HK1013598A1 - 1-(5- Isoquinolinesulfonyl) homopipe razine hydrochloride hydrates - Google Patents

1-(5- Isoquinolinesulfonyl) homopipe razine hydrochloride hydrates

Info

Publication number: HK1013598A1
Authority: HK; Hong Kong
Prior art keywords: homopipe; isoquinolinesulfonyl; hydrochloride hydrates; razine; razine hydrochloride
Prior art date: 1995-07-03

Application number

HK98112655A

Other languages

English (en)

Inventor

Hiromu Kawakubo

Masaru Ohno

Original Assignee

Asahi Chemical Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-03

Filing date

1998-12-02

Publication date

1999-09-03

1998-12-02 Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind

1999-09-03 Publication of HK1013598A1 publication Critical patent/HK1013598A1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

HK98112655A 1995-07-03 1998-12-02 1-(5- Isoquinolinesulfonyl) homopipe razine hydrochloride hydrates HK1013598A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP16746095		1995-07-03
PCT/JP1996/001698 WO1997002260A1 (fr)	1995-07-03	1996-06-19	Hydrochlorates de 1-(5-isoquinoleine sulfonyl)homopiperazine

Publications (1)

Publication Number	Publication Date
HK1013598A1 true HK1013598A1 (en)	1999-09-03

Family

ID=15850096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98112655A HK1013598A1 (en)	1995-07-03	1998-12-02	1-(5- Isoquinolinesulfonyl) homopipe razine hydrochloride hydrates

Country Status (8)

Country	Link
US (1)	US5942505A (xx)
EP (1)	EP0870767B1 (xx)
KR (1)	KR100236853B1 (xx)
CN (1)	CN1080721C (xx)
DE (1)	DE69606721T2 (xx)
ES (1)	ES2142065T3 (xx)
HK (1)	HK1013598A1 (xx)
WO (1)	WO1997002260A1 (xx)

