HK1204942A1 - Pharmaceutical composition comprising (1r,4r)-6-fluoro-n,n-dimethyl- 4-phenyl-4,9-dihydro-3h-spiro[cyclohexane-1,1-pyrano- [3,4,b]indol]-4-amine and a propionic acid derivative (1r4r)-6--nn--4--49--3h-[- 11-[34b]]-4- - Google Patents
Pharmaceutical composition comprising (1r,4r)-6-fluoro-n,n-dimethyl- 4-phenyl-4,9-dihydro-3h-spiro[cyclohexane-1,1-pyrano- [3,4,b]indol]-4-amine and a propionic acid derivative (1r4r)-6--nn--4--49--3h-[- 11-[34b]]-4-Info
- Publication number
- HK1204942A1 HK1204942A1 HK15105573.7A HK15105573A HK1204942A1 HK 1204942 A1 HK1204942 A1 HK 1204942A1 HK 15105573 A HK15105573 A HK 15105573A HK 1204942 A1 HK1204942 A1 HK 1204942A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrano
- indol
- spiro
- dihydro
- cyclohexane
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12003935 | 2012-05-18 | ||
PCT/EP2013/001466 WO2013170967A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1204942A1 true HK1204942A1 (en) | 2015-12-11 |
Family
ID=48468206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15105573.7A HK1204942A1 (en) | 2012-05-18 | 2015-06-11 | Pharmaceutical composition comprising (1r,4r)-6-fluoro-n,n-dimethyl- 4-phenyl-4,9-dihydro-3h-spiro[cyclohexane-1,1-pyrano- [3,4,b]indol]-4-amine and a propionic acid derivative (1r4r)-6--nn--4--49--3h-[- 11-[34b]]-4- |
Country Status (23)
Country | Link |
---|---|
US (2) | US9320729B2 (xx) |
EP (1) | EP2849745B1 (xx) |
JP (1) | JP6116674B2 (xx) |
CN (1) | CN104284659A (xx) |
AU (1) | AU2013262073B2 (xx) |
BR (1) | BR112014028571A2 (xx) |
CA (1) | CA2873656A1 (xx) |
CY (1) | CY1119786T1 (xx) |
DK (1) | DK2849745T3 (xx) |
EA (1) | EA028200B1 (xx) |
ES (1) | ES2658216T3 (xx) |
HK (1) | HK1204942A1 (xx) |
HR (1) | HRP20171693T1 (xx) |
HU (1) | HUE035112T2 (xx) |
IL (1) | IL235655B (xx) |
LT (1) | LT2849745T (xx) |
MX (1) | MX354687B (xx) |
NO (1) | NO2849745T3 (xx) |
PL (1) | PL2849745T3 (xx) |
PT (1) | PT2849745T (xx) |
RS (1) | RS56771B1 (xx) |
SI (1) | SI2849745T1 (xx) |
WO (1) | WO2013170967A1 (xx) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9855286B2 (en) | 2012-05-18 | 2018-01-02 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component |
US20130310435A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol |
US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
JP6673924B2 (ja) | 2015-01-23 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 肝機能障害および/または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール |
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EP0189788B1 (de) | 1985-01-23 | 1989-09-13 | ASTA Pharma Aktiengesellschaft | Synergistische Kombination von Flupirtin und nicht-steroidalen Antiphlogistika |
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RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
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DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
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HUE028436T2 (hu) * | 2010-08-04 | 2016-12-28 | Gruenenthal Gmbh | Gyógyszerészeti adagolási forma, amely tartalmaz-6'-fluor-(N-metil- vagy N,N-dimetil)-4-fenil-4',9'-dihidro-3'H-spiro[ciklohexán-1,1'-pirano[3,4B]indol]-4-amint |
SI2600838T1 (sl) * | 2010-08-04 | 2015-12-31 | Gruenenthal Gmbh | Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin |
