GEP20084571B - Triazole derivatives as vasopressin antagonists - Google Patents
Triazole derivatives as vasopressin antagonistsInfo
- Publication number
- GEP20084571B GEP20084571B GEAP20049469A GEAP2004009469A GEP20084571B GE P20084571 B GEP20084571 B GE P20084571B GE AP20049469 A GEAP20049469 A GE AP20049469A GE AP2004009469 A GEAP2004009469 A GE AP2004009469A GE P20084571 B GEP20084571 B GE P20084571B
- Authority
- GE
- Georgia
- Prior art keywords
- triazole derivatives
- vasopressin antagonists
- vasopressin
- antagonists
- derivati
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0329693A GB0329693D0 (en) | 2003-12-22 | 2003-12-22 | Compounds useful in therapy |
GB0408789A GB0408789D0 (en) | 2004-04-20 | 2004-04-20 | Triazole derivatives |
PCT/IB2004/004059 WO2005063754A1 (en) | 2003-12-22 | 2004-12-09 | Triazole derivatives as vasopressin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
GEP20084571B true GEP20084571B (en) | 2008-12-25 |
Family
ID=34740750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GEAP20049469A GEP20084571B (en) | 2003-12-22 | 2004-12-09 | Triazole derivatives as vasopressin antagonists |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1701959A1 (es) |
JP (1) | JP4698604B2 (es) |
KR (1) | KR100854872B1 (es) |
AP (1) | AP2331A (es) |
AR (1) | AR047340A1 (es) |
AU (1) | AU2004309164B2 (es) |
BR (1) | BRPI0417267A (es) |
CA (1) | CA2551038C (es) |
CR (1) | CR8481A (es) |
DO (1) | DOP2004001062A (es) |
EA (1) | EA010132B1 (es) |
EC (1) | ECSP066647A (es) |
GE (1) | GEP20084571B (es) |
HK (1) | HK1095822A1 (es) |
IL (1) | IL176349A (es) |
IS (1) | IS8472A (es) |
MA (1) | MA28393B1 (es) |
NL (1) | NL1027833C2 (es) |
NO (1) | NO20063380L (es) |
OA (1) | OA13347A (es) |
PA (1) | PA8620501A1 (es) |
PE (1) | PE20051051A1 (es) |
TW (1) | TWI287541B (es) |
UY (1) | UY28693A1 (es) |
WO (1) | WO2005063754A1 (es) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
US7880009B2 (en) | 2004-05-26 | 2011-02-01 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
US7897632B2 (en) | 2006-03-09 | 2011-03-01 | Eisai R&D Management Co., Ltd. | Multi-cyclic cinnamide derivatives |
US7923563B2 (en) | 2004-10-26 | 2011-04-12 | Eisai R&D Management Co., Ltd. | Amorphous object of cinnamide compound |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
US9453000B2 (en) | 2007-08-31 | 2016-09-27 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
CA2580787A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
CN101083992A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物 |
AR051092A1 (es) * | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
EP2269610A3 (en) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
CA2616937A1 (en) * | 2005-07-29 | 2007-02-08 | F. Hoffman-La Roche Ag | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
WO2008013622A2 (en) | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
CA2670671A1 (en) * | 2006-12-07 | 2008-06-12 | F. Hoffmann-La Roche Ag | Spiro-piperidine derivatives |
CA2670674A1 (en) | 2006-12-07 | 2008-06-12 | F. Hoffmann-La Roche Ag | Spiro-piperidine derivatives as via receptor antagonists |
JP2010513385A (ja) * | 2006-12-22 | 2010-04-30 | エフ.ホフマン−ラ ロシュ アーゲー | スピロ−ピペリジン誘導体 |
BRPI0720827A2 (pt) * | 2006-12-29 | 2014-03-04 | Hoffmann La Roche | Derivados de azaspiro |
CL2008000582A1 (es) | 2007-02-28 | 2008-06-27 | Eisai R&D Man Co Ltd | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
WO2010051245A1 (en) | 2008-11-03 | 2010-05-06 | Merck Sharp & Dohme Corp. | Benzimidazole and aza-benzimidazole carboxamides |
NZ608729A (en) | 2010-10-01 | 2014-08-29 | Taisho Pharmaceutical Co Ltd | 1,2,4-triazolone derivative |
EP2970104B1 (en) | 2013-03-14 | 2019-04-24 | Zeno Royalties & Milestones, LLC | Bicyclic analgesic compounds |
