HK1069827A1 - Pyranones useful as atm inhibitors. - Google Patents

Pyranones useful as atm inhibitors.

Info

Publication number: HK1069827A1
Authority: HK; Hong Kong
Prior art keywords: atm inhibitors; pyranones; useful; pyranones useful; sulfonamino
Prior art date: 2002-02-25

Application number

HK05103310A

Other languages

English (en)

Inventor

Graeme Cameron Murray Smith

Niall Morrison Barr Martin

Stephen Philip Jackson

Mark James O'connor

Alan Yin Kai Lau

Xiao-Ling Fan Cockcroft

Ian Timothy Williams Matthews

Keith Allan Menear

Laurent Jean Martin Rigoreau

Marc Geoffrey Hummersone

Roger John Griffin

Original Assignee

Kudos Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-25

Filing date

2005-04-19

Publication date

2005-06-03

2002-02-25 Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en

2005-04-19 Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd

2005-06-03 Publication of HK1069827A1 publication Critical patent/HK1069827A1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Cardiology (AREA)
Neurology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HK05103310A 2002-02-25 2005-04-19 Pyranones useful as atm inhibitors. HK1069827A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0204350.3A GB0204350D0 (en)	2002-02-25	2002-02-25	ATM inhibitors
US39588402P	2002-07-15	2002-07-15
PCT/GB2003/000770 WO2003070726A1 (en)	2002-02-25	2003-02-24	Pyranones useful as atm inhibitors

Publications (1)

Publication Number	Publication Date
HK1069827A1 true HK1069827A1 (en)	2005-06-03

Family

ID=27758841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK05103310A HK1069827A1 (en)	2002-02-25	2005-04-19	Pyranones useful as atm inhibitors.

Country Status (20)

Country	Link
EP (2)	EP1485377B9 (da)
JP (1)	JP2005521689A (da)
CN (1)	CN100358891C (da)
AT (1)	ATE451365T1 (da)
AU (1)	AU2003209990B8 (da)
BR (1)	BR0307944A (da)
CA (1)	CA2473100A1 (da)
CY (1)	CY1109835T1 (da)
DE (1)	DE60330442D1 (da)
DK (1)	DK1485377T5 (da)
ES (1)	ES2336206T3 (da)
GB (1)	GB2401606B (da)
HK (1)	HK1069827A1 (da)
MX (1)	MXPA04007809A (da)
NO (1)	NO329806B1 (da)
NZ (1)	NZ534821A (da)
PL (1)	PL370074A1 (da)
PT (1)	PT1485377E (da)
SI (1)	SI1485377T1 (da)
WO (1)	WO2003070726A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7151102B2 (en)	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
GB0119865D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
GB0119863D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
DE60335359D1 (de)	2002-04-30	2011-01-27	Kudos Pharm Ltd	Phthalazinonderivate
US7413738B2 (en)	2002-08-13	2008-08-19	Enzon Pharmaceuticals, Inc.	Releasable polymeric conjugates based on biodegradable linkers
US7122189B2 (en)	2002-08-13	2006-10-17	Enzon, Inc.	Releasable polymeric conjugates based on aliphatic biodegradable linkers
GB0305681D0 (en)	2003-03-12	2003-04-16	Kudos Pharm Ltd	Phthalazinone derivatives
US7449464B2 (en)	2003-03-12	2008-11-11	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
EP1618386A2 (en) *	2003-05-01	2006-01-25	Kudos Pharmaceuticals Limited	Methods and means for the treatment of disorders associated with cellular senescence
KR20060066722A (ko) *	2003-08-13	2006-06-16	쿠도스 파마슈티칼스 리미티드	아미노피론 및 ａｔｍ억제제로서의 이의 용도
DK2305221T3 (da)	2003-12-01	2015-08-24	Kudos Pharm Ltd	DNA-skadereparationshæmmere til behandling af cancer
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
US20070238731A1 (en)	2004-09-20	2007-10-11	Kudos Pharmaceuticals Limited	Dna-Pk Inhibitors
CN101115747A (zh)	2005-02-09	2008-01-30	库多斯药物有限公司	Atm抑制剂
AR054438A1 (es)	2005-04-15	2007-06-27	Kudos Pharm Ltd	Inhibidores de adn -pk
US20070049588A1 (en) *	2005-08-31	2007-03-01	Kudos Pharmaceuticals Limited	Atm inhibitor
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
CN101809017A (zh)	2007-09-14	2010-08-18	阿斯利康(瑞典)有限公司	酞嗪酮衍生物
EP2346495B2 (en)	2008-10-07	2023-05-24	Kudos Pharmaceuticals Limited	Pharmaceutical formulation 514
EP2486923B1 (en) *	2011-02-11	2015-09-09	Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG	Histone deacetylase (HDAC) inhibiting compounds and method of making same
WO2013003112A1 (en)	2011-06-27	2013-01-03	The Jackson Laboratory	Methods and compositions for treatment of cancer and autoimmune disease
EP3042900B1 (en) *	2013-08-29	2020-09-23	Fujifilm Corporation	Novel morpholine derivative or salt thereof
EP4171651A1 (en)	2020-06-24	2023-05-03	AstraZeneca UK Limited	Combination of antibody-drug conjugate and atm inhibitor
CN112094210A (zh) *	2020-09-24	2020-12-18	江苏扬农化工股份有限公司	一种取代的亚磺酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4282155A (en) *	1980-02-04	1981-08-04	Merck & Co., Inc.	Antihypercholesterolemic compounds
EP0331250B1 (en) *	1988-03-02	1994-04-13	Merck & Co. Inc.	Antihypercholesterolemic agents
ATE128128T1 (de) *	1990-06-29	1995-10-15	Upjohn Co	Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one.
IL129871A (en) *	1994-05-06	2003-11-23	Pharmacia & Upjohn Inc	Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
JP3851661B2 (ja) *	1996-05-14	2006-11-29	第一製薬株式会社	新規生理活性物質及びその製造方法
FR2765579A1 (fr) *	1997-07-01	1999-01-08	Lipha	Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
WO1999016763A1 (fr) *	1997-09-26	1999-04-08	Toray Industries, Inc.	Derive de cetone et son utilisation en medecine
CN1170827C (zh) *	1998-03-12	2004-10-13	帝人株式会社	苯并呋喃基吡喃酮衍生物

