GB969772A - Toxoids and their production - Google Patents

Toxoids and their production

Info

Publication number
GB969772A
GB969772A GB50861A GB50861A GB969772A GB 969772 A GB969772 A GB 969772A GB 50861 A GB50861 A GB 50861A GB 50861 A GB50861 A GB 50861A GB 969772 A GB969772 A GB 969772A
Authority
GB
United Kingdom
Prior art keywords
diphtheria
toxoids
aliphatic diamine
formaldehyde
vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB50861A
Inventor
Clifford George Pope
Frank Valentine Linggood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB50861A priority Critical patent/GB969772A/en
Priority to ES0273263A priority patent/ES273263A1/en
Priority to CH1513061A priority patent/CH455146A/en
Publication of GB969772A publication Critical patent/GB969772A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Toxoids are obtained from purified bacterial toxins by treating said toxins in an aqueous medium with formaldehyde in the presence of an aliphatic diamine of molecular weight below 200 which contains a primary or secondary amino group. The toxoids are believed to be represented by the formula [t] (CH2.Y)n, in which [t] represents the radical formed from a bacterial toxin molecule by the loss of one or more hydrogen atoms on groups reactive with formaldehyde, Y represents the radical formed by the loss of a hydrogen atom from an amino group of a molecule of an aliphatic diamine of molecular weight below 200, and n is a positive number. Specified aliphatic diamines, as defined above, are lysine and ethylenediamine. The said aliphatic diamines may be used in admixture with other amines, e.g. alanine. Examples illustrate the preparation of diphtheria toxoids, aqueous solutions of which may be used as diphtheria vaccines, including diphtheria-tetanus and diphtheria-pertussiotetanus vaccines. According to the Provisional Specification, arginine is a further example of a suitable aliphatic diamine, as defined above.
GB50861A 1961-01-05 1961-01-05 Toxoids and their production Expired GB969772A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB50861A GB969772A (en) 1961-01-05 1961-01-05 Toxoids and their production
ES0273263A ES273263A1 (en) 1961-01-05 1961-12-27 Toxoids and their production
CH1513061A CH455146A (en) 1961-01-05 1961-12-29 Process for making diphtheria toxoids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB50861A GB969772A (en) 1961-01-05 1961-01-05 Toxoids and their production

Publications (1)

Publication Number Publication Date
GB969772A true GB969772A (en) 1964-09-16

Family

ID=9705586

Family Applications (1)

Application Number Title Priority Date Filing Date
GB50861A Expired GB969772A (en) 1961-01-05 1961-01-05 Toxoids and their production

Country Status (3)

Country Link
CH (1) CH455146A (en)
ES (1) ES273263A1 (en)
GB (1) GB969772A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003206A1 (en) * 1992-07-31 1994-02-17 The Wellcome Foundation Limited Tetanus vaccine production
GB2495341A (en) * 2011-11-11 2013-04-10 Novartis Ag Fermentation medium for increased yield of Corynebacterium diphtheriae toxin, and uses of the toxin.
EP2592137A1 (en) 2011-11-11 2013-05-15 Novartis AG Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
DE102011118371A1 (en) 2011-11-11 2013-05-16 Novartis Ag Fermentation medium, useful e.g. to cultivate strain of Corynebacterium diphtheriae to prepare diphtheria toxin, comprises water, nitrogen source, carbon source and iron additive, where medium is free of ingredients from animal origin
GB2498112A (en) * 2011-11-11 2013-07-03 Novartis Ag Preparation of a diphtheria toxoid by incubating toxin concentrate with an amino acid and formaldehyde
DE102011122891A1 (en) 2011-11-11 2013-07-04 Novartis Ag Fermentation medium, used to cultivate strain of Corynebacterium diphtheriae and to prepare diphtheria toxin or its derivative that is used to prepare vaccine for humans, comprises water, nitrogen source, carbon source, and iron additive

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003206A1 (en) * 1992-07-31 1994-02-17 The Wellcome Foundation Limited Tetanus vaccine production
AU690518B2 (en) * 1992-07-31 1998-04-30 Evans Vaccines Limited Tetanus vaccine production
US6060067A (en) * 1992-07-31 2000-05-09 Medeva Pharma Limited Process for the preparation of tetanus toxoid vaccine
GB2495341A (en) * 2011-11-11 2013-04-10 Novartis Ag Fermentation medium for increased yield of Corynebacterium diphtheriae toxin, and uses of the toxin.
EP2592137A1 (en) 2011-11-11 2013-05-15 Novartis AG Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
DE102011118371A1 (en) 2011-11-11 2013-05-16 Novartis Ag Fermentation medium, useful e.g. to cultivate strain of Corynebacterium diphtheriae to prepare diphtheria toxin, comprises water, nitrogen source, carbon source and iron additive, where medium is free of ingredients from animal origin
WO2013068568A1 (en) 2011-11-11 2013-05-16 Novartis Ag Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
GB2498112A (en) * 2011-11-11 2013-07-03 Novartis Ag Preparation of a diphtheria toxoid by incubating toxin concentrate with an amino acid and formaldehyde
DE102011122891A1 (en) 2011-11-11 2013-07-04 Novartis Ag Fermentation medium, used to cultivate strain of Corynebacterium diphtheriae and to prepare diphtheria toxin or its derivative that is used to prepare vaccine for humans, comprises water, nitrogen source, carbon source, and iron additive
GB2495341B (en) * 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
JP2014500269A (en) * 2011-11-11 2014-01-09 ノバルティス アーゲー Fermentation medium without animal-derived components for the production of diphtheria toxoids suitable for use as human vaccines
US9040058B2 (en) 2011-11-11 2015-05-26 Glaxosmithkline Biologicals Sa Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use

Also Published As

Publication number Publication date
CH455146A (en) 1968-04-30
ES273263A1 (en) 1962-07-01

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