JP6542794B2 (ja) | 2013-12-12 | 2019-07-10 | ゼノ ロイアルティー アンド マイルストーンズ リミテッド ライアビリティー カンパニー | 二環式アルキル化合物、および合成 |
CA2942144C (en) | 2014-03-07 | 2023-08-22 | Kalyra Pharmaceuticals, Inc. | Propellane derivates and synthesis |
CN106999451B (zh) * | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
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AU2000223275A1 (en) * | 2000-02-08 | 2001-08-20 | Yamanouchi Pharmaceutical Co..Ltd. | Novel triazole derivatives |
BR0110961A (pt) * | 2000-05-19 | 2004-06-29 | Merck Patent Gmbh | Derivados de triazol |
-
2004
- 2004-12-09 GE GEAP20049469A patent/GEP20084571B/en unknown
- 2004-12-09 JP JP2006546356A patent/JP4698604B2/ja not_active Expired - Fee Related
- 2004-12-09 AP AP2006003631A patent/AP2331A/xx active
- 2004-12-09 KR KR1020067012328A patent/KR100854872B1/ko not_active IP Right Cessation
- 2004-12-09 CA CA2551038A patent/CA2551038C/en not_active Expired - Fee Related
- 2004-12-09 EP EP04801354A patent/EP1701959A1/en not_active Withdrawn
- 2004-12-09 EA EA200600925A patent/EA010132B1/ru not_active IP Right Cessation
- 2004-12-09 WO PCT/IB2004/004059 patent/WO2005063754A1/en active Application Filing
- 2004-12-09 BR BRPI0417267-1A patent/BRPI0417267A/pt active Search and Examination
- 2004-12-09 AU AU2004309164A patent/AU2004309164B2/en not_active Ceased
- 2004-12-09 OA OA1200600206A patent/OA13347A/en unknown
- 2004-12-17 TW TW093139507A patent/TWI287541B/zh active
- 2004-12-21 UY UY28693A patent/UY28693A1/es unknown
- 2004-12-21 AR ARP040104826A patent/AR047340A1/es not_active Application Discontinuation
- 2004-12-21 NL NL1027833A patent/NL1027833C2/nl not_active IP Right Cessation
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- 2006-05-18 IS IS8472A patent/IS8472A/is unknown
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- 2006-06-15 IL IL176349A patent/IL176349A/en not_active IP Right Cessation
- 2006-06-22 MA MA29125A patent/MA28393B1/fr unknown
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7880009B2 (en) | 2004-05-26 | 2011-02-01 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
US7923563B2 (en) | 2004-10-26 | 2011-04-12 | Eisai R&D Management Co., Ltd. | Amorphous object of cinnamide compound |
US7897632B2 (en) | 2006-03-09 | 2011-03-01 | Eisai R&D Management Co., Ltd. | Multi-cyclic cinnamide derivatives |
US7973033B2 (en) | 2006-03-09 | 2011-07-05 | Eisai R&D Management Co., Ltd. | Multi-cyclic cinnamide derivatives |
US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
US9453000B2 (en) | 2007-08-31 | 2016-09-27 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
Also Published As
Publication number | Publication date |
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IL176349A0 (en) | 2006-10-05 |
BRPI0417267A (pt) | 2007-04-17 |
KR100854872B1 (ko) | 2008-08-28 |
UY28693A1 (es) | 2005-07-29 |
WO2005063754A1 (en) | 2005-07-14 |
NL1027833A1 (nl) | 2005-06-23 |
IL176349A (en) | 2011-11-30 |
AU2004309164B2 (en) | 2007-11-15 |
CR8481A (es) | 2007-12-04 |
MA28393B1 (fr) | 2007-01-02 |
DOP2004001062A (es) | 2005-06-30 |
IS8472A (is) | 2006-05-18 |
EA010132B1 (ru) | 2008-06-30 |
CA2551038C (en) | 2010-04-27 |
NL1027833C2 (nl) | 2006-03-06 |
TWI287541B (en) | 2007-10-01 |
JP2007515468A (ja) | 2007-06-14 |
PA8620501A1 (es) | 2005-08-04 |
EP1701959A1 (en) | 2006-09-20 |
NO20063380L (no) | 2006-09-22 |
HK1095822A1 (en) | 2007-07-06 |
AR047340A1 (es) | 2006-01-18 |
ECSP066647A (es) | 2006-10-25 |
AP2006003631A0 (en) | 2006-06-30 |
PE20051051A1 (es) | 2005-12-17 |
AU2004309164A1 (en) | 2005-07-14 |
CA2551038A1 (en) | 2005-07-14 |
AP2331A (en) | 2011-12-05 |
JP4698604B2 (ja) | 2011-06-08 |
KR20060101546A (ko) | 2006-09-25 |
TW200528099A (en) | 2005-09-01 |
OA13347A (en) | 2007-04-13 |
EA200600925A1 (ru) | 2006-12-29 |
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