HK1077500A1 - Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts - Google Patents

Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts

Info

Publication number
HK1077500A1
HK1077500A1 HK05109472.3A HK05109472A HK1077500A1 HK 1077500 A1 HK1077500 A1 HK 1077500A1 HK 05109472 A HK05109472 A HK 05109472A HK 1077500 A1 HK1077500 A1 HK 1077500A1
Authority
HK
Hong Kong
Prior art keywords
mitochondria
diagnostic imaging
imaging technology
invasive diagnostic
lipophilic salts
Prior art date
Application number
HK05109472.3A
Other languages
English (en)
Inventor
Igal Madar
Hayden T Ravert
Robert Dannals
Ursulla A Scheffel
James J Frost
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of HK1077500A1 publication Critical patent/HK1077500A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK05109472.3A 2002-02-06 2005-10-25 Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts HK1077500A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35456302P 2002-02-06 2002-02-06
PCT/US2003/003740 WO2003065882A2 (en) 2002-02-06 2003-02-06 Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts

Publications (1)

Publication Number Publication Date
HK1077500A1 true HK1077500A1 (en) 2006-02-17

Family

ID=27734391

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05109472.3A HK1077500A1 (en) 2002-02-06 2005-10-25 Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts

Country Status (10)

Country Link
US (2) US7112318B2 (xx)
EP (1) EP1474177A4 (xx)
JP (1) JP4530665B2 (xx)
CN (2) CN100577213C (xx)
AU (1) AU2003217349B2 (xx)
CA (1) CA2474142C (xx)
HK (1) HK1077500A1 (xx)
NZ (1) NZ534496A (xx)
TW (1) TWI266634B (xx)
WO (1) WO2003065882A2 (xx)

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CN100577213C (zh) * 2002-02-06 2010-01-06 约翰·霍普金斯大学 使用放射性同位素标示亲油性盐的用于线粒体机能障碍的非侵入性诊断显像技术
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
CN1839142B (zh) 2003-08-22 2010-06-16 澳新制药公司 用作靶向线粒体的抗氧化剂的线粒体醌衍生物
AU2011203177B2 (en) * 2004-02-24 2012-04-26 The General Hospital Corporation Catalytic radiofluorination
US7632485B2 (en) * 2004-02-24 2009-12-15 Massachusetts General Hospital Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) * 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US7738096B2 (en) 2004-10-21 2010-06-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
JP2006315958A (ja) * 2005-05-10 2006-11-24 Nihon Medi Physics Co Ltd 放射性ハロゲン標識有機化合物の製造方法
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US8163039B2 (en) 2006-08-03 2012-04-24 Hammersmith Imanet Limited Fluoride drying method
WO2008098304A1 (en) * 2007-02-16 2008-08-21 The University Of Sydney Carborane-phosphonium compounds and their use in boron neutron capture therapy and imaging
EP1990310A1 (en) * 2007-04-23 2008-11-12 Trasis S.A. Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step
WO2008151003A2 (en) * 2007-05-30 2008-12-11 Children's Medical Center Corporation Novel fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
US8388931B2 (en) * 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
CN102014969B (zh) 2008-02-29 2014-07-09 兰休斯医疗成像公司 用于包括灌注成像在内的应用的造影剂
MX2010010314A (es) 2008-03-21 2011-04-12 Gen Hospital Corp Compuestos y composiciones para la deteccion y el tratamiento de la enfermedad de alzheimer y trastornos relacionados.
EP2288336B8 (en) 2008-04-25 2017-03-22 Northwestern University Nanostructures suitable for sequestering cholesterol
JP5322527B2 (ja) * 2008-07-17 2013-10-23 浜松ホトニクス株式会社 アポトーシスの検出に適した化合物
US9687571B2 (en) 2009-04-15 2017-06-27 Lantheus Medical Imaging, Inc. Stabilization of radiopharmaceutical compositions using ascorbic acid
JP2012532164A (ja) 2009-07-10 2012-12-13 バイエル ファーマ アクチエンゲゼルシャフト 放射性トレーサーの精製のための低‐中圧液体クロマトグラフィーの使用
DK3323810T3 (da) 2010-02-08 2022-03-28 Lantheus Medical Imaging Inc Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler
GB201005624D0 (en) * 2010-04-01 2010-05-19 Medical Res Council Probe
US9205156B2 (en) 2010-05-27 2015-12-08 Hadasit Medical Research Services & Development Limited Molecular imaging agents
KR101172157B1 (ko) 2010-05-27 2012-08-07 전남대학교산학협력단 미토콘드리아 영상을 위한 방사성 약물의 제조 방법
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN102898470B (zh) * 2012-11-02 2014-12-10 北京师范大学 一类新型有机膦化合物及其制备方法和应用
EP3076918A4 (en) 2013-12-03 2017-06-07 Northwestern University Liposomal particles, methods of making same and uses thereof
AU2015328242A1 (en) 2014-10-06 2017-04-27 Exicure, Inc. Anti-TNF compounds
EP3216796B1 (en) * 2014-11-05 2020-08-19 Tohoku University Phosphonium compound and production method therefor
TWI611795B (zh) * 2016-07-18 2018-01-21 許百靈 多針孔單光子ｓｐｅｃｔ心肌血流絕對定量方法與用途
CN107233585B (zh) * 2017-06-09 2021-01-22 四川大学华西医院 黄连素或其衍生物在制备心肌灌注显像剂中的用途
CA3069909A1 (en) 2017-07-13 2019-02-14 Northwestern University General and direct method for preparing oligonucleotide-functionalized metal-organic framework nanoparticles
PL239871B1 (pl) * 2018-09-05 2022-01-24 Synektik Spolka Akcyjna Znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej, zastosowanie znakowanego radioizotopem związku w metodzie diagnostycznej pozytonowej tomografii emisyjnej, a także kompozycja farmaceutyczna zawierająca znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej
CN110577478A (zh) * 2018-10-25 2019-12-17 南方医科大学南方医院 一种正电子探针及其制备方法与应用
US20220347323A1 (en) * 2019-09-18 2022-11-03 The Regents Of The University Of California Positron Emission Tomography Guided Delivery of Mitochondral Complex I Inhibitors

