HK1207639A1 - 作為 受體活性調節劑的乙炔基衍生物 - Google Patents

作為 受體活性調節劑的乙炔基衍生物

Info

Publication number
HK1207639A1
HK1207639A1 HK15108283.2A HK15108283A HK1207639A1 HK 1207639 A1 HK1207639 A1 HK 1207639A1 HK 15108283 A HK15108283 A HK 15108283A HK 1207639 A1 HK1207639 A1 HK 1207639A1
Authority
HK
Hong Kong
Prior art keywords
mglur5
modulators
receptor activity
ethynyl derivatives
ethynyl
Prior art date
Application number
HK15108283.2A
Other languages
English (en)
Inventor
喬治．耶施克
洛塔爾．林德曼
安東尼奧．里奇
丹尼爾．呂厄
海因茨．施塔德勒
埃里克．維埃拉
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1207639A1 publication Critical patent/HK1207639A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Pyridine Compounds (AREA)
HK15108283.2A 2012-10-18 2015-08-26 作為 受體活性調節劑的乙炔基衍生物 HK1207639A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12188940 2012-10-18
PCT/EP2013/071500 WO2014060398A1 (en) 2012-10-18 2013-10-15 Ethynyl derivatives as modulators of mglur5 receptor activity

Publications (1)

Publication Number Publication Date
HK1207639A1 true HK1207639A1 (zh) 2016-02-05

Family

ID=47049067

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15108283.2A HK1207639A1 (zh) 2012-10-18 2015-08-26 作為 受體活性調節劑的乙炔基衍生物

Country Status (27)

Country Link
US (1) US9227959B2 (zh)
EP (1) EP2909180B1 (zh)
JP (1) JP5989250B2 (zh)
KR (1) KR101684816B1 (zh)
CN (1) CN104718192B (zh)
AR (1) AR093042A1 (zh)
AU (1) AU2013333988B2 (zh)
BR (1) BR112015006454A8 (zh)
CA (1) CA2882520A1 (zh)
CL (1) CL2015000891A1 (zh)
CO (1) CO7200248A2 (zh)
CR (1) CR20150144A (zh)
EA (1) EA025667B1 (zh)
ES (1) ES2599553T3 (zh)
HK (1) HK1207639A1 (zh)
IL (1) IL237380A (zh)
MA (1) MA38012B1 (zh)
MX (1) MX2015004898A (zh)
MY (1) MY168937A (zh)
NZ (1) NZ705144A (zh)
PE (1) PE20150629A1 (zh)
PH (1) PH12015500398A1 (zh)
SG (1) SG11201501392TA (zh)
TW (1) TWI490208B (zh)
UA (1) UA114529C2 (zh)
WO (1) WO2014060398A1 (zh)
ZA (1) ZA201500856B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20150733A1 (es) * 2012-10-18 2015-05-17 Hoffmann La Roche Derivados de etinilo como moduladores de la actividad del receptor mglur5
MX2017015043A (es) * 2015-06-03 2018-02-26 Hoffmann La Roche Derivados de etinilo.
CN108271370B (zh) * 2015-09-25 2021-03-19 (由卫生与公众服务部部长代表的)***合众国 作为p2y14受体拮抗剂的***衍生物
HUE056667T2 (hu) 2017-12-08 2022-02-28 Boehringer Ingelheim Int Imidazopiridin-származékok és gyógyszerként történõ alkalmazásuk
US11155539B2 (en) 2018-10-17 2021-10-26 Boehringer Ingelheim International Gmbh 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament
TW202035395A (zh) * 2018-10-17 2020-10-01 德商百靈佳殷格翰國際股份有限公司 4-嘧啶-5-基甲基-嗎啉衍生物及其作為藥物之用途
MX2021004418A (es) * 2018-10-17 2021-07-06 Boehringer Ingelheim Int Derivados de 4 pirazin 2 ilmetil-morfolina y su uso como medicamento.
JP7318015B2 (ja) 2019-06-04 2023-07-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 特に抑うつ病性障害の処置のための、ｎｒ２ｂネガティブ調節剤としてのプリン誘導体および医薬としてのその使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
WO2008151184A1 (en) * 2007-06-03 2008-12-11 Vanderbilt University Benzamide mglur5 positive allosteric modulators and methods of making and using same
US8853392B2 (en) * 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
US8389536B2 (en) * 2009-10-27 2013-03-05 Hoffmann-La Roche Inc. Positive allosteric modulators (PAM)
WO2013049255A1 (en) * 2011-09-26 2013-04-04 Vanderbilt University Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors

Also Published As

Publication number Publication date
AR093042A1 (es) 2015-05-13
WO2014060398A1 (en) 2014-04-24
KR20150055044A (ko) 2015-05-20
ZA201500856B (en) 2016-08-31
PH12015500398B1 (en) 2015-04-27
UA114529C2 (uk) 2017-06-26
TW201420571A (zh) 2014-06-01
MY168937A (en) 2019-01-10
AU2013333988A1 (en) 2015-02-26
MA38012B1 (fr) 2016-12-30
CN104718192B (zh) 2016-08-31
JP2015531392A (ja) 2015-11-02
IL237380A (en) 2017-02-28
NZ705144A (en) 2018-09-28
IL237380A0 (en) 2015-04-30
PE20150629A1 (es) 2015-05-11
SG11201501392TA (en) 2015-05-28
US9227959B2 (en) 2016-01-05
BR112015006454A2 (pt) 2017-07-04
EP2909180A1 (en) 2015-08-26
EA201590699A1 (ru) 2015-07-30
PH12015500398A1 (en) 2015-04-27
CL2015000891A1 (es) 2015-09-11
MX2015004898A (es) 2015-07-21
ES2599553T3 (es) 2017-02-02
TWI490208B (zh) 2015-07-01
AU2013333988B2 (en) 2017-03-09
EP2909180B1 (en) 2016-10-05
US20150225385A1 (en) 2015-08-13
CR20150144A (es) 2015-04-30
KR101684816B1 (ko) 2016-12-20
CO7200248A2 (es) 2015-02-27
JP5989250B2 (ja) 2016-09-07
MA38012A1 (fr) 2016-05-31
EA025667B1 (ru) 2017-01-30
CN104718192A (zh) 2015-06-17
BR112015006454A8 (pt) 2019-08-20
CA2882520A1 (en) 2014-04-24

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