938415A4 (en) | MATERIALS AND METHOD | |
HK1201050A1 (en) | Polypeptides and their use | |
EP2852662A4 (en) | HERPESVIRUS COMPOSITIONS AND RELATED METHODS | |
HK1211042A1 (en) | Inflammation-enabling polypeptides and uses thereof | |
EP2803396A4 (en) | SAMPLE CONCENTRATION CONTAINER AND SAMPLE CONCENTRATION METHOD THEREWITH | |
HK1213579A1 (zh) | 大環酮酰胺免疫蛋白酶體抑制劑 | |
ZA201504462B (en) | TGFß-DERIVED POLYPEPTIDES AND USES THEREOF | |
PL2895751T3 (pl) | Śruba i jej zastosowanie | |
EP2819713A4 (en) | WATER-BASED HUMIDITY INDICATOR COMPOSITION AND SENSOR | |
GB201210303D0 (en) | Polypeptides and methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20210814 |