HK1102481A1 - Hyaluronic acid/methotrexate compound - Google Patents

Hyaluronic acid/methotrexate compound

Info

Publication number
HK1102481A1
HK1102481A1 HK07110660.1A HK07110660A HK1102481A1 HK 1102481 A1 HK1102481 A1 HK 1102481A1 HK 07110660 A HK07110660 A HK 07110660A HK 1102481 A1 HK1102481 A1 HK 1102481A1
Authority
HK
Hong Kong
Prior art keywords
hyaluronic acid
methotrexate compound
methotrexate
compound
hyaluronic
Prior art date
Application number
HK07110660.1A
Other languages
English (en)
Inventor
Hitoshi Ikeya
Tadashi Morikawa
Koichi Takahashi
Tatsuya Tamura
Akira Okamachi
Takenori Ishizawa
Haruhiko Sato
Yoshinobu Higuchi
Original Assignee
Denki Kagaku Kogyo Kk
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo Kk, Chugai Pharmaceutical Co Ltd filed Critical Denki Kagaku Kogyo Kk
Publication of HK1102481A1 publication Critical patent/HK1102481A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HK07110660.1A 2004-03-05 2007-10-03 Hyaluronic acid/methotrexate compound HK1102481A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004062616 2004-03-05
JP2004167755 2004-06-04
PCT/JP2005/003739 WO2005085294A1 (ja) 2004-03-05 2005-03-04 ヒアルロン酸−メトトレキサート結合体

Publications (1)

Publication Number Publication Date
HK1102481A1 true HK1102481A1 (en) 2007-11-23

Family

ID=34921707

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07110660.1A HK1102481A1 (en) 2004-03-05 2007-10-03 Hyaluronic acid/methotrexate compound

Country Status (10)

Country Link
US (1) US8088916B2 (ko)
EP (1) EP1724287A4 (ko)
JP (1) JP4927536B2 (ko)
KR (1) KR101234476B1 (ko)
CN (1) CN1946743B (ko)
AU (1) AU2005219733C1 (ko)
CA (1) CA2559188C (ko)
HK (1) HK1102481A1 (ko)
TW (1) TWI359665B (ko)
WO (1) WO2005085294A1 (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006122954A2 (en) * 2005-05-18 2006-11-23 Eurand Pharmaceuticals Limited Antiproliferative conjugates comprising hyaluronic acid and n-derivatives of glutamic acid
EP1905456A4 (en) * 2005-07-06 2010-12-22 Seikagaku Kogyo Co Ltd PHARMACEUTICAL LIGHT-NETWORKED HYALURONIC DERIVATIVE GEL
JP5043364B2 (ja) * 2006-05-01 2012-10-10 生化学工業株式会社 多糖誘導体の製造方法
DE102006035083A1 (de) * 2006-07-28 2008-01-31 medac Gesellschaft für klinische Spezialgeräte mbH Proteinbindende Methotrexat-Derivate und diese enthaltende Arzneimittel
JP5683957B2 (ja) * 2008-09-30 2015-03-11 電気化学工業株式会社 光安定化された医薬組成物
WO2012008722A2 (ko) * 2010-07-12 2012-01-19 신풍제약 주식회사 조직 증강용 충전 조성물
UA117556C2 (uk) 2011-05-16 2018-08-27 Джензайм Корпорейшн Спосіб збільшення ефективності терапевтичного засобу шляхом введення метотрексату
KR101445265B1 (ko) 2012-09-18 2014-09-30 포항공과대학교 산학협력단 히알루론산-핵산 접합체 및 이를 포함하는 핵산 전달용 조성물
MX363462B (es) * 2012-10-11 2019-03-25 Ascendis Pharma As Diagnostico, prevencion y tratamiento de enfermedades de la articulacion.
KR101467076B1 (ko) * 2013-02-20 2014-12-02 성균관대학교산학협력단 히알루론산-메토트렉세이트 접합체를 포함하는 관절염 예방 또는 치료용 약학적 조성물 및 이의 제조방법
US9572832B2 (en) * 2013-08-29 2017-02-21 Holy Stone Healthcare Co., Ltd. Compound of glycosaminoglycan and its fabrication method as well as application
KR101616623B1 (ko) * 2014-07-24 2016-04-29 연세대학교 산학협력단 양이온성 고분자가 결합된 소수성 약물 및 음이온성 고분자가 결합된 친수성 약물을 포함하는 나노입자
IT201700110784A1 (it) * 2017-10-03 2019-04-03 Fidia Farm Spa Composizioni farmaceutiche contenenti Acido Ialuronico e Carnosina e relativo uso
IT201800003841A1 (it) * 2018-03-21 2019-09-21 Acme Drugs S R L Coniugati di stanozololo e acido ialuronico
CN108888775A (zh) * 2018-07-24 2018-11-27 西北大学 一种透明质酸-甲氨蝶呤自组装纳米胶束及其制备方法
CN111732675A (zh) * 2020-08-18 2020-10-02 山东华熙海御生物医药有限公司 透明质酸-氨基葡萄糖接枝共聚物、制法及其应用
CN111821470B (zh) * 2020-09-01 2022-08-12 中南大学 包载甲氨蝶呤的铁-鞣酸配合物及其制备方法与应用
CN115444840B (zh) * 2022-09-15 2023-08-25 四川大学 一种前药、两性离子水凝胶及其制备方法、应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083367A1 (en) * 1981-07-02 1983-07-13 WALTON, Alan G. Glycosaminoglycan drug complexes
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
JPH0689026B2 (ja) * 1987-08-06 1994-11-09 帝人株式会社 メソトレキセート誘導体およびその製造方法
JP2604930B2 (ja) 1990-12-14 1997-04-30 株式会社ディ・ディ・エス研究所 ヒアルロン酸およびコンドロイチン誘導体
DE563249T1 (de) * 1990-12-19 1994-03-03 Advanced Magnetics Inc Targeting von therapeutischen mitteln durch verwendung von polysacchariden.
US5902795A (en) * 1992-06-16 1999-05-11 Trustees Of Tufts College Oligosaccharides reactive with hyaluronan-binding protein and their methods of use
JP2527885B2 (ja) * 1992-09-02 1996-08-28 株式会社ディ・ディ・エス研究所 ヘパリン誘導体
WO1994013327A1 (en) * 1992-12-15 1994-06-23 The Wellcome Foundation Limited Immunoreactive reagents employing dihydrofolate reductase
EP0640622B1 (en) 1993-02-26 2000-08-09 Drug Delivery System Institute, Ltd. Polysaccharide derivative and drug carrier
US6322815B1 (en) * 1994-07-22 2001-11-27 W. Mark Saltzman Multipart drug delivery system
JP3001381B2 (ja) * 1994-09-16 2000-01-24 株式会社ディ・ディ・エス研究所 臓器移行性を有する多糖誘導体および薬物担体
JP4018181B2 (ja) * 1995-11-07 2007-12-05 生化学工業株式会社 グリコサミノグリカン誘導体およびその製造法
TW577758B (en) 1997-10-27 2004-03-01 Ssp Co Ltd Intra-articular preparation for the treatment of arthropathy
JPH11222425A (ja) 1997-10-27 1999-08-17 Ss Pharmaceut Co Ltd 関節疾患治療用関節内投与製剤
AU752280C (en) 1998-05-20 2005-03-03 Chugai Seiyaku Kabushiki Kaisha Conjugate of therapeutic agent for joint disease and hyaluronic acid.
EP1176985A2 (en) * 1999-04-28 2002-02-06 Vectramed, Inc. Enzymatically activated polymeric drug conjugates
IT1318403B1 (it) 2000-03-17 2003-08-25 Cooperativa Ct Ricerche Poly T Esteri polisaccaridici di n-derivati di acido glutammico.
JP2004292465A (ja) 2000-11-30 2004-10-21 Denki Kagaku Kogyo Kk ヒドロキサム酸誘導体とヒアルロン酸の結合体
CA2750725C (en) 2004-01-07 2014-10-21 Seikagaku Corporation Spacer derivative for hyaluronic acid and non-steroidal anti-inflammatory drug residues
TW200536861A (en) * 2004-04-02 2005-11-16 Denki Kagaku Kogyo Kk Hyaluronic acid/methotrexate compound
DE102005017196A1 (de) 2005-04-13 2006-10-19 Henkel Kgaa Pastenförmige Blondiermittel mit cyclischen Kohlensäureestern und Silikaten

