HK1119090A1 - Coated lipid complexes and their use - Google Patents
Coated lipid complexes and their useInfo
- Publication number
- HK1119090A1 HK1119090A1 HK08113257.3A HK08113257A HK1119090A1 HK 1119090 A1 HK1119090 A1 HK 1119090A1 HK 08113257 A HK08113257 A HK 08113257A HK 1119090 A1 HK1119090 A1 HK 1119090A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lipid complexes
- coated lipid
- coated
- complexes
- lipid
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04030846 | 2004-12-27 | ||
PCT/EP2005/014074 WO2006069782A2 (en) | 2004-12-27 | 2005-12-27 | Lipid complexes coated with peg and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1119090A1 true HK1119090A1 (en) | 2009-02-27 |
Family
ID=36540272
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08113257.3A HK1119090A1 (en) | 2004-12-27 | 2008-12-05 | Coated lipid complexes and their use |
HK16110655.7A HK1222541A1 (zh) | 2004-12-27 | 2016-09-07 | 塗層脂質複合體和它們的用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16110655.7A HK1222541A1 (zh) | 2004-12-27 | 2016-09-07 | 塗層脂質複合體和它們的用途 |
Country Status (17)
Country | Link |
---|---|
US (2) | US8852472B2 (zh) |
EP (2) | EP2992902A1 (zh) |
JP (1) | JP5292572B2 (zh) |
KR (1) | KR101366482B1 (zh) |
CN (1) | CN101287497B (zh) |
AU (1) | AU2005321469B2 (zh) |
BR (1) | BRPI0519468A2 (zh) |
CA (1) | CA2593032C (zh) |
DK (1) | DK1830888T3 (zh) |
ES (1) | ES2548515T3 (zh) |
HK (2) | HK1119090A1 (zh) |
IL (1) | IL183775A (zh) |
MX (1) | MX2007007913A (zh) |
PL (1) | PL1830888T3 (zh) |
SG (1) | SG158175A1 (zh) |
WO (1) | WO2006069782A2 (zh) |
ZA (1) | ZA200704168B (zh) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE350473T2 (de) | 2002-08-05 | 2007-01-15 | Atugen Ag | Weitere neue formen von interferierende rns moleküle |
BRPI0509471A8 (pt) | 2004-05-05 | 2017-07-25 | Atugen Ag | Lipídios, complexos de lipídio e uso dos mesmos |
EP2992902A1 (en) | 2004-12-27 | 2016-03-09 | Silence Therapeutics GmbH | Lipid complexes coated with peg and their uses |
SG161311A1 (en) * | 2005-05-04 | 2010-05-27 | Noxxon Pharma Ag | Novel use of spiegelmers |
EP2992875A1 (en) * | 2006-04-20 | 2016-03-09 | Silence Therapeutics GmbH | Lipoplex formulations for specific delivery to vascular endothelium |
CN102321626B (zh) * | 2006-07-21 | 2014-12-10 | 赛伦斯治疗有限公司 | 用于抑制蛋白激酶3表达的方法 |
EP2125031B1 (en) | 2006-12-19 | 2017-11-01 | Marina Biotech, Inc. | Lipids and lipid assemblies comprising transfection enhancer elements |
EP2326351B1 (en) | 2008-08-19 | 2017-12-27 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
JP2012517815A (ja) | 2009-02-18 | 2012-08-09 | サイレンス・セラピューティクス・アーゲー | Ang2の発現を阻害するための手段 |
WO2011035065A1 (en) | 2009-09-17 | 2011-03-24 | Nektar Therapeutics | Monoconjugated chitosans as delivery agents for small interfering nucleic acids |
US8359883B2 (en) * | 2009-11-13 | 2013-01-29 | Hasmukh Dholakiya | Gemstone setting |
JP2013528665A (ja) | 2010-03-26 | 2013-07-11 | メルサナ セラピューティックス, インコーポレイテッド | ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法 |
WO2011133658A1 (en) | 2010-04-22 | 2011-10-27 | Boston Medical Center Corporation | Compositions and methods for targeting and delivering therapeutics into cells |
WO2012113413A1 (en) * | 2011-02-21 | 2012-08-30 | Curevac Gmbh | Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates |
TW201726600A (zh) | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
WO2014018375A1 (en) | 2012-07-23 | 2014-01-30 | Xenon Pharmaceuticals Inc. | Cyp8b1 and uses thereof in therapeutic and diagnostic methods |
AU2014310934B2 (en) | 2013-08-21 | 2019-09-12 | CureVac SE | Respiratory syncytial virus (RSV) vaccine |
KR20160095003A (ko) * | 2013-12-05 | 2016-08-10 | 사일런스 테라퓨틱스 게엠베하 | 폐 특이적 전달을 위한 수단 |
