BR0110961A - Derivados de triazol - Google Patents
Derivados de triazolInfo
- Publication number
- BR0110961A BR0110961A BR0110961-8A BR0110961A BR0110961A BR 0110961 A BR0110961 A BR 0110961A BR 0110961 A BR0110961 A BR 0110961A BR 0110961 A BR0110961 A BR 0110961A
- Authority
- BR
- Brazil
- Prior art keywords
- triazole derivatives
- useful
- inhibiting activity
- glycine transport
- transport inhibiting
- Prior art date
Links
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- 239000004471 Glycine Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
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- Hospice & Palliative Care (AREA)
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- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE TRIAZOL". A invenção refere-se a derivados de triazol que têm uma atividade de inibição de transporte da glicina e são úteis como drogas; e novos derivados da triazol. Devido a ter uma excelente atividade de inibição do transporte da glicina, os derivados da triazol acima são úteis como remédios.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2000148419 | 2000-05-19 | ||
JP2001047921 | 2001-02-23 | ||
PCT/JP2001/004128 WO2001087855A1 (fr) | 2000-05-19 | 2001-05-17 | Derives de triazole |
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BR0110961A true BR0110961A (pt) | 2004-06-29 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR0110961-8A BR0110961A (pt) | 2000-05-19 | 2001-05-17 | Derivados de triazol |
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US (1) | US7084164B2 (pt) |
EP (1) | EP1293503A4 (pt) |
JP (1) | JP3873746B2 (pt) |
KR (1) | KR100776119B1 (pt) |
CN (1) | CN1237055C (pt) |
AR (1) | AR030933A1 (pt) |
AU (1) | AU2001256769A1 (pt) |
BR (1) | BR0110961A (pt) |
CA (1) | CA2409819C (pt) |
CZ (1) | CZ20023763A3 (pt) |
HU (1) | HUP0302415A2 (pt) |
MX (1) | MXPA02011373A (pt) |
NO (1) | NO20025517L (pt) |
PL (1) | PL359340A1 (pt) |
RU (1) | RU2002133666A (pt) |
SK (1) | SK16242002A3 (pt) |
WO (1) | WO2001087855A1 (pt) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR032653A1 (es) * | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
DE10149370A1 (de) * | 2001-10-06 | 2003-04-10 | Merck Patent Gmbh | Pyrazolderivate |
US20050154039A1 (en) * | 2001-11-28 | 2005-07-14 | Marie-Odile Glacera Contour | 5-Sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine |
WO2003104265A1 (ja) * | 2002-05-13 | 2003-12-18 | 大正製薬株式会社 | グリシントランスポーター阻害活性を有する化合物 |
US7084145B2 (en) | 2002-10-25 | 2006-08-01 | Pfizer Inc. | Triazole compounds useful in therapy |
GB0224919D0 (en) * | 2002-10-25 | 2002-12-04 | Pfizer Ltd | Triazole compounds useful in therapy |
JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
KR20060004967A (ko) * | 2003-04-30 | 2006-01-16 | 하. 룬트벡 아크티에 셀스카브 | 방향족 옥시페닐 및 방향족 설파닐페닐 유도체 |
GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
EP1673355A1 (en) * | 2003-09-22 | 2006-06-28 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
US7291640B2 (en) | 2003-09-22 | 2007-11-06 | Pfizer Inc. | Substituted triazole derivatives as oxytocin antagonists |
US7745630B2 (en) | 2003-12-22 | 2010-06-29 | Justin Stephen Bryans | Triazolyl piperidine arginine vasopressin receptor modulators |
GEP20084571B (en) * | 2003-12-22 | 2008-12-25 | Pfizer | Triazole derivatives as vasopressin antagonists |
GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
EP1708718A1 (en) * | 2004-01-22 | 2006-10-11 | Pfizer Limited | Triazole derivatives which inhibit vasopressin antagonistic activity |
CA2558224A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
US7563905B2 (en) | 2004-03-12 | 2009-07-21 | Wyeth | Triazole derivatives and method of using the same to treat HIV infections |
ES2594874T3 (es) * | 2004-11-18 | 2016-12-23 | Synta Pharmaceuticals Corp. | Compuestos de triazol que modulan la actividad de HSP90 |
AP2007004047A0 (en) * | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
ES2313626T3 (es) * | 2005-03-21 | 2009-03-01 | Pfizer Limited | Derivados de triazol sustituidos como antagonistas de oxitocina. |
EP1863484A1 (en) * | 2005-03-21 | 2007-12-12 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
US20080188478A1 (en) * | 2005-04-26 | 2008-08-07 | Pfizer Inc. | Compounds Useful In Therapy |
EP2308852A1 (de) | 2005-08-21 | 2011-04-13 | Abbott GmbH & Co. KG | 5-Ring-Heteroaromaten-Verbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為p2x7調節劑之雙環雜芳基化合物與其用途 |
TW200811160A (en) * | 2006-07-14 | 2008-03-01 | Astellas Pharma Inc | Crystal of benzoxadiazole derivative |
