HK1080074A1 - 作為酪氨酸蛋白激酶抑制劑的4，6-二氨基取代-2-[氧基或氨氧基]-[1，3，5]三嗪 - Google Patents

作為酪氨酸蛋白激酶抑制劑的4，6-二氨基取代-2-[氧基或氨氧基]-[1，3，5]三嗪

Info

Publication number
HK1080074A1
HK1080074A1 HK06100020.8A HK06100020A HK1080074A1 HK 1080074 A1 HK1080074 A1 HK 1080074A1 HK 06100020 A HK06100020 A HK 06100020A HK 1080074 A1 HK1080074 A1 HK 1080074A1
Authority
HK
Hong Kong
Prior art keywords
diaminosubstituted
aminoxy
triazines
oxy
tyrosine kinase
Prior art date
Application number
HK06100020.8A
Other languages
English (en)
Inventor
Mark R Player
Nand Baindur
Benjamin Brandt
Davoud Asgari
Naresh Chadha
Original Assignee
Johnson & Johnson Pharmaceutical Res & Development Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Pharmaceutical Res & Development Inc filed Critical Johnson & Johnson Pharmaceutical Res & Development Inc
Publication of HK1080074A1 publication Critical patent/HK1080074A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
HK06100020.8A 2002-10-01 2006-01-03 作為酪氨酸蛋白激酶抑制劑的4，6-二氨基取代-2-[氧基或氨氧基]-[1，3，5]三嗪 HK1080074A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41463602P 2002-10-01 2002-10-01
PCT/US2003/030491 WO2004031184A1 (en) 2002-10-01 2003-09-29 4,6-diaminosubstituted-2-[oxy or aminoxy]-[1,3,5]triazines as protein tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1080074A1 true HK1080074A1 (zh) 2006-04-21

Family

ID=32069745

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06100020.8A HK1080074A1 (zh) 2002-10-01 2006-01-03 作為酪氨酸蛋白激酶抑制劑的4，6-二氨基取代-2-[氧基或氨氧基]-[1，3，5]三嗪

Country Status (6)

Country Link
US (1) US20040110758A1 (zh)
EP (1) EP1549645A1 (zh)
JP (1) JP2006503864A (zh)
AU (1) AU2003272740A1 (zh)
HK (1) HK1080074A1 (zh)
WO (1) WO2004031184A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006246958A1 (en) * 2005-05-19 2006-11-23 Prometic Biosciences Inc. Triazine compounds and compositions thereof for the treatment of cancers
EP2001880A2 (en) 2006-03-07 2008-12-17 Array Biopharma, Inc. Heterobicyclic pyrazole compounds and methods of use
CN101528702A (zh) * 2006-06-08 2009-09-09 阿雷生物药品公司 喹啉化合物和使用方法
EP2175933B1 (en) * 2007-07-25 2012-08-22 Bristol-Myers Squibb Company Triazine kinase inhibitors
AU2009262199B2 (en) 2008-06-27 2012-08-09 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
JP2012501188A (ja) * 2008-08-29 2012-01-19 ジェネンテック， インコーポレイテッド Ｖｅｇｆ非依存性腫瘍についての診断薬および治療
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
RU2016141385A (ru) 2014-03-24 2018-04-28 Дженентек, Инк. Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
JP6538077B2 (ja) * 2014-04-23 2019-07-03 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 除草剤としてのジアミノトリアジン化合物
CN108848668B (zh) * 2015-12-24 2022-04-26 加利福尼亚大学董事会 Cftr调节剂及其使用方法
US11839616B2 (en) 2017-08-24 2023-12-12 The Regents Of The University Of California Ocular pharmaceutical compositions

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US3563971A (en) * 1968-09-26 1971-02-16 Phillips Petroleum Co Nucleation of polypropylene
DE3322318A1 (de) * 1983-06-21 1985-01-03 Bayer Ag, 5090 Leverkusen Kationische enaminfarbstoffe, ihre herstellung und verwendung
JPS62126178A (ja) * 1985-11-26 1987-06-08 Mitsubishi Petrochem Co Ltd 新規トリアジン誘導体及びこれを含む除草剤
IT1244870B (it) * 1990-09-11 1994-09-12 Ministero Dall Uni E Della Ric Composti ammelinici
IT1244869B (it) * 1990-09-11 1994-09-12 Ministero Dall Uni E Della Ric Composizioni polimeriche autoestinguenti.
IT1252291B (it) * 1991-11-14 1995-06-08 Mini Ricerca Scient Tecnolog Composizioni polimeriche autoestinguenti
US5508193A (en) * 1993-08-31 1996-04-16 Regents Of The University Of Minnesota Pseudomonas strain for degradation of s-triazines in soil and water
US5429949A (en) * 1994-02-22 1995-07-04 Ohio State Research Foundation S-triazine degrading bacteria
EP0708197A3 (de) * 1994-09-29 1996-08-28 Ciba Geigy Ag Verwendung von Hydroxybenzotriazolen zur Erhöhung des Sonnenschutzfaktors von cellulosehaltigen Fasermaterialien
US6284522B1 (en) * 1995-10-23 2001-09-04 Regents Of The University Of Minnesota Isolated and purified DNA molecule and protein for the degradation of triazine compounds
DE69816060T2 (de) * 1997-04-18 2004-04-22 Janssen Pharmaceutica N.V. Verwendung von 5ht3 antagonisten zum fördern der darmspülung
US6100254A (en) * 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US6342395B1 (en) * 1998-04-22 2002-01-29 The Regents Of The University Of California Compact assay system with digital information
EP1206260A4 (en) * 1999-06-30 2002-10-30 Merck & Co Inc SRC-KINASE INHIBITING COMPOUNDS
WO2001047921A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Pyrimidine and triazine kinase inhibitors
US20020065270A1 (en) * 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression

Also Published As

Publication number Publication date
EP1549645A1 (en) 2005-07-06
US20040110758A1 (en) 2004-06-10
JP2006503864A (ja) 2006-02-02
AU2003272740A1 (en) 2004-04-23
WO2004031184A1 (en) 2004-04-15

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