ATE493129T1 - Depot formulierungen von iloperidone und einem sternförmigen polymer - Google Patents

Depot formulierungen von iloperidone und einem sternförmigen polymer

Info

Publication number
ATE493129T1
ATE493129T1 AT02785330T AT02785330T ATE493129T1 AT E493129 T1 ATE493129 T1 AT E493129T1 AT 02785330 T AT02785330 T AT 02785330T AT 02785330 T AT02785330 T AT 02785330T AT E493129 T1 ATE493129 T1 AT E493129T1
Authority
AT
Austria
Prior art keywords
iloperidone
star
shaped polymer
depot formulations
polymer
Prior art date
Application number
AT02785330T
Other languages
English (en)
Inventor
Markus Ahlheim
Rolf Loeffler
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE493129T1 publication Critical patent/ATE493129T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT02785330T 2001-10-30 2002-10-29 Depot formulierungen von iloperidone und einem sternförmigen polymer ATE493129T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33903601P 2001-10-30 2001-10-30
PCT/EP2002/012073 WO2003037337A1 (en) 2001-10-30 2002-10-29 Depot formulations of iloperidone and a star polymer

Publications (1)

Publication Number Publication Date
ATE493129T1 true ATE493129T1 (de) 2011-01-15

Family

ID=23327202

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02785330T ATE493129T1 (de) 2001-10-30 2002-10-29 Depot formulierungen von iloperidone und einem sternförmigen polymer

Country Status (12)

Country Link
US (2) US7767230B2 (de)
EP (2) EP1441727B1 (de)
JP (1) JP5067998B2 (de)
CN (2) CN1578664A (de)
AT (1) ATE493129T1 (de)
BR (1) BRPI0213564B8 (de)
CA (1) CA2463158C (de)
CY (1) CY1111357T1 (de)
DE (1) DE60238780D1 (de)
ES (2) ES2358416T3 (de)
HK (2) HK1068263A1 (de)
WO (1) WO2003037337A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4848113B2 (ja) * 1999-09-09 2011-12-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 血管新生血管に対するタキサンの陽イオン性リポソーム送達
CN1578664A (zh) * 2001-10-30 2005-02-09 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
CA3113166A1 (en) 2004-09-30 2006-04-13 Vanda Pharmaceuticals Inc. Methods for the administration of iloperidone
US20100063093A1 (en) * 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
DE102005051342A1 (de) * 2005-10-25 2007-04-26 Goldschmidt Gmbh Verkapselung und kontrollierte Freisetzung biologisch aktiver Wirkstoffe mit enzymatisch abbaubaren hyperverzweigten Trägerpolymeren
PL1940905T3 (pl) 2005-10-25 2011-02-28 Evonik Degussa Gmbh Preparaty zawierające hiperrozgałęzione polimery
KR20090029200A (ko) 2006-05-22 2009-03-20 반다 파마슈티칼즈, 인코퍼레이티드. 우울증 질환에 대한 치료
CN100460441C (zh) * 2006-09-25 2009-02-11 南开大学 生物可降解星型结构聚乙丙交酯载药微球及其制备方法
EP2236546B1 (de) 2006-10-31 2011-12-28 Surmodics Pharmaceuticals, Inc. Kugelförmige Polymer-Partikel
WO2009036100A2 (en) * 2007-09-10 2009-03-19 Vanda Pharmaceuticals, Inc. Prediction of qt prolongation based on snp genotype
EP2222300B1 (de) 2007-12-13 2014-06-11 Vanda Pharmaceuticals Inc. Verfahren und zusammensetzung zur behandlung eines zustands, der durch den serotonin-rezeptor vermittelt wird
WO2009076663A1 (en) 2007-12-13 2009-06-18 Vanda Pharmaceuticals Inc. Method and composition for treating an alpha adrenoceptor-mediated condition
EP2453891A1 (de) 2009-07-16 2012-05-23 Vanda Pharmaceuticals Inc. Verwendung eines melatoninagonisten zur behandlung von schlafstörungen, u.a. primärer insomnie
BR112012015084A2 (pt) * 2009-12-23 2017-03-07 Lupin Ltd composição farmacêutica de liberação lenta de iloperidone
CN102311430A (zh) * 2010-06-29 2012-01-11 大道隆达（北京）医药科技发展有限公司 伊潘立酮的新晶态及其制备方法
WO2012123963A2 (en) * 2011-02-24 2012-09-20 Megafine Pharma (P) Ltd. A process for preparation of iloperidone and amorphous co- precipitate of iloperidone with pharmaceutically acceptable excipient
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
EP3620794A1 (de) 2012-01-26 2020-03-11 Vanda Pharmaceuticals Inc. Bestimmung der circadianen rhythmik
IN2014DN10691A (de) 2012-05-18 2015-08-28 Vanda Pharmaceuticals Inc
MX2015007909A (es) 2012-12-18 2016-04-25 Vanda Pharmaceuticals Inc Tratamiento de trastornos del ritmo circadiano.
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
CN103599074A (zh) * 2013-11-26 2014-02-26 重庆医药工业研究院有限责任公司 一种伊潘立酮缓释微球及其制备方法
CN104352443A (zh) * 2014-10-21 2015-02-18 河北科技大学 伊潘立酮缓释微球及其制备方法
CN116211857A (zh) 2015-02-17 2023-06-06 万达制药公司 用于治疗精神***症的伊潘立酮
US11071728B2 (en) 2015-12-11 2021-07-27 Vanda Pharmaceuticals Inc. Treatment of schizophrenia
MX2021006601A (es) * 2018-12-04 2021-07-07 Vanda Pharmaceuticals Inc Administracion de iloperidona de liberacion lenta.
US11607408B2 (en) 2019-10-15 2023-03-21 Vanda Pharmaceuticals Inc. Method of treatment of schizophrenia

