AR093029A1 - Derivados de etilino - Google Patents
Derivados de etilinoInfo
- Publication number
- AR093029A1 AR093029A1 ARP130103749A ARP130103749A AR093029A1 AR 093029 A1 AR093029 A1 AR 093029A1 AR P130103749 A ARP130103749 A AR P130103749A AR P130103749 A ARP130103749 A AR P130103749A AR 093029 A1 AR093029 A1 AR 093029A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- disease
- ethylin
- formula
- gerd
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de etinilo de la fórmula (1), en la que: Y es N o CH, R¹ es flúor o cloro, o a una sal de adición de ácido farmacéuticamente aceptable, a una mezcla racémica, o a sus correspondientes enantiómeros y/o isómeros ópticos y/o estereoisómeros. Ahora se ha encontrado que los compuestos de la fórmula general (1) son antagonistas de receptores metabotrópicos de glutamato (moduladores alostéricos negativos) que pueden utilizarse para el tratamiento de la ansiedad y el dolor, la depresión, el síndrome de la X frágil, los trastornos del espectro autista, la enfermedad de Parkinson y la enfermedad del reflujo gastroesofágico (GERD).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12188943 | 2012-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR093029A1 true AR093029A1 (es) | 2015-05-13 |
Family
ID=47049068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103749A AR093029A1 (es) | 2012-10-18 | 2013-10-16 | Derivados de etilino |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9359301B2 (es) |
| EP (1) | EP2909178B1 (es) |
| JP (1) | JP6263542B2 (es) |
| KR (1) | KR20150070102A (es) |
| CN (1) | CN104603110B (es) |
| AR (1) | AR093029A1 (es) |
| AU (1) | AU2013331782B2 (es) |
| BR (1) | BR112015002320A2 (es) |
| CA (1) | CA2879489A1 (es) |
| CL (1) | CL2015000890A1 (es) |
| CR (1) | CR20150158A (es) |
| EA (1) | EA026941B1 (es) |
| ES (1) | ES2599507T3 (es) |
| HK (1) | HK1206715A1 (es) |
| IL (1) | IL237217A (es) |
| MA (1) | MA38010B1 (es) |
| MX (1) | MX2015002823A (es) |
| MY (1) | MY171517A (es) |
| NZ (1) | NZ703537A (es) |
| PE (1) | PE20150733A1 (es) |
| PH (1) | PH12015500346B1 (es) |
| SG (1) | SG11201500729SA (es) |
| TW (1) | TWI504593B (es) |
| UA (1) | UA114008C2 (es) |
| WO (1) | WO2014060384A1 (es) |
| ZA (1) | ZA201500343B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA120309C2 (uk) * | 2015-06-03 | 2019-11-11 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні |
| RS58929B1 (sr) | 2015-07-15 | 2019-08-30 | Hoffmann La Roche | Derivati etinila kao modulatori metabotropnih glutamatnih receptora |
| CN108883104A (zh) | 2016-03-30 | 2018-11-23 | 森泰克希斯公司 | 用于在治疗成熟脑损伤中使用的mGluR5的负性变构调节剂 |
| RU2745068C2 (ru) | 2016-07-18 | 2021-03-18 | Ф. Хоффманн-Ля Рош Аг | Производные этинила |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| US7531529B2 (en) * | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US8853392B2 (en) * | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
| US20100273772A1 (en) * | 2009-04-23 | 2010-10-28 | Wyeth Llc | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) |
| US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| US8586581B2 (en) * | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| SI2702051T1 (sl) * | 2011-04-26 | 2015-06-30 | F. Hoffmann-La Roche Ag | Etinilni derivati kot pozitivni alosteriäśni modulatorji mglur5 |
| WO2013049255A1 (en) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors |
| UA110995C2 (uk) * | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як модулятори метаботропного глутаматного рецептора |
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
| PE20150184A1 (es) * | 2012-07-17 | 2015-02-13 | Hoffmann La Roche | Derivados de ariletinilo |
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| MX366136B (es) * | 2012-09-27 | 2019-06-28 | Hoffmann La Roche | Derivados de ariletinilo. |
| EA025667B1 (ru) * | 2012-10-18 | 2017-01-30 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ ЭТИНИЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ АКТИВНОСТИ РЕЦЕПТОРА mGluR5 |
| UA114934C2 (uk) * | 2012-10-18 | 2017-08-28 | Ф. Хоффманн-Ля Рош Аг | Похідне етинілу як модулятор активності метаботропного глутаматного рецептора підтипу 5 |
-
2013
- 2013-10-15 MX MX2015002823A patent/MX2015002823A/es unknown
- 2013-10-15 MY MYPI2015000250A patent/MY171517A/en unknown
- 2013-10-15 UA UAA201504679A patent/UA114008C2/uk unknown
- 2013-10-15 NZ NZ703537A patent/NZ703537A/en not_active IP Right Cessation
- 2013-10-15 SG SG11201500729SA patent/SG11201500729SA/en unknown
- 2013-10-15 WO PCT/EP2013/071476 patent/WO2014060384A1/en active Application Filing
- 2013-10-15 PE PE2015000287A patent/PE20150733A1/es not_active Application Discontinuation
- 2013-10-15 AU AU2013331782A patent/AU2013331782B2/en not_active Ceased
- 2013-10-15 ES ES13776507.9T patent/ES2599507T3/es active Active
- 2013-10-15 JP JP2015537217A patent/JP6263542B2/ja active Active
- 2013-10-15 CA CA2879489A patent/CA2879489A1/en not_active Abandoned
- 2013-10-15 EA EA201590676A patent/EA026941B1/ru not_active IP Right Cessation
- 2013-10-15 CN CN201380046124.7A patent/CN104603110B/zh active Active
- 2013-10-15 BR BR112015002320A patent/BR112015002320A2/pt not_active Application Discontinuation
- 2013-10-15 EP EP13776507.9A patent/EP2909178B1/en active Active
- 2013-10-15 KR KR1020157006701A patent/KR20150070102A/ko active IP Right Grant
- 2013-10-16 AR ARP130103749A patent/AR093029A1/es unknown
- 2013-10-17 TW TW102137559A patent/TWI504593B/zh not_active IP Right Cessation
-
2015
- 2015-01-16 ZA ZA2015/00343A patent/ZA201500343B/en unknown
- 2015-02-12 IL IL237217A patent/IL237217A/en not_active IP Right Cessation
- 2015-02-17 PH PH12015500346A patent/PH12015500346B1/en unknown
- 2015-03-20 CR CR20150158A patent/CR20150158A/es unknown
- 2015-04-09 CL CL2015000890A patent/CL2015000890A1/es unknown
- 2015-04-17 MA MA38010A patent/MA38010B1/fr unknown
- 2015-04-17 US US14/689,387 patent/US9359301B2/en active Active
- 2015-07-27 HK HK15107144.3A patent/HK1206715A1/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR093042A1 (es) | Derivados de etinilo | |
| AR096824A1 (es) | Derivados de etinilo | |
| AR093029A1 (es) | Derivados de etilino | |
| ECSP13012990A (es) | Derivados de pirazolidin-3-ona | |
| AR093043A1 (es) | Derivados de etinilo | |
| AR091764A1 (es) | Derivados de ariletinilo | |
| CY1118595T1 (el) | Αρυλοαιθινυλο πυριμιδινες | |
| CO2017012260A2 (es) | Derivados de etinilo | |
| TH167680B (th) | อนุพันธ์เอไทนิลในฐานะโมดูเลเตอร์ของฤทธิ์ของ mglur5 รีเซปเตอร์ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |