HK1074447A1 - 6-11 bicyclic ketolide derivatives - Google Patents
6-11 bicyclic ketolide derivativesInfo
- Publication number
- HK1074447A1 HK1074447A1 HK05106185.7A HK05106185A HK1074447A1 HK 1074447 A1 HK1074447 A1 HK 1074447A1 HK 05106185 A HK05106185 A HK 05106185A HK 1074447 A1 HK1074447 A1 HK 1074447A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- present
- compounds
- subject
- ketolide derivatives
- invention further
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14455802A | 2002-05-13 | 2002-05-13 | |
US10/429,485 US6878691B2 (en) | 2002-05-13 | 2003-05-05 | 6-11 bicyclic ketolide derivatives |
PCT/US2003/014669 WO2003097659A1 (en) | 2002-05-13 | 2003-05-09 | 6-11 bicyclic ketolide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1074447A1 true HK1074447A1 (en) | 2005-11-11 |
Family
ID=34134634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05106185.7A HK1074447A1 (en) | 2002-05-13 | 2005-07-21 | 6-11 bicyclic ketolide derivatives |
Country Status (11)
Country | Link |
---|---|
US (1) | US6878691B2 (da) |
KR (1) | KR100687956B1 (da) |
CN (1) | CN102127133B (da) |
AT (1) | ATE455786T1 (da) |
CY (1) | CY1109970T1 (da) |
DE (1) | DE60331056D1 (da) |
DK (1) | DK1506214T3 (da) |
ES (1) | ES2339647T3 (da) |
HK (1) | HK1074447A1 (da) |
PT (1) | PT1506214E (da) |
TW (1) | TWI327573B (da) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1509538A1 (en) * | 2002-05-13 | 2005-03-02 | Enanta Pharmaceuticals, Inc. | 6,11 bicyclic erythromycin derivatives |
US6841664B2 (en) * | 2002-07-25 | 2005-01-11 | Enanra Pharmaceuticals, Inc. | 6,11-4-carbon bridged ketolides |
US7910558B2 (en) * | 2002-05-13 | 2011-03-22 | Enanta Pharmaceuticals, Inc. | Bridged macrocyclic compounds and processes for the preparation thereof |
US7135573B2 (en) * | 2002-05-13 | 2006-11-14 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine |
US7273853B2 (en) * | 2002-05-13 | 2007-09-25 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
AR043050A1 (es) * | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
CN1780846A (zh) * | 2003-03-05 | 2006-05-31 | Rib-X医药品有限公司 | 双官能杂环化合物及其制备和使用方法 |
WO2005028493A1 (en) * | 2003-09-12 | 2005-03-31 | Chiron Corporation | Antimicrobial derivatives |
US20070149463A1 (en) * | 2003-10-30 | 2007-06-28 | Oyelere Adegboyega K | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
US20070270357A1 (en) * | 2003-11-18 | 2007-11-22 | Farmer Jay J | Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same |
WO2005067564A2 (en) * | 2004-01-07 | 2005-07-28 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic erythromycin derivatives |
WO2005070113A2 (en) * | 2004-01-09 | 2005-08-04 | Enanta Pharmaceuticals, Inc. | 9n-substituted 6-11 bicyclic erythromycin derivatives |
US7384921B2 (en) * | 2004-02-20 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | Polymorphic forms of 6-11 bicyclic ketolide derivatives |
CN102816194A (zh) | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
US20060058247A1 (en) * | 2004-09-16 | 2006-03-16 | Yujiro Hata | Methods and compositions for treating cystic fibrosis |
US7538225B2 (en) * | 2005-05-02 | 2009-05-26 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of o-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine |
US7384922B2 (en) * | 2005-05-04 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | 6-11 bridged oxime erythromycin derivatives |
US20060252710A1 (en) * | 2005-05-04 | 2006-11-09 | Guoqiang Wang | 6-11 Bridged oxime erythromycin derivatives |
US7517859B2 (en) * | 2005-05-04 | 2009-04-14 | Enanta Pharmaceuticals, Inc. | Spirocyclic bicyclolides |
JP2008540432A (ja) * | 2005-05-04 | 2008-11-20 | エナンタ ファーマシューティカルズ インコーポレイテッド | 6−11橋かけオキシムエリスロマイシン誘導体 |
US20060264386A1 (en) * | 2005-05-17 | 2006-11-23 | Rongqi Sun | Pharmaceutical formulations of 6-11 bicyclic ketolide derivatives and related macrolides and methods for preparation thereof |
US7589067B2 (en) * | 2005-10-12 | 2009-09-15 | Enanta Pharmaceuticals, Inc. | 6, 11-bridged tricyclic macrolides |
EP1960413A2 (en) * | 2005-11-23 | 2008-08-27 | Ranbaxy Laboratories Limited | Macrolides derivatives as antibacterial agents |
US7563877B2 (en) * | 2006-03-02 | 2009-07-21 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182 |
US20070231368A1 (en) * | 2006-03-30 | 2007-10-04 | Enanta Pharmaceuticals, Inc. | Pharmaceutical formulations of 6-11 bicyclic macrolide derivative known as edp-182 and methods for preparation thereof |
US20070281894A1 (en) * | 2006-06-05 | 2007-12-06 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted erythromycin analogs |
