HK1068263A1 - Depot formulations of iloperidone and a star polymer - Google Patents

Depot formulations of iloperidone and a star polymer

Info

Publication number
HK1068263A1
HK1068263A1 HK05100401.8A HK05100401A HK1068263A1 HK 1068263 A1 HK1068263 A1 HK 1068263A1 HK 05100401 A HK05100401 A HK 05100401A HK 1068263 A1 HK1068263 A1 HK 1068263A1
Authority
HK
Hong Kong
Prior art keywords
iloperidone
star polymer
depot formulations
polymer
depot
Prior art date
Application number
HK05100401.8A
Other languages
English (en)
Inventor
Markus Ahlheim
Rolf Loeffler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1068263A1 publication Critical patent/HK1068263A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
HK05100401.8A 2001-10-30 2005-01-14 Depot formulations of iloperidone and a star polymer HK1068263A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33903601P 2001-10-30 2001-10-30
PCT/EP2002/012073 WO2003037337A1 (en) 2001-10-30 2002-10-29 Depot formulations of iloperidone and a star polymer

Publications (1)

Publication Number Publication Date
HK1068263A1 true HK1068263A1 (en) 2005-04-29

Family

ID=23327202

Family Applications (2)

Application Number Title Priority Date Filing Date
HK05100401.8A HK1068263A1 (en) 2001-10-30 2005-01-14 Depot formulations of iloperidone and a star polymer
HK11109677.8A HK1155381A1 (en) 2001-10-30 2011-09-14 Depot formulations of iloperidone with a polymer

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK11109677.8A HK1155381A1 (en) 2001-10-30 2011-09-14 Depot formulations of iloperidone with a polymer

Country Status (12)

Country Link
US (2) US7767230B2 (xx)
EP (2) EP1441727B1 (xx)
JP (1) JP5067998B2 (xx)
CN (2) CN1578664A (xx)
AT (1) ATE493129T1 (xx)
BR (1) BRPI0213564B8 (xx)
CA (1) CA2463158C (xx)
CY (1) CY1111357T1 (xx)
DE (1) DE60238780D1 (xx)
ES (2) ES2436439T3 (xx)
HK (2) HK1068263A1 (xx)
WO (1) WO2003037337A1 (xx)

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WO2003037337A1 (en) * 2001-10-30 2003-05-08 Novartis Ag Depot formulations of iloperidone and a star polymer
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
US20100063093A1 (en) 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
CA3113166A1 (en) 2004-09-30 2006-04-13 Vanda Pharmaceuticals Inc. Methods for the administration of iloperidone
DE102005051342A1 (de) * 2005-10-25 2007-04-26 Goldschmidt Gmbh Verkapselung und kontrollierte Freisetzung biologisch aktiver Wirkstoffe mit enzymatisch abbaubaren hyperverzweigten Trägerpolymeren
JP5264492B2 (ja) 2005-10-25 2013-08-14 エボニック デグサ ゲーエムベーハー 超分岐ポリマーを含有する調製物
EP2029136A4 (en) 2006-05-22 2010-01-06 Vanda Pharmaceuticals Inc TREATMENT FOR DEPRESSION DISEASES
CN100460441C (zh) * 2006-09-25 2009-02-11 南开大学 生物可降解星型结构聚乙丙交酯载药微球及其制备方法
WO2008054725A2 (en) 2006-10-31 2008-05-08 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
CA2698534C (en) * 2007-09-10 2018-10-09 Vanda Pharmaceuticals, Inc. Prediction of qt prolongation based on snp genotype
SI2222300T1 (sl) 2007-12-13 2014-11-28 Vanda Pharmaceuticals Inc. Postopek in sestavek za zdravljenje stanja, posredovanega z receptorjem serotonina
JP5729808B2 (ja) * 2007-12-13 2015-06-03 ヴァンダ ファーマシューティカルズ インコーポレイテッド αアドレナリン受容体介在状態を治療する方法及び組成物
WO2011009102A1 (en) 2009-07-16 2011-01-20 Vanda Pharmaceuticals Inc. Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia
MX2012007365A (es) * 2009-12-23 2012-08-15 Lupin Ltd Composiciones farmaceuticas de liberacion lenta de iloperidona.
CN102311430A (zh) * 2010-06-29 2012-01-11 大道隆达（北京）医药科技发展有限公司 伊潘立酮的新晶态及其制备方法
WO2012123963A2 (en) * 2011-02-24 2012-09-20 Megafine Pharma (P) Ltd. A process for preparation of iloperidone and amorphous co- precipitate of iloperidone with pharmaceutically acceptable excipient
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
CA2861111C (en) 2012-01-26 2021-11-23 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
CA2872324C (en) 2012-05-18 2017-06-06 Vanda Pharmaceuticals Inc. Metabolites of (1r-trans)-n-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide
ES2805376T3 (es) 2012-12-18 2021-02-11 Vanda Pharmaceuticals Inc Tasimelteón para el tratamiento de trastornos del ritmo circadiano
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
CN103599074A (zh) * 2013-11-26 2014-02-26 重庆医药工业研究院有限责任公司 一种伊潘立酮缓释微球及其制备方法
CN104352443A (zh) * 2014-10-21 2015-02-18 河北科技大学 伊潘立酮缓释微球及其制备方法
KR20170118830A (ko) 2015-02-17 2017-10-25 반다 파마슈티칼즈, 인코퍼레이티드. 조현병의 치료를 위한 일로페리돈
US11071728B2 (en) 2015-12-11 2021-07-27 Vanda Pharmaceuticals Inc. Treatment of schizophrenia
JP2022510454A (ja) * 2018-12-04 2022-01-26 バンダ・ファーマシューティカルズ・インコーポレイテッド イロペリドンの持効性投与
US11607408B2 (en) 2019-10-15 2023-03-21 Vanda Pharmaceuticals Inc. Method of treatment of schizophrenia
WO2024137439A1 (en) 2022-12-19 2024-06-27 Vanda Pharmaceuticals Inc. Dosage regime of iloperidone for treating bipolar i disorder and schizophrenia

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WO2003037337A1 (en) * 2001-10-30 2003-05-08 Novartis Ag Depot formulations of iloperidone and a star polymer
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
BRPI0213564B8 (pt) 2021-05-25
DE60238780D1 (de) 2011-02-10
CN101912367A (zh) 2010-12-15
HK1155381A1 (en) 2012-05-18
JP5067998B2 (ja) 2012-11-07
ES2436439T3 (es) 2014-01-02
EP1441727A1 (en) 2004-08-04
US20100233217A1 (en) 2010-09-16
ES2358416T3 (es) 2011-05-10
WO2003037337A1 (en) 2003-05-08
WO2003037337A8 (en) 2004-05-13
US7767230B2 (en) 2010-08-03
EP2295058B1 (en) 2013-09-04
EP1441727B1 (en) 2010-12-29
CA2463158C (en) 2013-07-30
CY1111357T1 (el) 2015-08-05
EP2295058A1 (en) 2011-03-16
ATE493129T1 (de) 2011-01-15
BR0213564A (pt) 2004-08-31
BRPI0213564B1 (pt) 2016-08-02
CN1578664A (zh) 2005-02-09
CA2463158A1 (en) 2003-05-08
US20030091645A1 (en) 2003-05-15
JP2005508975A (ja) 2005-04-07
US8815293B2 (en) 2014-08-26

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Legal Events

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PE Patent expired

Effective date: 20221028