WO2008143019A1 (en) * | 2007-05-17 | 2008-11-27 | Semiconductor Energy Laboratory Co., Ltd. | Triazole derivative, and light-emitting element, light-emitting device, and electronic device with the use of triazole derivative |
MY154000A (en) * | 2008-09-22 | 2015-04-30 | Cayman Chem Co | Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
EP2942346B1 (en) * | 2009-02-17 | 2020-05-06 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as cxcr2 modulators |
AU2011293612B2 (en) | 2010-08-23 | 2015-11-26 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
US8466181B2 (en) * | 2010-12-10 | 2013-06-18 | Hoffmann-La Roche Inc. | 1,2,3-triazole-imidazole compounds |
US9598395B2 (en) | 2012-03-23 | 2017-03-21 | The Regents Of The University Of California | Premature-termination-codons readthrough compounds |
WO2014104009A1 (ja) * | 2012-12-27 | 2014-07-03 | Hoya株式会社 | マスクブランク用基板処理装置、マスクブランク用基板処理方法、マスクブランク用基板の製造方法、マスクブランクの製造方法、及び転写用マスクの製造方法 |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
US9573936B2 (en) | 2015-05-20 | 2017-02-21 | Amgen Inc. | Triazole agonists of the APJ receptor |
US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
MA46824A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
EP3541804A1 (en) | 2016-11-16 | 2019-09-25 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
WO2018093580A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
EP3541805B1 (en) | 2016-11-16 | 2020-10-14 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
WO2018097944A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
EP3704122B1 (en) | 2017-11-03 | 2021-09-01 | Amgen Inc. | Fused triazole agonists of the apj receptor |
TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素V1a受體拮抗劑之三環化合物 |
HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
CN110467579B (zh) * | 2019-07-30 | 2020-08-25 | 浙江理工大学 | 一种5-三氟甲基取代的1,2,4-三氮唑化合物的制备方法 |
CN113004250B (zh) * | 2019-12-19 | 2022-07-26 | 上海森辉医药有限公司 | 一种制备取代的***衍生物的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3808283A1 (de) * | 1988-03-12 | 1989-09-21 | Boehringer Ingelheim Kg | Neue 3,4,5-substituierte 4h-1,2,4-triazole, ihre herstellung und verwendung |
DE4302051A1 (de) * | 1993-01-26 | 1994-07-28 | Thomae Gmbh Dr K | 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
GB9605027D0 (en) * | 1996-03-09 | 1996-05-08 | Pfizer Ltd | Quinoxalinediones |
AP982A (en) * | 1997-02-27 | 2001-07-16 | Pfizer | Quinoxalinediones. |
JP2000063363A (ja) * | 1998-08-12 | 2000-02-29 | Yamanouchi Pharmaceut Co Ltd | 新規なトリアゾール誘導体 |
AU2000223275A1 (en) | 2000-02-08 | 2001-08-20 | Yamanouchi Pharmaceutical Co..Ltd. | Novel triazole derivatives |
-
2001
- 2001-05-17 BR BR0110961-8A patent/BR0110961A/pt not_active Application Discontinuation
- 2001-05-17 MX MXPA02011373A patent/MXPA02011373A/es unknown
- 2001-05-17 CA CA002409819A patent/CA2409819C/en not_active Expired - Fee Related
- 2001-05-17 JP JP2001584251A patent/JP3873746B2/ja not_active Expired - Fee Related
- 2001-05-17 SK SK1624-2002A patent/SK16242002A3/sk unknown
- 2001-05-17 CZ CZ20023763A patent/CZ20023763A3/cs unknown
- 2001-05-17 CN CNB018096166A patent/CN1237055C/zh not_active Expired - Fee Related
- 2001-05-17 KR KR1020027015529A patent/KR100776119B1/ko not_active IP Right Cessation
- 2001-05-17 RU RU2002133666/04A patent/RU2002133666A/ru unknown
- 2001-05-17 AU AU2001256769A patent/AU2001256769A1/en not_active Abandoned
- 2001-05-17 EP EP01930192A patent/EP1293503A4/en not_active Withdrawn
- 2001-05-17 PL PL01359340A patent/PL359340A1/xx unknown
- 2001-05-17 WO PCT/JP2001/004128 patent/WO2001087855A1/ja not_active Application Discontinuation
- 2001-05-17 HU HU0302415A patent/HUP0302415A2/hu unknown
- 2001-05-18 AR ARP010102360A patent/AR030933A1/es unknown
-
2002
- 2002-11-18 NO NO20025517A patent/NO20025517L/no not_active Application Discontinuation
-
2005
- 2005-09-22 US US11/232,011 patent/US7084164B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO20025517D0 (no) | 2002-11-18 |
HUP0302415A2 (hu) | 2003-11-28 |
CA2409819C (en) | 2009-09-15 |
CN1429215A (zh) | 2003-07-09 |
AR030933A1 (es) | 2003-09-03 |
CA2409819A1 (en) | 2002-11-18 |
RU2002133666A (ru) | 2007-05-10 |
WO2001087855A1 (fr) | 2001-11-22 |
EP1293503A4 (en) | 2008-04-02 |
US7084164B2 (en) | 2006-08-01 |
KR100776119B1 (ko) | 2007-11-16 |
CN1237055C (zh) | 2006-01-18 |
SK16242002A3 (sk) | 2003-04-01 |
CZ20023763A3 (cs) | 2003-03-12 |
KR20030019386A (ko) | 2003-03-06 |
US20060025461A1 (en) | 2006-02-02 |
EP1293503A1 (en) | 2003-03-19 |
NO20025517L (no) | 2002-11-18 |
PL359340A1 (en) | 2004-08-23 |
JP3873746B2 (ja) | 2007-01-24 |
AU2001256769A1 (en) | 2001-11-26 |
MXPA02011373A (es) | 2003-06-26 |
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