EA201590347A1 - Азагетероциклы в качестве ингибиторов bir2 и/или bir3 - Google Patents

Азагетероциклы в качестве ингибиторов bir2 и/или bir3

Info

Publication number
EA201590347A1
EA201590347A1 EA201590347A EA201590347A EA201590347A1 EA 201590347 A1 EA201590347 A1 EA 201590347A1 EA 201590347 A EA201590347 A EA 201590347A EA 201590347 A EA201590347 A EA 201590347A EA 201590347 A1 EA201590347 A1 EA 201590347A1
Authority
EA
Eurasian Patent Office
Prior art keywords
azheterocycles
bir2
bir3
inhibitors
bir3 inhibitors
Prior art date
Application number
EA201590347A
Other languages
English (en)
Inventor
Джоан Хизер Хогг
Кан Лэ
Ян Лоу
Стивен Грегори Мишке
Стейси Ремисзевски
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48948413&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201590347(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201590347A1 publication Critical patent/EA201590347A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Описаны соединения формулы (I) или их фармацевтически приемлемые соли, где R, R, R, m, n и q приведены в этой заявке, и способы применения указанных соединений в лечении рака.
EA201590347A 2012-08-15 2013-08-06 Азагетероциклы в качестве ингибиторов bir2 и/или bir3 EA201590347A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261683253P 2012-08-15 2012-08-15
PCT/EP2013/066458 WO2014026882A1 (en) 2012-08-15 2013-08-06 Azaheterocycles as bir2 and/or bir3 inhibitors

Publications (1)

Publication Number Publication Date
EA201590347A1 true EA201590347A1 (ru) 2015-05-29

Family

ID=48948413

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590347A EA201590347A1 (ru) 2012-08-15 2013-08-06 Азагетероциклы в качестве ингибиторов bir2 и/или bir3

Country Status (21)

Country Link
US (1) US9422332B2 (ru)
EP (1) EP2885275A1 (ru)
JP (1) JP6203261B2 (ru)
KR (1) KR20150042792A (ru)
CN (1) CN104540806B (ru)
AU (1) AU2013304214A1 (ru)
BR (1) BR112015003201A2 (ru)
CA (1) CA2878106A1 (ru)
CL (1) CL2015000333A1 (ru)
CO (1) CO7180196A2 (ru)
CR (1) CR20150041A (ru)
EA (1) EA201590347A1 (ru)
HK (1) HK1209427A1 (ru)
IL (1) IL237063A0 (ru)
MA (1) MA37896A1 (ru)
MX (1) MX2015001905A (ru)
PE (1) PE20150674A1 (ru)
PH (1) PH12015500185A1 (ru)
SG (1) SG11201500581WA (ru)
WO (1) WO2014026882A1 (ru)
ZA (1) ZA201500342B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
CN109476631B (zh) * 2016-03-22 2021-04-06 国家健康与医学研究院 新衍生物及其作为胱天蛋白酶-2的选择性抑制剂的用途
JP6953435B2 (ja) * 2016-05-09 2021-10-27 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 二量体化合物
CN106265764B (zh) 2016-08-18 2018-03-16 广州威溶特医药科技有限公司 Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017295A2 (en) * 2004-07-12 2006-02-16 Idun Pharmaceuticals, Inc. Tetrapeptide analogs
AP2007003894A0 (en) * 2004-07-12 2007-02-28 Bin Chao Tetrapeptide analogs
EP2784076A1 (en) * 2009-10-28 2014-10-01 Joyant Pharmaceuticals, Inc. Dimeric SMAC mimetics

Also Published As

Publication number Publication date
CN104540806A (zh) 2015-04-22
KR20150042792A (ko) 2015-04-21
CN104540806B (zh) 2017-05-03
CA2878106A1 (en) 2014-02-20
BR112015003201A2 (pt) 2017-07-04
CO7180196A2 (es) 2015-02-09
PE20150674A1 (es) 2015-05-06
ZA201500342B (en) 2017-09-27
MX2015001905A (es) 2015-06-05
HK1209427A1 (en) 2016-04-01
AU2013304214A1 (en) 2015-02-12
SG11201500581WA (en) 2015-04-29
JP6203261B2 (ja) 2017-09-27
EP2885275A1 (en) 2015-06-24
PH12015500185B1 (en) 2015-04-20
MA37896A1 (fr) 2016-09-30
US9422332B2 (en) 2016-08-23
IL237063A0 (en) 2015-03-31
CL2015000333A1 (es) 2015-11-06
CR20150041A (es) 2015-03-13
PH12015500185A1 (en) 2015-04-20
WO2014026882A1 (en) 2014-02-20
JP2015526436A (ja) 2015-09-10
US20150210739A1 (en) 2015-07-30

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