DK2600851T3 (en) * | 2010-08-04 | 2018-06-25 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN |
US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
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2013
- 2013-05-13 US US13/892,786 patent/US9320729B2/en active Active
- 2013-05-16 RS RS20180056A patent/RS56771B1/sr unknown
- 2013-05-16 PT PT137236725T patent/PT2849745T/pt unknown
- 2013-05-16 AU AU2013262073A patent/AU2013262073B2/en not_active Ceased
- 2013-05-16 CA CA2873656A patent/CA2873656A1/en not_active Abandoned
- 2013-05-16 PL PL13723672T patent/PL2849745T3/pl unknown
- 2013-05-16 EA EA201401266A patent/EA028200B1/ru not_active IP Right Cessation
- 2013-05-16 NO NO13723672A patent/NO2849745T3/no unknown
- 2013-05-16 ES ES13723672.5T patent/ES2658216T3/es active Active
- 2013-05-16 DK DK13723672.5T patent/DK2849745T3/en active
- 2013-05-16 MX MX2014013148A patent/MX354687B/es active IP Right Grant
- 2013-05-16 CN CN201380025641.6A patent/CN104284659A/zh active Pending
- 2013-05-16 WO PCT/EP2013/001466 patent/WO2013170967A1/en active Application Filing
- 2013-05-16 JP JP2015511953A patent/JP6116674B2/ja active Active
- 2013-05-16 LT LTEP13723672.5T patent/LT2849745T/lt unknown
- 2013-05-16 EP EP13723672.5A patent/EP2849745B1/en active Active
- 2013-05-16 HU HUE13723672A patent/HUE035112T2/en unknown
- 2013-05-16 BR BR112014028571A patent/BR112014028571A2/pt not_active IP Right Cessation
- 2013-05-16 SI SI201330918T patent/SI2849745T1/en unknown
-
2014
- 2014-11-12 IL IL235655A patent/IL235655B/en active IP Right Grant
-
2015
- 2015-06-11 HK HK15105573.7A patent/HK1204942A1/xx not_active IP Right Cessation
-
2016
- 2016-03-21 US US15/075,606 patent/US10076510B2/en active Active
-
2017
- 2017-11-06 HR HRP20171693TT patent/HRP20171693T1/hr unknown
-
2018
- 2018-01-16 CY CY20181100052T patent/CY1119786T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO2849745T3 (xx) | 2018-03-31 |
CY1119786T1 (el) | 2018-06-27 |
HUE035112T2 (en) | 2018-05-02 |
MX354687B (es) | 2018-03-15 |
MX2014013148A (es) | 2015-01-19 |
IL235655B (en) | 2018-08-30 |
US20130324581A1 (en) | 2013-12-05 |
EA028200B1 (ru) | 2017-10-31 |
EP2849745A1 (en) | 2015-03-25 |
US9320729B2 (en) | 2016-04-26 |
ES2658216T3 (es) | 2018-03-08 |
SI2849745T1 (en) | 2018-03-30 |
AU2013262073A1 (en) | 2015-01-22 |
JP2015516447A (ja) | 2015-06-11 |
HRP20171693T1 (hr) | 2017-12-15 |
WO2013170967A1 (en) | 2013-11-21 |
LT2849745T (lt) | 2018-01-25 |
BR112014028571A2 (pt) | 2017-06-27 |
CA2873656A1 (en) | 2013-11-21 |
JP6116674B2 (ja) | 2017-04-19 |
US10076510B2 (en) | 2018-09-18 |
EP2849745B1 (en) | 2017-11-01 |
US20160199349A1 (en) | 2016-07-14 |
IL235655A0 (en) | 2015-01-29 |
CN104284659A (zh) | 2015-01-14 |
PL2849745T3 (pl) | 2018-04-30 |
EA201401266A1 (ru) | 2016-05-31 |
PT2849745T (pt) | 2018-02-07 |
RS56771B1 (sr) | 2018-04-30 |
AU2013262073B2 (en) | 2018-01-18 |
DK2849745T3 (en) | 2017-12-04 |
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CORR | Corrigendum |
Free format text: CORRECTED DATA OF SECTION 20 TO JOURNAL OF 20151211: (54) PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'- FLUORO-N,N-DIMETHYL- 4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO(CYCLOHEXANE-1,1'- PYRANO-: (3,4,B)INDOL)-4-AMINE AND A PROPIONIC ACID DERIVATIVE |
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20220513 |