2003
- 2003-02-24 AU AU2003209990A patent/AU2003209990B8/en not_active Ceased
- 2003-02-24 MX MXPA04007809A patent/MXPA04007809A/es active IP Right Grant
- 2003-02-24 WO PCT/GB2003/000770 patent/WO2003070726A1/en active Application Filing
- 2003-02-24 NZ NZ534821A patent/NZ534821A/en not_active IP Right Cessation
- 2003-02-24 BR BR0307944-9A patent/BR0307944A/pt not_active IP Right Cessation
- 2003-02-24 EP EP03742608A patent/EP1485377B9/en not_active Expired - Lifetime
- 2003-02-24 AT AT03742608T patent/ATE451365T1/de not_active IP Right Cessation
- 2003-02-24 DK DK03742608.7T patent/DK1485377T5/da active
- 2003-02-24 JP JP2003569633A patent/JP2005521689A/ja active Pending
- 2003-02-24 ES ES03742608T patent/ES2336206T3/es not_active Expired - Lifetime
- 2003-02-24 PL PL03370074A patent/PL370074A1/xx not_active Application Discontinuation
- 2003-02-24 PT PT03742608T patent/PT1485377E/pt unknown
- 2003-02-24 CA CA002473100A patent/CA2473100A1/en not_active Abandoned
- 2003-02-24 GB GB0419534A patent/GB2401606B/en not_active Expired - Fee Related
- 2003-02-24 EP EP09014921A patent/EP2174939A1/en not_active Withdrawn
- 2003-02-24 SI SI200331759T patent/SI1485377T1/sl unknown
- 2003-02-24 CN CNB038045478A patent/CN100358891C/zh not_active Expired - Fee Related
- 2003-02-24 DE DE60330442T patent/DE60330442D1/de not_active Expired - Lifetime
2004
- 2004-09-24 NO NO20044063A patent/NO329806B1/no not_active IP Right Cessation
2005
- 2005-04-19 HK HK05103310A patent/HK1069827A1/xx not_active IP Right Cessation
2010
- 2010-02-18 CY CY20101100162T patent/CY1109835T1/el unknown