US11097974B2 (en) | 2014-07-31 | 2021-08-24 | Corning Incorporated | Thermally strengthened consumer electronic glass and related systems and methods |
US10611664B2 (en) | 2014-07-31 | 2020-04-07 | Corning Incorporated | Thermally strengthened architectural glass and related systems and methods |
WO2016083623A1 (en) * | 2014-11-28 | 2016-06-02 | Silence Therapeutics Gmbh | Means for the treatment of pre-eclampsia |
CN108698922B (zh) | 2016-01-12 | 2020-02-28 | 康宁股份有限公司 | 薄的热强化和化学强化的玻璃基制品 |
US11795102B2 (en) | 2016-01-26 | 2023-10-24 | Corning Incorporated | Non-contact coated glass and related coating system and method |
CN106038517A (zh) * | 2016-03-14 | 2016-10-26 | 苏州博创康源生物技术有限公司 | 一种多糖药物载药组织粘贴膜及其制备方法 |
CN105832709A (zh) * | 2016-03-14 | 2016-08-10 | 苏州博创康源生物技术有限公司 | 一种核酸药物载药组织粘贴膜及其制备方法 |
CN105687165A (zh) * | 2016-03-14 | 2016-06-22 | 苏州博创康源生物技术有限公司 | 一种蛋白或多肽药物载药组织粘贴膜及其制备方法 |
CN106038516A (zh) * | 2016-03-14 | 2016-10-26 | 苏州博创康源生物技术有限公司 | 一种化合物药物载药组织粘贴膜及其制备方法 |
CN105902523A (zh) * | 2016-03-14 | 2016-08-31 | 苏州博创康源生物技术有限公司 | 一种载药组织粘贴膜及其制备方法 |
WO2018035388A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
CN110312799A (zh) | 2016-08-17 | 2019-10-08 | 博德研究所 | 新型crispr酶和*** |
US11485673B2 (en) | 2017-08-24 | 2022-11-01 | Corning Incorporated | Glasses with improved tempering capabilities |
KR102338449B1 (ko) | 2017-09-21 | 2021-12-10 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 |
WO2019094983A1 (en) | 2017-11-13 | 2019-05-16 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway |
TWI785156B (zh) | 2017-11-30 | 2022-12-01 | 美商康寧公司 | 具有高熱膨脹係數及對於熱回火之優先破裂行為的非離子交換玻璃 |
US10968257B2 (en) | 2018-04-03 | 2021-04-06 | The Broad Institute, Inc. | Target recognition motifs and uses thereof |
US20210163944A1 (en) | 2018-08-07 | 2021-06-03 | The Broad Institute, Inc. | Novel cas12b enzymes and systems |
WO2020191102A1 (en) | 2019-03-18 | 2020-09-24 | The Broad Institute, Inc. | Type vii crispr proteins and systems |
US20220220469A1 (en) | 2019-05-20 | 2022-07-14 | The Broad Institute, Inc. | Non-class i multi-component nucleic acid targeting systems |
WO2021016075A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
CN114514115B (zh) | 2019-08-06 | 2023-09-01 | 康宁股份有限公司 | 具有用于阻止裂纹的埋入式应力尖峰的玻璃层压体及其制造方法 |
CN115667531A (zh) | 2020-03-24 | 2023-01-31 | 世代生物公司 | 非病毒DNA载体和其用于表达戈谢(Gaucher)治疗剂的用途 |
CA3172572A1 (en) | 2020-03-24 | 2021-09-30 | Generation Bio Co. | Non-viral dna vectors and uses thereof for expressing factor ix therapeutics |
US20230193311A1 (en) | 2020-05-20 | 2023-06-22 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
TW202206097A (zh) | 2020-05-20 | 2022-02-16 | 美商旗艦先鋒創新有限責任公司 | 冠狀病毒抗原組成物及其用途 |
MX2022015042A (es) | 2020-05-29 | 2023-03-09 | Flagship Pioneering Innovations Vi Llc | Composiciones de trem y métodos relacionados con las mismas. |
US20230203509A1 (en) | 2020-05-29 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods relating thereto |
IL299925A (en) | 2020-07-27 | 2023-03-01 | Anjarium Biosciences Ag | Compounds of DNA molecules, methods for their preparation and methods of using them |
IL300947A (en) | 2020-09-03 | 2023-04-01 | Flagship Pioneering Innovations Vi Llc | Immunogenic compositions and uses thereof |
CA3206285A1 (en) | 2020-12-23 | 2022-06-30 | Flagship Pioneering, Inc. | Compositions of modified trems and uses thereof |
AU2022246895A1 (en) | 2021-03-31 | 2023-10-19 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
EP4326860A1 (en) | 2021-04-20 | 2024-02-28 | Anjarium Biosciences AG | Compositions of dna molecules encoding amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase, methods of making thereof, and methods of use thereof |
