GB924252A - 16ª -methyl-allopregnanes substituted in the 21-position and process for their manufacture - Google Patents
16ª -methyl-allopregnanes substituted in the 21-position and process for their manufactureInfo
- Publication number
- GB924252A GB924252A GB2298459A GB2298459A GB924252A GB 924252 A GB924252 A GB 924252A GB 2298459 A GB2298459 A GB 2298459A GB 2298459 A GB2298459 A GB 2298459A GB 924252 A GB924252 A GB 924252A
- Authority
- GB
- United Kingdom
- Prior art keywords
- free
- hydroxyl group
- methyl
- manufacture
- allopregnane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises a compound of the formula: <FORM:0924252/IV(a)/1> in which R1 and R2 each represent an oxo group, or a hydrogen atom together with a free or esterified hydroxyl group, and R3 represents a bromine atom or a free or esterified hydroxyl group and a process for the manufacture of a 16a -methyl-21-acyloxy-allopregnane-17a -ol-3,20-dione by brominating a 21-unsubstituted-16a -methyl-allopregnane-3b ,17a -diol-20-one in an alcohol-containing solvent to which a lower aliphatic acyl halide has been added, reacting the resulting 21-bromide with an alkali metal salt of a lower fatty acid, oxidising the free 3b -hydroxyl group without isolating the intermediate product and if desired esterifying a free 11a -hydroxyl group that may be present. The bromination may be effected, for example in chloroform containing an alcohol to which acetyl chloride has been added. Specifications 924,251 and 924,254 are referred to.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH6138258 | 1958-07-04 | ||
CH6771058A CH382735A (en) | 1958-12-24 | 1958-12-24 | Process for the preparation of 16a-methyl-17a-hydroxy compounds of the allopregnan series |
CH7132759A CH401961A (en) | 1959-03-26 | 1959-03-26 | Process for the preparation of 16a-methyl-allopregnan-17a, 21-diol-3,20-diones esterified in the 21-position |
Publications (1)
Publication Number | Publication Date |
---|---|
GB924252A true GB924252A (en) | 1963-04-24 |
Family
ID=27178492
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2298459A Expired GB924252A (en) | 1958-07-04 | 1959-07-03 | 16ª -methyl-allopregnanes substituted in the 21-position and process for their manufacture |
GB2298359A Expired GB924251A (en) | 1958-07-04 | 1959-07-03 | 16ªÍ-methyl-17ªÍ-hydroxy-compounds of the allopregnane series and process for their manufacture |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2298359A Expired GB924251A (en) | 1958-07-04 | 1959-07-03 | 16ªÍ-methyl-17ªÍ-hydroxy-compounds of the allopregnane series and process for their manufacture |
Country Status (1)
Country | Link |
---|---|
GB (2) | GB924252A (en) |
-
1959
- 1959-07-03 GB GB2298459A patent/GB924252A/en not_active Expired
- 1959-07-03 GB GB2298359A patent/GB924251A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB924251A (en) | 1963-04-24 |
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