ES2059320T3 - Nuevos diarilalcanoides que tienen actividad como inhibidores de lipoxigenasa. - Google Patents
Nuevos diarilalcanoides que tienen actividad como inhibidores de lipoxigenasa.Info
- Publication number
- ES2059320T3 ES2059320T3 ES87105330T ES87105330T ES2059320T3 ES 2059320 T3 ES2059320 T3 ES 2059320T3 ES 87105330 T ES87105330 T ES 87105330T ES 87105330 T ES87105330 T ES 87105330T ES 2059320 T3 ES2059320 T3 ES 2059320T3
- Authority
- ES
- Spain
- Prior art keywords
- alkanoids
- activity
- new
- lipoxigenase inhibitors
- lipoxigenase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
- C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
- C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/38—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS DIARILALCANOIDES QUE TIENEN ACTIVIDAD COMO INHIBIDORES DE LA LIPOXIGENASA, NUEVAS COMPOSICIONES FARMACOLOGICAS DE ESTAS Y NUEVOS METODOS PARA USARLOS EN EL TRATAMIENTO DEL ASMA, ALERGIAS, ENFERMEDADES CARDIOVASCULARES, JAQUECAS, PSORIASIS Y ENFERMEDADES INMUNOINFLAMATORIAS. LOS COMPUESTOS DE ESTA INVENCION SON TAMBIEN UTILES COMO AGENTES CITOPROTECTORES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85100386A | 1986-04-11 | 1986-04-11 | |
US07/016,897 US4810716A (en) | 1986-04-11 | 1987-03-03 | Diarylalkanoids having activity as lipoxygenase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2059320T3 true ES2059320T3 (es) | 1994-11-16 |
Family
ID=26689193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87105330T Expired - Lifetime ES2059320T3 (es) | 1986-04-11 | 1987-04-10 | Nuevos diarilalcanoides que tienen actividad como inhibidores de lipoxigenasa. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4810716A (es) |
EP (1) | EP0241043B1 (es) |
CA (1) | CA1303048C (es) |
DE (1) | DE3787192T2 (es) |
ES (1) | ES2059320T3 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5077411A (en) * | 1986-04-11 | 1991-12-31 | Warner-Lambert Co. | Dairylalkanoids having activity as lipoxygenase inhibitors |
US4971959A (en) * | 1987-04-14 | 1990-11-20 | Warner-Lambert Company | Trisubstituted phenyl analogs having activity for congestive heart failure |
US5461075A (en) * | 1988-06-17 | 1995-10-24 | The Procter & Gamble Company | Use of vanilloids for the prevention of lesions due to herpes simplex infections |
US5120538A (en) * | 1990-02-05 | 1992-06-09 | Pt Darya-Varia Laboratoria | Combinations of compounds isolated from curcuma spp as anti-inflammatory agents |
US5234939A (en) * | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents |
US5234937A (en) * | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxphenyl oxazolyl methanones and related compounds as antiinflammatory agents |
US5086064A (en) * | 1990-03-27 | 1992-02-04 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents |
US5187175A (en) * | 1992-03-06 | 1993-02-16 | Warner-Lambert Company | 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
JPH08165267A (ja) * | 1994-12-14 | 1996-06-25 | Yakult Honsha Co Ltd | ジアリルヘプタノイド誘導体およびこれを含有する抗炎症剤 |
US5811453A (en) * | 1994-12-23 | 1998-09-22 | Alcon Laboratories, Inc. | Viscoelastic compositions and methods of use |
US5643943A (en) * | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
US5607966A (en) * | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
US5767147A (en) * | 1995-04-21 | 1998-06-16 | The Regents Of The University Of California | Inhibition of glutathione transferase by haloenol lactones |
US5741926A (en) * | 1997-02-12 | 1998-04-21 | Shaman Pharmaceuticals, Inc. | Aniline derivatives having antihyperglycemic activity |
US6194432B1 (en) * | 1998-10-13 | 2001-02-27 | Fred D. Sheftell | Prevention and treatment of migraine, cluster and other recurrent headaches using leukotriene antagonist drugs |
LT2486942T (lt) | 2004-11-24 | 2019-01-25 | Meda Pharmaceuticals Inc. | Kompozicijos, apimančios azelastiną ir jų panaudojimo būdai |
US8758816B2 (en) * | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
EP1858865B1 (en) | 2005-03-10 | 2009-09-16 | Pfizer Inc. | Substituted n-sulfonylaminophenylethyl-2-phenoxy acetamide compounds |
GB0613518D0 (en) * | 2006-07-06 | 2006-08-16 | Phytopharm Plc | Chemical compounds |
CA3016289A1 (en) * | 2016-03-03 | 2017-09-08 | Universite De Moncton | Modulators of lipoxygenase and cyclooxygenase enzyme activity |
CN114853587B (zh) * | 2022-04-25 | 2024-03-12 | 南京工业大学 | 一种生物基双酚、生物基环氧树脂单体及其树脂的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2381765A2 (fr) * | 1977-02-23 | 1978-09-22 | Unicler | Alcools et cetones a-ethyleniques, leur preparation et leur application comme medicaments |
ATE2043T1 (de) * | 1978-06-08 | 1983-01-15 | Shell Internationale Research Maatschappij B.V. | Benzoinoxime-derivate, verfahren zu ihrer herstellung, zusammensetzungen die solche derivate enthalten und ihre verwendung als fungizide. |
JPS5998026A (ja) * | 1982-11-25 | 1984-06-06 | Rikagaku Kenkyusho | プロスタグランジン生合成阻害物質 |
DD235450B1 (de) * | 1983-12-29 | 1988-02-03 | Humboldt Uni Z Berlin | Verfahren zur herstellung neuer 1-(2-hydroxyaryl)-alkan-1-on-oxime |
EP0464859A1 (en) * | 1984-05-23 | 1992-01-08 | Green Cross Corporation | A lipoxygenase inhibitor |
-
1987
- 1987-03-03 US US07/016,897 patent/US4810716A/en not_active Expired - Fee Related
- 1987-03-13 CA CA000532053A patent/CA1303048C/en not_active Expired - Fee Related
- 1987-04-10 ES ES87105330T patent/ES2059320T3/es not_active Expired - Lifetime
- 1987-04-10 EP EP87105330A patent/EP0241043B1/en not_active Expired - Lifetime
- 1987-04-10 DE DE87105330T patent/DE3787192T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3787192T2 (de) | 1994-01-20 |
EP0241043A2 (en) | 1987-10-14 |
CA1303048C (en) | 1992-06-09 |
US4810716A (en) | 1989-03-07 |
EP0241043A3 (en) | 1988-09-14 |
DE3787192D1 (de) | 1993-10-07 |
EP0241043B1 (en) | 1993-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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