HK1133552A1 - 碳硼烷基卟啉及其用途 - Google Patents
碳硼烷基卟啉及其用途Info
- Publication number
- HK1133552A1 HK1133552A1 HK10101467.0A HK10101467A HK1133552A1 HK 1133552 A1 HK1133552 A1 HK 1133552A1 HK 10101467 A HK10101467 A HK 10101467A HK 1133552 A1 HK1133552 A1 HK 1133552A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- carboranylporphyrins
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
- A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Radiology & Medical Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Radiation-Therapy Devices (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/633,139 US8287839B2 (en) | 2006-12-04 | 2006-12-04 | Carboranylporphyrins and uses thereof |
PCT/US2007/024767 WO2008133664A2 (en) | 2006-12-04 | 2007-12-03 | Carboranylporphyrins and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1133552A1 true HK1133552A1 (zh) | 2010-04-01 |
Family
ID=39476019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10101467.0A HK1133552A1 (zh) | 2006-12-04 | 2010-02-09 | 碳硼烷基卟啉及其用途 |
Country Status (18)
Country | Link |
---|---|
US (2) | US8287839B2 (zh) |
EP (1) | EP2099304B1 (zh) |
JP (1) | JP5340953B2 (zh) |
CN (1) | CN101605459B (zh) |
AU (1) | AU2007352392B2 (zh) |
CA (1) | CA2671849C (zh) |
CY (1) | CY1115816T1 (zh) |
DK (1) | DK2099304T3 (zh) |
ES (1) | ES2504173T3 (zh) |
HK (1) | HK1133552A1 (zh) |
MX (1) | MX2009005904A (zh) |
NZ (1) | NZ577386A (zh) |
PL (1) | PL2099304T3 (zh) |
PT (1) | PT2099304E (zh) |
RU (1) | RU2477161C2 (zh) |
SI (1) | SI2099304T1 (zh) |
WO (1) | WO2008133664A2 (zh) |
ZA (1) | ZA200903906B (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013113391A2 (en) * | 2012-02-02 | 2013-08-08 | Brainlab Ag | Method for determining an infusion parameter |
GB201212409D0 (en) * | 2012-07-12 | 2012-08-22 | Morex Dev Partners Llp | Cancer treatment |
GB201221125D0 (en) * | 2012-11-23 | 2013-01-09 | Morex Dev Partners Llp | Pharmaceutial formulations |
CN104151339B (zh) * | 2013-05-17 | 2017-05-03 | 中国科学院近代物理研究所 | 含硼吖啶衍生物、其制备方法和应用 |
CN103936747B (zh) * | 2014-04-18 | 2016-06-22 | 济南大学 | 一种烷基取代树枝状金属卟啉及其制备方法和应用 |
JP6711284B2 (ja) * | 2015-02-03 | 2020-06-17 | ソニー株式会社 | 情報処理装置、情報処理方法およびプログラム |
JP6699004B2 (ja) * | 2015-08-25 | 2020-05-27 | 住友重機械工業株式会社 | 中性子捕捉療法システム及び中性子捕捉療法システムの制御方法 |
IT202000001048A1 (it) | 2020-01-21 | 2021-07-21 | Univ Degli Studi Padova | Nanoparticelle multifunzionali a base di nanoleghe metalliche per usi diagnostici e terapeutici. |
CN112358494B (zh) * | 2020-04-09 | 2021-09-28 | 南京大学 | 一种基于吖啶的碳硼烷衍生物及其在生物显影中的应用 |
CN113735886B (zh) * | 2020-05-13 | 2022-06-03 | 北京大学 | Pdt化合物及其制备方法和用途 |
IT202100001049A1 (it) | 2021-01-21 | 2022-07-21 | Univ Degli Studi Padova | Nanoparticelle multifunzionali a base di nanoleghe metalliche per usi diagnostici e terapeutici. |
CN116333037A (zh) * | 2021-12-17 | 2023-06-27 | 化学与精细化工广东省实验室 | 含巯基肽与氟代卟啉类偶联用作生物探针 |
Family Cites Families (49)
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US4824659A (en) * | 1985-06-07 | 1989-04-25 | Immunomedics, Inc. | Antibody conjugates |
US4783529A (en) * | 1985-12-03 | 1988-11-08 | Research Corporation Technologies | Rapid synthesis of radiolabeled porphyrin complexes for medical application |
US5707604A (en) * | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
US5162231A (en) * | 1989-10-25 | 1992-11-10 | Cole Dean A | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
US4892941A (en) * | 1987-04-17 | 1990-01-09 | Dolphin David H | Porphyrins |
US4977268A (en) * | 1988-04-08 | 1990-12-11 | Duke University | Boron dipeptide compounds |
US4959356A (en) * | 1989-05-26 | 1990-09-25 | The United States Of America As Represented By The United States Department Of Energy | Porphyrins for boron neutron capture therapy |
