ATE323703T1 - Synthese von verbindungen die zur herstellung von ketorolac dienen - Google Patents

Synthese von verbindungen die zur herstellung von ketorolac dienen

Info

Publication number
ATE323703T1
ATE323703T1 AT99937220T AT99937220T ATE323703T1 AT E323703 T1 ATE323703 T1 AT E323703T1 AT 99937220 T AT99937220 T AT 99937220T AT 99937220 T AT99937220 T AT 99937220T AT E323703 T1 ATE323703 T1 AT E323703T1
Authority
AT
Austria
Prior art keywords
ketorolac
synthesis
produce
compounds used
compound
Prior art date
Application number
AT99937220T
Other languages
English (en)
Inventor
John R Duchek
Henry J Buehler
Douglas C Caskey
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE323703T1 publication Critical patent/ATE323703T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT99937220T 1998-07-10 1999-07-08 Synthese von verbindungen die zur herstellung von ketorolac dienen ATE323703T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9240898P 1998-07-10 1998-07-10

Publications (1)

Publication Number Publication Date
ATE323703T1 true ATE323703T1 (de) 2006-05-15

Family

ID=22233070

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99937220T ATE323703T1 (de) 1998-07-10 1999-07-08 Synthese von verbindungen die zur herstellung von ketorolac dienen

Country Status (8)

Country Link
US (3) US6376681B1 (de)
EP (1) EP1097152B1 (de)
JP (1) JP2002520313A (de)
AT (1) ATE323703T1 (de)
AU (1) AU5209699A (de)
DE (1) DE69930940T2 (de)
ES (1) ES2259475T3 (de)
WO (1) WO2000002855A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070906A1 (en) * 1999-11-30 2005-03-31 Ron Clark Endosteal tibial ligament fixation with adjustable tensioning
GB0000569D0 (en) 2000-01-12 2000-03-01 Ici Plc Organometallic compositions
GB0112901D0 (en) 2001-05-29 2001-07-18 Ici Plc Organometallic compositions
US7341502B2 (en) * 2002-07-18 2008-03-11 Micron Technology, Inc. Methods and systems for planarizing workpieces, e.g., microelectronic workpieces
LU91605B1 (fr) 2009-09-07 2011-03-08 Terra Nobilis S A Procédé de sécurisation du stockage de déchets radioactifs de longue vie.
CN113087619A (zh) * 2020-01-09 2021-07-09 鲁南制药集团股份有限公司 一种酮咯酸氨丁三醇中间体化合物
CN113087626A (zh) * 2020-01-09 2021-07-09 鲁南制药集团股份有限公司 一种酮咯酸氨丁三醇中间体化合物ⅵ
CN113087710A (zh) * 2020-01-09 2021-07-09 鲁南制药集团股份有限公司 一种酮咯酸氨丁三醇中间体的制备方法
CN112898307A (zh) * 2021-02-07 2021-06-04 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种酮咯酸杂质c及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
CH616808B (fr) * 1978-06-14 Piquerez Sa Ervin Procede de fabrication d'une boite de montre et boite de montre obtenue par ce procede.
US4458081A (en) * 1980-10-20 1984-07-03 Syntex (U.S.A.) Inc. 5-Aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-decarboxylates
US5082951A (en) * 1990-10-12 1992-01-21 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor
KR0140134B1 (ko) * 1994-11-16 1998-06-01 강재헌 피롤리진 유도체의 제조방법

Also Published As

Publication number Publication date
EP1097152A2 (de) 2001-05-09
US20030036660A1 (en) 2003-02-20
US6559319B2 (en) 2003-05-06
ES2259475T3 (es) 2006-10-01
DE69930940T2 (de) 2006-12-14
EP1097152B1 (de) 2006-04-19
US20020137945A1 (en) 2002-09-26
DE69930940D1 (de) 2006-05-24
JP2002520313A (ja) 2002-07-09
WO2000002855A2 (en) 2000-01-20
US6489491B2 (en) 2002-12-03
US6376681B1 (en) 2002-04-23
WO2000002855A3 (en) 2000-02-24
AU5209699A (en) 2000-02-01

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