GR3031265T3 - PNA-synthesis using a base labile aminoprotecting group. - Google Patents

PNA-synthesis using a base labile aminoprotecting group.

Info

Publication number
GR3031265T3
GR3031265T3 GR990402363T GR990402363T GR3031265T3 GR 3031265 T3 GR3031265 T3 GR 3031265T3 GR 990402363 T GR990402363 T GR 990402363T GR 990402363 T GR990402363 T GR 990402363T GR 3031265 T3 GR3031265 T3 GR 3031265T3
Authority
GR
Greece
Prior art keywords
polymer
formula
pna
opt
coupling
Prior art date
Application number
GR990402363T
Other languages
English (en)
Inventor
Gerhard Dr Breipohl
Eugen Dr Uhlmann
Jochen Dr Knolle
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of GR3031265T3 publication Critical patent/GR3031265T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR990402363T 1994-03-14 1999-09-22 PNA-synthesis using a base labile aminoprotecting group. GR3031265T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4408533A DE4408533A1 (de) 1994-03-14 1994-03-14 PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe

Publications (1)

Publication Number Publication Date
GR3031265T3 true GR3031265T3 (en) 1999-12-31

Family

ID=6512697

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990402363T GR3031265T3 (en) 1994-03-14 1999-09-22 PNA-synthesis using a base labile aminoprotecting group.

Country Status (12)

Country Link
US (2) US6121418A (el)
EP (1) EP0672701B1 (el)
JP (1) JP4098836B2 (el)
AT (1) ATE182602T1 (el)
AU (1) AU683714B2 (el)
CA (1) CA2144473C (el)
DE (2) DE4408533A1 (el)
DK (1) DK0672701T3 (el)
ES (1) ES2136755T3 (el)
FI (1) FI120262B (el)
GR (1) GR3031265T3 (el)
NO (1) NO321035B1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7825215B1 (en) * 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
US6133444A (en) 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
JP2001518054A (ja) 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド Ｐｎａ−ｄｎａキメラと、このキメラ合成用のｐｎａシントン
DE19712530A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren
US20030228619A1 (en) * 2002-06-10 2003-12-11 Xenoport, Inc. Peptide nucleic acids as tags in encoded libraries
WO2004022578A2 (en) * 2002-09-08 2004-03-18 Applera Corporation Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
AU2007210014B2 (en) * 2006-02-01 2012-11-01 Merck Sharp & Dohme Corp. Potassium channel inhibitors
CA2832553A1 (en) 2011-04-08 2012-10-11 Srinivas RAPIREDDY Conformationally-preorganized, minipeg-containing gamma-peptide nucleic acids
CN104211619B (zh) * 2014-08-19 2016-08-17 苏州维泰生物技术有限公司 一种N-(2-Fmoc-氨乙基)甘氨酸甲酯盐酸盐的合成方法
JP2020511550A (ja) * 2017-03-23 2020-04-16 トゥルーコード ジーン リペアー， インコーポレイテッド 直交保護エステル部分を有するペプチド核酸（ｐｎａ）モノマー

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT41715A (en) * 1984-12-28 1987-05-28 Monsanto Co Process for preparing n-substituted alpha-aminoacids and derivatives thereof
DE3635670A1 (de) 1986-10-21 1988-04-28 Hoechst Ag Synthese von peptid-aminoalkylamiden und peptidhydraziden mittels festphasenmethode
DE3713433A1 (de) 1987-04-22 1988-11-03 Werner Grossmann Einrichtung zum entfernen von schmutzteilchen vom plattenzylinder einer offsetdruckmaschine
DE3887670D1 (de) 1987-12-22 1994-03-17 Hoechst Ag Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode.
DE4016596A1 (de) 1990-05-23 1991-11-28 Hoechst Ag Ein neues kupplungsreagenz fuer die peptidsynthese
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis

Also Published As

Publication number Publication date
ATE182602T1 (de) 1999-08-15
US6121418A (en) 2000-09-19
AU1480095A (en) 1995-09-21
ES2136755T3 (es) 1999-12-01
NO950958D0 (no) 1995-03-13
JPH07291909A (ja) 1995-11-07
NO950958L (no) 1995-09-15
CA2144473C (en) 2008-07-15
NO321035B1 (no) 2006-03-06
FI951129A (fi) 1995-09-15
AU683714B2 (en) 1997-11-20
DE4408533A1 (de) 1995-09-28
FI120262B (fi) 2009-08-31
CA2144473A1 (en) 1995-09-15
US6316595B1 (en) 2001-11-13
FI951129A0 (fi) 1995-03-10
DE59506432D1 (de) 1999-09-02
EP0672701B1 (de) 1999-07-28
DK0672701T3 (da) 2000-01-03
JP4098836B2 (ja) 2008-06-11
EP0672701A1 (de) 1995-09-20

Similar Documents

Publication Publication Date Title
GR3030883T3 (en) PNA-synthesis using an aminoprotecting group which is labile against weak acids.
GR3031265T3 (en) PNA-synthesis using a base labile aminoprotecting group.
US5962674A (en) Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
HUP0102900A2 (hu) Javított szilárd fázisú peptidszintézis és a szintézisben alkalmazható anyagok
JP2003530311A5 (el)
HUP0203149A2 (en) Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
Hernández et al. Synthesis and ring‐opening (co) polymerization of L‐lysine N‐carboxyanhydrides containing labile side‐chain protective groups
Geckeler Soluble polymer supports for liquid-phase synthesis
US6172226B1 (en) Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
WO2005108411A2 (en) Substituted pixyl protecting groups for oligonucleotide synthesis
CA2245496A1 (en) Receptor protein designated 2f1
SG90120A1 (en) Process of preparing curable compositions and compositions therefrom
EP0702682B1 (en) Process for the preparation of amino acid esters of nucleoside analogues
CA2210031A1 (en) Solid phase synthesis of oligonucleotides
Wang et al. Solid phase synthesis of neutral oligonucleotide analogues
Uhlmann et al. Synthesis of polyamide nucleic acids (PNAs), PNA/DNA-chimeras and phosphonic ester nucleic acids (PHONAs)
CA2406168A1 (en) Polyamide nucleic acid derivatives, agents and methods for producing same
Sigmund et al. A new type of fluorescence labeling of nucleosides, nucleotides and oligonucleotides
Adamiak et al. STUDIES ON OLIGORIBONUCLEOTIDES
Ikeda et al. Facile synthesis of puromycin-tethered oligonucleotides at the 3′-end
CA1179954A (en) Process for de-cyanoethylating blocked nucleotides
JPS6163696A (ja) 新しいペプチド
Repkova et al. Oligoribonucleotides containing an aminoalkyl group at the N (4) atom of cytosine as precursors of new reagents for site-specific modifications of biopolymers
CS260187B1 (cs) Způsob výroby polyaramidů
Van Hout et al. Method for the Continuous Preparation of Aromatic Polycarbonate Having a High Molecular Weight