FR2656866B1 (fr) * | 1990-01-10 | 1992-05-15 | Cis Bio Int | Derives de porphyrine et metalloporphyrines eventuellement couples a une molecule biologiquement active, et composition pharmaceutique les contenant. |
US5149801A (en) * | 1990-11-21 | 1992-09-22 | The Regents Of The University Of California | Boronated porphyrin compounds |
US5654423A (en) * | 1990-11-21 | 1997-08-05 | Regents Of The University Of California | Boronated metalloporphyrine and therapeutic methods |
US5312896A (en) * | 1992-10-09 | 1994-05-17 | Sri International | Metal ion porphyrin-containing poly(imide) |
DE4305523A1 (de) * | 1993-02-17 | 1994-08-18 | Diagnostikforschung Inst | Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
US5466679A (en) * | 1993-05-17 | 1995-11-14 | The Ohio State University Research Foundation | Carboranyl uridines and their use in boron neutron capture therapy |
US5489673A (en) * | 1993-08-16 | 1996-02-06 | University Of Washington | Iodinated borane cage molecules as X-ray contrast media |
US5599796A (en) * | 1993-12-02 | 1997-02-04 | Emory University | Treatment of urogenital cancer with boron neutron capture therapy |
JPH07330773A (ja) * | 1994-06-07 | 1995-12-19 | Toyo Hatsuka Kogyo Kk | ポルフィリン誘導体とその用途 |
US5563132A (en) * | 1994-06-21 | 1996-10-08 | Bodaness; Richard S. | Two-step cancer treatment method |
JP2685128B2 (ja) * | 1995-07-21 | 1997-12-03 | 東北大学長 | カルボラン含有ガドリニウム−dtpa錯体、その中間体、およびこれらの製造方法 |
US5877165A (en) * | 1995-11-02 | 1999-03-02 | Brookhaven Science Associates | Boronated porhyrins and methods for their use |
US5776925A (en) * | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
US5955586A (en) * | 1996-03-22 | 1999-09-21 | Sessler; Jonathan L. | Highly boronated derivatives of texaphyrins |
US6375930B2 (en) * | 1996-06-04 | 2002-04-23 | Board Of Regents, The University Of Texas System | Membrane incorporation of texaphyrins |
US6270749B1 (en) * | 1996-12-11 | 2001-08-07 | Pharmacyclics, Inc. | Use of Texaphyrin in ocular diagnosis and therapy |
US6066628A (en) * | 1997-01-09 | 2000-05-23 | Emory University | Non-iron metalloporphyrins and methods of use |
US6010805A (en) * | 1998-05-26 | 2000-01-04 | United States Of America As Represented By The Secretary Of The Air Force | Ion conducting electrolyte material containing a lithium porphyrin complex |
NZ519096A (en) * | 1999-12-03 | 2002-08-28 | Bhp Steel Jla Pty Ltd | Method and apparatus of coating a moving substrate surface |
US7067653B2 (en) * | 2000-05-09 | 2006-06-27 | The Regents Of The University Of California | Porphyrin Based neuton capture agents for cancer therapy |
US6765092B2 (en) * | 2000-07-21 | 2004-07-20 | North Carolina State University | Regioisomerically pure oxochlorins and methods of synthesis |
FR2812637B1 (fr) * | 2000-08-01 | 2002-10-25 | Anulm Ass Nantaise Pour L Util | Nouveaux composes derives de dihydroporphyrine et leurs applications |
US6958389B2 (en) * | 2000-09-08 | 2005-10-25 | San-Ei Gen F.F.I. Inc. | Tetraphenylbacteriochlorin derivatives and compositions containing the same |
US6849607B2 (en) * | 2001-05-09 | 2005-02-01 | Health Research, Inc. | Galectin recognized photosensitizers for photodynamic therapy |
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US6566517B2 (en) * | 2001-06-06 | 2003-05-20 | Brookhaven Science Associates, Llc | Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy |
CN1279907C (zh) | 2001-06-06 | 2006-10-18 | 布鲁克黑文科学联合会 | 新的金属卟啉化合物及其在放射疗法中用作放射增敏剂的用途 |
EP1279676A1 (en) * | 2001-07-19 | 2003-01-29 | Institut Curie | Porphyrin derivatives for photodynamic therapy |
US20040019095A1 (en) * | 2002-01-29 | 2004-01-29 | Ziwei Xiao | N, N'-dimethylated N-confused porphyrins |
US7087214B2 (en) * | 2002-02-01 | 2006-08-08 | Zentaris Gmbh | Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases |
RU2236411C2 (ru) * | 2002-06-06 | 2004-09-20 | Московская государственная академия тонкой химической технологии им. М.В. Ломоносова | Металлокомплексы карборанилпорфиринов, обладающие противоопухолевой активностью |
AU2003262833A1 (en) * | 2002-08-23 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent glycosides and methods for their use |
GB0222945D0 (en) | 2002-10-03 | 2002-11-13 | Psimei Pharmaceuticals Plc | Therapeutic compositions |
US7267990B2 (en) | 2002-11-15 | 2007-09-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Chelation of charged and uncharged molecules with porphyrin-based compounds |
ITFI20030063A1 (it) | 2003-03-11 | 2004-09-12 | Molteni & C | Metallo ftalocianine boronate, loro preparazione, composizioni |
US6989443B2 (en) * | 2004-06-28 | 2006-01-24 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
US20070093463A1 (en) * | 2004-05-20 | 2007-04-26 | Brookhaven Science Associates, Llc | Radiation enhancement agent for X-ray radiation therapy and boron neutron-capture therapy |
US6995260B2 (en) * | 2004-05-20 | 2006-02-07 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
GB0415663D0 (en) * | 2004-07-13 | 2004-08-18 | Psimei Pharmaceuticals Plc | Compound |
GB0427589D0 (en) * | 2004-12-16 | 2005-01-19 | Psimei Pharmaceuticals Plc | Process for the preparation of a substituted porphyrin |
US7582751B2 (en) * | 2005-07-29 | 2009-09-01 | North Carolina State University | Methods and intermediates for the synthesis of porphyrins |
-
2006
- 2006-12-04 US US11/633,139 patent/US8287839B2/en not_active Expired - Fee Related
-
2007
- 2007-12-03 RU RU2009121323/04A patent/RU2477161C2/ru active
- 2007-12-03 MX MX2009005904A patent/MX2009005904A/es active IP Right Grant
- 2007-12-03 PT PT78741600T patent/PT2099304E/pt unknown
- 2007-12-03 CN CN200780044807.3A patent/CN101605459B/zh not_active Expired - Fee Related
- 2007-12-03 EP EP07874160.0A patent/EP2099304B1/en active Active
- 2007-12-03 JP JP2009540246A patent/JP5340953B2/ja not_active Expired - Fee Related
- 2007-12-03 PL PL07874160T patent/PL2099304T3/pl unknown
- 2007-12-03 DK DK07874160.0T patent/DK2099304T3/da active
- 2007-12-03 CA CA2671849A patent/CA2671849C/en not_active Expired - Fee Related
- 2007-12-03 SI SI200731513T patent/SI2099304T1/sl unknown
- 2007-12-03 ZA ZA200903906A patent/ZA200903906B/xx unknown
- 2007-12-03 WO PCT/US2007/024767 patent/WO2008133664A2/en active Application Filing
- 2007-12-03 NZ NZ577386A patent/NZ577386A/en not_active IP Right Cessation
- 2007-12-03 ES ES07874160.0T patent/ES2504173T3/es active Active
- 2007-12-03 AU AU2007352392A patent/AU2007352392B2/en not_active Ceased
-
2010
- 2010-02-09 HK HK10101467.0A patent/HK1133552A1/zh not_active IP Right Cessation
-
2012
- 2012-09-10 US US13/608,305 patent/US8673265B2/en not_active Expired - Fee Related
-
2014
- 2014-09-24 CY CY20141100781T patent/CY1115816T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200903906B (en) | 2010-08-25 |
WO2008133664A3 (en) | 2008-12-31 |
EP2099304A4 (en) | 2011-03-16 |
DK2099304T3 (da) | 2014-10-06 |
CA2671849C (en) | 2015-11-24 |
SI2099304T1 (sl) | 2014-11-28 |
CN101605459A (zh) | 2009-12-16 |
AU2007352392B2 (en) | 2012-09-20 |
RU2009121323A (ru) | 2011-01-20 |
CA2671849A1 (en) | 2008-11-06 |
ES2504173T3 (es) | 2014-10-08 |
EP2099304B1 (en) | 2014-06-25 |
CN101605459B (zh) | 2014-12-31 |
PT2099304E (pt) | 2014-10-02 |
MX2009005904A (es) | 2009-08-24 |
WO2008133664A2 (en) | 2008-11-06 |
US8287839B2 (en) | 2012-10-16 |
US20080131376A1 (en) | 2008-06-05 |
PL2099304T3 (pl) | 2014-11-28 |
AU2007352392A1 (en) | 2008-11-06 |
JP5340953B2 (ja) | 2013-11-13 |
NZ577386A (en) | 2011-11-25 |
US8673265B2 (en) | 2014-03-18 |
EP2099304A2 (en) | 2009-09-16 |
JP2010511704A (ja) | 2010-04-15 |
RU2477161C2 (ru) | 2013-03-10 |
US20130004419A1 (en) | 2013-01-03 |
CY1115816T1 (el) | 2017-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20211207 |