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US4446123A (en) * 1982-10-13 1984-05-01 Hahnemann University Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations
WO1999011590A1 (en) * 1997-09-03 1999-03-11 Immunomedics, Inc. Fluorination of proteins and peptides for f-18 positron emission tomography
JPH11295494A (ja) * 1998-04-08 1999-10-29 Nippon Meji Physics Kk ［ｆ−１８］−フッ化物イオンの製造方法
AU2001271248A1 (en) * 2000-04-28 2001-11-12 Duke University 18f-labeled choline analogs
DE60134366D1 (de) * 2000-06-21 2008-07-24 Canon Kk Elektrophotographisches photoempfindliches Element, Prozesskartusche und elektrophotographischer Apparat
CN100577213C (zh) * 2002-02-06 2010-01-06 约翰·霍普金斯大学 使用放射性同位素标示亲油性盐的用于线粒体机能障碍的非侵入性诊断显像技术
WO2004032621A2 (en) * 2002-08-01 2004-04-22 The Johns Hopkins University Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence

Also Published As

Publication number Publication date
AU2003217349A1 (en) 2003-09-02
TWI266634B (en) 2006-11-21
JP2005532262A (ja) 2005-10-27
US7112318B2 (en) 2006-09-26
JP4530665B2 (ja) 2010-08-25
AU2003217349B2 (en) 2008-05-22
US8524193B2 (en) 2013-09-03
CA2474142A1 (en) 2003-08-14
EP1474177A2 (en) 2004-11-10
WO2003065882A3 (en) 2004-02-19
CN1627962A (zh) 2005-06-15
US20040033197A1 (en) 2004-02-19
CN100577213C (zh) 2010-01-06
EP1474177A4 (en) 2010-07-21
WO2003065882A2 (en) 2003-08-14
US20050182027A1 (en) 2005-08-18
CN101838289A (zh) 2010-09-22
NZ534496A (en) 2006-08-31
CA2474142C (en) 2013-02-05
TW200307524A (en) 2003-12-16

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140206