WO2022232286A1 (en) | 2021-04-27 | 2022-11-03 | Generation Bio Co. | Non-viral dna vectors expressing anti-coronavirus antibodies and uses thereof |
US20240226324A1 (en) | 2021-04-27 | 2024-07-11 | Generation Bio Co. | Non-viral dna vectors expressing therapeutic antibodies and uses thereof |
CN113372226B (zh) * | 2021-06-08 | 2023-05-26 | 深圳市人民医院 | 一种脂质分子、脂质纳米粒及其制备方法和应用 |
WO2023009547A1 (en) | 2021-07-26 | 2023-02-02 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and uses thereof |
TW202330916A (zh) | 2021-09-17 | 2023-08-01 | 美商旗艦先鋒創新有限責任公司 | 用於產生環狀多核糖核苷酸之組成物和方法 |
WO2023069397A1 (en) | 2021-10-18 | 2023-04-27 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
CA3236235A1 (en) | 2021-11-08 | 2023-05-11 | Orna Therapeutics, Inc. | Lipid nanoparticle compositions for delivering circular polynucleotides |
CA3239266A1 (en) | 2021-11-24 | 2023-06-01 | Flagship Pioneering Innovations Vi, Llc | Coronavirus immunogen compositions and their uses |
CA3238735A1 (en) | 2021-11-24 | 2023-06-01 | Jennifer A. Nelson | Immunogenic compositions and their uses |
AU2022397292A1 (en) | 2021-11-24 | 2024-05-30 | Flagship Pioneering Innovations Vi, Llc | Varicella-zoster virus immunogen compositions and their uses |
TW202340460A (zh) | 2021-12-17 | 2023-10-16 | 美商旗艦先鋒創新有限責任公司 | 用於在變性條件下富集環狀rna之方法 |
AU2022417517A1 (en) | 2021-12-22 | 2024-06-27 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
CA3241026A1 (en) | 2021-12-23 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
WO2023135273A2 (en) | 2022-01-14 | 2023-07-20 | Anjarium Biosciences Ag | Compositions of dna molecules encoding factor viii, methods of making thereof, and methods of use thereof |
WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
WO2023183616A1 (en) | 2022-03-25 | 2023-09-28 | Senda Biosciences, Inc. | Novel ionizable lipids and lipid nanoparticles and methods of using the same |
WO2023196818A1 (en) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | Genetic complementation compositions and methods |
WO2023196634A2 (en) | 2022-04-08 | 2023-10-12 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
WO2023220083A1 (en) | 2022-05-09 | 2023-11-16 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods of use for treating proliferative disorders |
TW202409283A (zh) | 2022-05-13 | 2024-03-01 | 美商旗艦先鋒創新有限責任(Vii)公司 | 雙股dna組合物及相關方法 |
WO2023239756A1 (en) | 2022-06-07 | 2023-12-14 | Generation Bio Co. | Lipid nanoparticle compositions and uses thereof |
WO2023250112A1 (en) | 2022-06-22 | 2023-12-28 | Flagship Pioneering Innovations Vi, Llc | Compositions of modified trems and uses thereof |
WO2024030856A2 (en) | 2022-08-01 | 2024-02-08 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory proteins and related methods |
WO2024035952A1 (en) | 2022-08-12 | 2024-02-15 | Remix Therapeutics Inc. | Methods and compositions for modulating splicing at alternative splice sites |
WO2024040222A1 (en) | 2022-08-19 | 2024-02-22 | Generation Bio Co. | Cleavable closed-ended dna (cedna) and methods of use thereof |
WO2024049979A2 (en) | 2022-08-31 | 2024-03-07 | Senda Biosciences, Inc. | Novel ionizable lipids and lipid nanoparticles and methods of using the same |
US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
WO2024097664A1 (en) | 2022-10-31 | 2024-05-10 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
WO2024102799A1 (en) | 2022-11-08 | 2024-05-16 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for producing circular polyribonucleotides |
WO2024102730A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Lipids and nanoparticle compositions for delivering polynucleotides |
