GB903808A - New steroid compounds and processes for their preparation - Google Patents
New steroid compounds and processes for their preparationInfo
- Publication number
- GB903808A GB903808A GB137661A GB137661A GB903808A GB 903808 A GB903808 A GB 903808A GB 137661 A GB137661 A GB 137661A GB 137661 A GB137661 A GB 137661A GB 903808 A GB903808 A GB 903808A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- pregnan
- processes
- acyloxy
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises the 11,18-lactones of 11b - hydroxy - 16a -methyl-5b -pregnan-18b -oic acid of the formula: <FORM:0903808/IV (b)/1> where R represents a hydrogen atom or an acyl radical and processes for the preparation thereof in which a 3a -acyloxy-16a -methyl-5b -pregna-11,20-dione is reduced to give 3a -acyloxy - 16a - methyl - 20-hydroxy-5b -pregnan-11-one, which is reacted with lead tetracetate to yield a 3a -acyloxy-16a -methyl-18,20-epoxy-5b -pregnan-11-one and this latter compound is oxidised and saponified to yield 3a ,20-dihydroxy-16a -methyl-18,20-epoxy - 5b - pregna-11,18-dione which is then reduced and treated with acid to form the 11,18-lactone of 3a , 11b , 20b -trihydroxy-16a -methyl - 5b - pregnan - 18b -oic acid. The latter compound may be esterified to obtain the corresponding 11,18-lactone of 3a ,20b - diacyloxy-11b -hydroxy-16a -methyl-5b -pregnan-18b -oic acid. The reductive steps may be effected with lithium aluminium hydride and the oxidation step with chromic acid.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR815786A FR1254574A (en) | 1960-01-15 | 1960-01-15 | New 18-oxygenated steroids and method of preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB903808A true GB903808A (en) | 1962-08-22 |
Family
ID=8723870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB137661A Expired GB903808A (en) | 1960-01-15 | 1961-01-12 | New steroid compounds and processes for their preparation |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE599083A (en) |
CH (1) | CH394190A (en) |
FR (1) | FR1254574A (en) |
GB (1) | GB903808A (en) |
-
1960
- 1960-01-15 FR FR815786A patent/FR1254574A/en not_active Expired
-
1961
- 1961-01-12 GB GB137661A patent/GB903808A/en not_active Expired
- 1961-01-12 CH CH38061A patent/CH394190A/en unknown
- 1961-01-13 BE BE599083A patent/BE599083A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FR1254574A (en) | 1961-02-24 |
CH394190A (en) | 1965-06-30 |
BE599083A (en) | 1961-07-13 |
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