HK1201831A1 - 作為 激酶抑制劑的取代的吡唑並嘧啶 - Google Patents

作為 激酶抑制劑的取代的吡唑並嘧啶

Info

Publication number
HK1201831A1
HK1201831A1 HK15102319.3A HK15102319A HK1201831A1 HK 1201831 A1 HK1201831 A1 HK 1201831A1 HK 15102319 A HK15102319 A HK 15102319A HK 1201831 A1 HK1201831 A1 HK 1201831A1
Authority
HK
Hong Kong
Prior art keywords
akt
kinase inhibitors
substituted pyrazolopyrimidines
pyrazolopyrimidines
substituted
Prior art date
Application number
HK15102319.3A
Other languages
English (en)
Inventor
．貝爾法克爾
．斯科特
．哈格巴爾特
．雷溫克爾
．波利茨
．諾伊豪斯
．伯默
Original Assignee
Bayer Ip Gmbh
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh
Publication of HK1201831A1 publication Critical patent/HK1201831A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15102319.3A 2012-01-10 2015-03-06 作為 激酶抑制劑的取代的吡唑並嘧啶 HK1201831A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12150559 2012-01-10
PCT/EP2013/050200 WO2013104611A1 (en) 2012-01-10 2013-01-08 Substituted pyrazolopyrimidines as akt kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1201831A1 true HK1201831A1 (zh) 2015-09-11

Family

ID=47603610

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102319.3A HK1201831A1 (zh) 2012-01-10 2015-03-06 作為 激酶抑制劑的取代的吡唑並嘧啶

Country Status (8)

Country Link
US (1) US9370517B2 (zh)
EP (1) EP2802588B1 (zh)
JP (1) JP6106694B2 (zh)
CN (1) CN104066736B (zh)
CA (1) CA2860724A1 (zh)
ES (1) ES2589955T3 (zh)
HK (1) HK1201831A1 (zh)
WO (1) WO2013104611A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10214537B2 (en) 2014-10-22 2019-02-26 Bristol-Myers Squibb Company Bicyclic heteroaryl amine compounds
EP3209665B1 (en) 2014-10-22 2019-08-14 Bristol-Myers Squibb Company Substituted pyrrolotriazine amine compounds as pi3k inhibitors
MX2021004769A (es) 2018-10-30 2021-08-24 Kronos Bio Inc Compuestos, composiciones, y metodos para modular la actividad cdk9.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001287574A1 (en) 2000-06-30 2002-01-08 Ingenium Pharmaceuticals Ag Human g protein-coupled receptor igpcr20, and uses thereof
RU2008117298A (ru) * 2005-10-06 2009-11-20 Шеринг Корпорейшн (US) Пиразолопиримидины как ингибиторы протеинкиназ
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
PE20090596A1 (es) 2007-08-14 2009-06-07 Bayer Schering Pharma Ag Imidazoles biciclicos fusionados
US20110288090A1 (en) 2009-02-02 2011-11-24 Armstrong Donna J Inhibitors of AKT Activity
EP2405756B1 (en) 2009-03-12 2013-07-03 Merck Sharp & Dohme Corp. Inhibitors of akt activity
WO2010114780A1 (en) * 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
WO2011033265A1 (en) 2009-09-18 2011-03-24 Almac Discovery Limited Pharmaceutical compounds
GB0919380D0 (en) * 2009-11-04 2009-12-23 Almac Discovery Ltd Pharmaceutical compouds
JP5830094B2 (ja) * 2010-07-12 2015-12-09 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換イミダゾ［１，２−ａ］ピリミジンおよび−ピリジン
JO3068B1 (ar) * 2011-04-07 2017-03-15 Bayer Ip Gmbh إيميدازوبيريميدينات كمثبطات كيناز akt

Also Published As

Publication number Publication date
JP6106694B2 (ja) 2017-04-05
US9370517B2 (en) 2016-06-21
ES2589955T3 (es) 2016-11-17
CN104066736B (zh) 2017-03-08
EP2802588B1 (en) 2016-05-25
CN104066736A (zh) 2014-09-24
CA2860724A1 (en) 2013-07-18
WO2013104611A1 (en) 2013-07-18
US20150306102A1 (en) 2015-10-29
JP2015503602A (ja) 2015-02-02
EP2802588A1 (en) 2014-11-19

Similar Documents

Publication Publication Date Title
IL265007B (en) Pyrazolopyrimidine compounds as kinase inhibitors
IL261282A (en) Furinone compounds as kinase inhibitors
HK1215253A1 (zh) 作為激酶抑制劑的吡咯並嘧啶化合物
HK1210775A1 (zh) 作為激酶抑制劑的咪唑並三嗪甲腈
HK1208442A1 (zh) 作為 激酶抑制劑的取代的吡咯並嘧啶基氨基－苯並噻唑酮
AP3597A (en) Imidazopyridazines as akt kinase inhibitors
HK1201830A1 (zh) 作為 激酶抑制劑的取代的咪唑並吡嗪
IL228103A0 (en) Amino-quinolines as kinase inhibitors
EP2685992A4 (en) AMINO-QUINOLINES AS KINASE INHIBITORS
HK1213252A1 (zh) 雙環二氫吡啶酮激酶抑制劑
PL2634185T3 (pl) Inhibitory kinazy TYK2
SG11201500973WA (en) Amino-quinolines as kinase inhibitors
EP2847186A4 (en) SUBSTITUTED AMINOCHINAZOLINES USE AS CHINESE HEMMER
HK1213181A1 (zh) 雙環氧雜內酰胺激酶抑制劑
HK1201831A1 (zh) 作為 激酶抑制劑的取代的吡唑並嘧啶
GB201206048D0 (en) Novel compounds and their use as kinase inhibitors

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220108