Also Published As

Publication number	Publication date
GB0419534D0 (en)	2004-10-06
SI1485377T1 (sl)	2010-04-30
CA2473100A1 (en)	2003-08-28
PL370074A1 (en)	2005-05-16
DK1485377T3 (da)	2010-04-19
AU2003209990B8 (en)	2008-10-30
NZ534821A (en)	2006-07-28
EP2174939A1 (en)	2010-04-14
EP1485377B1 (en)	2009-12-09
NO329806B1 (no)	2010-12-20
BR0307944A (pt)	2005-02-01
MXPA04007809A (es)	2004-10-15
DK1485377T5 (da)	2010-12-06
AU2003209990A1 (en)	2003-09-09
EP1485377B9 (en)	2010-10-06
CY1109835T1 (el)	2014-09-10
NO20044063L (no)	2004-09-24
CN1639154A (zh)	2005-07-13
EP1485377B8 (en)	2010-02-24
ES2336206T9 (es)	2011-03-24
WO2003070726A1 (en)	2003-08-28
EP1485377A1 (en)	2004-12-15
DE60330442D1 (de)	2010-01-21
ATE451365T1 (de)	2009-12-15
GB2401606A (en)	2004-11-17
PT1485377E (pt)	2010-03-12
JP2005521689A (ja)	2005-07-21
ES2336206T3 (es)	2010-04-09
CN100358891C (zh)	2008-01-02
AU2003209990B2 (en)	2008-10-09
GB2401606B (en)	2005-08-31

Legal Events

Date	Code	Title	Description
2011-10-07	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20110224

Publication	Publication Date	Title
HK1069827A1 (en)	2005-06-03	Pyranones useful as atm inhibitors.
HK1097273A1 (en)	2007-06-22	Aminopyrones and their use as atm inhibitors
GB0226593D0 (en)	2002-12-24	Compounds
TWI266761B (en)	2006-11-21	Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents
MXPA02011974A (es)	2004-09-06	Derivados de quinazolina sustituidos y su uso como inhibidores.
HRP20070307T3 (en)	2007-09-30	Derivatives of n-[ phenyl(pyrrolidine-2-yl)methyl]benzamide and n-[ (azepan-2-yl)phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics
UA88329C2 (en)	2009-10-12	Dna-pk inhibitors
CY1111310T1 (el)	2015-08-05	Ενωσεις για την αγωγη μεταβολικων διαταραχων
HUP0301607A2 (hu)	2003-12-29	Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
GEP20125523B (en)	2012-05-25	Metabolites of (thio) carbamoyl-cyclohexane derivatives
TW200612920A (en)	2006-05-01	Novel imidazolidine derivatives
FI931763A (fi)	1993-10-21	4,1-bensoxazepinderivat och deras anvaendning
DK1044967T3 (da)	2004-11-22	2-pyridinylguanidinurokinaseinhibitor
RS51193B (sr)	2010-10-31	Hidantoinski derivati korisni kao inhibitori metaloproteinaza
WO2001098248A3 (en)	2003-07-10	Hiv integrase inhibitors
TW200638938A (en)	2006-11-16	ATM inhibitors
FI935798A0 (fi)	1993-12-22	Alkylsubstituerade heterocykliska foereningar
GB0116312D0 (en)	2001-08-29	"Compositions containing N-acyl homoserine lactones"
ATE500243T1 (de)	2011-03-15	Carbonsäureamidverbindung und deren verwendung
NZ506908A (en)	2003-04-29	Cephalosporines having cyclic aminoguanidine substituents as antibiotics
ES2166710A1 (es)	2003-12-01	Nuevos compuestos heterociclicos con actividad antiinflamatoria.
IL178548A (en)	2010-12-30	Derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol and applications thereof
TR200402333T4 (tr)	2004-12-21	Artropodisidal karboksanilidler