HK1213252A1 - 雙環二氫吡啶酮激酶抑制劑 - Google Patents
雙環二氫吡啶酮激酶抑制劑Info
- Publication number
- HK1213252A1 HK1213252A1 HK16101133.8A HK16101133A HK1213252A1 HK 1213252 A1 HK1213252 A1 HK 1213252A1 HK 16101133 A HK16101133 A HK 16101133A HK 1213252 A1 HK1213252 A1 HK 1213252A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- dihydropyridone
- bicyclic
- kinase inhibitors
- kinase
- inhibitors
- Prior art date
Links
- ZPOODPZCZLCUAN-UHFFFAOYSA-N 3,4-dihydro-1h-pyridin-2-one Chemical compound O=C1CCC=CN1 ZPOODPZCZLCUAN-UHFFFAOYSA-N 0.000 title 1
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706681P | 2012-09-27 | 2012-09-27 | |
| PCT/US2013/000224 WO2014051653A1 (en) | 2012-09-27 | 2013-09-27 | Bicyclic dihydropyridone kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1213252A1 true HK1213252A1 (zh) | 2016-06-30 |
Family
ID=50388821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16101133.8A HK1213252A1 (zh) | 2012-09-27 | 2016-02-01 | 雙環二氫吡啶酮激酶抑制劑 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9533986B2 (zh) |
| EP (1) | EP2900639B1 (zh) |
| HK (1) | HK1213252A1 (zh) |
| WO (1) | WO2014051653A1 (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2900639B1 (en) | 2012-09-27 | 2017-08-16 | Portola Pharmaceuticals, Inc. | Bicyclic dihydropyridone kinase inhibitors |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
| TW202202498A (zh) * | 2020-07-01 | 2022-01-16 | 大陸商四川海思科製藥有限公司 | 一種並環雜環衍生物及其在醫藥上的應用 |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| US11780840B2 (en) | 2020-07-02 | 2023-10-10 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| CN112062770A (zh) * | 2020-08-21 | 2020-12-11 | 台州学院 | 一种稠环二氢吡啶酮的制备方法 |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
| WO2023179567A1 (zh) * | 2022-03-22 | 2023-09-28 | 上海维申医药有限公司 | 作为Toll样受体激动剂的嘧啶并哒嗪酮类化合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080091948A (ko) * | 2007-04-10 | 2008-10-15 | 에스케이케미칼주식회사 | 락탐형 피리딘 화합물을 포함하는 허혈성 질환의 예방 및치료용 약학조성물 |
| AR075854A1 (es) | 2009-03-13 | 2011-05-04 | Vitae Pharmaceuticals Inc | Inhibidores de beta- secretasa |
| TW201105669A (en) * | 2009-07-30 | 2011-02-16 | Irm Llc | Compounds and compositions as Syk kinase inhibitors |
| CA2779105C (en) | 2009-10-29 | 2016-08-16 | Hong Woo Kim | Kinase inhibitors |
| ME02186B (me) | 2009-12-23 | 2016-02-20 | Takeda Pharmaceuticals Co | Fuzionisani heteroaromatski pirolidinoni kao syk inhibitori |
| US8846928B2 (en) | 2010-11-01 | 2014-09-30 | Portola Pharmaceuticals, Inc. | Benzamides and nicotinamides as Syk modulators |
| AU2011340721A1 (en) | 2010-12-07 | 2013-06-20 | Bayer Intellectual Property Gmbh | Substituted 1-benzylcycloalkylcarboxlic acids and use thereof |
| AR084515A1 (es) * | 2010-12-22 | 2013-05-22 | Merz Pharma Gmbh & Co Kgaa | Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras |
| EP2900639B1 (en) | 2012-09-27 | 2017-08-16 | Portola Pharmaceuticals, Inc. | Bicyclic dihydropyridone kinase inhibitors |
-
2013
- 2013-09-27 EP EP13842615.0A patent/EP2900639B1/en active Active
- 2013-09-27 US US14/432,146 patent/US9533986B2/en active Active
- 2013-09-27 WO PCT/US2013/000224 patent/WO2014051653A1/en active Application Filing
-
2016
- 2016-02-01 HK HK16101133.8A patent/HK1213252A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20150266871A1 (en) | 2015-09-24 |
| EP2900639A1 (en) | 2015-08-05 |
| US9533986B2 (en) | 2017-01-03 |
| EP2900639A4 (en) | 2016-04-20 |
| EP2900639B1 (en) | 2017-08-16 |
| WO2014051653A1 (en) | 2014-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL265007B (en) | Pyrazolopyrimidine compounds as kinase inhibitors | |
| IL261282A (en) | Furinone compounds as kinase inhibitors | |
| HK1254429A1 (zh) | 絲氨酸/蘇氨酸激酶抑制劑 | |
| HK1244004A1 (zh) | 内酰胺激酶抑制劑 | |
| HK1210775A1 (zh) | 作為激酶抑制劑的咪唑並三嗪甲腈 | |
| HK1208442A1 (zh) | 作為 激酶抑制劑的取代的吡咯並嘧啶基氨基－苯並噻唑酮 | |
| HK1215577A1 (zh) | 蛋白激酶抑制劑 | |
| HK1213252A1 (zh) | 雙環二氫吡啶酮激酶抑制劑 | |
| PL2634185T3 (pl) | Inhibitory kinazy TYK2 | |
| HK1211574A1 (zh) | 絲氨酸/蘇氨酸激酶抑制劑 | |
| HK1209726A1 (zh) | 蛋白激酶抑制劑 | |
| HK1205506A1 (zh) | 炔類化合物的蛋白激酶抑制劑 | |
| SG11201500973WA (en) | Amino-quinolines as kinase inhibitors | |
| HK1208460A1 (zh) | 蛋白激酶抑制劑 | |
| HK1213181A1 (zh) | 雙環氧雜內酰胺激酶抑制劑 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230923 |