GR69706B - - Google Patents

Info

Publication number
GR69706B
GR69706B GR59823A GR790159823A GR69706B GR 69706 B GR69706 B GR 69706B GR 59823 A GR59823 A GR 59823A GR 790159823 A GR790159823 A GR 790159823A GR 69706 B GR69706 B GR 69706B
Authority
GR
Greece
Application number
GR59823A
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of GR69706B publication Critical patent/GR69706B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR59823A 1978-08-15 1979-08-13 GR69706B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7833431 1978-08-15
GB7848348 1978-12-13

Publications (1)

Publication Number Publication Date
GR69706B true GR69706B (el) 1982-07-09

Family

ID=26268543

Family Applications (1)

Application Number Title Priority Date Filing Date
GR59823A GR69706B (el) 1978-08-15 1979-08-13

Country Status (9)

Country Link
US (1) US4296114A (el)
EP (1) EP0008864A1 (el)
AU (1) AU4985379A (el)
DK (1) DK338379A (el)
FI (1) FI792507A (el)
GR (1) GR69706B (el)
IL (1) IL58038A0 (el)
NO (1) NO792653L (el)
PT (1) PT70064A (el)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030795A3 (en) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives
DE3032994A1 (de) * 1980-09-02 1982-04-22 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyrazino-azepine, deren herstellung und diese sie enthaltende arzneimittel
JPS62198671A (ja) * 1986-02-25 1987-09-02 Toyo Jozo Co Ltd １−置換アルキル１，２−ジヒドロ−２−ピラジノン誘導体
JPS62281878A (ja) * 1986-02-26 1987-12-07 Taisho Pharmaceut Co Ltd アザアントラセン化合物
JPH0678319B2 (ja) * 1986-03-11 1994-10-05 東ソー株式会社 キノキサリノン誘導体
JPS6450868A (en) * 1987-08-21 1989-02-27 Toyo Jozo Kk 1-substituted alkyl-2-oxo-1,2-dihydroquinoxaline derivative
JPH0276860A (ja) * 1987-10-05 1990-03-16 Toyo Jozo Co Ltd ６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
GB9413975D0 (en) * 1994-07-11 1994-08-31 Fujisawa Pharmaceutical Co New heterobicyclic derivatives
AU9049391A (en) * 1990-12-20 1992-07-22 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
FR2696456B1 (fr) * 1992-10-07 1995-01-06 Pf Medicament Dérivés de dihydro-1,2 oxo amino-3 quinoxalines, leur préparation et leur application en thérapeutique.
DE4340045A1 (de) * 1993-11-24 1995-06-01 Basf Ag Neue Chinoxaline und Arzneimittel daraus
AU1599395A (en) * 1994-01-03 1995-08-01 Cocensys, Inc. 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor
GB2291422A (en) * 1994-07-18 1996-01-24 Fujisawa Pharmaceutical Co 4-phenyl-pyrido[2,3-b]pyrazin-4-ones
FR2731221B1 (fr) * 1995-03-01 1997-05-30 Pf Medicament Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
GB9526558D0 (en) * 1995-12-27 1996-02-28 Fujisawa Pharmaceutical Co Heterobicyclic derivatives
ZA973884B (en) * 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
EP1380298A3 (en) * 1996-05-23 2004-04-07 Bristol-Myers Squibb Pharma Company Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders, anorexia, inflammation
US5869487A (en) * 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
IL142147A0 (en) * 1998-09-29 2002-03-10 Fujisawa Pharmaceutical Co Methanesulfonate pyridopyrazine derivatives and pharmaceutical compositions containing the same
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
JP2003501389A (ja) 1999-06-04 2003-01-14 メルク エンド カムパニー インコーポレーテッド トロンビン阻害物質
EP1392309B1 (en) * 2001-05-14 2007-01-17 Bristol-Myers Squibb Company Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands
SE0302323D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302324D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
CA2540638A1 (en) * 2003-09-30 2005-04-14 Janssen Pharmaceutica N.V. Quinoxaline compounds
MXPA06005019A (es) * 2003-11-03 2006-07-06 Warner Lambert Co Nuevos inhibidores de la recaptacion de norpinefrina para el tratamiento de transtornos del sistema nervioso central.
CN1901917A (zh) * 2004-01-06 2007-01-24 詹森药业有限公司 作为糖原磷酸化酶抑制剂用于治疗糖尿病和肥胖症的(3－氧代－3，4－二氢－喹喔啉－2－基－氨基)－苯甲酰胺衍生物和相关化合物
MX2007001615A (es) * 2004-08-09 2007-04-10 Warner Lambert Co Nuevos inhibidores de la recaptacion de norepinefrina de quinoxalinona para el tratamiento de trastornos del sistema nervioso central.
US7601716B2 (en) * 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
DE102007050673A1 (de) 2007-10-19 2009-04-23 Friedrich-Schiller-Universität Jena Neue Hexaaza-acene und Verfahren zu ihrer Herstellung
JP2011502982A (ja) 2007-11-06 2011-01-27 アストラゼネカ・アクチエボラーグ 好中球エラスターゼの阻害剤としてのある種の２−ピラジノン誘導体およびその使用
JP5530370B2 (ja) * 2008-03-05 2014-06-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング インスリン分泌刺激剤としてのピラジノン誘導体、それらを得る方法および糖尿病を治療するためのそれらの使用
PT2247292T (pt) 2008-03-05 2017-07-17 Merck Patent Gmbh Derivados de piridopirazinonas como estimulantes da secreção de insulina, procedimentos para a sua obtenção e a sua utilização no tratamento da diabetes
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
TWI460159B (zh) 2009-06-26 2014-11-11 Ihara Chemical Ind Co 酮基丙二酸化合物或其水合物之製造方法
WO2011039528A1 (en) 2009-10-02 2011-04-07 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
JP5921500B2 (ja) 2013-07-19 2016-05-24 イハラケミカル工業株式会社 ケトマロン酸化合物の製造方法
KR102134407B1 (ko) 2014-02-17 2020-07-15 구미아이 가가쿠 고교 가부시키가이샤 유통 반응기를 사용한 케토말론산 화합물의 연속 제조방법
PL3394046T3 (pl) * 2015-12-24 2022-06-13 The Regents Of The University Of California Regulatory cftr i sposoby ich zastosowania
EP3672598A4 (en) 2017-08-24 2021-04-28 The Regents of The University of California OCULAR PHARMACEUTICAL COMPOSITIONS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1189552B (de) * 1959-07-03 1965-03-25 Donau Pharmazie Ges M B H Verfahren zur Herstellung von 2-Oxo-1, 2-dihydrochinoxalinen und von deren Salzen und quaternaeren Ammoniumverbindungen
US4077955A (en) * 1977-02-17 1978-03-07 E. R. Squibb & Sons, Inc. Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,2-b]-pyrazine carboxylic acids and esters

Also Published As

Publication number Publication date
EP0008864A1 (en) 1980-03-19
DK338379A (da) 1980-02-16
IL58038A0 (en) 1979-12-30
NO792653L (no) 1980-02-18
PT70064A (en) 1979-09-01
US4296114A (en) 1981-10-20
AU4985379A (en) 1980-02-21
FI792507A (fi) 1980-02-16

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