GB1129210A - Tricyclic n-alkylated derivatives of ethylamine - Google Patents

Tricyclic n-alkylated derivatives of ethylamine

Info

Publication number
GB1129210A
GB1129210A GB1039168A GB1039168A GB1129210A GB 1129210 A GB1129210 A GB 1129210A GB 1039168 A GB1039168 A GB 1039168A GB 1039168 A GB1039168 A GB 1039168A GB 1129210 A GB1129210 A GB 1129210A
Authority
GB
United Kingdom
Prior art keywords
group
hydrogen atom
alkyl radical
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1039168A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of GB1129210A publication Critical patent/GB1129210A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/16—Eight-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1,129,210. Tricyclic amines. C. F. BOEHRINGER & SOEHNE G.m.b.H. 6 April, 1967 [9 April, 1966], No. 10391/68. Divided out of 1,129,209. Heading C2C. Novel compounds of Formula I, in which X is an oxygen or sulphur atom or an ethylene or thiomethylene group, R 1 is a hydrogen atom or an hydroxy group, each of R 3 and R 4 is a hydrogen atom or a C 1-3 alkyl radical, R 5 is a C 1-3 alkyl group and R 2 is a hydrogen atom or R 1 and R 2 together represent a further valency bond, with the proviso that when X is an oxygen atom and R 1 and R 2 together represent a further valency bond, then R 5 must be an alkyl radical, and their acid-addition salts, are prepared (a) by reducing a compound of Formula II to convert the amido group into an amino group and, if desired, when R 1 is an hydroxy group, dehydrating the compound before or after reduction of the amido group, and thereafter, if desired, reducing the double bond so formed and, if desired, when R 4 is an alkyl radical, subsequently introducing or splitting off this subsequent, or (b) by N-alkylating a compound of Formula III.
GB1039168A 1966-04-09 1967-04-06 Tricyclic n-alkylated derivatives of ethylamine Expired GB1129210A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB0086610 1966-04-09

Publications (1)

Publication Number Publication Date
GB1129210A true GB1129210A (en) 1968-10-02

Family

ID=6983446

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1039168A Expired GB1129210A (en) 1966-04-09 1967-04-06 Tricyclic n-alkylated derivatives of ethylamine
GB1581767A Expired GB1129209A (en) 1966-04-09 1967-04-06 Tricyclic n-alkylated derivatives of acetamide

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1581767A Expired GB1129209A (en) 1966-04-09 1967-04-06 Tricyclic n-alkylated derivatives of acetamide

Country Status (4)

Country Link
AT (1) AT269883B (en)
DE (1) DE1568104C3 (en)
GB (2) GB1129210A (en)
NL (1) NL6703341A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056752A1 (en) * 1997-06-11 1998-12-17 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6211245B1 (en) 1993-02-08 2001-04-03 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6750244B2 (en) 1993-02-08 2004-06-15 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en) 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6211245B1 (en) 1993-02-08 2001-04-03 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6750244B2 (en) 1993-02-08 2004-06-15 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7268166B2 (en) 1993-02-08 2007-09-11 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en) 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
WO1998056752A1 (en) * 1997-06-11 1998-12-17 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases

Also Published As

Publication number Publication date
DE1568104A1 (en) 1970-03-26
DE1568104B2 (en) 1973-06-07
NL6703341A (en) 1967-10-10
DE1568104C3 (en) 1974-02-14
GB1129209A (en) 1968-10-02
AT269883B (en) 1969-04-10

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