Also Published As

Publication number Publication date
AU2005219733B2 (en) 2010-05-06
JP4927536B2 (ja) 2012-05-09
EP1724287A1 (en) 2006-11-22
CN1946743A (zh) 2007-04-11
US20070197465A1 (en) 2007-08-23
EP1724287A4 (en) 2010-10-27
CA2559188A1 (en) 2005-09-15
TW200533363A (en) 2005-10-16
JPWO2005085294A1 (ja) 2007-12-13
AU2005219733A1 (en) 2005-09-15
KR101234476B1 (ko) 2013-02-18
TWI359665B (en) 2012-03-11
CA2559188C (en) 2013-01-08
CN1946743B (zh) 2010-06-02
KR20070006798A (ko) 2007-01-11
AU2005219733C1 (en) 2010-12-16
US8088916B2 (en) 2012-01-03
WO2005085294A1 (ja) 2005-09-15

Similar Documents

Publication Publication Date Title
HK1102481A1 (en) Hyaluronic acid/methotrexate compound
EP1739097A4 (en) HYALURONIC ACID / METHOTREXATE COMPOUND
IL189895A0 (en) Triarylcarboxylic acid derivative
EP1961772A4 (en) CATIONIZED HYALURONIC ACID
EP1939202A4 (en) NEW COMPOUND OF ADENINE
EP1939201A4 (en) NEW ADENINE CONNECTION
EP1939198A4 (en) NEW ADENINE CONNECTION
EP1939199A4 (en) NEW ADENINE CONNECTION
EP1939200A4 (en) NEW ADENINE CONNECTION
EP1728792A4 (en) 8-OXOADENINE COMPOUND
EP1732566A4 (en) 6-azaindole COMPOUND
GB0500492D0 (en) Compound
ZA200702266B (en) 2-morpholino-4-pyrimidone compound
GB0415663D0 (en) Compound
HK1101881A1 (en) Antithrombotic compound
GB0411066D0 (en) Photoelectrochemical system
GB0509829D0 (en) Compound
GB0408771D0 (en) Compound
GB0427403D0 (en) Novel compounds I
GB0428384D0 (en) Eicosapentaenoic acid
GB0421106D0 (en) Compound
GB0411562D0 (en) Compound
GB0425969D0 (en) Compound
GB2419241B (en) DC lighting systems
GB0428295D0 (en) Compound

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190302