WO2024102677A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Circular rna compositions |
WO2024102762A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Lipids and lipid nanoparticle compositions for delivering polynucleotides |
WO2024119051A1 (en) | 2022-12-01 | 2024-06-06 | Generation Bio Co. | Novel polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same |
WO2024119103A1 (en) | 2022-12-01 | 2024-06-06 | Generation Bio Co. | Lipid nanoparticles comprising nucleic acids and lipid-anchored polymers |
WO2024119039A2 (en) | 2022-12-01 | 2024-06-06 | Generation Bio Co. | Stealth lipid nanoparticles and uses thereof |
WO2024119074A1 (en) | 2022-12-01 | 2024-06-06 | Generation Bio Co. | Stealth lipid nanoparticle compositions for cell targeting |
WO2024129988A1 (en) | 2022-12-14 | 2024-06-20 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for delivery of therapeutic agents to bone |
WO2024151685A1 (en) | 2023-01-09 | 2024-07-18 | Beth Israel Deaconess Medical Center, Inc. | Recombinant nucleic acid molecules and their use in wound healing |
WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
WO2024151583A2 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
US20240238473A1 (en) | 2023-01-09 | 2024-07-18 | Beth Israel Deaconess Medical Center, Inc. | Recombinant nucleic acid molecules and their use in wound healing |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5475096A (en) | 1990-06-11 | 1995-12-12 | University Research Corporation | Nucleic acid ligands |
GB2270920B (en) | 1992-09-25 | 1997-04-02 | Univ Keele | Alginate-bioactive agent conjugates |
FR2698628B1 (fr) | 1992-12-02 | 1995-02-17 | Fournier Ind & Sante | Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique. |
US5504103A (en) | 1993-08-25 | 1996-04-02 | Eli Lilly And Company | Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof |
US5777153A (en) | 1994-07-08 | 1998-07-07 | Gilead Sciences, Inc. | Cationic lipids |
US5820873A (en) * | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
CA2222328C (en) * | 1995-06-07 | 2012-01-10 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US7422902B1 (en) * | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
NZ313839A (en) | 1995-07-21 | 1998-12-23 | Genta Inc | Amide-based cationic lipids |
WO1998008856A2 (de) | 1996-08-30 | 1998-03-05 | Fuerste Jens Peter | Spiegelselektion und spiegelevolution von nucleinsäuren |
US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
US6958239B2 (en) | 1996-11-21 | 2005-10-25 | Oligos Etc Inc. | Three component chimeric antisense oligonucleotides |
CA2217550A1 (en) | 1996-10-22 | 1998-04-22 | F. Hoffmann-La Roche Ag | Cationic lipids for gene therapy |
US6358523B1 (en) | 1996-12-06 | 2002-03-19 | The Regents Of The University Of California | Macromolecule-lipid complexes and methods for making and regulating |
WO1998044909A1 (en) | 1997-04-04 | 1998-10-15 | Valentis Inc. | Improved methods of delivery using cationic lipids and helper lipids |
WO1998051285A2 (en) | 1997-05-15 | 1998-11-19 | Genzyme Corporation | Cationic amphiphile formulations |
CO4750643A1 (es) | 1997-06-13 | 1999-03-31 | Lilly Co Eli | Formulacion estable de la insulina que contiene l-arginina y protamina |
US20030073640A1 (en) * | 1997-07-23 | 2003-04-17 | Ribozyme Pharmaceuticals, Inc. | Novel compositions for the delivery of negatively charged molecules |
US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
EP0998306A1 (en) * | 1997-07-24 | 2000-05-10 | Inex Pharmaceuticals Corp. | Liposomal compositions for the delivery of nucleic acid catalysts |
US6150345A (en) | 1998-08-10 | 2000-11-21 | Regents Of The University Of California | Methods for promoting survival of myelin producing cells |