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US5140031A (en) *	1989-05-31	1992-08-18	E. R. Squibb & Sons, Inc.	Pyranyl cyanoguanidine derivatives
EP1110553B1 (en) *	1998-08-10	2013-03-27	Asahi Kasei Pharma Corporation	Sustained release oral preparations of fasudil hydrochloride
DE10232113A1 (de) *	2002-07-16	2004-01-29	Bayer Ag	Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
SE0203092D0 (en) *	2002-10-18	2002-10-18	Astrazeneca Ab	Method for the synthesis of a benzimidazole compound
US20050014783A1 (en) *	2003-05-29	2005-01-20	Schering Aktiengesellschaft	Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
WO2005073218A1 (ja) *	2004-01-29	2005-08-11	Asahi Kasei Pharma Corporation	バイパス術に伴う血管攣縮治療剤
CN1929847B (zh) *	2004-03-16	2011-01-19	旭化成制药株式会社	含有法舒地尔的制剂及改善其稳定性的方法
MY139797A (en) *	2004-11-29	2009-10-30	Kowa Co	(s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate
EP2111863B1 (en)	2005-10-26	2012-03-28	Asahi Kasei Pharma Corporation	Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
ATE513929T1 (de) *	2006-01-27	2011-07-15	Translational Genomics Res Inst	Gene mit einfluss auf die menschliche gedächtnisleistung
CN101092413B (zh) *	2006-06-23	2011-05-18	山东轩竹医药科技有限公司	法舒地尔的药用盐的水合物
EP2061314A4 (en) *	2006-08-10	2010-08-04	Translational Genomics Res Inst	COMPOUNDS FOR IMPROVING LEARNING AND MEMORY
CN102002036B (zh) *	2009-08-31	2013-01-30	秦引林	一种法舒地尔的精制方法
CN102020635B (zh) *	2009-09-10	2013-04-17	河北凯盛医药科技有限公司	一种盐酸法舒地尔半水合物的制备方法
EP2332917B1 (en)	2009-11-11	2012-08-01	Sygnis Bioscience GmbH & Co. KG	Compounds for PIM kinase inhibition and for treating malignancy
CN101985444B (zh) *	2010-08-20	2013-04-24	天津红日药业股份有限公司	盐酸法舒地尔的v晶型及其制备方法和用途
CN101962379B (zh) *	2010-09-28	2013-02-27	山西普德药业股份有限公司	一种磺酰基异喹啉衍生物的精制方法
CN102020636A (zh) *	2010-11-25	2011-04-20	江苏万邦生化医药股份有限公司	盐酸法舒地尔的合成及提纯方法
CN102060845B (zh) *	2010-12-28	2013-07-03	天津红日药业股份有限公司	一种法舒地尔的晶型ⅲ及其制备方法和用途
CN102225929B (zh) *	2011-05-12	2014-07-16	天津市汉康医药生物技术有限公司	一种稳定的盐酸法舒地尔水合物化合物
CN102229601B (zh) *	2011-05-12	2013-07-03	天津市汉康医药生物技术有限公司	六氢-1-(5-异喹啉磺酰基)-1(h)-1,4-二氮杂卓盐酸盐无定形化合物
EP2825175B1 (en)	2012-03-12	2017-07-26	Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin	Rho kinase inhibitors for use in treating amyotrophic lateral sclerosis
US8715764B2 (en)	2012-06-21	2014-05-06	Choco Finesse LLC	Eutectic mixtures of esterified propoxylated glycerols with digestible fats
CN104327052A (zh) *	2014-10-20	2015-02-04	郑州四环医药用品有限公司	一种高纯度盐酸法舒地尔的制备方法
CN104945381B (zh) *	2015-06-24	2019-05-03	山东罗欣药业集团股份有限公司	一种盐酸法舒地尔化合物、其制备方法及其药物组合物
WO2019084293A1 (en)	2017-10-25	2019-05-02	Arizona Board Of Regents On Behalf Of The University Of Arizona	COMPOSITIONS AND METHODS FOR ADMINISTERING PHARMACEUTICAL AGENTS
EA202191339A1 (ru)	2018-12-17	2021-08-27	Д. Вестерн Терапьютикс Инститьют, Инк.	Новая форма изохинолинсульфонамида
CN109776497A (zh) *	2019-03-07	2019-05-21	山东新华制药股份有限公司	一种盐酸法舒地尔半水合物的制备方法
WO2020193802A1 (en)	2019-03-28	2020-10-01	Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe	Polymeric conjugates and uses thereof
CN113968841B (zh) *	2020-07-23	2024-05-14	合肥久诺医药科技有限公司	一种盐酸法舒地尔半水合物的制备方法
WO2023076812A1 (en)	2021-10-30	2023-05-04	Aneuryst, Inc.	Treatments for disturbed cerebral homeostasis
US11944633B2 (en)	2022-02-17	2024-04-02	Woolsey Pharmaceuticals, Inc.	Oral formulations of fasudil with ion exchange resin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4678783B1 (en) *	1983-11-04	1995-04-04	Asahi Chemical Ind	Substituted isoquinolinesulfonyl compounds
JPS61152658A (ja) *	1984-12-27	1986-07-11	Asahi Chem Ind Co Ltd	置換されたイソキノリンスルホンアミド誘導体
JPS6293643A (ja) *	1985-10-19	1987-04-30	Fuji Photo Film Co Ltd	核酸の塩基配列決定のための信号処理方法
JP2720348B2 (ja) *	1989-03-30	1998-03-04	旭化成工業株式会社	脳細胞機能障害改善剤
JPH04278094A (ja) *	1991-03-07	1992-10-02	Asahi Chem Ind Co Ltd	１−ヒドロキシ−イソキノリンスルホンアミド誘導体の製造方法
JPH05569A (ja) *	1991-06-25	1993-01-08	Kanzaki Paper Mfg Co Ltd	感熱記録体
JPH0680569A (ja) *	1992-09-03	1994-03-22	Asahi Chem Ind Co Ltd	血小板凝集阻害剤
JP3464012B2 (ja) *	1993-04-05	2003-11-05	旭化成株式会社	精神症候治療剤
JPH0741424A (ja) *	1993-07-28	1995-02-10	Asahi Chem Ind Co Ltd	抗炎症剤

