GT199900167A - Nuevos bis-benzimidazoles. - Google Patents

Nuevos bis-benzimidazoles.

Info

Publication number
GT199900167A
GT199900167A GT199900167A GT199900167A GT199900167A GT 199900167 A GT199900167 A GT 199900167A GT 199900167 A GT199900167 A GT 199900167A GT 199900167 A GT199900167 A GT 199900167A GT 199900167 A GT199900167 A GT 199900167A
Authority
GT
Guatemala
Prior art keywords
benzimidazoles
treatment
new bis
formula
tautomeral
Prior art date
Application number
GT199900167A
Other languages
English (en)
Inventor
Joachim Mittenford
Rolf Henning
Siegfried Raddzatz
Karl-Heinz Schlemmer
Makiko Hiraoka
Hiroshi Kadono
Muneto Mogi
Toshiya Moriwaki
Toshiki Murata
Sachiko Sakakibara
Mitsuyuki Shimada
Nagahiro Yoshida
Takashi Yoshino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199900167A publication Critical patent/GT199900167A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

LA PRESENTE INVENCION SE REFIERE A NOVEDOSOS BISBENZIMIDAZOLES COMPUESTOS ASOCIADOS CON LA FORMULA (I) A SUS FORMAS TAUTOMERAS Y ESTEREISOMERAS, EN ESTA FORMULA ESTRUCTURAL GENERICA LAS LETRAS "R" REPRESENTAN POSIBLES GRUPOS FUNCIONALES QUE PUEDEN SER INTERCAMBIADOS (EL LISTADO ESPECIFICO DE LOS MISMOS SE HALLA EN EL DOCUMENTO ORIGINAL) A PROCESOS PARA SU PREPARACION Y A SU UTILIZACION PARA SU PROFILAXIS Y TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON LA ACTIVIDAD DE LA TRIPTASA, EN PARTICULAR PARA EL TRATAMIENTO DEL ASMA Y DE LA RINITIS ALERGICA.
GT199900167A 1998-10-01 1999-09-28 Nuevos bis-benzimidazoles. GT199900167A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10271198P 1998-10-01 1998-10-01
US11726999P 1999-01-26 1999-01-26
US12327799P 1999-03-09 1999-03-09

Publications (1)

Publication Number Publication Date
GT199900167A true GT199900167A (es) 2001-03-21

Family

ID=27379394

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199900167A GT199900167A (es) 1998-10-01 1999-09-28 Nuevos bis-benzimidazoles.

Country Status (9)

Country Link
EP (1) EP1117651A1 (es)
JP (1) JP2002526537A (es)
AR (1) AR021838A1 (es)
AU (1) AU5998199A (es)
CA (1) CA2346040A1 (es)
CO (1) CO5261509A1 (es)
GT (1) GT199900167A (es)
PE (1) PE20001057A1 (es)
WO (1) WO2000020401A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5370679A1 (es) * 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
BR0315166A (pt) * 2002-10-11 2005-08-16 Astrazeneca Ab Uso de um composto ou de um sal farmaceuticamente aceitável do mesmo, composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para produzir um efeito inibidor de 11betahsd1 em um animal de sangue quente, tal como o homem, que necessita de tratamento
WO2012027495A1 (en) 2010-08-27 2012-03-01 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
JP6248048B2 (ja) * 2012-01-09 2017-12-13 エックス−アールエックス，インコーポレーテッド キナーゼ阻害活性を有するトリプトリン誘導体及びその使用
ES2705247T3 (es) * 2013-03-14 2019-03-22 Univ Columbia 4-fenilpiperidinas, su preparación y uso
WO2016086060A1 (en) * 2014-11-26 2016-06-02 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008540A1 (en) * 1993-09-22 1995-03-30 The Wellcome Foundation Limited Bis(amidinobenzimidazolyl)alkanes as antiviral agents
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
JP2001519806A (ja) * 1997-04-07 2001-10-23 アクシス ファーマシューティカルズ，インコーポレイティド セリンプロテアーゼ活性、特にトリプターゼ活性に関連する疾病を処理するための化合物及び組成物
WO1999026932A1 (en) * 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. By amidino group substituted heterocyclic derivatives and their use as anticoagulants

Also Published As

Publication number Publication date
CA2346040A1 (en) 2000-04-13
WO2000020401A1 (en) 2000-04-13
EP1117651A1 (en) 2001-07-25
JP2002526537A (ja) 2002-08-20
PE20001057A1 (es) 2001-01-03
AR021838A1 (es) 2002-08-07
AU5998199A (en) 2000-04-26
CO5261509A1 (es) 2003-03-31

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