FR2788275B1 (fr) | 1999-01-11 | 2002-06-14 | Lipha | ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique |
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
US7015040B2 (en) * | 1999-02-26 | 2006-03-21 | Mirus Bio Corporation | Intravascular delivery of nucleic acid |
WO2000073469A2 (en) | 1999-05-28 | 2000-12-07 | Sugen, Inc. | Protein kinases |
EP1064944A1 (en) | 1999-06-25 | 2001-01-03 | Schering Aktiengesellschaft | Protein kinase N inhibitor comprising Fasudil |
JP2003504390A (ja) * | 1999-07-15 | 2003-02-04 | イネックス ファーマスーティカルズ コーポレイション | 脂質小胞の製造のための方法および装置 |
US6133032A (en) | 1999-09-09 | 2000-10-17 | Isis Pharmaceutical Inc. | Antisense modulation of PI3 kinase p110 beta expression |
KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
MXPA02009485A (es) | 2000-03-31 | 2003-03-10 | Kirin Brewery | Preparacion en polvo para administracion a traves de la mucosa, que comprende un farmaco de alto peso molecular y que muestra una estabilidad mejorada en almacenamiento. |
AU2001254548B2 (en) | 2000-04-20 | 2006-09-28 | The University Of British Columbia | Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane |
DE60126801T2 (de) * | 2000-10-25 | 2007-12-06 | The University Of British Columbia, Vancouver | Lipidformulierungen zur zielgerichteten abgabe |
CZ302719B6 (cs) | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
US20030135033A1 (en) | 2002-01-04 | 2003-07-17 | Anke Klippel-Giese | Compounds and methods for the identification and/ or validation of a target |
AU2003207708A1 (en) | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
US20040156816A1 (en) | 2002-08-06 | 2004-08-12 | David Anderson | Lipid-drug complexes in reversed liquid and liquid crystalline phases |
MXPA05001766A (es) | 2002-08-14 | 2005-08-19 | Atugen Ag | Uso de proteina quinasa n beta. |
EP1393742A1 (en) | 2002-08-14 | 2004-03-03 | atugen AG | Use of protein kinase N beta |
US7635770B2 (en) | 2002-11-14 | 2009-12-22 | Dharmacon, Inc. | siRNA targeting protein kinase N-3 (PKN-3) |
US7482117B2 (en) | 2002-12-20 | 2009-01-27 | Celera Corporation | Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
WO2005037911A2 (en) * | 2003-08-26 | 2005-04-28 | Smithkline Beecham Corporation | Heterofunctional copolymers of glycerol and polyethylene glycol, their conjugates and compositions |
BRPI0509471A8 (pt) | 2004-05-05 | 2017-07-25 | Atugen Ag | Lipídios, complexos de lipídio e uso dos mesmos |
CN101123879A (zh) | 2004-08-20 | 2008-02-13 | 约翰·霍普金斯大学 | 血管新生治疗方法 |
CA2587337A1 (en) | 2004-11-19 | 2006-05-26 | Novosom Ag | Improvements in or relating to pharmaceutical compositions for local administration |
EP2992902A1 (en) | 2004-12-27 | 2016-03-09 | Silence Therapeutics GmbH | Lipid complexes coated with peg and their uses |
WO2006074546A1 (en) | 2005-01-13 | 2006-07-20 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
US20090252783A1 (en) | 2006-04-20 | 2009-10-08 | Silence Therapeutics Ag | Means for inhibiting the expression of cd31 |
EP2992875A1 (en) | 2006-04-20 | 2016-03-09 | Silence Therapeutics GmbH | Lipoplex formulations for specific delivery to vascular endothelium |
CN102321626B (zh) | 2006-07-21 | 2014-12-10 | 赛伦斯治疗有限公司 | 用于抑制蛋白激酶3表达的方法 |
-
2005
- 2005-12-27 EP EP15179144.9A patent/EP2992902A1/en not_active Withdrawn
- 2005-12-27 AU AU2005321469A patent/AU2005321469B2/en not_active Ceased
- 2005-12-27 CA CA2593032A patent/CA2593032C/en not_active Expired - Fee Related
- 2005-12-27 CN CN2005800450816A patent/CN101287497B/zh not_active Expired - Fee Related
- 2005-12-27 EP EP05822677.0A patent/EP1830888B1/en not_active Not-in-force
- 2005-12-27 SG SG200908620-8A patent/SG158175A1/en unknown
