HK1206715A1 - 作爲 受體活性的調節劑的乙炔基衍生物 - Google Patents

作爲 受體活性的調節劑的乙炔基衍生物

Info

Publication number
HK1206715A1
HK1206715A1 HK15107144.3A HK15107144A HK1206715A1 HK 1206715 A1 HK1206715 A1 HK 1206715A1 HK 15107144 A HK15107144 A HK 15107144A HK 1206715 A1 HK1206715 A1 HK 1206715A1
Authority
HK
Hong Kong
Prior art keywords
mglur5
modulators
receptor activity
ethynyl derivatives
ethynyl
Prior art date
Application number
HK15107144.3A
Other languages
English (en)
Inventor
喬治．耶施克
洛塔爾．林德曼
安東尼奧．里奇
丹尼爾．吕厄
海因茨．施塔德勒
埃里克．維埃拉
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1206715A1 publication Critical patent/HK1206715A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK15107144.3A 2012-10-18 2015-07-27 作爲 受體活性的調節劑的乙炔基衍生物 HK1206715A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12188943 2012-10-18
PCT/EP2013/071476 WO2014060384A1 (en) 2012-10-18 2013-10-15 Ethynyl derivatives as modulators of mglur5 receptor activity

Publications (1)

Publication Number Publication Date
HK1206715A1 true HK1206715A1 (zh) 2016-01-15

Family

ID=47049068

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107144.3A HK1206715A1 (zh) 2012-10-18 2015-07-27 作爲 受體活性的調節劑的乙炔基衍生物

Country Status (26)

Country Link
US (1) US9359301B2 (zh)
EP (1) EP2909178B1 (zh)
JP (1) JP6263542B2 (zh)
KR (1) KR20150070102A (zh)
CN (1) CN104603110B (zh)
AR (1) AR093029A1 (zh)
AU (1) AU2013331782B2 (zh)
BR (1) BR112015002320A2 (zh)
CA (1) CA2879489A1 (zh)
CL (1) CL2015000890A1 (zh)
CR (1) CR20150158A (zh)
EA (1) EA026941B1 (zh)
ES (1) ES2599507T3 (zh)
HK (1) HK1206715A1 (zh)
IL (1) IL237217A (zh)
MA (1) MA38010B1 (zh)
MX (1) MX2015002823A (zh)
MY (1) MY171517A (zh)
NZ (1) NZ703537A (zh)
PE (1) PE20150733A1 (zh)
PH (1) PH12015500346A1 (zh)
SG (1) SG11201500729SA (zh)
TW (1) TWI504593B (zh)
UA (1) UA114008C2 (zh)
WO (1) WO2014060384A1 (zh)
ZA (1) ZA201500343B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017015043A (es) * 2015-06-03 2018-02-26 Hoffmann La Roche Derivados de etinilo.
LT3322701T (lt) 2015-07-15 2019-07-10 F. Hoffmann-La Roche Ag Etinilo dariniai kaip metabotropinių glutamato receptorių moduliatoriai
KR102648875B1 (ko) 2016-03-30 2024-03-15 신탁시스 아베 성숙 뇌 손상의 치료에 사용하기 위한 ｍＧｌｕＲ５의 음성 알로스테릭 조절제
CA3030788A1 (en) 2016-07-18 2018-01-25 F. Hoffmann-La Roche Ag Ethynyl derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US7531529B2 (en) * 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US8853392B2 (en) * 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
WO2010124047A1 (en) * 2009-04-23 2010-10-28 Wyeth Llc Bisaryl alkynylamides as negative allosteric modulators of metabotropic glutamate receptor 5 (mglur5)
US8389536B2 (en) * 2009-10-27 2013-03-05 Hoffmann-La Roche Inc. Positive allosteric modulators (PAM)
US8586581B2 (en) * 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
US8772300B2 (en) * 2011-04-19 2014-07-08 Hoffmann-La Roche Inc. Phenyl or pyridinyl-ethynyl derivatives
WO2012146551A1 (en) * 2011-04-26 2012-11-01 F. Hoffmann-La Roche Ag Ethynyl derivatives as positive allosteric modulators of the mglur5
WO2013049255A1 (en) * 2011-09-26 2013-04-04 Vanderbilt University Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
UA110995C2 (uk) * 2011-10-07 2016-03-10 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як модулятори метаботропного глутаматного рецептора
CA2871389C (en) * 2012-07-17 2020-08-25 F. Hoffmann-La Roche Ag Arylethynyl derivatives
UA113223C2 (xx) * 2012-08-13 2016-12-26 Арилетинілпіримідини
EA025482B1 (ru) * 2012-09-27 2016-12-30 Ф. Хоффманн-Ля Рош Аг Производные арилэтинила
EP2909179B1 (en) * 2012-10-18 2016-10-05 F. Hoffmann-La Roche AG Ethynyl derivatives as modulators of mglur5 receptor activity
SG11201501392TA (en) * 2012-10-18 2015-05-28 Hoffmann La Roche Ethynyl derivatives as modulators of mglur5 receptor activity

Also Published As

Publication number Publication date
UA114008C2 (xx) 2017-04-10
PH12015500346B1 (en) 2015-04-20
KR20150070102A (ko) 2015-06-24
IL237217A0 (en) 2015-04-30
AU2013331782A1 (en) 2015-01-29
EP2909178B1 (en) 2016-10-05
IL237217A (en) 2016-11-30
JP6263542B2 (ja) 2018-01-17
MA38010B1 (fr) 2016-10-31
TWI504593B (zh) 2015-10-21
TW201420575A (zh) 2014-06-01
EP2909178A1 (en) 2015-08-26
ZA201500343B (en) 2016-01-27
EA201590676A1 (ru) 2015-08-31
CR20150158A (es) 2015-04-30
ES2599507T3 (es) 2017-02-02
AR093029A1 (es) 2015-05-13
SG11201500729SA (en) 2015-06-29
US20150225345A1 (en) 2015-08-13
PH12015500346A1 (en) 2015-04-20
EA026941B1 (ru) 2017-06-30
CN104603110A (zh) 2015-05-06
MA38010A1 (fr) 2016-01-29
PE20150733A1 (es) 2015-05-17
AU2013331782B2 (en) 2017-03-09
WO2014060384A1 (en) 2014-04-24
CN104603110B (zh) 2016-08-31
JP2015534961A (ja) 2015-12-07
US9359301B2 (en) 2016-06-07
CA2879489A1 (en) 2014-04-24
CL2015000890A1 (es) 2015-08-07
MX2015002823A (es) 2015-05-15
BR112015002320A2 (pt) 2017-07-04
NZ703537A (en) 2018-06-29
MY171517A (en) 2019-10-16

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