EA201401266A1 - Фармацевтическая композиция, которая содержит (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и производное пропионовой кислоты - Google Patents
Фармацевтическая композиция, которая содержит (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и производное пропионовой кислотыInfo
- Publication number
- EA201401266A1 EA201401266A1 EA201401266A EA201401266A EA201401266A1 EA 201401266 A1 EA201401266 A1 EA 201401266A1 EA 201401266 A EA201401266 A EA 201401266A EA 201401266 A EA201401266 A EA 201401266A EA 201401266 A1 EA201401266 A1 EA 201401266A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- spiro
- dihydro
- fluoro
- dimethyl
- amine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к фармацевтической композиции, содержащей первый фармакологически активный компонент, который выбирают из (1r,4r)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амина и его физиологически приемлемых солей, и второй фармакологически активный компонент, который представляет собой производное пропионовой кислоты, выбранное из группы, состоящей из ибупрофена, напроксена, кетопрофена, флурбипрофена, фенопрофена, фенбуфена, супрофена, пирпрофена, индопрофена, тиапрофеновой кислоты, оксапрозина, ибупроксама, флуноксапрофена, альминопрофена, напроксцинода, и их физиологически приемлемых солей.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12003935 | 2012-05-18 | ||
EP12003935.9 | 2012-05-18 | ||
PCT/EP2013/001466 WO2013170967A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201401266A1 true EA201401266A1 (ru) | 2016-05-31 |
EA028200B1 EA028200B1 (ru) | 2017-10-31 |
Family
ID=48468206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201401266A EA028200B1 (ru) | 2012-05-18 | 2013-05-16 | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ СОДЕРЖИТ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН И ПРОИЗВОДНОЕ ПРОПИОНОВОЙ КИСЛОТЫ, ВЫБРАННОЕ ИЗ ГРУППЫ, СОСТОЯЩЕЙ ИЗ ИБУПРОФЕНА И ЕГО ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ, И НАБОР, СОДЕРЖАЩИЙ УКАЗАННЫЕ СОЕДИНЕНИЯ |
Country Status (23)
Country | Link |
---|---|
US (2) | US9320729B2 (ru) |
EP (1) | EP2849745B1 (ru) |
JP (1) | JP6116674B2 (ru) |
CN (1) | CN104284659A (ru) |
AU (1) | AU2013262073B2 (ru) |
BR (1) | BR112014028571A2 (ru) |
CA (1) | CA2873656A1 (ru) |
CY (1) | CY1119786T1 (ru) |
DK (1) | DK2849745T3 (ru) |
EA (1) | EA028200B1 (ru) |
ES (1) | ES2658216T3 (ru) |
HK (1) | HK1204942A1 (ru) |
HR (1) | HRP20171693T1 (ru) |
HU (1) | HUE035112T2 (ru) |
IL (1) | IL235655B (ru) |
LT (1) | LT2849745T (ru) |
MX (1) | MX354687B (ru) |
NO (1) | NO2849745T3 (ru) |
PL (1) | PL2849745T3 (ru) |
PT (1) | PT2849745T (ru) |
RS (1) | RS56771B1 (ru) |
SI (1) | SI2849745T1 (ru) |
WO (1) | WO2013170967A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9855286B2 (en) | 2012-05-18 | 2018-01-02 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component |
US20130310435A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol |
US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
JP6673924B2 (ja) | 2015-01-23 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 肝機能障害および/または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール |
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2013
- 2013-05-13 US US13/892,786 patent/US9320729B2/en active Active
- 2013-05-16 RS RS20180056A patent/RS56771B1/sr unknown
- 2013-05-16 PT PT137236725T patent/PT2849745T/pt unknown
- 2013-05-16 AU AU2013262073A patent/AU2013262073B2/en not_active Ceased
- 2013-05-16 CA CA2873656A patent/CA2873656A1/en not_active Abandoned
- 2013-05-16 PL PL13723672T patent/PL2849745T3/pl unknown
- 2013-05-16 EA EA201401266A patent/EA028200B1/ru not_active IP Right Cessation
- 2013-05-16 NO NO13723672A patent/NO2849745T3/no unknown
- 2013-05-16 ES ES13723672.5T patent/ES2658216T3/es active Active
- 2013-05-16 DK DK13723672.5T patent/DK2849745T3/en active
- 2013-05-16 MX MX2014013148A patent/MX354687B/es active IP Right Grant
- 2013-05-16 CN CN201380025641.6A patent/CN104284659A/zh active Pending
- 2013-05-16 WO PCT/EP2013/001466 patent/WO2013170967A1/en active Application Filing
- 2013-05-16 JP JP2015511953A patent/JP6116674B2/ja active Active
- 2013-05-16 LT LTEP13723672.5T patent/LT2849745T/lt unknown
- 2013-05-16 EP EP13723672.5A patent/EP2849745B1/en active Active
- 2013-05-16 HU HUE13723672A patent/HUE035112T2/en unknown
- 2013-05-16 BR BR112014028571A patent/BR112014028571A2/pt not_active IP Right Cessation
- 2013-05-16 SI SI201330918T patent/SI2849745T1/en unknown
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2014
- 2014-11-12 IL IL235655A patent/IL235655B/en active IP Right Grant
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2015
- 2015-06-11 HK HK15105573.7A patent/HK1204942A1/xx not_active IP Right Cessation
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2016
- 2016-03-21 US US15/075,606 patent/US10076510B2/en active Active
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2017
- 2017-11-06 HR HRP20171693TT patent/HRP20171693T1/hr unknown
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2018
- 2018-01-16 CY CY20181100052T patent/CY1119786T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HK1204942A1 (en) | 2015-12-11 |
NO2849745T3 (ru) | 2018-03-31 |
CY1119786T1 (el) | 2018-06-27 |
HUE035112T2 (en) | 2018-05-02 |
MX354687B (es) | 2018-03-15 |
MX2014013148A (es) | 2015-01-19 |
IL235655B (en) | 2018-08-30 |
US20130324581A1 (en) | 2013-12-05 |
EA028200B1 (ru) | 2017-10-31 |
EP2849745A1 (en) | 2015-03-25 |
US9320729B2 (en) | 2016-04-26 |
ES2658216T3 (es) | 2018-03-08 |
SI2849745T1 (en) | 2018-03-30 |
AU2013262073A1 (en) | 2015-01-22 |
JP2015516447A (ja) | 2015-06-11 |
HRP20171693T1 (hr) | 2017-12-15 |
WO2013170967A1 (en) | 2013-11-21 |
LT2849745T (lt) | 2018-01-25 |
BR112014028571A2 (pt) | 2017-06-27 |
CA2873656A1 (en) | 2013-11-21 |
JP6116674B2 (ja) | 2017-04-19 |
US10076510B2 (en) | 2018-09-18 |
EP2849745B1 (en) | 2017-11-01 |
US20160199349A1 (en) | 2016-07-14 |
IL235655A0 (en) | 2015-01-29 |
CN104284659A (zh) | 2015-01-14 |
PL2849745T3 (pl) | 2018-04-30 |
PT2849745T (pt) | 2018-02-07 |
RS56771B1 (sr) | 2018-04-30 |
AU2013262073B2 (en) | 2018-01-18 |
DK2849745T3 (en) | 2017-12-04 |
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