US20080027012A1 (en) * | 2006-07-24 | 2008-01-31 | Heejin Kim | Bridged carbamate macrolides |
US20080039406A1 (en) * | 2006-08-04 | 2008-02-14 | Yao-Ling Qiu | 3,6-bridged tylosin derivatives |
WO2008061189A1 (en) * | 2006-11-16 | 2008-05-22 | Enanta Pharmaceuticals, Inc. | C-9 alkenylidine bridged macrolides |
US7524512B2 (en) * | 2007-07-13 | 2009-04-28 | Di Bartolomeo Joseph R | Composition and method for the prevention and relief of the symptoms of an incompetent or patulous Eustachian tube |
US8354383B2 (en) * | 2007-09-17 | 2013-01-15 | Enanta Pharmaceuticals, Inc. | 6,11-bridged biaryl macrolides |
KR20120132577A (ko) * | 2007-09-17 | 2012-12-05 | 이난타 파마슈티칼스, 인코포레이티드 | 6,11-다리걸친 바이아릴 매크로라이드 |
US8273720B2 (en) * | 2007-09-17 | 2012-09-25 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclolides: bridged biaryl macrolide derivatives |
WO2009064953A1 (en) * | 2007-11-15 | 2009-05-22 | Enanta Pharmaceuticals, Inc. | Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases |
WO2009137787A1 (en) * | 2008-05-09 | 2009-11-12 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives |
US7842813B2 (en) * | 2008-05-09 | 2010-11-30 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of O-[5-(4-amino-thiazol-2-yl)-pyridin-2-ylmethyl]-hydroxylamine |
TW200946109A (en) * | 2008-05-09 | 2009-11-16 | Enanta Pharm Inc | Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides |
KR101118597B1 (ko) * | 2008-12-24 | 2012-02-27 | 한국전자통신연구원 | 모바일용 컴퓨터 그래픽 랜더링 방법 및 시스템 |
US8796474B1 (en) | 2010-08-23 | 2014-08-05 | Rutgers, The State University Of New Jersey | Macrolide compounds and methods and intermediates useful for their preparation |
CA2894831C (en) * | 2011-12-19 | 2020-09-08 | Biosynthetic Technologies, Llc | Processes for preparing estolide base oils and oligomeric compounds that include cross metathesis |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960000434B1 (ko) | 1986-12-17 | 1996-01-06 | 다이쇼 세이야꾸 가부시끼가이샤 | 에리스로마이신 a유도체 및 그의 제조 방법 |
US4921836A (en) | 1989-05-17 | 1990-05-01 | Burroughs Wellcome Co. | Substituted glutamic acids |
IL99995A (en) | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
US5403923A (en) | 1990-11-28 | 1995-04-04 | Taisho Pharmaceutical Co., Ltd. | 6-0-methylerythromycin A derivatives |
US5202434A (en) | 1991-04-05 | 1993-04-13 | Merck & Co., Inc. | 8a-aza-8a-homoerythromycin lactams |
US5556839A (en) | 1991-04-29 | 1996-09-17 | Eli Lilly And Company | Form II Dirithromycin |
DK0638584T3 (da) | 1992-04-22 | 1996-04-15 | Taisho Pharmaceutical Co Ltd | 5-O-desosaminyl-erythronolid-A-derivat |
US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
US5441939A (en) | 1994-03-04 | 1995-08-15 | Pfizer Inc. | 3"-desmethoxy derivatives of erythromycin and azithromycin |
FR2738571B1 (fr) | 1995-09-11 | 1997-10-17 | Roussel Uclaf | Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs |
UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
US6046171A (en) | 1997-10-29 | 2000-04-04 | Abbott Laboratories | 6,11-bridged erythromycin derivatives |
US6124269A (en) | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
WO2000062783A2 (en) | 1999-04-16 | 2000-10-26 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
-
2003
- 2003-05-05 US US10/429,485 patent/US6878691B2/en not_active Expired - Lifetime
- 2003-05-09 PT PT03733983T patent/PT1506214E/pt unknown
- 2003-05-09 AT AT03733983T patent/ATE455786T1/de active
- 2003-05-09 CN CN201010586722.1A patent/CN102127133B/zh not_active Expired - Fee Related
- 2003-05-09 DK DK03733983.5T patent/DK1506214T3/da active
- 2003-05-09 KR KR1020047018368A patent/KR100687956B1/ko not_active IP Right Cessation
- 2003-05-09 ES ES03733983T patent/ES2339647T3/es not_active Expired - Lifetime
- 2003-05-09 DE DE60331056T patent/DE60331056D1/de not_active Expired - Lifetime
- 2003-05-12 TW TW092112790A patent/TWI327573B/zh not_active IP Right Cessation
-
2005
- 2005-07-21 HK HK05106185.7A patent/HK1074447A1/xx not_active IP Right Cessation
-
2010
- 2010-04-14 CY CY20101100332T patent/CY1109970T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1109970T1 (el) | 2014-09-10 |
DE60331056D1 (de) | 2010-03-11 |
PT1506214E (pt) | 2010-04-27 |
ES2339647T3 (es) | 2010-05-24 |
CN102127133B (zh) | 2015-04-15 |
US6878691B2 (en) | 2005-04-12 |
US20050037982A1 (en) | 2005-02-17 |
DK1506214T3 (da) | 2010-05-25 |
KR20050003455A (ko) | 2005-01-10 |
CN102127133A (zh) | 2011-07-20 |
ATE455786T1 (de) | 2010-02-15 |
TWI327573B (en) | 2010-07-21 |
TW200400969A (en) | 2004-01-16 |
KR100687956B1 (ko) | 2007-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20180509 |