- 2005-12-27 ES ES05822677.0T patent/ES2548515T3/es active Active
- 2005-12-27 MX MX2007007913A patent/MX2007007913A/es active IP Right Grant
- 2005-12-27 PL PL05822677T patent/PL1830888T3/pl unknown
- 2005-12-27 DK DK05822677.0T patent/DK1830888T3/en active
- 2005-12-27 KR KR1020077014611A patent/KR101366482B1/ko active IP Right Grant
- 2005-12-27 US US11/722,948 patent/US8852472B2/en not_active Expired - Fee Related
- 2005-12-27 BR BRPI0519468-7A patent/BRPI0519468A2/pt active Search and Examination
- 2005-12-27 WO PCT/EP2005/014074 patent/WO2006069782A2/en active Search and Examination
- 2005-12-27 JP JP2007548751A patent/JP5292572B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-22 ZA ZA200704168A patent/ZA200704168B/en unknown
- 2007-06-07 IL IL183775A patent/IL183775A/en not_active IP Right Cessation
-
2008
- 2008-12-05 HK HK08113257.3A patent/HK1119090A1/xx not_active IP Right Cessation
-
2014
- 2014-10-06 US US14/507,045 patent/US9387262B2/en not_active Expired - Fee Related
-
2016
- 2016-09-07 HK HK16110655.7A patent/HK1222541A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007007913A (es) | 2007-08-14 |
EP1830888A2 (en) | 2007-09-12 |
US9387262B2 (en) | 2016-07-12 |
JP5292572B2 (ja) | 2013-09-18 |
SG158175A1 (en) | 2010-01-29 |
CN101287497B (zh) | 2013-03-06 |
BRPI0519468A2 (pt) | 2009-01-27 |
IL183775A (en) | 2016-12-29 |
IL183775A0 (en) | 2007-09-20 |
CA2593032A1 (en) | 2006-07-06 |
DK1830888T3 (en) | 2015-10-19 |
EP1830888B1 (en) | 2015-08-05 |
EP2992902A1 (en) | 2016-03-09 |
ES2548515T3 (es) | 2015-10-19 |
US8852472B2 (en) | 2014-10-07 |
JP2008525514A (ja) | 2008-07-17 |
WO2006069782A2 (en) | 2006-07-06 |
PL1830888T3 (pl) | 2015-12-31 |
KR101366482B1 (ko) | 2014-02-21 |
AU2005321469A1 (en) | 2006-07-06 |
CN101287497A (zh) | 2008-10-15 |
WO2006069782A9 (en) | 2009-04-30 |
HK1222541A1 (zh) | 2017-07-07 |
AU2005321469B2 (en) | 2012-04-05 |
KR20070090956A (ko) | 2007-09-06 |
ZA200704168B (en) | 2008-05-28 |
US20100062967A1 (en) | 2010-03-11 |
WO2006069782A3 (en) | 2007-04-12 |
CA2593032C (en) | 2015-12-22 |
US20150031752A1 (en) | 2015-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL183775A0 (en) | Coated lipid complexes and their use | |
IL178879A0 (en) | Lipids, lipid complexes and use thereof | |
EP1731506A4 (en) | 5-HYDROXYINDOL-3-CARBOXYLATE DERIVATIVES AND THEIR USE | |
IL218117A (en) | A tablet containing saxagliptin and several layers of coating | |
IL179093A0 (en) | Anti-il-13 antibodies and complexes | |
HK1101911A1 (en) | Tetrahydrocarbozoles and derivatives | |
ZA200701820B (en) | Substituted phenylaminothiazoles and use thereof | |
EP1814841A4 (en) | CERAMIDES AND LIGANDS OF SIGNALING APOPTOSIS | |
IL178888A0 (en) | Arylphenylamino-, arylphenylamide-, and arylphenylether-sulfide derivatives | |
IL189252A0 (en) | Dihydroxyanthraquinones and their use | |
EP1786415A4 (en) | METABOLISM MODULATION AGENTS AND USES THEREOF | |
EP1810976A4 (en) | BENZONAPHTHACENEGLYCOSIDE DERIVATIVE AND THE USE THEREOF | |
GB0426903D0 (en) | Complexes and methods | |
GB0700332D0 (en) | Dispenser and components thereof | |
EP1816136A4 (en) | GPR7 SELECTIVE LIGAND AND APPLICATION THEREOF | |
EP1736544A4 (en) | GM1 PROMOTER AND ITS USE | |
GB0515322D0 (en) | Ligands and use thereof | |
HU0400218V0 (en) | Coated curd-dessert | |
GB0402903D0 (en) | Compounds and their use | |
GB0411071D0 (en) | Compounds and their use | |
GB0423234D0 (en) | Compounds and their use | |
GB0405306D0 (en) | Compounds and their use | |
GB0405304D0 (en) | Compounds and their use | |
GB0409378D0 (en) | Compounds and their use | |
GB0403953D0 (en) | Compounds and their use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20161227 |