1996
- 1996-06-19 WO PCT/JP1996/001698 patent/WO1997002260A1/ja active IP Right Grant
- 1996-06-19 ES ES96918854T patent/ES2142065T3/es not_active Expired - Lifetime
- 1996-06-19 EP EP96918854A patent/EP0870767B1/en not_active Expired - Lifetime
- 1996-06-19 KR KR1019970707804A patent/KR100236853B1/ko not_active IP Right Cessation
- 1996-06-19 US US08/930,910 patent/US5942505A/en not_active Expired - Lifetime
- 1996-06-19 DE DE69606721T patent/DE69606721T2/de not_active Expired - Lifetime
- 1996-06-19 CN CN96193768A patent/CN1080721C/zh not_active Expired - Fee Related
1998
- 1998-12-02 HK HK98112655A patent/HK1013598A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69606721T2 (de)	2000-06-21
EP0870767B1 (en)	2000-02-16
EP0870767A1 (en)	1998-10-14
KR100236853B1 (ko)	2000-02-01
US5942505A (en)	1999-08-24
CN1080721C (zh)	2002-03-13
ES2142065T3 (es)	2000-04-01
KR19990008278A (ko)	1999-01-25
DE69606721D1 (de)	2000-03-23
CN1183782A (zh)	1998-06-03
EP0870767A4 (xx)	1998-10-14
WO1997002260A1 (fr)	1997-01-23

Legal Events

Date	Code	Title	Description
2004-12-15	PF	Patent in force
2016-01-15	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20150619

Publication	Publication Date	Title
HK1013598A1 (en)	1999-09-03	1-(5- Isoquinolinesulfonyl) homopipe razine hydrochloride hydrates
EG24195A (en)	2008-10-14	Heterocyclic compounds
PL331795A1 (en)	1999-08-02	Heterocyclic metaloprotease inhibitors
ZA9610020B (en)	1997-06-01	Heterocyclic compounds
PL327406A1 (en)	1998-12-07	1-(1,2-disubstituted-piperidinyl)-4-substituted derivatives of piperazine
GB9512697D0 (en)	1995-08-23	Heterocyclic compounds
GB9518552D0 (en)	1995-11-08	New heterocyclic compounds
PL332593A1 (en)	1999-09-27	N-substituted azaheterocyclic compounds
AP9700968A0 (en)	1997-04-30	Apolipoprotein-B synthesis inhibitors
GB9504361D0 (en)	1995-04-26	Heterocyclic compounds
ZA959084B (en)	1997-04-29	Apolipoprotein-b synthesis inhibitors
PL332592A1 (en)	1999-09-27	N-substituted azaheterocyclic compounds
HU9503783D0 (en)	1996-04-29	Squvalen syntetase inhibitors
GB9505865D0 (en)	1995-05-10	Hydrate Inhibitors
AU4376997A (en)	1998-05-05	N-substituted azaheterocyclic compounds
ZA962734B (en)	1997-01-03	Heterocyclic compounds
GB9404942D0 (en)	1994-04-27	Heterocyclic compound
IL126564A (en)	2001-03-19	1-(1-Oxoindan-2-yl) imidazole-2-carboxylate derivatives
HUT71675A (en)	1996-01-29	Guanidyl-substituted heterocyclic thrombin inhibitors
GB9521102D0 (en)	1995-12-20	New Heterocyclic compounds
GB9512339D0 (en)	1995-08-16	New heterocyclic compounds
GB9500521D0 (en)	1995-03-01	Heterocyclic compounds
GB9515085D0 (en)	1995-09-20	Heterocyclic compounds
GB9511072D0 (en)	1995-07-26	Heterocyclic compounds
GB9504839D0 (en)	1995-04-26	Heterocyclic compounds