GR3006211T3 - - Google Patents

Info

Publication number
GR3006211T3
GR3006211T3 GR920402021T GR920402021T GR3006211T3 GR 3006211 T3 GR3006211 T3 GR 3006211T3 GR 920402021 T GR920402021 T GR 920402021T GR 920402021 T GR920402021 T GR 920402021T GR 3006211 T3 GR3006211 T3 GR 3006211T3
Authority
GR
Greece
Prior art keywords
drug
conjugate
monoclonal antibody
antitumor drug
antibody conjugate
Prior art date
Application number
GR920402021T
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3006211T3 publication Critical patent/GR3006211T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
GR920402021T 1987-11-23 1992-11-12 GR3006211T3 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/124,313 US4952394A (en) 1987-11-23 1987-11-23 Drug-monoclonal antibody conjugates

Publications (1)

Publication Number Publication Date
GR3006211T3 true GR3006211T3 (el) 1993-06-21

Family

ID=22414122

Family Applications (1)

Application Number Title Priority Date Filing Date
GR920402021T GR3006211T3 (el) 1987-11-23 1992-11-12

Country Status (16)

Country Link
US (1) US4952394A (el)
EP (1) EP0317957B1 (el)
JP (1) JPH02111731A (el)
KR (1) KR910005887B1 (el)
AT (1) ATE81986T1 (el)
AU (1) AU617380B2 (el)
CA (1) CA1303524C (el)
DE (1) DE3875700T2 (el)
DK (1) DK651088A (el)
FI (1) FI885361A (el)
GR (1) GR3006211T3 (el)
IL (1) IL88428A0 (el)
NO (1) NO169958C (el)
NZ (1) NZ226955A (el)
PT (1) PT89062B (el)
ZA (1) ZA886811B (el)

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US7691962B2 (en) * 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
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AU2005281359A1 (en) * 2004-08-26 2006-03-16 Apparao Satyam Prodrugs and codrugs containing novel bio-cleavable disulfide linkers
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BRPI0617546A2 (pt) * 2005-09-26 2011-07-26 Medarex Inc conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
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JP5532486B2 (ja) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
CA3128656A1 (en) 2007-08-22 2009-02-26 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
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US9155801B2 (en) 2009-05-28 2015-10-13 The United States Government As Represented By The Department Of Veterans Affairs Amino acid sequences which enhance peptide conjugate solubility
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KR20220147720A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
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Also Published As

Publication number Publication date
AU2582488A (en) 1989-05-25
NO885199L (no) 1989-05-24
NO885199D0 (no) 1988-11-22
NZ226955A (en) 1991-11-26
US4952394A (en) 1990-08-28
KR910005887B1 (ko) 1991-08-06
AU617380B2 (en) 1991-11-28
NO169958B (no) 1992-05-18
FI885361A0 (fi) 1988-11-18
FI885361A (fi) 1989-05-24
EP0317957B1 (en) 1992-11-04
JPH02111731A (ja) 1990-04-24
EP0317957A3 (en) 1989-07-05
ATE81986T1 (de) 1992-11-15
KR890007724A (ko) 1989-07-05
PT89062A (pt) 1989-11-30
ZA886811B (en) 1989-07-26
IL88428A0 (en) 1989-06-30
DK651088A (da) 1989-05-24
NO169958C (no) 1992-08-26
CA1303524C (en) 1992-06-16
DE3875700D1 (de) 1992-12-10
EP0317957A2 (en) 1989-05-31
DK651088D0 (da) 1988-11-22
DE3875700T2 (de) 1993-03-18
PT89062B (pt) 1993-07-30

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