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
DE3511587A1 (de) 1985-03-27 1986-10-02 Schering AG, Berlin und Bergkamen, 1000 Berlin Glykoester des estradiols und estriols
US4886370A (en) 1987-08-25 1989-12-12 Nkk Corporation Method for detecting a state of substance existing in pipe
ES2076253T3 (es) * 1989-05-19 1995-11-01 Hoechst Roussel Pharma N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5538739A (en) 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
AU636043B2 (en) 1990-06-04 1993-04-08 Schering Corporation Method for preparing interferon alpha-2 crystals
NZ276088A (en) * 1993-11-19 1999-07-29 Janssen Pharmaceutica Nv [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone)
HUP0002106A3 (en) 1997-05-26 2001-11-28 Akzo Nobel Nv Aromatic sulfonates of trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz-[2,3:6,7]oxepino[4,5-c]pyrrole and pharmaceutical compositions containing it
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
DE19816070A1 (de) 1998-04-09 1999-10-14 Aventis Res & Tech Gmbh & Co Retardtablette hergestellt aus linearen wasserunlöslichen Polysacchariden
KR20010072878A (ko) * 1998-10-16 2001-07-31 디르크 반테 인식을 개선하기 위한 아세틸콜린에스테라제 억제제와배합된 비정형 항정신병제
JP2003535106A (ja) 2000-06-02 2003-11-25 ノボ ノルディスク アクティーゼルスカブ グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出
US20050020632A1 (en) 2001-08-31 2005-01-27 Dominique Grimler Optical isomers of an iloperidone metabolite
CN1578664A (zh) * 2001-10-30 2005-02-09 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
US20100233217A1 (en) 2010-09-16
HK1155381A1 (en) 2012-05-18
CN101912367A (zh) 2010-12-15
CN1578664A (zh) 2005-02-09
JP5067998B2 (ja) 2012-11-07
ES2436439T3 (es) 2014-01-02
ES2358416T3 (es) 2011-05-10
CA2463158A1 (en) 2003-05-08
EP2295058B1 (de) 2013-09-04
WO2003037337A8 (en) 2004-05-13
BR0213564A (pt) 2004-08-31
EP1441727B1 (de) 2010-12-29
CY1111357T1 (el) 2015-08-05
DE60238780D1 (de) 2011-02-10
CA2463158C (en) 2013-07-30
JP2005508975A (ja) 2005-04-07
US8815293B2 (en) 2014-08-26
EP1441727A1 (de) 2004-08-04
EP2295058A1 (de) 2011-03-16
BRPI0213564B1 (pt) 2016-08-02
WO2003037337A1 (en) 2003-05-08
BRPI0213564B8 (pt) 2021-05-25
US7767230B2 (en) 2010-08-03
US20030091645A1 (en) 2003-05-15
HK1068263A1 (en) 2005-04-29

Similar Documents

Publication Publication Date Title
ATE493129T1 (de) Depot formulierungen von iloperidone und einem sternförmigen polymer
DE60235083D1 (de) Substituierte tetracyclin-verbindungen zur behandlung von malaria
ATE282653T1 (de) Saure polymilchsäure polymere
DE69812946D1 (de) Ethylenpolymerzusammensetzungen und daraus hergestellte gegenstände
EP1852437A3 (de) 42-O-Alkoxyalkyl-Rapamycin-Derivate und Zusammensetzungen damit
AU2001259651A1 (en) Polymers containing oxygen and sulfur alicyclic units and photoresist compositions comprising same
DE69626589D1 (de) Polymer, Verfahren zur Herstellung, Haarbehandlungszusammensetzungen und kosmetische Zusammensetzungen
DE60144375D1 (de) 7-, 8- und 9-substitutierte tetracyclinverbindungen
DE69923359D1 (de) Zusammensetzungen und daraus hergestellte gegenstände
ATE296642T1 (de) Reverse-phase zusamensetzung zur bindegewebsreparatur
EP0711506A3 (de) Kaugummi
ATE404605T1 (de) Funktionalisierte alkydpolyesterpolymere zur medizinischen verwendung
ID15948A (id) Komposisi-komposisi insektisida berdasarkan polimer-polimer
DE60020206D1 (de) Zusammensetzung und Verfahren zur Herstellung von dehnbaren Polymeren und dadurch geformte Gegenstände
DE60214853D1 (de) Biologisch abbaubare kaugummigrundmasse
DE60120416D1 (de) Polyaminoestern und deren verwendung zur herstellung von dentalmassen
DE69132415T2 (de) Umweltfreundliche Polymerzusammensetzungen sowie Anwendungen desselben
DE19882607T1 (de) Verfahren zur Herstellung von Olefinpolymeren oder -copolymeren sowie Olefinpolymere oder -copolymere und Anwendungen davon
DE69705108D1 (de) Mischungen ausgehend von eugenia jambolana lamarck samen, herstellung und verwendung solcher mischungen sowie einiger inhaltsstoffe als medikamente
FR2818128B1 (fr) Compositions cosmetiques antisolaires a base d'un melange synergetique de filtres et utilisations
DE69901023D1 (de) Knochenimplantat
ATE204266T1 (de) Taxoide, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE60121522D1 (de) Verfahren zur Herstellung von Ethylencopolymeren und die erhaltenen Ethylenecopolymere
DE60141735D1 (de) Verfahren zur Herstellung von Ethylencopolymeren und die erhaltenen Ethylencopolymere
AU2001255754A1 (en) Methods and compositions for the manufacture of molecular beacons

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1441727

Country of ref document: EP